February 2019
Antidiabetic effect of aqueous extract of ripe Carica papaya Linnaeus seed in alloxan-induced diabetic albino rats
This research was carried out to evaluate the antidiabetic effect of aqueous extract of ripe Carica papaya L. seed in alloxan-induced diabetic albino rats. Diabetes is a metabolic disease associated with sustained hyperglycaemia. Diabetes has become a global threat because its incidence is increasing on daily basis. Pathogenesis of diabetes mellitus and the possibility of its management by therapeutic agents without any...
January 2019
Knowledge regarding diabetic complications among diabetic clients attending outpatient department in a tertiary hospital, Kathmandu
Diabetes, a known medical problem for more than two millennia, provokes complication in many parts of body and increase risk of premature death. Prevalence of diabetes is steadily increasing everywhere, most markedly in the world's low and middle- income countries. Diabetes Mellitus (DM) is a devastating disease but complications of Diabetes Mellitus can be prevented or delayed through proper awareness and...
January 2019
Antihyperglycaemic effect of aqueous extract of Moringa oleifera leaf on alloxan-induced diabetic male Wistar rats
This research was designed to investigate antihyperglycaemic impact of aqueous extract of Moringa oleifera leaf on alloxan-induced diabetic male wistar rats. Diabetes is a metabolic disease linked to weakened sugar metabolism. Managing diabetes devoid of any adverse effect remains an issue to health system. Therefore, there is an increase in the search for better anti-diabetic medicine. M. oleifera leaves were...
September 2018
Antidiabetic and anti- hyperlipidemic effects of ethanolic extract of Dryopteris dilatata leaves
The incidence of diabetes mellitus (DM) is increasing globally and it is a major source of concern. This study was undertaken to assess the antidiabetic effect of the ethanolic leaf extract of Dryopteris dilatata (ELEDD).Thirty adult Wistar rats with body weight (BW) of 120-150 g were randomly assigned to groups of five rats each (n=5). Groups 1 served as normal control; Groups 2-6 were diabetic groups; group 2 served...
May 2018
Lycopene attenuates diabetes-induced oxidative stress in Wistar rats
The purpose of this study is to evaluate the capacity of lycopene against diabetes-induced oxidative damage in Wistar rats. Thirty Wistar rats of both sexes, twenty-five of which were diabetic, were used. Diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ) 60 mg/kg body weight and it was confirmed by the elevated blood glucose ≥200 mg/dl after three days. The rats were divided randomly...
February 2018
Lower BMI cut-off than the World Health Organization-based classification is appropriate for Nigerians
Universally, Body Mass Index (BMI) is used to diagnose obesity, and is associated with cardiovascular disease, as well as significant morbidity and mortality. Because the effect of obesity on health risk is influenced by ethnic background, age, and gender, using a universal BMI cut-off been questioned by some authorities or workers. Reports on appropriate BMI for Nigerians are scanty. Results of a cross-sectional...
August 2017
Vitamin D and Insulin resistance in gestational diabetes mellitus
This study was designed to demonstrate the relationship between 25-hydroxy vitamin D (25(OH)D) levels and insulin resistance (IR) in normal pregnancy and in gestational diabetes mellitus (GDM). The study included 103 pregnant women classified into two main groups: normal pregnant (n= 48) and GDM (n= 55). Further classification for each group was carried out based on 25(OH)D status (deficient, insufficient and...
July 2017
Effects of glycosylated hemoglobin levels on neutrophilic phagocytic functions
It is well established that diabetic patients with poor glycemic control have increased susceptibility to infections, but glucose levels have not been directly associated with this increase. The assessment of the effects of glycosylated hemoglobin (A1 c) on the body’s ability to fight infections may be useful directly in establishing a link between elevated blood sugar and the risk of infections. A total of 127...
January 2017
The utilization of HbA1c test in the screening and diagnosis of type 2 diabetes mellitus: An outpatient clinics survey in Botswana
This study aimed to assess HbA1c performance against single fasting blood glucose (FBG) for diagnosis of undiagnosed type 2 diabetes (T2D) and impaired fasting glycaemia (IFG) among general medical outpatients in Botswana. Participants aged, ≥20 years were cross-sectionally surveyed from August to October, 2014. All the participants underwent testing for HbA1c and FBG. The HbA1c sensitivity, specificity and...
September 2016
Reversal of Idiopathic hypogonadotropic hypogonadism triggered by testosterone therapy
A 21-year-old male presented to us with delayed development of secondary sexual characteristics. Based on examination and investigations, a diagnosis of idiopathic hypogonadotropic hypogonadism was made and the patient was started on testosterone therapy. After around a year of therapy the patient had an increase in bilateral testicular volume with increased serum luteinizing hormone (LH) values. The patient was advised...
April 2016
Ectopic growth hormone-releasing hormone (GHRH) acromegaly secondary to adrenal phaeochromocytoma: A case report
Ectopic growth hormone releasing hormone (GHRH) secretion is a rare cause of acromegaly and accounts for <1% of cases. It is most commonly secondary to gastropancreatic neuroendocrine tumours and bronchial carcinoid tumours. We report a case of 57 years old man with adrenal phaeochromocytoma and acromegaly due to ectopic GHRH secretion in a patient with neurofibromatosis type 1. He presented with headache, sweating...
April 2015
Dyslipidemia among diabetic patients in Southern Ethiopia: Cross-sectional study
Diabetes mellitus (DM) is a common endocrine metabolic disorder and a leading cause of death worldwide. Dyslipidemia is a well-recognized manifestation of uncontrolled DM, because insulin has important regulatory effects on lipid metabolism. This study was conducted to determine the frequency and pattern of dyslipidaemia in diabetic patients. Cross-sectional study was conducted on a total of two hundred ninety five...
March 2015
High prevalence of central obesity in rural South-Western Nigeria: Need for targeted prevention
Obesity has reached epidemic proportions globally, and is now prevalent in low-income and middle-income countries. This study sets out to determine the prevalence of obesity as well as its predictors in rural South-Western Nigeria. Cross-sectional descriptive survey of 416 participants aged 20 to 70 years in two rural communities in Remo North Local Government area of Ogun State, Nigeria was taken. Relevant clinical and...
February 2015
Elevation of oxidative stress markers in Type 1 diabetic children
Children’s diabetes is represented by the Type 1 diabetes mellitus (T1DM). In T1DM, the persistence of hyperglycemia has been reported to cause increased production of oxygen free radicals through glucose autooxidation and nonenzymatic glycation. The aim of this study was to evaluate markers of oxidant/antioxidant status in diabetic children of Western Algeria. This study included 40 children with T1DM with mean...
January 2015
Pulmonary artery hypertension and type 1 diabetes mellitus with suspected autoimmune polyendocrine syndrome in a pediatric patient
The objective of this study was to describe a constellation of rare pediatric disorders, pulmonary arterial hypertension (PAH) and autoimmune polyendocrine syndromes (APS). This study present a brief report of a child diagnosed with autoimmune type 1 diabetes mellitus (T1DM) at age 11 and with PAH three years later, when he was re-presented with symptoms of chest pain, lethargy, syncope and vomiting. Following a saline...
May 2014
Minocycline decreases blood glucose and triglyceride levels and reverses histological and immunohisto-chemical alterations in pancreas, liver and kidney of alloxan-induced diabetic rats
Increasing evidence suggests that oxidative stress and inflammation play major roles in diabetes mellitus and its complications. Furthermore, hyperglycemia increases the production of free radicals, resulting in oxidative stress. Minocycline presents potent anti-inflammatory and antioxidant activities, as evaluated by in vivo and in vitro models. In the present study, the minocycline anti-diabetic effect was assessed in...
April 2014
Protective effect of Commiphora wightii in metabolic activity of streptozotocin (STZ) induced diabetes in rats
Herbal products are an affective move towards the treatment of diabetes and impeding its complications. However, there have been no reports to date on Commiphora wightii (EACWR) for the treatment of diabetes and its associated metabolism. Oral administration of EACWR (400 mg/kg body weight) to streptozotocin (STZ) induced diabetic rats effectively elevated body weight, plasma insulin level, hepatic and skeletal muscle...
February 2014
Quality of life in diabetic and non diabetic patients on hemodialysis therapy
Chronic kidney disease is a worldwide public health problem and a chronic disease that deteriorates the quality of life (QOL). Diabetes is recognized as co-morbidity in patients of end stage renal disease (ESRD). This study evaluated QOL in diabetic and non-diabetic patients on maintenance dialysis therapy. A cross-sectional study was conducted on ESRD with or without diabetes on hemodialysis therapy for at least three...
January 2014
Could the antiglycemic role of vinegar be investigated in a double-blind trial?
We read with great interest the Mahmoodi et al.'s (2013) article published in the January issue of the Journal of Diabetes and Endocrinology. The authors investigated some hematological and blood biochemical factors in type 2 diabetic patients in a double blind randomized controlled trial (RCT). One of the queries about this study is the random allocation. According to the standard criteria for RCT study design...
January 2014
Conjunctive group therapy: A case study of an adult type I diabetes mellitus patient
A 30-year-old woman diagnosed with type 1 diabetes mellitus attended 2-year Conjunctive Group Therapy in parallel with medical treatment at a Greek state hospital. The study focuses on the patient’s changes in terms of attitudes and metabolic control after termination of the intervention. Qualitative data was collected from focused interviews before and after the intervention and thematic analysis was performed;...
September 2013
Hepatoprotective and anti-diabetic effect of combined extracts of Moringa oleifera and Vernonia amygdalina in streptozotocin-induced diabetic albino Wistar rats
This study was carried out to investigate the hepato-protective properties of combined extracts of Moringa oleifera (MO) and Vernonia amygdalina (VA) in streptozotocin (STZ) induced diabetic albino Wistar rats. The study design involved 42 rats weighing 120 to 180 g which were divided into 7 groups of 6 rats each. Groups 1 and 2 representing normal and diabetic control (NC and DC) received 0.5 ml of...
September 2013
Comparison between the clinical efficacy of linagliptin and sitagliptin
After the introduction of dipeptidylpeptidase-4 (DPP-4) inhibitors into the treatment for diabetes, these drugs have been widely used because of their capability and safety. Therefore, the clinical efficacy of linagliptin to sitagliptin was compared. Patients with type 2 diabetes, in whom pharmacological treatment was recently started, were randomly assigned to two separate groups, namely sitagliptin (50 mg/day) group...
August 2013
An overview on management of diabetic dyslipidemia
Type 2 diabetes mellitus (DM) has recently been described as “coronary risk equivalent”. Lipoprotein metabolism disorder in type 2 DM is known as diabetic dyslipidemia. Dyslipidemia contributes to a substantial percentage in cardiovascular mortality and morbidity in diabetic patients. National Cholesterol Education Program (NCEP) and American Diabetic Association (ADA) have provided recent guidelines for...
August 2013
Diabetes Objective Control and Education (DOCE) Project Study: Continued education and multiprofessional care in type 1 diabetes contribute to long-term glycemic control?
The purpose of this study was to assess the effectiveness of continued education and multiprofessional care for type 1 diabetes mellitus patients as a strategy for long-term glycemic control evaluated by glycosylated hemoglobin (A1C) levels. This study is a retrospective, observational study of the Diabetes Objective Control and Education (DOCE) Project. A group of 74 patients accompanied by family member attended...
March 2013
Carotid intimo-medial thickness [cIMT] and correlation to cardiac risk factors in adolescent type 1 diabetics
Carotid intimo medial thickness (cIMT) is a sensitive screening tool for cardiac evaluation, but there are limited studies evaluating its role in type 1 diabetes mellitus (T1DM) in developing countries. Thirty diagnosed adolescent type 1 diabetics on conventional insulin regime were included. Their glycated hemoglobin (HbA1C) and lipid profile were measured. Their cardiovascular function (determined by cIMT) was...
March 2013
Obesity and ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) polymorphism and their association with pathophysiology diabetes type 2 in Central Indian population
Diabetes is a metabolic disorder characterized by hyperglycemia (excessive amount of glucose) and is associated with abnormal lipid and protein metabolism.This was the first study done in Vindhyan region. The population size selected in this study was 400 (190 cases of diabetes and 210 healthy control). Anthropometric data was collected during sample collection. Genetic polymorphism study of ectonucleotide...
January 2013
The effect of white vinegar on some blood biochemical factors in type 2 diabetic patients
Type 2 diabetes is one of the most prevalent endocrine disorders worldwide. Traditionally, herbal plants and their derivatives are used to lessen complications of type 2 diabetes. The hypoglycemic and hypolipidemic properties have been reported for vinegar, but some cases of discrepant effects were also observed. In the current study, the impact of apple vinegar on some hematological and blood biochemical factors in...
January 2013
Ghrelin levels in obese children of diabetic parents
Obesity beginning in childhood often leads to hyperinsulinemic state. Ghrelin, a recently discovered growth hormone (GH) secretagogue with orexigenic effects, is proposed to be a regulator of energy balance. It is thought to be associated with obesity and metabolic syndrome. Increased abdominal fat may lead to the development of metabolic syndrome in children and has been strongly associated with insulin...
December 2012
Morinda citrifolia L. (Noni): A review of the scientific validation for its nutritional and therapeutic properties
Morinda citrifolia, commonly called noni, has a long history as a medicinal plant and its use as a botanical dietary supplement has grown tremendously in recent years. This has prompted a concomitant increase in research on the phytochemical constituents and biological activity of noni. It has been reported for its antibacterial, antiviral, antifungal, antitumor, antihelminthic, analgesic, hypotensive, anti-inflammatory...
December 2012
Adiponectin biochemical and histopathological effects on obesity/type-II diabetes mellitus and pancreatic ß-cell dysfunction in experimental rats
A comparison was done for serum lipid profile, glucose, adiponectin and insulin levels with/without hyperlipidemia; and with/without diabetes mellitus-II Wistar rat; with histopathological and immunohistochemical studies on pancreatic Langerhans islets and ß-cells (endocrine secretary portion of insulin). Sixty four adult Wistar rats were divided into 8 groups with 14 weeks study duration. The study is an...
November 2012
Hypothyroidism in adults: A review and recent advances in management
Hypothyroidism is a common endocrine disorder resulting from deficiency of thyroid hormone or, more rarely, from their impaired activity at tissue level. In its clinically overt form, hypothyroidism is a relatively common condition, with an approximate prevalence of 2% in adult women and 0.2% in adult men. Deficiency of the hormone has a wide range of effects, because all metabolically active cells require thyroid...
November 2012
Presenting anti-diabetic plants in Iranian traditional medicine
The high prevalence of diabetes mellitus and its complications, increase in usage of complementary therapies (especially herbal therapies), and need of developing countries for indigenous medical methods inspired us to introduce some plants in Iranian traditional medicine that are used in the treatment of diabetes. By studying the topic of “ziabetes” (the synonym of diabetes) mentioned in some Iranian...
October 2012
Comparative study between the effect of Coccinia cordifolia (leaf and root) powder on hypoglycemic and hypolipidemic activity of alloxan induced type 2 diabetic Long-Evans rats
The aim of this study is to investigate the hypoglycemic and hypolipidemic effects of Coccinia cordifolia leaf and root powder on alloxan induced type 2 diabetic Long-Evans rats. Oral feeding of the C. cordifolia leaf and root powder slightly decreased serum total cholesterol, triglyceride levels and LDL-cholesterol as compared with leaf, root and standard drug. C. cordifolia leaf showed...
October 2012
Complementary and alternative medicine for type 2 diabetes mellitus: Role of medicinal herbs
Complementary and alternative medicine (CAM) with glucose-lowering effect is increasingly being sought by patients and health care professionals. Its use is estimated at 17 to 80% among diabetic patients. Not only is this rarely reported to healthcare providers, but also that some CAM therapies have no empirical evidence. A review of commonly used CAM is therefore essential for safe and effective control of blood...
May 2012
A comparative study on the anti-diabetic activity of extracts of some Algerian and Sudanese plants
The present comparative study was undertaken to determine the hypoglycemic effect of 96% ethanolic extracts of Eucalyptus globulus (Myrtaceae) leaves, Salviaofficinalis (Lamiaceae) leaves growing in Algeria and Guiera senegalensis(Combretaceae) leaves growing in Sudan in glucose loaded albino rats and to assess their toxicity. Preliminary phytochemical screening of leaf extracts of the...
March 2012
Review of therapeutic groups for type 1 diabetes mellitus patients
The present review examines therapeutic groups for type 1 diabetes mellitus patients. There is a report on the history of group therapeutic interventions for diabetes patients and a presentation of the four types of groups namely; a) medical, b) educational or psychoeducational, c) psychotherapeutic or social and emotional support groups, and d) groups with combined approaches and techniques. The transition from medical...
March 2012
Does critical illness cause reversible Cushing’s like syndrome? A case study of two case reports and review of the literature
An activation of the hypothalamic-pituitary-adrenal axis (HPA) and elevated cortisol levels are common during critical illness. Clinically evident Cushing’s syndrome, triggered by life threatening illness, has not been previously reported. We describe two patients with adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome, which developed during the life threatening illness and later...
March 2012
Sex hormones and free androgen index in non-diabetic male hemodialysis and renal transplanted patients
Ageing and diabetes mellitus (DM) are known to affect sex hormones. Several studies have reported on sex hormones in male hemodialysis patients (HDPs) and renal transplant recipients (RTRs). None of those studies had excluded the effect of either ageing or DM, which might be one of the reasons why those studies had contradicting results. The aim of this study was to calculate free androgen index (FAI), assess the level...
January 2012
Early microalbuminuria in adolescent Type 1 diabetic patients: Experience from a pediatric endocrine clinic in a developing country
There are no studies of early microalbuminuria in adolescent Type 1 diabetic patients in the developing world where patients are considerably undernourished and follow conventional treatment regimens in most part. The objective was to assess the presence of microalbuminuria in Type 1 adolescent diabetes mellitus (DM) patients where patients still use conventional treatment regimen. The subjects (n = 30), in the age...
December 2011
Gestational diabetes: Maternal weight gain in relation to fetal growth, treatment modality, body mass index (BMI) and glycemic control
We sought to determine the impact of maternal weight gain on fetal growth in gestational diabetes (GDM) in relation to treatment modality, body mass index (BMI) and glycemic control. 2454 GDMs were evaluated. Obesity was defined as BMI >29; good glycemic control ≤ 100 mg/dl; maternal age < and >30 years; parity ±1; large for gestational age (LGA) >90th percentile and small for gestational age...
December 2011
Detecting incident type 2 diabetes mellitus in South Eastern Nigeria: The role of adiposity indices in relation to gender
This work assessed the predicting power of different adiposity indices on incident type 2 diabetes mellitus among adult males and females in Uyo Metropolis, Nigeria. A cross-sectional survey of 3500 adult civil servants (1532 men and 1968 women), aged 18 to 60 years, selected by multi-steps random sampling technique were assessed using 2011 Expert Committee Revised criteria for diagnosing diabetes. Overall cases of...
December 2011
A case report of anti-parathyroid hormone immunotherapy for parathyroid carcinoma
Parathyroid carcinoma is a unique malignant tumor, the primary clinical manifestations of which are hyperfunction of the parathyroid gland, various metabolic disorders secondary to hypercalcemia and corresponding impairment of tissues and organs. A complete laboratory examination, accurate imaging, and reliable histopathologic findings are critical to the diagnosis of parathyroid carcinoma. Parathyroid carcinoma is...
December 2011
Prevalence of overweight and obesity, and status of chronic non- communicable diseases and some related risk factors among Egyptian adolescents
Obesity is a major threat to children's health today. The prevalence of obesity has been steadily increasing; over the past 25 years, the number of obese children has nearly tripled and is more likely to have risk factors for cardiovascular disease, such as type 2 diabetes high cholesterol or high blood pressure. Research objectives were to study the current prevalence of overweight and obesity among...
June 2011
Landmarks in the field of diabetes
Many advances have occurred in field of diabetes in the past 25 years which have changed our practice of diabetes management. Changes like human insulin, insulin delivering devices, insulin pumps and glucometer along with DPP-IVinhibitors that have placebo like tolerability have revolutionized the treatment of diabetes. Studies like DCCT (Diabetes Control and Complications Trial), UKPDS (United Kingdom Prospective...
May 2011
Oxidative stress and not endothelial nitric oxide synthase gene polymorphism involved in diabetic nephropathy
Diabetic Nephropathy (DN) poses a major health problem. There is strong evidence for a potential role of the eNOS gene. The aim of this case control study was to investigate the possible role of genetic variants of the endothelial Nitric Oxide Synthase (eNOS) gene and oxidative stress in the pathogenesis of nephropathy in patients with diabetes mellitus. The study included 124 diabetic patients; 68 of these patients had...
April 2011
Awareness of diabetes mellitus among Saudi non-diabetic population in Al-Qassim region, Saudi Arabia
An understanding of the level of public awareness of disease conditions is helpful for health educators to plan for future programmes. This descriptive cross-sectional study was conducted for the very first time in the central region of Saudi Arabia; to evaluate the awareness level of diabetes mellitus among non-diabetic population. A total of 2007 Saudi citizens from all 11 provinces of Al-Qassim region were evaluated....
April 2011
Identification of the window period for oxidative stress intervention
A window period was proposed for oxidative stress attenuating intervention, which explained controversial results from using an anti-oxidation treatment in chronic disease prevention. In this study, a method is reported for identifying the WPOS using a NIDDM diabetes animal model when using any single oxidative stress biomarker. Abnormal oxidative stress was initiated using streptozotocin, and the concentration of TBARS...
February 2011
Syndrome of isolated FT3 toxicosis: A pilot study
When free thyroxine (FT4) concentration is elevated and thyrotropin (TSH) concentrarion is suppressed, hyperthyroidism is diagnosed. Some patient have normal FT4 concentration and elevated free triiodothyronine(FT3) concentration. This condition is named T3 toxicosis. The aim of the study was to describe the new syndrome of isolated FT3 toxicosis presenting normal TSH and FT4 levels and high FT3 with...
January 2011
Anti-diabetic and some haematological effects of ethylacetate and n-butanol fractions of Indigofera pulchra extract on alloxan-induced diabetic Wistar rats
The current orthodox treatment modalities for diabetes mellitus have many drawbacks including undesirable side-effects and the high cost of long-term treatment. The aim of this study is to determine the anti-diabetic and some haematological effects of ethylacetate and n-butanol fractions of Indigofera pulchraextract in alloxan-induced diabetic. Preliminary phytochemical screening and acute toxicity studies of...
January 2011
Significant correlation of hepatic ISI with BMI/BW after short term pioglitazone therapy via triglyceride metabolism in Type 2 Diabetes Mellitus
Analysis of pharmacological effect of pioglitazone on hepatic insulin sensitivity index (hISI), peripheral resistance (IR), body mass index (BMI), body weight (BW) and lipids in type II diabetes mellitus. Patients were treated with 30 mg of pioglitazone (PIO) daily and investigated for BW, BMI, FBS, fasting insulin (FI) and triglycerides (TG). hISI and IR were calculated by McAuley (McA), HOMA & QUICKI indices ISI...
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