African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2142

Table of Content: 15 October, 2012; 6(38)

October 2012

Induction of remifentanil by bradycardia and hypotension through distinct biochemical mechanisms

Remifentanil has been well known to cause much more significant bradycardia and hypotension as compared with other opioids. However, the underlying mechanism is still poorly understood. The present study hypothesized that remifentanil led to bradycardia and hypotension with distinct mechanisms and aimed to test this hypothesis. Testing the hypothesis would broaden our understanding the underlying mechanism of...

Author(s): Yong Yang, Qu-Lian Guo, Di Fu, Hui Wu and Ru-Ping Dai

October 2012

Drug-drug interactions in ageing HIV-infected individuals

The effectiveness of antiretroviral therapy has significantly improved life expectancy of HIV-infected individuals. Global campaigns and awareness programmes have led to substantial drop in the rate of new infections. Consequently, the proportion of ageing HIV-infected individuals continues to increase. HIV-associated and age-related comorbidity necessitates polypharmacy in ageing individuals living with HIV/AIDS. The...

Author(s): Pius S. Fasinu and Bernd Rosenkranz

October 2012

Effects of PEGylation on the Lowry method for the content determination of trichosanthin

The current study was designed to establish a method for examining whether the content of PEG-TCS could be determined by the Lowry method. The research applicability of the Lowry method on the determination of PEGylated trichosanthin (PEG-TCS) protein content was proposed for the first time. Procedures were designed to determine whether residual PEG interfered with the result of protein content determination, PEG...

Author(s): Yan Ping Li, Li Hu Zhang, Li Ying Jiang, Long Fu Rong, Xian Yu Du, and Li Hua Song,

October 2012

Effects of supplementing qi and activating blood circulation herbs on expressions of basic fibroblast growth factor and platelet endothelial cell adhesion molecule-1 in ischemic myocardium of rats with acute myocardial infarction

The objective of this study was to investigate the effects of supplementing qi and activating blood circulation herbs on the expressions of basic fibroblast growth factor (bFGF) and platelet endothelial cell adhesion molecule (PECAM-1) in ischemic myocardium of rats with acute myocardial infarction (AMI). Acute myocardial infarction (AMI control) of male Sprague-Dawley rats was established by ligating left anterior...

Author(s): Shuwen Guo, Chenglong Zheng, Peipei Huang, Lu Zhang, Panchu Yang, Jiufeng Zhang, Jianyu Zhou, Kun Huang, Dandan Yang and Qin Sun

October 2012

Expression and significance of glyceraldehyde-3-phosphate dehydrogenase in patients with osteosarcoma

To observe the expression of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in patients with osteosarcoma and its relationship with surgical stage, 60 patients with osteosarcoma, including 20 cases in Stage I, 17 cases in Stage II and 23 cases in Stage III were sequentially enrolled in this study. The expression of GAPDH in osteosarcoma and osteochondroma tissues on mRNA and protein levels were measured by fluorescent...

Author(s): Dan Fei, Hejia Zhang, Zhongli Gao, Dan Jiao, Guoqing Sui and Kaijun Zhao

October 2012

Up-regulation of heme oxygenase-1 by sevoflurane attenuates LPS-induced acute lung injury in a rat model

To investigate heme oxygenase-1(HO-1) expression induced by sevoflurane in lipopolysaccharide (LPS)-induced acute lung injury (ALI). Forty-eight rats were randomly designated into six groups to receive normal saline (NS), ZnPPIX(a specific HO-1 inhibitor), or sevoflurane: A (control, NS only), B (ZnPPIX only), C (sevoflurane only), D (LPS + 1.0 minimum alveolar concentration (MAC) sevoflurane), E (ZnPPIX...

Author(s): Zhao Shuangping, Wu Jiao, Zhang Zhong and  Ai  Yuhuang

October 2012

Acupuncture effect on the magnetic resonance imaging (MRI) test for mild cognitive impairment leukoaraiosis

Vascular cognitive impairment refers to the risk factors derived from blood vessels caused by a variety of levels and types of cognitive impairment, such as vascular mild cognitive impairment, vascular dementia and mixed dementia. Using acupuncture for mild cognitive impairment leukoaraiosis has impacts on the functional magnetic resonance. To know the neurotransmitter changes before and after acupuncture intervention...

Author(s): Xiaobin Hou, Mingqi Wang, Yunling Zhang and Jingwei Liu