Immunomodulatory effects the aqueous extract of Strychnos camptoneura (Loganiaceae) leaves in Swiss mice
December 2022
Strychnos camptoneura (Loganiaceae) is used in Congolese traditional medicine to treat various diseases such as malaria and diabetes, but not much is known about its effects on the immune system. Therefore, the purpose of this study was to investigate the immunomodulatory properties of S. camptoneura leaves. Mice were treated with the aqueous extract of S. camptoneura leaves (100 and 200 mg/kg); those administered with...
Effect of haemolysis, icterus and lipemia on prothrombin time (PT), activated partial thromboplastin time (aPTT) and fibrinogen measured using Sysmex CA50 Hemostasis Analyzer
February 2020
Plasma prothrombin time (PPT) and activated partial thromboplastin time (aPTT) are coagulation tests routinely performed in laboratories to evaluate the function of the coagulation system. Generally, samples with haemolysis, icterus and lipaemia are rejected in different laboratories which delays medical care and cause discomfort to patients. This was a cross sectional study conducted to determine the effect of...
Immunopathological effects of some Biomphalaria pfeifferi proteins against Schistosoma mansoni infection in BALB/c mice
April 2019
Intestinal schistosomiasis remains a major cause of morbidity and mortality in most parts of the world, despite decades of widespread chemotherapy use. The present study determined the intermediate host proteins expressing the immunogenic properties against the parasite by determining the efficacy. Digestive gland and foot parts were isolated by dissection from the Biomphalaria pfeifferi, processed and the concentration...
The heterogeneity and distribution patterns of ABO and RH D phenotypes in the voluntary blood donors of Kenya
October 2017
Blood groups (antigens) are proteins, glycoproteins or glycolipids inherited surface markers on the red blood cell membranes, which determine the blood phenotypes of human beings. There are 36 blood group systems with over 300 antigens. Among them, ABO and Rh are of clinical significance. For a safe transfusion, a blood donor and recipient should be ABO and Rh D compatible. The heterogeneity of ABO and RhD blood...
Interferon-gamma (IFN-γ) and Interleukin-2 (IL2) as immunological markers in pulmonary tuberculosis
July 2016
Early diagnosis and treatment are important in prevention of tuberculosis (TB) infection. World commonly diagnose pulmonary TB using ZN stain, culture and TST. These tests are either low sensitive or required a long time. Recently intracellular interferon gamma flow cytometry assay has been available for diagnosis of pulmonary TB. We assess this diagnostic method in the diagnosis of pulmonary TB with special concern on...
Blood tissue cytological status of prognosis and predictive markers in the natural history of solid cancer development
June 2015
Cancer is the major burden of disease worldwide. Each year, tens of millions of people are diagnosed with cancer around the world, and more than half of the patients eventually die from it. In many countries, cancer ranks the second most common cause of death following cardiovascular diseases. With significant improvement in treatment and prevention of cardiovascular diseases, cancer has or will soon become the number...
Sharing information and internet resources of immunological interest
April 2013
Human genome project produce vast quantities of data with new sequences being added to Deoxy ribonucleic acid (DNA) databases on an average of once a minute. It is expected that over 1,000 genome will be sequenced within the next 5 to 10 years. Internet access has turned into an important part of any biological study. The extensive range of information available on the internet can save individual researcher time and...
Cytokine levels associated with experimental malaria pathology during Plasmodium berghei ANKA infection in a mouse model
April 2013
Successful recovery from malaria involves striking a balance between counteracting cytokines. The cytokine imbalance contributes to pathological features, but their exact levels have not been elucidated. This study aimed at investigating the role played by circulating cytokines in pathophysiology of cerebral malaria using experimental cerebral malaria (ECM) model by profiling four serum cytokines using cytometric bead...
The antibiogram and role of antibody in prophylaxis of albino rats against diarrhoea caused by Escherichia coli O157:H7
November 2012
The antibiogram and role of antibody in prophylaxis to Escherichia coli O157:H7 infection in albino rats was investigated in this study. 500 stool samples were collected from apparently healthy individuals, out of which 80 were positive for the organism. The sensitivity patterns of the isolate to conventional antibiotics were investigated. Moreover, the role of antibodies to actively or passively protect...
Allergen-specific immunoglobulin E (IgE) antibodies and skin test reactivity in patients with asthma in Nigeria
November 2012
Studies have shown that allergens are important sensitizing agents in asthma, but the study on prevalence of allergy markers in Nigerian asthmatic patients is scarce. Also, no study on serum concentration of allergen specific immunoglobulin E (IgE) in Nigerian was encountered. This study was therefore designed to investigate this dearth of knowledge. Serum samples of eighty adult asthmatic patients recruited for this...
Determination of effective praziquantel dose in different mouse strains: BALB/c and Swiss mice in treatment of Schistosoma mansoni
March 2012
Schistosomiasis is a parasitic disease, second to malaria, affecting human’s tropics and sub-tropics. The disease condition varies in severity depending on parasite species and strain, organ system infected, geographical region, genetic constitution of the individual and nutritional status. The drug praziquantel has been the choice of drug for the treatment of schistosomisias; however, the effective dose, 450...
Job’s syndrome: A rare presentation of pulmonary Koch’s with multiple splenic abscess
March 2012
Job’s syndrome is an immunodeficiency disorder with defect in leukocyte chemotaxis in some patients. It is also called hyper IgE recurrent infection syndrome. Major manifestations are pruritic dermatitis, recurrent Staphylococcal pneumonias, mucocutaneous candidiasis, restrictive lung disease, scoliosis with other various features. A 20 year old boy who was presented to us with heart failure, abdominal pain and...
Differentiation of stem and progenitor cells in activated immune cells with anti-malignant properties
January 2012
Studies on the biology of immune cells are mainly focused on their role as immune activators and modulators. In their appropriate cultivation and/or modifications, they have shown abilities for an enhanced expression of specific effective molecules. These properties have characterized them as promising candidates for construction of novel safe vaccines and gene-engineering products on their basis. In this aspect, in the...
Determining the correlation between the scar size of Bacille Calmette-Guérin (BCG) vaccination and suffering from asthma in children, by assessing the level of T helper 1 / T helper 2
January 2012
The Bacille Calmette-Guérin (BCG) vaccine is used more than any other vaccines in the world, whereas a lot of studies have spoken about allergy and its relationship with the BCG vaccine. It is believed that many factors can influence this relationship and its symptoms, can be observed via the occurred scar following BCG vaccination. The aim of this study was to determine the relationship between the levels...
Effect of measles infection on cellular immunity in tuberculosis patients
August 2011
This study was applied on 60 TB patients admitted in the Babylon Center of Tuberculosis and Chest Diseases in Hilla, Iraq. TB patients consisted of 38 males and 22 females with 40 healthy individuals as control group. Blood samples were collected from patients and control group to estimate phagocytic index, interferon gamma (IFN-γ), and anti-measles IgG level. The level of anti-measles IgG showed a significant...
Epidermal cyst of the bony external auditory canal in adult
August 2011
The objective of the study is to present a rare case of epidermal cyst of the bony external auditory canal in adult. Epidermal cyst of the bony external auditory canal, though very rare, was kept in the list of differential diagnosis of a skin lined mass of the external auditory canal. A case report method and review of literature was used for the diagnosis. Epidermal cyst is very rare in the...
Autoantibodies against reactive oxygen species modified immunoglobulin G in patients with type 1 diabetes mellitus
January 2011
The role of hydroxyl radicals (.OH) damaged immunoglobulin G (IgG) in insulin dependent diabetes mellitus has been investigated. IgG was isolated from normal human serum and modified by hydroxyl radicals, generated by UV irradiation of hydrogen peroxide. .OH-induced modification on IgG has been studied by ultra-violet (UV) absorption spectroscopy, tryptophan/tyrosine fluorescence, circular dichrosim, SDS-PAGE and...
The effect of garlic (Allium sativum) on growth and immune responses of hybrid tilapia (Oreochromis niloticus x Oreochromis aureus)
January 2011
Garlic (Allium sativum) was incorporated into diets (0 (control group), 0.5 and 1 g/kg (test groups)) of juvenile hybrid tilapia, Oreochromis niloticus x O. aureus. The fish initial weight was 25.5 ± 1.0 g (mean ± SD) with no significant size difference among the treatments. Innate immune response responses were evaluated for 2 to 4 weeks. Total leucocyte count, respiratory burst,...
Propranolol effect on proliferation and vascular endothelial growth factor secretion in human immunocompetent cells
August 2010
Beta-blockers are widely used drugs in cardiovascular diseases. Propranolol is a non selective beta-adrenergic blocker extensively used in treatment of arrhythmias, hypertension and several other cardiac problems. The inhibitory effects of propranolol on tumor growth, inflammation and angiogenesis have been shown by many investigations. Peripheral blood mononuclear cells (PBMCs) play important role in...
Association of HLA-G 14bp insertion/deletion polymorphism with autoantibody production in patients with autoimmune rheumatic diseases
August 2010
HLA-G is a non-classical HLA-class Ib molecule and has multiple immunoregulatory properties. A 14bp insertion/deletion polymorphism in the HLA-G gene has been suggested to influence the expression of HLA-G and then to associate with certain pathological conditions, including autoimmune diseases. The aim of study was to evaluate the possible association of the HLA-G 14bp insertion (+14bp) and deletion (-14bp)...
Benign monoclonal gammopathy in a dog exhibiting a low antibody titer to Ehrlichia canis
April 2010
The occurrence of a remarkable benign g-monoclonal gammopathy in a 2.5-year-old intact male bichon frise dog, secondary to acute Ehrlichia canis infection, with no travel history outside of Ontario. Exceptionally high levels of serum IgG (104.0 g/L) as a result of benign monoclonal gammopathy were noted during the disease state that returned to normal subsequent to recovery. Treatment with doxycyline and...
Discoid lupus erythematosus: Description of 130 cases and review of their natural history and clinical course
April 2010
Discoid lupus erythematosus (DLE) is one of the most common forms of cutaneous lupus erythematosus (CLE). The purpose of this study was to evaluate the clinical manifestations, laboratory findings and the natural course of Thai patients with DLE, as well as the factors that may incline DLE patients to develop systemic lupus erythematosus (SLE). We retrospectively studied 130 patients with DLE between January 2002 and...
Survey of the feline AIDS prevalence in the Slovak Republic
November 2009
The authors have carried out an epizootiological and serological survey in the Slovak Republic aimed to the determination of the prevalence of Feline Immunodeficiency Virus (FIV) in autochthon domestic and stray cat populations. At the same time the prevalence of feline leukaemia and toxoplasmosis was also researched in the cat populations. One hundred and ninty eight cats of younger and older age categories were...
Evaluation of some medicinal plants used in traditional wound healing preparations for antibacterial property against some pathogenic bacteria
November 2009
A total of sixteen extracts of four plants (Acacia nilotica, Annona squamosa, Azadirachta indica, and Ocimum sanctum) used in traditional formulation in India were investigated for their antibacterial property. Different concentrations (0.5 – 10 mg/ml) of extracts (by the extraction in different organic solvents and water) of plant parts were tested for growth inhibitory activity against infection caused...
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