African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 384

AJBR Articles

April 2009

Efficacy of defatted soy flour supplement in Gulabjamun

  Study was undertaken to determine the efficacy of defatted soy flour mix levels inGulabjamun (sweet dessert comprised of fried milk balls dipped in sugar syrup)and its impact on the quality parameters. Soy flour was fortified in three levels (3.33, 6.66 and 9.99%) w/w to prepare different compositions of Gulabjamuns by replacing wheat-flour in control recipe. 10 g spherical...

Author(s): Awadhesh Kumar Singh, Dattatreya Mahadev Kadam, Mili Saxena and R. P. Singh

  • Article Number: CA6F24310571

April 2009

Effects of ethanolic and aqueous leaf extracts of Landolphia owariensis on the serum lipid profile of rats

  The lipid profile of normal adult male rats administered both ethanolic and aqueous leaf extracts of Landolphia owariensis (P. Beauv) were determined. The animals were distributed into two sets of four groups with five animals in each group. Each set had one group, which served as control while the other three groups in the two sets were administered different concentrations of the ethanolic and...

Author(s): Nwangwu Spencer C., Ike Francisca, Olley Misan, Oke James M., Uhunmwangho Esosa, Amegor, O. F. Ubaoji Kingsley  and  Nwangwu Udoka

  • Article Number: 65C53BD10587

April 2009

Effect of Hibiscus sabdariffa anthocyanins on 2,4-dinitrophenylhydrazine-induced hematotoxicity in rabbits

  In this study, the 2,4-dinitrophenylhydrazine-induced biochemical and hematological changes in rabbits were examined under the administrative protocol of anthocyanin extract from Hibiscus sabdariffa calyces. Blood levels of reduced glutathione (GSH) and  malondialdehyde (MDA)  as well as red blood cell counts (RBC), white blood cell counts (WBC), packed cell volume (PCV) and hemoglobin...

Author(s): A. Ologundudu, A. O.Ologundudu, I. A. Ololade and F. O. Obi

  • Article Number: 391788D10592

April 2009

Kinetics studies of protease in fermenting locust beans (Parkia biglobosa) and melon seed (Citrullus vulgaris)

  Melon seed (Citrullus vulgaris) and locust bean (Parkia biglobosa) were separately subjected to a natural solid – substrate fermentation for 5 days. The peak of protease (P.I) production from the fermenting melon seeds was 48 h while that of the protease (P.II) from fermenting locust bean was 96 h. Both P.I and P.II demonstrated maximum activity at 40°C. The peak of activity for P.I was observed...

Author(s): C. Egwim Evans, J. Yisa and P. O. Egwim

  • Article Number: 0BF73AB10599

April 2009

Peripheral blood and C-reactive protein levels (CRP) in chronic periodontitis

  Evidence for a potential link between periodontal disease and coronary heart disease (CHD) has accumulated in recent years. C-reactive protein is potential marker of cardiovascular risk and associated with periodontal disease. CRP levels were analyzed in 26 periodontitis patients and 23 healthy controls along with hemoglobin, red blood cell count (RBC), leukocyte cell count (total and differential WBC),...

Author(s): Balwant Rai, Jasdeep Kaur , Simmi Kharb, Rajnish Jain, S. C. Anand and Jaipaul Singh

  • Article Number: CBB922010605

March 2009

D-3-hydroxybutyrate oxidation in mitochondria by D-3-Hydroxybutyrate dehydrogenase in Tetrahymena pyriformis

  Tetrahymena pyriformis a ciliated protozoan, is considered a good indicator of water pollution. However its energy supply is poorly understood. This work was focused on the metabolism of hydroxybutyrate through the study of the membrane bound mitochondrial NAD+-dependent D-3-hydroxybutyrate dehydro-genase (EC. (BDH), a ketone body catalysing enzyme involvedin the interconversion of...

Author(s): Omar Akil, Zakaria El Kebbaj, Norbert Latruffe and M’Hammed Saïd El Kebbaj

  • Article Number: AD5BF9810390

March 2009

Selected heavy metals and electrolyte levels in blood of workers and residents of industrial communities

  The study focused on the determination of the levels of lead, cadmium, sodium and potassium in the blood of selected industrial workers (n = 36), residents of the neighboring communities (n = 36) as well as the residents of the communities further away from any industrial setting (which controls) (n = 12). The subjects were recruited from the granite served as the, ceramic and cement industries at Ewekoro,...

Author(s): Babalola O. O and Babajide S. O

  • Article Number: 719996510397

March 2009

Utilization of enzymes in the production of liquid sugar from dates

  Date palm fruits Phoenix dactylifera cultivated in the Kingdom of Saudi Arabia were used for the production of high quality date syrup. This syrup is suitable for the manufacture of different food products. Date syrup was prepared from Reziz date (Soft variety) at different ratios of water/date (2:1, 2.5:1 and 3:1). Pectinase and cellulase were used to obtain the maximum date syrup extraction....

Author(s): Gamal A. El-Sharnouby  , Salah  M. Al-Eid  and  Mutlag M. Al – Otaibi 

  • Article Number: B20F75D10410

March 2009

Toxicological effects of chlorpyrifos and methidathion in young chickens

  The objective of this work is assessment of the toxicological effects of the organophosphorus compounds (methidathion and chlorpyrifos) and the usefulness of some parameters as bioindicators. Haematology and serum biochemistry were assayed in 15 cockrels at random age of 4 - 6 weeks. The birds were randomly assigned to 3 oral (by mouth) pulse-dose treatments of 0, 3.5 mg/kg chlorpyrifos, and 7.5 mg/kg...

Author(s): Ojezele, Matthew Obaineh and Abatan, Oluwole Matthew

  • Article Number: CD195C610418

March 2009

Degradation of pyrimidine ribonucleosides by extracts of Aspergillus terreus

  Cell-free extracts of nitrate-grown mycelia of Aspergillus terreus could catalyze the hydrolytic deamination of cytidine to uridine and ammonia followed by the hydrolytic cleavage of the N-glycosidic bond of the produced uridine to the corresponding base (uracil) and ribose. The same extracts could not catalyze the hydrolytic deamination of cytosine. Addition of inorganic arsenate to the reaction...

Author(s): Osama M. Abdel-Fatah, Maysa A. Elsayed and Ali M. Elshafei

  • Article Number: 549D4B110430

March 2009

Effect of 50 Hz electromagnetic fields on acid phosphatase activity

  The effect of extremely low frequency (ELF) electromagnetic field (EMF) (50 Hz 0.5 mT) on the activity of acid phosphatase (EC was studied. In addition the factors affecting the enzyme activity such as the temperature, pH and substrate concentration were also investigated. The results show that ELF EMF have significant influence on enzyme activity. Upon EMF...

Author(s): K. S. Prashanth, T. R. S. Chouhan and Snehalatha Nadiger

  • Article Number: 8A63F7210437

March 2009

Lipid profile of a population of diabetic patients attending Nigerian National Petroleum Corporation Clinic, Abuja

  This study was conducted to compare the lipid profile of diabetic patients and healthy controls. The lipid profiles and lipoprotein levels of 50 known diabetic patients and 50 healthy subjects were studied. Total cholesterol (TC), Triacylglycerols (TG), Low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) levels were assayed for each group using standard biochemical...

Author(s): Ugwu, C. E. , Ezeanyika, L. U. S., Daikwo, M. A. and Amana, R.

  • Article Number: 8FC0A2110458

March 2009

The effect of allelic variation on forage quality of brown midrib sorghum mutants with reduced caffeic acid O-methyl transferase activity

  Sorghum brown midrib (bmr) mutants have reddish-brown vascular tissues in their leaves and stems as a result of changes in lignin content and subunit composition. Past research at Purdue University has generated a set of bmr sorghum mutants via chemical mutagenesis and established some to be allelic to each other. More recently, we identified additional spontaneous mutants in true breeding lines with...

Author(s):   R. K. Vogler, T. T. Tesso, K. D. Johnson and G. Ejeta  

  • Article Number: 3A582B040785

February 2009

Isolation and preliminary characterization of conophor nut (Tetracarpidium conophorum) lipase

  Lipase in oilseeds helps to hydrolyze the ester bonds of storage triacylglycerols. The crude lipase from the conophor nut (Tetracarpidium conophorum) was isolated and assayed via quantification of the free fatty acids liberated by the hydrolysis of the oilseed triacylglycerols. Optimum pH and temperature for the enzyme activity of the conophor nut lipase was pH 8.0 and at 30°C with substantial lipolysis...

Author(s): Victor N. Enujiugha

  • Article Number: 0F48A5810348

February 2009

A study on the combined administration of chloroquine and insulin effect on serum transferases and phosphatases activity during increased dietary fat and calcium consumption

  Previous studies reported on relationship between chloroquine administration, insulin and glucose homeostasis, but the role of dietary fat and the combined effect of the drugs on liver function have not been exploited. The present study was set up to investigate the effect of combined administration of insulin and chloroquine on serum transferase and phosphates activity during increased dietary fat and...

Author(s): Ajani E. O., Salau B. A., Ezima E. N. , Oyefuga O. H. and Osineye P. O.

  • Article Number: 1C8C55710356

February 2009

Antinociceptive properties of Trigonella foenumgreacum seeds extracts

  Trigonella foenum-graecum L. (Leguminosae), known in Morocco as “Helba”, is used in folk medicine for its anti-ulcer, anti-inflammatory, cicatrizing activities and to treat various pain-related physiological conditions. In the present study, we attempted to verify the possible antinociceptive action of different extracts obtained from the seeds of this plant. Three experimental models...

Author(s): A. Laroubi, L. Farouk, R. Aboufatima, A. Benharref , A. Bagri and A. Chait

  • Article Number: A5D5A3610364

February 2009

Toxicological assessment of oral administration of some antisickling agents in rats

  This study investigated the toxicological effects of oral administration of hydroxyurea, tellurite and thiocyanate on some biochemical parameters in rats. The drugs were administered orally to rats daily at their therapeutic dose for 28 days after which some biochemical parameters were measured. All the drugs caused growth depression and significant elevation (P < 0.05) of serum alkaline...

Author(s): Oyewole, O. I. and Malomo, S. O.

  • Article Number: C6EE06110375

January 2009

Regenerative action of Cochlospermum tinctorium aqueous root extract on experimentally induced hepatic damage in rats

  The hepatoprotective effect of aqueous root extract of Cochlospermum tinctoriumon carbon tetrachloride (CCl4) on induced hepatic damage in rats was reported. The present study examined the curative action of the plant extract on experimentally induced hepatic damage in rats. Wistar rats were divided into normal control, induction control, extract and prednisolone treated groups. Hepatotoxicity was...

Author(s): Etuk E. U., Francis U. U. and Garba I.

  • Article Number: F9A7D9B10319

January 2009

Efficacy of Dissotis rotundifolia on Trypanosoma brucei brucei infection in rats

  The therapeutic potential of the crude extract of Dissotis rotundifolia was   investigated in rats infected with Trypanosoma b. brucei. Animals were treated orally or intraperitoneally at 200, 600 and 800 mg/kg body weight. At 800 mg/kg, parasitemia was reduced by 66.7 and 78.4% after oral and intraperitoneal administration respectively. In vitro exposure of blood forms to...

Author(s): Abdullahi Mann, Evans C. Egwim, Barnabas Banji, Nda-Umar Abdukadir, Mohammed Gbate and J. T. Ekanem

  • Article Number: A5997BB10334

December 2008

Lipid peroxidation and tyrosinase inhibition by lichen symbionts grown in vitro

  The symbionts of lichen species Arthothelium awasthii, Heterodermia podocarpa, and Parmotrema tinctorum were isolated and cultured on various nutrient media incubated in a growth chamber. Methanolic extracts of one year old symbiont cultures were taken for evaluating their potential to inhibit lipid peroxidation and tyrosinase enzyme activity. The extracts of all cultured...

Author(s): Neeraj Verma, Bhaskar C. Behera, Anjali Sonone and Urmila Makhija

  • Article Number: AAFAD2B10254

December 2008

Maytenus ilicifolia as source of antioxidants and anti-radicals agents and its action on neutrophils peroxidase (myeloperoxidase)

  Maytenus ilicifolia is an important plant with a great potential for cancer treatment and has a popular and diffused use, as tea, in Brazil and in other countries against gastric ulcers, dyspepsia and others gastric problems. In this paper, the antioxidant and anti-radical activities of this plant were compared with trolox and uric acid by their abilities as scavengers of DPPH·, ABTS·+,...

Author(s): J. C. R. Vellosa, O. A. K. Khalil, N. M. Khalil, V. A. F. F. M. Santos, R. A.  Hakime -Silva, M. Furlan, I. L. Brunetti and O. M. M. F. Oliveira

  • Article Number: AC5B10410277

December 2008

Effects of Landolphia owariensis leaf extract on the liver function profile and haemoglobin concentration of albino rats

  The effects of aqueous extract of Landolphia owariensis leaves on the biochemical indices of liver function were investigated in Wister strain of albino rats. Preliminary phytochemical analysis of the plant leaves showed the presence of tannins, alkaloids, flavonoids and saponins. Acute toxicity tests of the extract gave an LD50of 3370 mg/kg. Liver function tests revealed that the serum...

Author(s): L. A. Nwogu, C. U. Igwe and A. A. Emejulu

  • Article Number: FDF293010284

November 2008

Two-stage anaerobic digestion of aerobic pre-treated sisal leaf decortications residues: hydrolases activities and biogas production profile

  A two-stage system was investigated for anaerobic digestion (AD) of aerobically pre-treated sisal leaf decortication residue (SLDR) with regard to hydrolytic enzymes and biogas production. The system consisted of a solid-bed bioreactor for hydrolysis connected to methanogenic bioreactor packed with sisal fibre decortication residues (SFDR) as biofilm carriers. Some of the enzymes produced by microorganisms to...

Author(s): Anthony Manoni Mshandete, Lovisa Björnsson, Amelia Kajumulo Kivaisi, Mugassa Steven Thomas Rubindamayugi and Bo Mattiasson

  • Article Number: A6738E610216

November 2008

Study of sensitivity and ability of adenosine deaminase in response to pre-unfolding and especially pathological temperatures via changing the enzyme structure and activity

    Adenosine deaminase (ADA) is an important enzyme of the purine metabolic pathway, which catalyzes the conversion of adenosine and deoxyadenosine to their respective inosine derivatives plus ammonia, in a rapid and irreversible reaction. In this work, we studied the structural and kinetic properties of bovine ADA as a function of temperature in the range, 20 - 80°C by circular dichroism (CD) and...

Author(s): Mostafa Rezaei-Tavirani, Saeed Hesami-Takallu, Seyed Hassan Moghaddamnia, Shiva Kalantari, Bijan Ranjbar,  Seyedeh Zahra Moosavi-Nejad, Sayed-Amir Marashi, Mohammad Rahmati Roodsari and Farhad Malekzad

  • Article Number: CCB88D410233

October 2008

Attenuation of N-nitrosodiethylamine-induced liver carcinogenesis in rats by naturally occurring diallyl sulfide

  The present study was aimed to investigate the chemopreventive effects of diallyl sulfide (DAS),  organosulfur compounds present in high amounts in garlic, against N-nitrosodiethylamine (NDEA) induced  hepatocarcinogenesis in rats. NDEA treatment to rats resulted in significantly elevated levels of serum  aspartate transaminase, alkaline phosphatase, lactate dehydrogenase and...

Author(s): Sherine M. Rizk and Safinaz S. Ibrahim

  • Article Number: DA8B70C10187

October 2008

Some properties of extracellular protease from Bacillus licheniformis LBBL-11 isolated from “iru”, a traditionally fermented African locust bean condiment

  Twelve strains of Bacillus licheniformis isolated from traditionally fermented African locust bean (iru) were evaluated in respect to production of protease on skim milk agar. B. licheniformis LBBL-11 exhibited the highest proteolytic activity with a diameter of clear zone measuring 35.0 mm. Production of protease from B. licheniformis LBBL-11 was further studied by growing...

Author(s): Folasade M.  Olajuyigbe and Joshua O. Ajele

  • Article Number: 5F6025A10198

September 2008

Protein profiles of adrenal gland of neonatal rat treated with monosodium glutamate

  Exposure to excessive monosodium glutamate (MSG) during neonatal life has been correlated with loss of function in stress response that might be involved in changes of adrenal activity. This study was designed to investigate the protein pattern and examine the mRNA level of proteins in the adrenal glands following MSG stimulation. Neonatal rats were subcutaneously administered with MSG at a concentration of 4...

Author(s): Anuwat Wanthong, Sompong Thammasirirak and Khomsorn Lomthaisong

  • Article Number: 3A8EE2510151

September 2008

Nicotinamide: A cytoprotectant against streptozotocin-induced diabetic damage in Wister rat brains

  Nicotinamide is being used in experimental and clinical trials examining the prevention of type-1 diabetes mellitus. However, the precise mechanisms underlying the antidiabetic and neuroprotective effects of nicotinamide require further analysis. Our goals are to evaluate the protective effect and the cellular and molecular mechanisms of nicotinamide against brain damage induced by type-1 diabetes in...

Author(s): Safinaz S. Ibrahim and Sherine M. Rizk

  • Article Number: 036529510160

August 2008

A 22-bp sequence of the core promoter from the Indica rice sucrose-phosphate synthase gene (sps1) is sufficient to confer basal transcription activity

  The 5’ region of the sucrose-phosphate synthase gene (sps1) of the Indica riceconsists of an atypical promoter which lacks TATA box but has a putative initiator sequence overriding a second transcription initiation site. Analysis of the transient expression of truncated versions of the sps1 promoter (from -148 to +21) fused to the uidA reporter gene was performed. The...

Author(s): Miguel Martínez-Trujillo, Gamaliel Valdivia-Rojas, Gloria Solís Guzmán, José Luis Cabrera-Ponce

  • Article Number: B70275410124

August 2008

Nicotinamide: A cytoprotectant against streptozotocin-induced diabetic damage in Wister rat brains

  Nicotinamide is being used in experimental and clinical trials examining the prevention of type-1 diabetes mellitus. However, the precise mechanisms underlying the antidiabetic and neuroprotective effects of nicotinamide require further analysis. Our goals are to evaluate the protective effect and the cellular and molecular mechanisms of nicotinamide against brain damage induced by type-1 diabetes in...

Author(s): Safinaz S. Ibrahim and Sherine M. Rizk

  • Article Number: C33811110128

August 2008

Comparative study on the determination of assay for laccase of Trametes sp.

The aim of this work was to determine the sensitivity among compounds in common use for detecting laccase activity. In this study, three assay procedures to measure laccase activity of Trametes sp. were performed in Kirk’s basal salts mediums of three dyes. In the assay methods, three substrates were employed, which were 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate) (ABTS), ο-dianisidine...

Author(s): Airong Li, Yue Zhu, Liang Xu, Wenqing Zhu and Xingjun Tian

  • Article Number: 99BF1C210135

July 2008

Nitric oxide scavenging ability of ethyl acetate fraction of methanolic leaf extracts of Chromolaena odorata (Linn.)

  The nitric oxide (NO.) scavenging activities of Chromolaena odorata (Linn) King and Robinson, was investigated and compared with standard Plant Phenolic antioxidant Quercetin. Disodium pentacyanonitrosyl ferrate (2- ) dihydrate (sodium nitroprusside) was used as a nitric oxide donor. On disintegration at a physiological pH (7.2), 5 mmol/l of sodium nitroprusside generated a time dependent nitric...

Author(s): Alisi, C. S and Onyeze, G. O. C

  • Article Number: 9E5A93110076

July 2008

Algal extracts improve antioxidant defense abilities and salt tolerance of wheat plant irrigated with sea water

  Effect of irrigation bread wheat plants (Triticum aestivum L., cv. Giza 94) with sea water (10 and 20% v/v), spraying with microalgae extracts obtained from Chlorella ellipoida and Spirulina maxima (5 gL-1 dry weight in 0.1% Tween solution) cultivated under normal and stress conditions were studied. Some plant bioregulators (BRGs, ascorbic acid and benzyl adenine, at 200...

Author(s): Hanaa H. Abd El-Baky, Hussein M. M.  and Game S. El-Baroty

  • Article Number: 82070DD10085

July 2008

Effect of administration of aqueous and ethanolic extracts of Enantia chlorantha stem bark on brewer’s yeast-induced pyresis in rats

  The phytochemical screening of aqueous and ethanolic extracts of the stem bark of Enantia chlorantha Oliv as well as the antipyretic effect of the solvent extracts at 25, 50, 100 and 200 mg/kg body weight was investigated in albino rats. Phytochemical analysis of the aqueous and ethanolic extracts of E. chloranthastem bark revealed the presence of phenolics, flavonoids, alkaloids, glycosides...

Author(s): Adesokan, A. A., Yakubu, M. T., Owoyele, B. V., Akanji, M. A., Soladoye, A. O. and Lawal, O. K.

  • Article Number: 08EFC5D10115

June 2008

Acid phosphatase from snail heamolymph: a cheap and convenient source of enzyme for kinetic parameters determination

  The study of enzymes occupies a very important position in biological, medical and industrial research. Also, the satisfactory performance of an enzyme assay provides a good introduction to biochemical techniques. This experiment presents a good introductory project to students for the estimation of the kinetic parameters of an enzyme. The spectrophotometric/colorimetric assay of acid phosphatase is very...

Author(s): Femi Kayode Agboola and Adeyinka Afolayan

  • Article Number: 01BA58F10057

June 2008

Influence of nitrogen application on grain yield and end use quality in segregating generations of bread wheat (Triticum aestivum L)

  Variation in bread making quality of wheat (Triticum aestivum L) is a major consideration for suppliers and bakers. Grain protein concentration, protein quality, ash content and carbohydrates are major quality attributes of bread wheat. Breeders and their cereal chemist colleagues use predictors of these end use quality factors in the early generations to develop improved cultivars. Six populations of bread...

Author(s): Bayoumi, T. Y and I. S. El- Demardash

  • Article Number: 102394A10063

June 2008

Hepatoprotective effect of Cichorium intybus on CCl4-induced liver damage in rats

  The purpose of this study was to evaluate the hepatoprotective activity of hydroalcholic extract of Cichorium intybus (Cichorium intybus) using a carbon tetrachloride (CCl4) - induced liver injury in rats. The leaf extract at oral dosage of 200, 400 and 500 mg/kg exhibited significant (P<0.05) protective effect against CCl4 induced hepatoxocity. Level of serum markers such as aspartate...

Author(s): Sadeghi Heibatollah, Nikbakht Mohammad Reza; Ghaitasi Izadpanah and Sabzali Sohailla

  • Article Number: 4B3032F10066

May 2008

Hepatotoxic and hemolytic effects of acute exposure of rats to artesunate overdose

  Hepatotoxic and hemolytic effects of artesunate overdose were examined in rats. Forty (40) rats were grouped randomly into four designated as A, B, C, and D. and were given oral administration of artesunate as follows: 0 mg/kg (control), 1 mg/kg (Under-dose), 2 mg/kg (Normal dose) and 4 mg/kg (Overdose) respectively.  The administration was continued for 5 days. Hepatotoxicity was monitored in the rats...

Author(s): Omotuyi I. O, Nwangwu S. C, Okugbo O. T, Okoye O. T, Ojieh G. C and Wogu D.M

  • Article Number: 7431B0F10043

May 2008

A comparative study on the atheroprotective potential of heparin and atorvastatin in hypercholesterolemic rats

  The present study is to evaluate the effect of standard drug heparin and atorvastatin on the atherogenic disturbances in hypercholesterolemic atherogenic animals. Six groups of male Wistar rats were employed in this study, of which three groups received atherogenic CCT diet (rat chow supplemented with 4% cholesterol, 1% cholic acid and 0.5% thiouracil) for 17 days. Two groups were treated with...

Author(s): Vijayabaskar P, Sethupathy S and Somasundaram S. T

  • Article Number: 0E6A5C310053

April 2008

Characterization of phospholipase A2 (PLA2) from Echis ocellatus venom

  Phospholipase A2 (EC. was isolated and partially characterized from the venom of Echis ocellatus. The enzyme was purified 13.5-fold with a yield of 86.69% on DEAE-Sephadex G-75 column. The PLA2 from E. ocellatus venom had broad pH and temperature ranges with optima of 7.5 and 40oC respectively.  Initial velocity studies for the determination of kinetic constants with...

Author(s): Sallau, A. B., Ibrahim, M. A., Salihu, A. and Patrick, F. U.

  • Article Number: E63CB3210016

April 2008

Decreased cardiovascular risk and resistance to hyperlipemia-induced hepatic damage in rats by aqueous extract of Urtica dioica

  Hyperlipemia and Hepatic metabolism was studied in hyperlipemic albino rats maintained on a high fat diet. Aqueous extract (100, 200, 300mg/kg/day) of Urtica dioica corrected dyslipidemia and restored hepatic chemistry in hyperlipemic animals. The extract was effective in normalizing the atherogenic lipoprotein phenotype. Total cholesterol (CHOL), Triglyceride (TG), Low density lipoprotein...

Author(s): Alisi C. S, Emejulu A. A, Alisi P. N. C, Nwaogu L. A and Onyema O. O

  • Article Number: FF0DF9010021

March 2008

RNA interference: a pathway to drug target identification and validation in trypanosome

    RNA interference (RNAi) is a phenomenon through which double stranded RNA (dsRNA) induces potent sequence-specific degradation of homologous transcripts. Besides its function in cellular defense and developmental regulation, it has emerged as an invaluable tool for elucidation of gene function and drug target validation. This is particularly useful when substantial genome sequence data are...

Author(s): Owino, A. Vincent. , , Masiga, K. Daniel , Limo, K. Moses.

  • Article Number: 6E30BA09947

March 2008

Study of the immunomodulatory and anti-inflammatory effects of evening primrose oil in adjuvant arthritis

  The present study was carried out to evaluate the anti-arthritic nature of evening primrose oil (EPO) rich in γ-linolenic acid (GLA), on adjuvant-induced arthritic rats. Results were compared to those of diclofenac sodium, a reference standard non-steroidal anti-inflammatory drug. Arthritis was induced by subcutaneous injection of complete Freund’s adjuvant (CFA) in the right hind paw of male...

Author(s): Manal F. Ismail, Shohda A. El-Maraghy, Nermin A.H. Sadik

  • Article Number: 87E44779961

March 2008

Diethylnitrosamine-induced hepatocarcinogenesis in rats: possible chemoprevention by blueberries

  Nitrosamine compounds are known hepatic carcinogens. This study was designed to study the efficacy of dietary supplementation with blueberries (BB) on diethylnitrosamine (DEN)-initiated hepatocarcinogenesis in male wistar rats. Rats were divided into three groups. The first group served as normal control group, the second group received DEN at a dose of 10 mg/kg body weight five times a week for 15 weeks. The...

Author(s): Nermin A.H. Sadik, Shohda A. EL-Maraghy and Manal F. Ismail

  • Article Number: 66CB55F9973

March 2008

Effects of intraperitoneal administration of vitamins C and E or A and E combinations on the severity of Trypanosoma brucei brucei infection in rats

  The effects of intraperitoneal administration of combinations of vitamins C and E (100mg/Kg b.w each) or vitamins A and E (10,000i.u/Kg, 100mg/Kg b. w., respectively)  on Trypanosoma brucei brucei  infection in rats were compared. The rats were infected intraperitoneally with the same parasite load and the experiment lasted for 17 days. The two vitamin combinations significantly (P<0.05) and...

Author(s): Umar, I. A. Rumah, B. L., Bulus, S. L., Kamla, A. A., Jobin, A., Asueliman, B. I., Mazai, M.H., Ibrahim, M. A. and Isah, S.

  • Article Number: 7197E489983

February 2008

Mineral and phytochemical contents in leaves of Amaranthus hybridus L and Solanum nigrum L. subjected to different processing methods

Mineral and phytochemical contents of leaves of Amaranthus hybridus L. andSolanum nigrum L. Subjected to different processing methods were evaluated. Processing procedures adopted include shredding, sun–drying, oven–drying, steaming and a combination of these. Minerals examined are Na, K, Ca, Mg, Fe, P, and Zn while the phytochemicals are alkaloids, flavonoids, hydrocyanic acid, phenols,...

Author(s): Akubugwo I. E, Obasi N. A, Chinyere G. C and Ugbogu A. E

  • Article Number: EDE85BB9240

February 2008

Trypanocidal potential of methanolic extract of Bridelia ferruginea benth bark in Rattus novergicus

    Full Length Research Paper   Trypanocidal potential of methanolic extract of Bridelia ferruginea benth bark in Rattus novergicus   J. T. Ekanem1, *O. M. Kolawole2, O. C. Abbah1   1Department of Biochemistry, Faculty of Basic Health Sciences,...

Author(s): J. T. Ekanem, O. M. Kolawole, O. C. Abbah

  • Article Number: 33CB5D79250

February 2008

Antihepatotoxic potential of Sargassum polycystum (Phaeophyceae) on antioxidant defense status in D-galactosamine-induced hepatitis in rats

We have examined the protective effect of ethanol extract of Sargassum polycystum on hepatic antioxidant status in D-galactosamine-induced hepatitis in rats. Levels of diagnostic marker enzymes [alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and creatine phosphokinase (CPK)] in plasma, lipid peroxides, reduced glutathione and the activities of glutathione...

Author(s): B. Meena, R. Anbin Ezhilan, R. Rajesh, A. Sheik Hussain, B. Ganesan, R. Anandan

  • Article Number: E14AE039260

February 2008

Relationship between somatic cell counts, dairy cattle milk yield and composition in Burkina Faso

The study was carried out on ten local dairy cows called Zebu at a research centre located in the west part of Burkina Faso. Dairy cows were supplemented 53.8 MJ metabolized energy and 735.7 g Crude Protein and were free access to natural pasture. Milk yield recording and individual milk sample collection took place within one month. Milk samples were analyzed for composition with the method of mid infrared spectroscopy...

Author(s): Ouédraogo G. A, Millogo V, Anago-Sidibé A. G and Kanwé B. A

  • Article Number: 3FF10D79270

February 2008

Hepatoprotective activity of Bi - herbal ethanolic extract on CCl4 induced hepatic damage in rats

The combined hepatoprotective effect of Bi- herbal ethanolic extract (BHEE) was evaluated against carbon tetra chloride (CCl4) induced hepatic damage in rats. Ethanolic extract from the leaves of Eclipta alba and seeds of Piper longum at a dose level of 50 mg/kg body weight was administered orally daily once for 14 days. The substantially elevated serum marker enzymes such as SGOT, SGPT, ALP, LDH,...

Author(s): Samudram P., Rajeshwari Hari, Vasuki R., Geetha A. and Sathiya Moorthi P.

  • Article Number: 5BC3F369277

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