African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 5233

Full Length Research Paper

Disruption of negative regulators (SP_nsdA and SP_nsdB) in Streptomyces peucetius causes doxorubicin overproduction

Jun-Ho Cho
  • Jun-Ho Cho
  • Department of Pharmaceutical Engineering, SunMoon University, #100, Kalsan-ri, Tangjeong-myeon, Asansi, Chungnam 336-708, Korea
  • Google Scholar
Mi-Kyeong Kim
  • Mi-Kyeong Kim
  • Department of Pharmaceutical Engineering, SunMoon University, #100, Kalsan-ri, Tangjeong-myeon, Asansi, Chungnam 336-708, Korea
  • Google Scholar
Kyoung-Hee Kwon
  • Kyoung-Hee Kwon
  • Department of Health Administration, Baekseok Culture University, #393, Anseo-dong, Dongnam-gu, Cheonan-si, Chungnam 330-705, Korea
  • Google Scholar
Kisup Ahn
  • Kisup Ahn
  • Department of Health Administration, Baekseok Culture University, #393, Anseo-dong, Dongnam-gu, Cheonan-si, Chungnam 330-705, Korea
  • Google Scholar
Jong Hwa Jang
  • Jong Hwa Jang
  • Department of Dental Hygiene, Hanseo University, #46, Hanseo 1-ro, Haemi-myun, Seosan-si, Chungnam 356-706, Korea
  • Google Scholar
Joo-Ho Lee
  • Joo-Ho Lee
  • Department of Pharmaceutical Engineering, SunMoon University, #100, Kalsan-ri, Tangjeong-myeon, Asansi, Chungnam 336-708, Korea
  • Google Scholar
Tae-Jin Oh*
  • Tae-Jin Oh*
  • Department of Pharmaceutical Engineering, SunMoon University, #100, Kalsan-ri, Tangjeong-myeon, Asansi, Chungnam 336-708, Korea
  • Google Scholar


  •  Received: 12 May 2014
  •  Accepted: 28 November 2014
  •  Published: 17 December 2014

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Li W, Ying X, Guo Y, Yu Z, Zhou X (2006). Identification of a gene negatively affecting antibiotic production and morphological differentiation in Streptomyces coelicolor A3(2). J. Bacteriol. 188:8368-8375.
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Liu JM, Yang KQ (2006). Functional analyses of TcrA− a TPR containing regulatory protein in Streptomyces coelicolor A3(2). Acta. Microbiol. Sin. 46:33-37.

 
 

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Marchler-Bauer A, Anderson JB, DeWeese-Scott C, Fedorova ND, Geer LY (2003). CDD: a curated Entrez database of conserved domain alignments. Nucleic Acids Res. 31:383-387.
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Ryding NJ, Anderson TB, Champness WC (2002). Regulation of the Streptomyces coelicolor calcium-dependent antibiotic by absA, encoding a cluster-linked two-component system. J. Bacteriol. 184:794-805.
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Sola-Landa A, Moura RS, Martin JF (2003). The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc. Natl. Acad. Sci. 100:6133-6138.
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Thuy ML, Kharel MK, Lamichhane R, Lee HC, Suh JW, Liou K, Sohng JK (2005). Expression of 2-deoxy-scyllo-inosose synthase (kanA) from kanamycin gene cluster in Streptomyces lividans. Biotechnol. Lett. 27:465-470.
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Uguru GC, Stephens KE, Stead JA, Towle JE, Baumberg S (2005). Transcriptional activation of the pathway-specific regulator of the actinorhodin biosynthetic genes in Streptomyces coelicolor. Mol. Microbiol. 58:131-150.
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Wang XJ, Guo SL, Guo WQ, Xi D, Xiang WS (2009). Role of nsdA in negative regulation of antibiotic production and morphological differentiation in Streptomyces bingchengensis. J. Antibiot. (Tokyo) 62:309-313.
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Zhang L, Li WC, Zhao CH, Chater KF, Tao MF (2007). NsdB, a TPR-like-domain-containing protein negatively affecting production of antibiotics in Streptomyces coelicolor A3 (2). Acta. Microbiol. Sin. 47:849-854.