April 2012
Down-regulation of ghrelin receptors in the stomach delays gastric emptying in vagotomized rats
Ghrelin promotes gastric emptying and small intestinal transit when injected through central or peripheral channels in experimental animals. When the vagal nerve is cut off, the central effect of ghrelin is abolished, the peripheral effect is still observed. Furthermore, the function of ghrelin receptor expressing nerve cells in gastric muscle layers is affected. Expressional changes in ghrelin receptors may affect the...
April 2012
Characterization and antioxidant activity of the complex of sesamol and hydroxypropyl-β-cyclodextrin
Sesamol is a natural antioxidant with good prospect in food and medicine industry. But its poor water solubility limits its application. In this study, the complex of sesamol and HP-β-CD was prepared to improve the water solubility of sesamol. The physicochemical properties of the complex were investigated by ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), differential scanning calorimetry (DSC)...
April 2012
Association of vitamin D receptor gene polymorphism in Han people with lumbar degenerative disc disease
Vitamin D receptor (VDR) gene polymorphism has a certain relationship in Han people with lumbar degenerative disc disease (LDDD), however, this relationship has not been definitely analyzed so far, thus, the purpose of this study is to analyze the polymorphism of three VDR gene loci and reflect the correlation between VDR gene polymorphism and lumbar degenerative disc disease in Han people. In this study, we collected...
April 2012
Comparison of antimicrobial effect of sodium hypochlorite (5.25%) and Iranian propolis on bacteria isolated from necrotizing single canal tooth with chronic apical periodontitis
The main goal of endodontic therapy is to reverse the process of periapical periodontics by removing such microorganisms from the root canal. Sodium hypochlorite (NaOCl) as common endodontic irrigant, possess problems of toxicity, odor and discoloration of operatory items. An equally effective, but safe irrigant is desirable. The purpose of this study was to compare the anti-microbial activity of propolis with that...
April 2012
No association of rs2501431 polymorphism of cannabinoid receptor 2 gene with bone mineral density in Chinese postmenopausal women
The aim of the study is to investigate the association of polymorphism of cannabinoid receptor 2 (CNR2) gene at site rs2501431 with bone mineral density (BMD) in Chinese postmenopausal women. 490 Chinese Han postmenopausal women were randomly enrolled and their BMD were measured by dual-energy X-ray absorptiometry (DEXA) at total body, lumbar spine (L2-L4), femoral neck and trochanter. Genotypes for the CNR2 rs2501431...
April 2012
Proteomic analysis of fluconazole resistance in Candida albicans
The pattern of azoles resistance-related proteins expression in Candida albicans may clarify the mechanism of drug resistance and identify new targets for treatment of Candida infection. We identified proteins differentially expressed in strains between fluconazole-sensitive (CA-3) and resistant (CA-16) C. albicans. Both strains were from the same parent. Proteins were analyzed using...
April 2012
The effects of tongdujianbu particle treatment on matrix metallopeptidase 9 (MMP-9), tissue inhibitor of metalloproteinase (TIMP)-1, and transformation growth factor (TGF)-β1 expression in a rat model of spinal core injury
This work investigated the effect of tongdujianbu particle (TP) on the expression patterns ofmatrix metallopeptidase 9 (MMP-9), tissue inhibitor of metalloproteinase (TIMP)-1 and transformation growth factor (TGF)-β1 and the behavioural changes in a rat model of spinal cord injured (SCI). A total of 105 adult Sprague-Dawley rats were used for the spinal cord injury as well as different groups of TP treatments. The...
April 2012
A calpain inhibitor elevated expressions of NF-κB in atrial fibrillation canine atria
This aim of this study is to observe the alterations of calpain proteolytic system and effect of a calpain I inhibitor on NF-κB expressions in rapid pacing canine atrial fibrillation (AF) models. Twenty-one dogs were divided equally into three groups: a sham operation group, a control AF group and a calpain inhibitor group. Rapid right atrium pacing at 600 beats per min was applied in the control AF group and the...
April 2012
Dual immuno-regulatory effects of Y-40138 in animal models of sepsis and aspiration pneumonitis
We evaluated the dual immuno-regulatory effects of Y-40138, inhibiting tumor necrosis factor (TNF)-α production and augmenting interleukin (IL)-10 productions, in animal models of organ dysfunction related to systemic inflammatory response syndrome. Male Sprague-Dawley rats received Y-40138 (1, 10 and 30 mg/kg) or saline subcutaneously, and were subjected to cecal ligation and puncture (CLP) surgery 15 min later....
April 2012
Study on the ethnopharmaceutical values and traditional uses of Capparis spinosa L.
This paper highlights the ethno-pharmaceutical importance of Capparis spinosa L. (Capparidaceae) used by many local people of district Chitral since century under the traditional system of medicine. In this context, a survey was conducted during summer 2010 in different ecologically and economically important sites of the study area. The aims, the current endeavour was to prepare an ethno-pharmaceutical...
April 2012
Constituents of the Essential Oil from Leaves and Buds of clove (Syzigium caryophyllatum (L.) Alston)
Essential oil obtained by hydrodistillation from fresh leaves and dry buds of Syzigium caryophyllatum were analyzed by gas chromatography mass spectrometer (GC-MS). Thirty eight components were identified in the leaf oil. The main components were eugenol (74.3%), eucalyptol (5.8%), caryophyllene (3.85%) and a-cadinol (2.43%). Thirty one components were identified in bud oil with the main components being...
April 2012
Effect of oxidative and temperature stress on viability and toxin production of environmental isolates of Escherichia coli
The effect of oxidative stress on expression of virulence factors and the effect of low temperature stress on toxin production among Escherichia coli serotypes isolated from wastewater and river water samples were determined. Oxidative stress due to chemicals, salts, alcohol or low temperature stress exerted various degrees of lethality to the bacterial cells with bacterial strains losing their potential to...
April 2012
Repair of bone defect using bioglass-chitosan as a pharmaceutical drug: An experimental study in an ovariectomised rat model
Bone loss associated with skeletal trauma or metabolic diseases often require bone grafting. The present study aimed to evaluate the performance of bioactive glass-chitosan composite (BG-CH) produced by a freeze-drying process. BG containing 17% wt% CH was implanted in the femoral condyl of an ovariectomised rat. The resected bone was prepared for analysis using several physico-chemical techniques such as fourier...
April 2012
Effect induced by Tabebuia rosea on glucose concentration in a rat diabetic model
Diabetes is an important human ailment afflicting many from various walks of life in different countries. Since several years ago, medicinal plants are being looked up once again for the treatment of diabetes. In this sense, the objective of this study was to evaluate the hypoglycemic activity of Tabebuia rosea in a diabetic rat model. The ethanolic and chloroformic extracts of T. rosea crust were...
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