Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2753

Full Length Research Paper

Effect of neutral mutation on HIV-1 drug resistance in highly active antiretroviral therapy

Guangyu HUANG1, Min CHEN2 and Kaifa WANG3*
1Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, 400038, P R China. 2Medical English Department, College of Basic Medical Sciences, Third Military Medical University, Chongqing, 400038, P R China. 3Department of Medical Device and Equipment, School of Biomedical Engineering and Medical Imaging, Third Military Medical University, Chongqing, 400038, P R China.
Email: [email protected]

  •  Accepted: 08 November 2011
  •  Published: 09 December 2011

Abstract

Human immunodeficiency virus 1 (HIV-1) drug resistance is a grave problem in highly active antiretroviral therapy (HAART) and neutral mutation is an important factor in the evolution of HIV-1. We consider the process of HIV-1 quasispecies transition in HAART to be transformation among three viral phenotypes: wild-type HIV-1, neutral-type HIV-1 and resistant-type HIV-1. A new model is proposed to study the transition dynamics of resistant-type HIV-1 induced by neutral mutation. The colonized time, the stable time and the stable size of the resistant species are simulated with the model. The results indicate that neutral mutation is closely related to the colonized pattern of resistant-type HIV-1 quasispecies which may lead to important strategies for predicting or checking HIV-1 drug resistance.

 

Key words: Human immunodeficiency virus -1, neutral mutation, drug resistance, highly active antiretroviral therapy, stability delay, stability.