Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007

JMPR Articles in press

Article in Press

Evaluation of active phytochemical constituents responsible for the analgesic and anti-inflammatory property of Cassia singueana Del. rootbark

Cassia singueana (root bark) is used traditionally in northern Nigeria for the management of pain related and other ailments. This study was aimed to investigate the phytochemical constituents responsible for the therapeutics claims of analgesic and anti-inflammatory activities of Cassia singueana extracts in rats and mice. The plant material was obtained and identified. The fingerprint profile of the plant material was...

Author(s):Bulus Adzu, Michael Sunday Uko, Aliyu Usman, Ibrahim Toma, Samuel E Okhale, Samuel T Magili

Article in Press

EVALUATION OF THE IN VIVO ANTIPLASMODIAL ACTIVITY OF ETHANOL LEAF EXTRACT AND FRACTIONS OF JATROPHA GOSSYPIFOLIA IN PLASMODIUM BERGHEI INFECTED MICE

The study evaluates the in vivo antiplasmodial activity of ethanol leaf extract and fractions of Jatropha gossypifolia in Plasmodium berghei infected mice. Phytochemical, physicochemical analyses, median lethal dose (LD50), effects on biochemical parameter were evaluated and the schizonticidal effects during early and established infections were investigated. The extract (50-200mg/kg) was screened for antimalarial...

Author(s):S.O Bruce, F.A Onyegbule, O.L Onyealisi and P.C Okoye

Article in Press

Cytotoxicity of Selected Ethiopian Medicinal Plants Used in Traditional Breast Cancer Treatment against Breast-Derived Cell Lines

Traditional medicine is widely practiced in Ethiopia. Here, we investigate the toxicity of extracts of seven medicinal plants traditionally used to treat breast cancer in Ethiopia. These plants, Sideroxylon oxyacanthum, Zanthoxylum chalybeum, Clematis simensis, Clematis longicauda, Dovyalis abyssinica, Vernonia leopoldi, and Clerodendrum myricoides, were selected based on recommendations by traditional healers and on the...

Author(s):Nigatu Tuasha, Daniel Seifu, Endalamaw Gadisa , Beyene Petros,Stina Oredsson

Article in Press

Chemical composition and antimicrobial activity of essential oils from Aframomum citratum, Aframomum daniellii, Piper capense and Monodora myristica

The high cost of antibiotics and the increasing number of therapeutic failures of bacterial and fungal diseases call to find other alternative treatments. This study was initiated to evaluate the chemical composition and in vitro antimicrobial activity of essential oils from four Cameroonian spices and to determine the therapeutic effect of a cream based on essential oil from Aframomum citratum. Essential oils were...

Author(s):Jean-De-Dieu Tamokou, Sylvie Carolle Meffo Dongmo, Guy Sedar Singor Njateng, Pierre Tane , Jules-Roger Kuiate

Article in Press

Dominant lethal mutations in rats fed on the seed extract of Mucuna urens

Dominant lethal mutation assay (DLMA) was carried out on rats after being treated with graded doses of ethanol extract of the seeds of Mucuna urens. Male albino rats(Wister strain) were caged in four groups labeled, group I, group II, group III and group IV and treated with graded dosages of the ethanol extract of the seeds of M. urens ; 70mg/kg BW, 140mg/kg BW and 210mg/kg BW, respectively, for 14 days. The positive...

Author(s):Hannah Edim Etta

Article in Press

Antihistaminic action of melaleuca linariifolia ointment

Melaleuca oil has great medicinal properties. The objetic was to develop a product based on Melaleuca sp. and to evaluate its antihistaminic action. To compare the antihistaminic effect and the protective effect of the oil and ointment of Melaleuca linariifolia. Assess pruritus intensity at sensitization points. Eighty volunteers, aged between 21 and 60 years, both sexes, participated in the study, without...

Author(s):Adriana Rodrigues dos Anjos Mendonça, Kassandra Elfrida Pauliello, Marcos Mesquita Filho, Manoel Araújo Teixeira, Diba Maria Sebba Tosta Souza

Article in Press

Modulation of cytokines production by extracts of ginger (Zingiber officinale Rosc.) rhizome, callus and callus treated with some elicitors

This study evaluated the effect of ginger rhizome and its callus as well as callus elicited by yeast extract, glycine and salicylic acid on the production of pro-inflammatory (TNF-α, IL-1 and IL-6) and anti-inflammatory (IL-10 and TGF-β) cytokines in vitro. Petroleum ether (PE) and chloroform: methanol (1:1) (CM) extracts of rhizome and callus were shown to significantly (P < 0.05) suppress in a dose-dependent manner the...

Author(s):Ammar Mohammed Ahmed Ali Ali, Mawahib ElAmin Mohamed El-Nour El-Nour, Owais Mohammad Mohammad, Sakina Mohamed Yagi Yagi

Article in Press

A review Ginseng species in different regions as a multipurpose herb in Traditional Chinese medicine, modern herbology and pharmacological science

Ginseng is the most famous of the Chinese herbs throughout the world, and has been one of the most valued herb in China. Traditional Chinese Medicine as an important component of complementary and alternative medicine, evolved over thousands of years with its own unique system of theories, diagnostics and therapies in Asian countries, especially China. In most parts of the world, especially western countries, Ginseng has...

Author(s):Dr. Mohamad Hesam Shahrajabian, Dr. Wenli Sun, and Prof. Dr. Qi Cheng

Article in Press

Ethnobotanical Study of Selected Medicinal Plants used against Bacterial infections in Nandi conty, Kenya

Globally, medicinal plants have been used to treat different human ailments from time immemorial. In Kenya, various plants are used by local people in the treatment of various diseases.This is a common practice in Nandi county due to scarce health facilities in the region, traditional beliefs, cultural barriers and availability of medicinal plants. The objective of this study was to carry out an ethnobotanical survey to...

Author(s):Philip A. Ogutu, Charles Mutai

Article in Press

In vitro evaluation of fruit extracts of Annona stenophylla diels and Flacourtia indica for incorporation into formulations for management of cancer

There are many reports which show a positive relationship between free radical damage and diseases such as cancer. Free radicals formed when humans are exposed to ionizing radiation or during oxidation process in human beings can damage tissues and may potentially lead to development of cancers. Since radiation may be used in the management of cancer, there is need for the development of a radioprotective herbal medicine...

Author(s):COSMAS JOSIAH MUSEWU, RUDO FIONA MAPANGA

Article in Press

Evaluation of acute toxicity and sub-acute toxicity of the methanolic extract of Aloe rabaiensis Rendle in BALB/c mice

The present study was undertaken to evaluate preclinical acute and sub-acute toxicity of Aloe rabaiensis leaf methanolic extract (ARLME) on BALB/c mice following OECD guidelines 423 and 407 respectively. In an acute oral toxicity test, ARLME was administered to the mice by oral gavage at a single dose of 1000, 2000, 3000, 4000, 5000 mg/Kg body weight. Mice were observed for toxic signs for 14 days. In sub-acute oral...

Author(s):MWANAISHA MKANGARA, ERNEST MBEGA, MUSA CHACHA

Article in Press

Assessment of Total Content of Secondary Metabolites, In Vitro Free Radical Scavenging Potential and peroxide value on Different Solvent Extracts of Rumex abyssinicus Jacq. Root

Medicinal plants have bioactive compounds which are used for curing of various human diseases and also play an important role in healing. Phytochemicals have two categories. These are primary and secondary constituents. Primary constituents have chlorophyll, proteins sugar and amino acids. Secondary constituents contains like terpenoids, flavonoids, saponins, tannins, alkaloids, glycosides and phenols. Secondary...

Author(s):Limenew Abate

Article in Press

Ethnobotanical survey and phytogeographical study of plants species from genus Acacia (Fabaceae) in Benin

The genus acacia, mainly distributed in the tropical and subtropical regions, has been used in traditional medicines for the treatment of microbial infections, malaria, diarrhea, oedema and inflammation. The present study aims to provide a comprehensive data on the distribution and medicinal use of acacia species. Ethnobotanical survey and phytogeographical study were undertook using field interviews. Informant Consensus...

Author(s):Mounirou Tchatchedre, Abdou Madjid Amoussa, Marcel Houinato, Hounnankpon Yedomonhan, Latifou Lagnika

Article in Press

Phenolic Profile from The Leaves Extracts of Annona Muricata L: Their Effect Antioxidant and Antiviral

Soursop (Annona muricata L.) is a perennial tree whose leaves have been used in traditional medicine. To assess the biological properties of Annona muricata L leaves characterizing phenolic compounds by Ultra Performance Liquid Chromatography (UPLC), evaluating their antioxidant effects on human erythrocytes and antiviral effectiveness by using enteric virus surrogates. The phenolics compounds were estimated using UPLC...

Author(s):SILVA BELTRÁN NORMA PATRICIA, BALDERRAMA CARMONA ANA PAOLA, RUÍZ CRUZ SAÚL, CHAIDEZ QUIROZ CRISTÓBAL, LÓPEZ MATA MARCO ANTONIO, NÚÑEZ GASTELÚM JOSÉ A

Article in Press

Antibacterial and Antioxidant Compounds from the Tubers Extracts of Plectranthus edulis

P. edulis is an indigenous plant which has been cultivated for its edible tuber. It is claimed to have antibacterial activity. But this was not supported by scientific investigation. Hence this work explores the antibacterial and antioxidant activities of extracts and isolated compounds from the tuber of P. edulis. The effects of the extracts and isolated compounds of tubers of P. edulis were evaluated against S. aureus,...

Author(s):Yadessa Melaku, Tolessa Duguma

Article in Press

Ethno botanical study of medicinal plants used to treat human disease in and around Ambo town, Western Ethiopia a

Ethiopia has numerous plants that can be used as sources of medicine for those who cannot access modern health care. This study was conducted to document the indigenous knowledge and medicinal plants in and around Ambo town. The study was carried out from April to August 2018. A total of 49 participants were selected randomly from the representative kebeles. Twenty two medicinal plants were collected and documented based...

Author(s):Tilahun Tolossa, Adelegn Bogale

Article in Press

Antibacterial, cytotoxic and antioxidant activities of Boscia Senegalensis and Tapinanthus dodoneifolius

Boscia senegalensis and Tapinanthus dodoneifolius are two plants mostly used by herders to treat animal diseases in the Far North Region of Cameroon. To evaluate the in vitro antibacterial, cytotoxic and antioxidant potentials of these plants. To achieve this, five extracts (water, methanol, chloroform and hexane) of both plants obtained by successive fractionation were used. Antibacterial activities of the different...

Author(s):Ronald Romuald B. Vougat Ngom, Ziebe Roland, Rebecca B. Garabed, Foyet Harquin Simplice

Article in Press

ETHNO-MEDICINAL STUDY OF PLANTS USED FOR TREATMENT OF HUMAN AND LIVESTOCK AILMENTS BY TRADITIONAL HEALERS IN GOBA WOREDA, BALE ZONE, OROMIA, ETHIOPIA

ABSTRACT The investigation of traditional medicinal plants was performed in Bale district from August to October 2018 in three kebeles Kedu, Elasa and Aloshe Tilo. In the study area diverse medicinal plant were used to treat many human and livestock disease. The data were collected from the informants through semi-structured interview, discussion and collected plant samples from the study areas that were used to treat...

Author(s):HABTAMU TEDILA MENGISTU

Article in Press

Chemical Fingerprint of Bacopa monnieri L. and Rosmarinus officinalis L. and their Neuroprotective Activity Against Alzheimer's disease in Rat Model is Putatively Modulated Via Cholinergic and Monoaminergic Pathways

Background: Alzheimer’s disease is characterized by progressive degeneration of cortical and hippocampal neurons Objective: To characterize the metabolic profiles of the hydro-ethanolic extracts of Bacopa monnieri L. (BM) and Rosmarinus officinalis L. (RO) cultivated in Egypt via UPLC–ESI/MS analyses and reveal their possible mechanism of the prophylactic effect(s) on neuro-degeneration in rat model of Alzheimer’s...

Author(s):Nora Aborehab, Nermein Waly and Mahitab El-Bishbishy

Article in Press

Acute and Sub-acute toxicity studies of the ethanolic stem and root extract of Aristolochia ringens (vahl) and Securidaca longepedunculata fresens in rats.

Aristolochia ringens (Vahl) and Securidaca longepedunculata Fresens are used in traditional African medicine for the treatment of arthritis, diarrhoea, asthma, snakebites and skin rashes. This present study examines the acute and sub-acute toxicity effects of these plants in rats. The animals (5 per group) were treated daily with the extract at doses of 100, 250, 500 mg/kg orally for 28 days. Control group received...

Author(s):Adedotun Adekunle and Adewale Lawal

Article in Press

Large cardamom (A. subulatum Roxb) is perhaps among the oldest spices to be known for mankind which is one livelihood option for mountain inhabitants

Large cardamom (Amomum. subulatum Roxb) commonly known as a badi elaichi, is a tall, perennial, evergreen, herbaceous monocot plant. Large cardamom is well known spice, which has medicinal value. The present study has been designed to explore the base line morphological characteristics, chemo-profile, to raise superior quality planting materials through micro propagation and large cardamom farming as an appropriate...

Author(s): ARVIND K BHANDARI

Article in Press

An Ethnobotanical Study of Traditionally Used Medicinal Plants for Treatment of Human Diseases in Goba District of Bale Zone, Southeast Ethiopia

An ethnobotanical study of traditionally used medicinal plants to trat human disease was conducted in Goba District of Bale Zone, Ethiopia. Information was gathered from 60 informants using semi-structured interview. For data collection the site and the informants were selected purposivelly. During the study, a total of 42 medicinal plant speceis belonging to 24 families were recorded. The family Euphorbiaceae has four...

Author(s):SEBSIBE AYALEW

Article in Press

Effect of dosage of methanol and omidun extracts of root of V. paradoxa on hematological parameters of diarrhea-induced Albino rats

Investigation was carried out on the effects of 50mg/mL and 100mg/mL concentration of methanol and omidun extracts of root of V. paradoxa on hematological parameters of diarrhea induced albino rats. A total of 5 test organisms ((Shigella dysenteriae, Salmonella typhi, Escherichia coli ATCC 25922,Enteropathogenic Escherichia coli ‘EPEC ATCC 43887’, Enterohemorrhagic Escherichia coli ‘EHEC ATCC 43889’) associated with...

Author(s):Falana M. B

Article in Press

Effects of aqueous mango leaf (Magnifera indica) on alloxan-induced diabetes in albino rats “Rattus rattus”

Studies on the medicinal (hypoglycemic) potential of Magnifera indica (M. indica) have been documented. However, little may still be known about the dose level and the effects it may have on haematocrit, liver enzymes and body weight of a diabetic individual. The present study was designed to investigate the hypoglycemic effect of aqueous M. indica leaves extract on alloxan-induced diabetes in albino rats Rattus rattus....

Author(s):Andong

Article in Press

The Effect of Chloroform Extract of Chasmenthera dependens Roots on some Liver marker enzymes on Carbon Tetrachloride (Ccl4) Induced Hepatotoxicity in Wistar Albino Rats.

This study evaluated the phytoconstituents of the chloroform extract of Chasmenthera dependens (C. dependens) roots and the effect of the extract on the liver serum/homogenate enzyme activities of carbon Tetrachloride Induced hepatoxicity in Wistar Albino Rats. Twenty-four (24) female albino rats were used for this study and were divided into groups of four rats each: Groups I rats were normal control. Hepatotoxicity was...

Author(s):CHIOMA ASSUMPTA ANOSIKE, JUSTUS NMADUKA NWACHUKWU, CHINEDU SAMUEL OGBOZOR, CHIDI AUGUSTINE MADUEKEU

Article in Press

A Review of the Ethnomedicinal uses of pteridophytes for treating various human ailments in India

Pteridophytes present significant evolutionary innovations such as development of true conducting system with xylem and phloem and dominant saprophytic phase. Pteridophytes are frequently used as ornamental plants because of the green long lasting large foliage and sturdy plant forms. They are being used as bio-indicators for pollution, phytoremediators, and some used as bio-fertilizers. During the invasion of land...

Author(s):Uniyal

Article in Press

Sub-chronic toxicity studies on the methanol stem bark extract of Uapaca togoensis (pax) in adult Wistar Rats

The stem bark and leaves of Uapaca togoensis has been used in traditional medicine to treat fever, epilepsy, rheumatism, vomiting and fatigue. The present study was designed to evaluate the acute and sub-chronic toxicity profile of the methanol stem bark extract of Uapaca togoensis as there are no reported toxicological studies on the plant. Preliminary phytochemical screening revealed the presence of alkaloids, steroids,...

Author(s):AMINA BUSOLA OLORUKOOBA, BEN AHMED CHINDO and JANE I EJIOFOR

Article in Press

Quantification of bioactive compounds in Leucas biflora through high performance liquid chromatography

L. biflora (Vahl) R. Br. is ethnobotanically considered as cancer plant. It is arare medicinal plant. It is applied for the treatment of conjunctivitis, nasal bleeding, white discharge etc. For the medicinal property identification and quantitation of the bioactive compounds in this plant not been reported previously. Therefore, high performance liquid chromatography fingerprinting profile has been reported till date....

Author(s):Pal

Article in Press

Ethno-Botanical Study on the use and knowledge of medicinal plants at three kebeles of Fedis district of Oromiya regional state; adjacent to the Babile Elephant Sanctuary, Eastern Ethiopia.

This study was carried out to collect and document indigenous knowledge on medicinal plants among the traditional healers of Fedis district of Oromiya regional state, East Ethiopia. The ethnobotanical data were collected from 36 traditional healers (24 male and 12 female) using semi-structured questionnaire, observation and guided field walks. The survey identified 64 medicinal plants distributed into 39 families and 59...

Author(s):AMBERBIR ABEBE

Article in Press

Determination of the total phenolic content and spectral study of the herbal drug, Chromolona odorata Linn by spectrophotometric method

Chromolaena odorata is a medicinal plant that is widely used in folk medicine many Nigerian communities for treatment of several ailments and diseases. In particular, local formulations of the herbal plant are used to treat wounds, burns and skin infections. The plant extracts have also shown anticancer, antidiabetic, hepaprotective, anti-inflammatory, antimicrobial and antioxidant properties. The aim of the study was to...

Author(s):Nworie

Article in Press

Evaluation of the wound healing properties of methanolic bark extract of Samadera indica Gaertner in vivo

In the present study, bark samples of Samadera indica were collected, allowed to shade dry for a week, then coarsely powdered and was extracted with methanol by soxhlation process. The extract was used for wound healing experiment. In the wound healing study using excision wound model, 18 healthy Albino rats of four each with average body weight of 150-200 g was selected randomly for the study, which will be divided into...

Author(s):Rama Bhat, P.

Article in Press

OPTIMIZATION OF EXTRACTION, CHEMICAL CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF ESSENTIAL OIL FROM BLACK CUMIN ( NIGELLA SATIVA L.) SEEDS BY USING CLEVENGER DISTILLATION

Essential oils are secondary metabolities that are highly concentrated substances extracted from flowers, leaves, stems, roots, seeds, barks, resins, or fruit rinds. Essential oils have been recognized as some of the most promising compounds in the development of novel products particularly in the pharmaceutical, agricultural, food and perfumery industries. Black cumin (Nigella sativa L.) belonging to family Rannunculaceae...

Author(s):Demis

Article in Press

Antifungal efficacy of crude extracts of Azadirachta indica and Vernonia amygdalina against Pathogenic Aspergillus niger (ATCC 16404)

This research work was conducted to assess the potency of ethanolic and hot water extract of Azadirachta indica and Vernonia amygdalina against pathogenic Aspergillus niger (ATCC 16404). Potato Dextrose Agar was the medium under which the antimicrobial sensitivity test was carried out. Streptomycin solution was also added to the medium to selectively inhibit the growth of bacterial cell. The results showed that, higher...

Author(s):Ninkuu, V, Adetunde, L.A, Sackey I and Diedong P

Article in Press

An Evaluation of the antioxidant and antimicrobial activities of Allium ampeloprasum var Iranicum, Echinophora platyloba L and Pistacia atlantica kurdica

The main aims of this study have been finding out the antioxidant and antimicrobial activities and preliminary phytochemical screening of three traditional plants of Iran namely, Allium ampeloprasum var. iranicum, Echinophora platyloba L and Pistacia atlantica kurdica were studied. In this experimental study, the maceration technique was used to prepare alcoholic extract. The effect of extract was analyzed based on disk...

Author(s):Avin Aghemiri, Asrin Aghemiri and Alireza Massiha

Article in Press

Ethnomedicinal importance of Gandrayan (Angelica glauca Edgew.) in the North-Western Indian Himalayan Region

Gandrayan (Angelica glauca Edgew., Family Apiaceae) is a high value medicinal herb and it is native and endemic to the Indian Himalayan Region. Its aromatic roots are used as spice and beside this the industrial demand of its essential oil is increasing for modern herbal medicines and aromatherapy. The present study was carried out to document its ethno-medicinal importance among local inhabitants of three Indian Himalayan...

Author(s):J. S. Butola, R. K. Vashistha, C. P. Kuniyal, A. R. Malik, S. S. Koranga and M. S. Rawat

Article in Press

Antibacterial and antioxidant activities of different cultivars of Zingiber officinale Roscoe grown in Sikkim Himalaya

Antimicrobial and antioxidant properties of different solvent extracts of five cultivars of Zingiber officinale were investigated. Out of the test organisms, Staphylococcus aureus was found most susceptible to chloroform extract of majhauley cultivar (26±0.1mm), while there was no activity recorded against Escherichia coli. The highest total phenol and flavonoid contents were recorded in the chloroform extract of...

Author(s):Sushen Pradhan, Arvind Kumar Goyal , Shiva Kumar Sharma and Pratap J. Handique

Article in Press

An investigation on environmental factors affecting the distribution of medicinal plants in North East Iran

The objective of this research was to investigate the effect of environmental factors on distribution of medicinal plants in Chaharbagh rangelands in North East Iran. Sampling of vegetation was performed in quadrats positioned in the study area using a randomized-systematic method. Vegetation data including medicinal plants and their density were estimated quantitatively within each quadrat. The topographic conditions...

Author(s):Behmanesh, B , Heshmati, G. A. and Mahiny, A. S.

Article in Press

Antimicrobial potential of parasitic plant Cuscuta reflexa with Nerium oleander host plant successive extract against selected test microbes

Cuscuta reflexa is a parasitic plant having many medicinal properties and used as traditional medicine in Ayurveda for the treatment of various disorders. In the present research work, researchers have investigated antimicrobial ability of C. reflexa with Nerium oleander host plant successive extracts against selected human pathogenic bacteria. Escherichia coli (MTCC 730), Proteus vulgaris (MTCC 1771), Staphylococcus...

Author(s):Pooja Saini , Ekta Menghani and Rekha Mithal

Article in Press

Evaluation of the aqueous and methanolic fresh leaf extracts of Cnidoscolous aconitifolius for anxiolytic activity

Cnidoscolous aconitifolius promotes anxiolysis in humans. Fresh leaf extracts are claimed to possess greater anxiolytic activity as compared to dry leaf extracts. This study investigated the anxiety alleviating activity of two fresh leaf extracts {aqueous fresh leaf extract (AFLE) and methanolic fresh leaf extract (MFLE)} and a dry leaf extract {methanolic dry leaf extract (MFLE)} of C. acontifolius. Swiss albino mice...

Author(s):Adebiyi O. A. , Adebiyi O. O. and Adu T. S.

Article in Press

Antioxidant, DNA protective and antibacterial activities of Terminalia bellerica extracts

Terminalia bellerica Roxb., commonly known as Beleric myrobalan, is a well-known large deciduous tree with various pharmaceutical properties. However, scientific information on T. bellerica, growing in India, as regards to its phytochemical constituents and pharmacological properties is very limited. With this in view, this study investigated the antioxidant, DNA protective and antibacterial activities of different parts...

Author(s):Rasna Gupta and Ram Lakhan Singh

Article in Press

Effect of aqueous leaf extracts of Leptadenia hastata Pers (Decne) on spermiogram and testicular histology in albino rats (Wistar strain)

This study was designed to determine the effects of prolonged oral administration of aqueous leaf extract of Leptadenia hastata Pers (Decne) on sperm concentration, sperm motility and testicular histology in Wistar rats. Rats were given graded doses (200, 400, 600 and 800 mg kg-1) of aqueous leaf extract of L. hastata orally for 28 days. Weekly changes in sperm concentration and motility as well as testicular weight and...

Author(s):Victoria Adam Maina, Innocent Damudu Peter, Dauda Yahi, Umar Kyari Sandabe and Godwin Onyeamaechi Egwu

Article in Press

Isolation, characterization and biological activity of organic extractives from Calodendrum capense (L.f.) Thunb.(Rutaceae)

A novel prenylfuroquinoline alkaloid capensenin (1), an alkaloid confusameline (2), two furanocoumarins psolaren (3) and bergapten (4), were isolated from hexane and dichloromethane crude extracts of stem bark, leaves and fruit pericarp of Calodendrum capense. Limonin (5) was also isolated from the stem bark, while limonin diosphenol (6) was isolated from the seeds. Capensenin (1) showed weak antimicrobial activity against...

Author(s):Okwemba R. I., Tarus P. K., Machocho A. K., Wanyonyi A. W., Waweru, I. M., Onyancha J. M., Onani M. O. and Amuka O.

Article in Press

Comparative quantification of Baicalein and heavy metal in various aerial parts of Oroxylum indicum (L.) Kurz from Jharkhand and Uttrakhand states of India

Oroxylum indicum (L.) Kurz (Shyonak, Indian trumpet tree, Midnight horror) belongs to the family Bignoniaceae and has been used as a single drug or as a component of certain poly-herbal drug preparations in Indian Ayurvedic system of medicine. Oroxylum indicum is reported to contain flavonoids, namely, chrysin, oroxylin-A, scutellarin, and baicalein. Baicalein is reported to have anti-cancerous activity and inhibits...

Author(s):Swati Sinha, Tapan K Nailwal and Anupam Pandey

Article in Press

Pharmaceutical topical gel containing proanthocyanidin polymers-rich fraction from Stryphnodendron adstringens

The stem bark of Stryphnodendron adstringens, popularly known in Brazil as "barbatimão", has many biological activities, including antifungal activity. Considering the increasing interest of using "barbatimão" extract in the treatment of vaginal candidiasis, the aim of this study was to propose a pharmaceutical topical gel containing a proanthocyanidin polymers-rich fraction for use as a pharmacological agent in vaginal...

Author(s):Marco Antonio Costa, Andressa Blainski, Vanessa Kaplum, Marli Miriam de Souza Lima, Tânia Ueda-Nakamura, Benedito Prado Dias Filho, João Carlos Palazzo de Mello and Celso Vataru Nakamura

Article in Press

In vitro antiviral activity of Brazilian Cerrado plant extracts against animal and human herpesviruses

The Brazilian savanna known as “Cerrado” is very rich in medicinal plants that are used by the local population for treatment of several illnesses. The herpesvirus is a serious problem worldwide, and affects both animal and human health. This work aimed to study the antiviral activity of eight extracts from plants natives of “Cerrado” region against human (HSV-1), equine (EqHV-1) and swine herpesviruses (SuHV-1). The...

Author(s):Marina A. Padilla, Isabela C. Simoni, Verônica Moreira H. Hoe, Maria J. Bittencourt Fernandes, Clarice W. Arns, Juliana R. Brito and João Henrique G. Lago

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