African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 407

AJBR Articles

Effects of ivermectin and albendazole on some liver and kidney function indices in rats

May 2009

  Evaluation of repeated administration of ivermectin and albendazole separately and in combination on some hepatic and renal function indices were examined in albino rats (Rattus novergicus). The experimental animals were randomly divided into four groups: those administered distilled water (control), those administered 0.4 mg/kg bodyweight of ivermectin (Iver), those administered 15 mg/kg body weight...

Author(s): R. O. Arise and S. O. Malomo

Effect of 3-hydroxymethyl xylitol on hepatic and renal functional markers and protein levels in streptozotocin-diabetic rats

May 2009

  Oral administration of 3-hydroxymethyl xylitol at 40 mg/kg body weight to diabetic rats for 45 days resulted in a significant reduction in blood glucose and significant increase in plasma insulin levels. In addition, the diabetic rats had decreased levels of plasma total protein, albumin, globulin and albumin/globulin ratio as compared to control rats. After treatment with 3-hydroxymethyl xylitol and...

Author(s): Govindasamy Chandramohan, Khalid S. Al-Numair and Kodukkur Viswanathan Pugalendi

Lipid composition of microsomal fraction of female rat liver at different stages of growth

May 2009

  It has been reported that lipids are the only macromolecules which display consistency in their pattern of biosynthesis for all living system. In this study, lipid biosynthesis in the liver microsomes of female Sprague-Dawley rats as they aged (3, 7, 12 , 16 and 20 weeks) was studied. The microsomes were isolated by homogenization and centrifugation. The aliquot of the microsomes and soluble enzymes fraction...

Author(s): Chidozie, V. N., Anekwe, G. E., Chukwu, O. O. C., Olabode, O. A., Igweh, A. C. and Adeyanju, O. N.

Glutathione S-transferase activity of erythrocyte genotypes HbAA, HbAS and HbSS in male volunteers administered with fansidar and quinine

May 2009

  In vivo investigations were carried out to ascertain the comparative levels of erythrocyte GST activity between non-malarious and malarious male subjects of HbAA, HbAS and HbSS erythrocyte genotypes, administered with fansidar and quinine. The incubation of human erythrocytes with 1-chloro-2,4-dinitrobenzene (CDNB) resulted in almost quantitative conjugation of glutathione (GSH) to form...

Author(s): P. C. Chikezie, A. A. Uwakwe and C. C. Monago

Hepatoprotective potential of crocin and curcumin against iron overload-induced biochemical alterations in rat

May 2009

  The present study was undertaken to evaluate the possible ameliorating effect of crocin and curcumin on certain biochemical alterations associated with iron overload-induced liver injury in rats. 5 groups of rats were used, a normal control group received daily i.p. injections of saline and 4 groups received daily i.p. injections of ferric nitrilotriacetate (FeNTA) for 8 successive...

Author(s): Shoddy A. EL-Maraghy, Sherine M. Rizk and Maha M. El-Sawalhi

Modulation of di- (2- ethylhexyl) phthalate induced hepatic toxicity by Apium graveolens L. seeds extract in rats

May 2009

  In the present study, the hepatoprotective activity of methanolic extract of Apiumgraveolens L. (celery) seeds was tested against Di-(2- ethylhexyl) phthalate(DEHP) induced hepatotoxicity in rats. Oral administration of DEHP (1000 mg/kg b.wt/day) for 6 weeks in rats caused a significant increase in the levels of serum marker enzymes like serum glutamate oxaloacetate transaminase (SGOT), serum...

Author(s): G. C. Jain, Hemant Pareek, B. S. Khajja, Kusum Jain, S. Jhalani, S. Agarwal and Sameer Sharma

Direct ex vivo effects of herbal extracts on serum bilirubin in neonatal blood samples

May 2009

  Herbal drug therapy is a common practice adopted in traditional and alternative medicine and has been used in the treatment of neonatal jaundice or hyperbilirubinemia from ancient times. This is done with the help of different herbal extracts and using different treatment methods. The knowledge of new possibilities and the fact that herbal drugs have been used in some communities for a long time, clarifies...

Author(s): Seyed Hessamedin Nabavizadeh, Ozair-bin Majid and Amir Anushiravani

Toxic effects of aqueous stem bark extract of Cassia sieberiana on some biochemical parameters in rats

May 2009

  The aqueous extract of Cassia sieberiana stem bark was administered to groups of 4 albino rats (160 ± 10 g) at 0, 20, 60 or 180 mg/kg body weight daily by gavages for six weeks. A 7% decrease in mean body weight gain was observed in the group treated with the highest concentration of the extract (180 mg/kg). Groups treated with the extract showed significant (p < 0.05) increase in serum...

Author(s): W. Obidah, U. A. Sa’ad and A. U. Wurochekke

Mechanisms of arsenic toxicity and carcinogenesis

May 2009

  Industrialization has excessively modified the discharge and distribution of arsenic in the environment through natural and anthropogenic activities. Gastrointestinal tract, Lung and Dermal absorptions account for various adverse effects associated with arsenic toxicity. The knowledge of arsenic biotransformation holds the trivalent species (DMA3+ and MMA3+) accountable for most arsenic toxicity with...

Author(s): Obinaju, Blessing Ebele

Effects of sodium ion and water hyacinth extract in the production of Curvularia pallescens in culture media

May 2009

  An investigation was conducted on the pH, nutritional and cost benefit of the use of different substrates for the production of Curvularia pallescens Boedijn. The growth of the organism was examined at pH range between 5.5 and 8.6 and on different growth media, potato carrot agar (PCA), potato dextrose agar (PDA), sabouraud agar (SA), tap water agar (TWA), water hyacinth agar (WHA) and Czapek-Dox...

Author(s): Okunowo Wahab Oluwanisola and Ogunkanmi Liasu Adebayo

Anti anaemic properties of Scoparia dulcis in Trypanosoma brucei infected rabbits

May 2009

  A major feature of infection with trypanosomes is the development of anaemia. In this study, the effect of Scoparia dulcis (Atiotiousha in Akoko-Edo) onTrypanosoma brucei induced anaemia was investigated in fifteen rabbits divided into three groups of n = 5 over a period of twenty eight days. Changes in Packed cell volume (PCV), Haemoglobin (Hb) concentration, Red blood cell count (RBC), Mean...

Author(s): Orhue N. E. J. and Nwanze E. A. C.

Purification and characterization of a laccase from the basidiomycete Funalia trogii (Berk.) isolated in Tanzania

May 2009

  A lignolytic basidiomycete fungus, Funalia trogii (Berk.), was isolated from decayed wood in coastal Tanzania and cultivated in submerged culture. Initially screened crude enzyme filtrate showed complete rhemazol brilliant blue - R (RBBR) decolorization 2,2’-azino-bis (3-ethylbenzthiazoline)-6-sulfonate and guaiacol oxidation after 7 days of incubation. The fungal...

Author(s): Ferdinandi Patrick, Godliving Mtui, Anthony Manoni Mshandete, Gunnar Johansson and Amelia Kivaisi

Effects of curcumin and tetrahydrocurcumin on diabetes induced endothelial dysfunction

May 2009

  Diabetes-induced endothelial dysfunction has been well recognized for its underlining causes of oxidative stress. Therefore, several studies have worked on testing active antioxidant agents such as vitamin C and E against diabetes induced oxidative stress to preserve endothelial cells. In the present study, we assessed the effects of plant-derived antioxidant, curcumin and its analog, tetrahydrocurcumin (THC)...

Author(s): Natchaya Wongeakin, Pattarin Sridulyakul, Amporn Jariyapongskul, Apichart Suksamrarn and Suthiluk Patumraj

Enhancing antioxidant availability in grains of wheat plants grown under seawater-stress in response to microalgae extracts treatments

April 2009

  This study investigated the antioxidant capacity and the levels of enhanced total carotenoids (TCAR), tocopherols (TOC) and phenolic (TPC) and protein (PC) contents in whole grains of wheat plants irrigated 10 and 20% (v/v) seawater (SW) in response to water extracts of microalgae Spirulina maxima (SME) and Chlorella ellipsoida (CEE) and exogenous plant growth enhancers of ascorbic acid...

Author(s): Hanaa H. Abd El-Baky

Effect of traditionally designed nutraceutical on stress induced immunoglobulin changes at Antarctica

April 2009

  This study was conducted to establish the effect of a traditionally designed nutraceutical on stress related changes in selected immunoglobulin levels in the body. The nutraceutical was prepared from different potent herbs described in Ayurveda using standard operative procedures and were tested for heavy metal and microbial load. Initially, 21 subjects were selected in addition to 7 volunteers for control...

Author(s): P. Bansal, R. Sannd, N. Srikanth and G. S. Lavekar

Fatty acid composition and properties of skin and digestive fat content oils from Rhynchophorus palmarum L. larva

April 2009

  Skin and digestive fat content (DFC) oils from Rhynchophorus palmarum L. larva (Curculionidae) were extracted and their physicochemical properties were characterized. Water content (0.41 %) of skin oil was higher than the amount of DFC (0.04 %). While, the lipid fraction of the skin (35.16%) was slightly lower than the DFC (49.05%). The fatty acid compositions of the both oils were determined....

Author(s): Edmond Ahipo Dué, Hervé César B. L. Zabri, Jean Parfait E.N. Kouadioand Lucien Patrice Kouamé

Cholesterol concentration in different parts of bovine meat sold in Nsukka, Nigeria: Implications for cardiovascular disease risk

April 2009

  Cardiovascular disease (CVD) is a leading cause of mortality globally. Reducing dietary fat and cholesterol intake is central to the reduction in the risk of CVD. In Nigeria and other developing countries, meat is a good source of protein and other nutrients, and its consumption is increasing. This study investigates the cholesterol concentration of ten parts of bovine meat – rib muscle, fore-limb...

Author(s): Chukwunonso E. C. C. Ejike and Tufon N. Emmanuel

Regenerative action of Cochlospermum tinctorium aqueous root extract on experimentally induced hepatic damage in rats

April 2009

  The hepatoprotective effect of aqueous root extract of Cochlospermum tinctoriumon carbon tetrachloride (CCl4) – induced hepatic damage in rats was reported. The present study examined the curative action of the plant extract on experimentally induced hepatic damage in rats. Wistar rats were divided into normal control, induction control, extract and prednisolone treated groups. Hepatotoxicity was...

Author(s): Etuk E. U., Francis U. U. and Garba I.

Antisickling property of Carica papaya leaf extract

April 2009

  Sickle cell disease (SCD) results from a mutation in the hemoglobin inside the red blood cells, where a glutamic acid at position 6 is replaced by a valine. Many phytomedicines have been identified as potential antisickling agents, stemming from reported usage as ethnomedicines by the local folk. This research examined methanolic leaf extracts of Carica papaya L. (Caricaceae) for possible in...

Author(s): N. O. A. Imaga, G. O. Gbenle, V. I. Okochi, S. O. Akanbi, S. O. Edeoghon, V. Oigbochie, M. O. Kehinde and S. B. Bamiro

Effect of experimental Schistosomiasis mansoni infection on serum levels of iron, zinc and copper in the olive baboon (Papio anubis)

April 2009

  Schistosoma mansoniasis is a disease of grave concern due to its high morbidity and mortality in parts of the world. This study aimed at providing insight into the pathogenesis of S. mansoniasis as an aid in the development of effective control methods. Iron, zinc and copper concentrations were spectrophotometrically measured in sequential serum specimens obtained from baboons throughout the...

Author(s): Mungatana N. W. K., Ngure R. M., Shitandi A. A., Mungatana C. K.  and Yole D. S.

Epidemiological and biochemical studies of human lymphatic filariasis and associated parasitoses in Oguta, South-Eastern, Nigeria

April 2009

  Possible organ infections associated with human filariasis, helminthiasis and malaria in Oguta Local Government Area of Imo State, South-Eastern Nigeria were investigated. Blood, urine and stool samples were collected in appropriate containers from 200 male and female respondents aged 31 – 85 years. Parasitological studies were carried out on blood samples for malaria and/or microfilariae parasites...

Author(s): Okey A. Ojiako and G. O. C. Onyeze

Effect of administration of acetylsalicylic acid on phosphatase enzymes in liver of metabisulphite treated rats

April 2009

  Membrane stabilization is an established attribute of most anti-inflammatory drugs. In this work the membrane stabilization capability of acetylsalicylic acid (ASA) was investigated in the liver of metabisulphite insulted experimental rats. Previous reports have shown that sodium metabisulphite administered to rats resulted in labilization of plasma membrane of some rat tissues while acetylsalicylic acid, an...

Author(s): J. E. Olajide, M. A. Akanji, J. Omale and N. O. Mohammad

Purification of human serum paraoxonase: A simple and rapid method

April 2009

  Paraoxonase/arylesterases (EC. is an enzyme found tightly associated with high density lipoprotein particle in serum. Because of its unique enzyme activity, antioxidant property and its role as an anti atherosclerotic molecule, various methods are used for its purification from human serum. Methods involved in its purification are elaborate and complicated. Also the yield and final activity are highly...

Author(s): A.J. Mahadesh Prasad, K. Kemparaju, Elizabeth A Frank and Cletus J.M. D’Souza.

Efficacy of defatted soy flour supplement in Gulabjamun

April 2009

  Study was undertaken to determine the efficacy of defatted soy flour mix levels inGulabjamun (sweet dessert comprised of fried milk balls dipped in sugar syrup)and its impact on the quality parameters. Soy flour was fortified in three levels (3.33, 6.66 and 9.99%) w/w to prepare different compositions of Gulabjamuns by replacing wheat-flour in control recipe. 10 g spherical...

Author(s): Awadhesh Kumar Singh, Dattatreya Mahadev Kadam, Mili Saxena and R. P. Singh

Effects of ethanolic and aqueous leaf extracts of Landolphia owariensis on the serum lipid profile of rats

April 2009

  The lipid profile of normal adult male rats administered both ethanolic and aqueous leaf extracts of Landolphia owariensis (P. Beauv) were determined. The animals were distributed into two sets of four groups with five animals in each group. Each set had one group, which served as control while the other three groups in the two sets were administered different concentrations of the ethanolic and...

Author(s): Nwangwu Spencer C., Ike Francisca, Olley Misan, Oke James M., Uhunmwangho Esosa, Amegor, O. F. Ubaoji Kingsley  and  Nwangwu Udoka

Effect of Hibiscus sabdariffa anthocyanins on 2,4-dinitrophenylhydrazine-induced hematotoxicity in rabbits

April 2009

  In this study, the 2,4-dinitrophenylhydrazine-induced biochemical and hematological changes in rabbits were examined under the administrative protocol of anthocyanin extract from Hibiscus sabdariffa calyces. Blood levels of reduced glutathione (GSH) and  malondialdehyde (MDA)  as well as red blood cell counts (RBC), white blood cell counts (WBC), packed cell volume (PCV) and hemoglobin...

Author(s): A. Ologundudu, A. O.Ologundudu, I. A. Ololade and F. O. Obi

Kinetics studies of protease in fermenting locust beans (Parkia biglobosa) and melon seed (Citrullus vulgaris)

April 2009

  Melon seed (Citrullus vulgaris) and locust bean (Parkia biglobosa) were separately subjected to a natural solid – substrate fermentation for 5 days. The peak of protease (P.I) production from the fermenting melon seeds was 48 h while that of the protease (P.II) from fermenting locust bean was 96 h. Both P.I and P.II demonstrated maximum activity at 40°C. The peak of activity for P.I was observed...

Author(s): C. Egwim Evans, J. Yisa and P. O. Egwim

Peripheral blood and C-reactive protein levels (CRP) in chronic periodontitis

April 2009

  Evidence for a potential link between periodontal disease and coronary heart disease (CHD) has accumulated in recent years. C-reactive protein is potential marker of cardiovascular risk and associated with periodontal disease. CRP levels were analyzed in 26 periodontitis patients and 23 healthy controls along with hemoglobin, red blood cell count (RBC), leukocyte cell count (total and differential WBC),...

Author(s): Balwant Rai, Jasdeep Kaur , Simmi Kharb, Rajnish Jain, S. C. Anand and Jaipaul Singh

D-3-hydroxybutyrate oxidation in mitochondria by D-3-Hydroxybutyrate dehydrogenase in Tetrahymena pyriformis

March 2009

  Tetrahymena pyriformis a ciliated protozoan, is considered a good indicator of water pollution. However its energy supply is poorly understood. This work was focused on the metabolism of hydroxybutyrate through the study of the membrane bound mitochondrial NAD+-dependent D-3-hydroxybutyrate dehydro-genase (EC. (BDH), a ketone body catalysing enzyme involvedin the interconversion of...

Author(s): Omar Akil, Zakaria El Kebbaj, Norbert Latruffe and M’Hammed Saïd El Kebbaj

Selected heavy metals and electrolyte levels in blood of workers and residents of industrial communities

March 2009

  The study focused on the determination of the levels of lead, cadmium, sodium and potassium in the blood of selected industrial workers (n = 36), residents of the neighboring communities (n = 36) as well as the residents of the communities further away from any industrial setting (which controls) (n = 12). The subjects were recruited from the granite served as the, ceramic and cement industries at Ewekoro,...

Author(s): Babalola O. O and Babajide S. O

Utilization of enzymes in the production of liquid sugar from dates

March 2009

  Date palm fruits Phoenix dactylifera cultivated in the Kingdom of Saudi Arabia were used for the production of high quality date syrup. This syrup is suitable for the manufacture of different food products. Date syrup was prepared from Reziz date (Soft variety) at different ratios of water/date (2:1, 2.5:1 and 3:1). Pectinase and cellulase were used to obtain the maximum date syrup extraction....

Author(s): Gamal A. El-Sharnouby  , Salah  M. Al-Eid  and  Mutlag M. Al – Otaibi 

Toxicological effects of chlorpyrifos and methidathion in young chickens

March 2009

  The objective of this work is assessment of the toxicological effects of the organophosphorus compounds (methidathion and chlorpyrifos) and the usefulness of some parameters as bioindicators. Haematology and serum biochemistry were assayed in 15 cockrels at random age of 4 - 6 weeks. The birds were randomly assigned to 3 oral (by mouth) pulse-dose treatments of 0, 3.5 mg/kg chlorpyrifos, and 7.5 mg/kg...

Author(s): Ojezele, Matthew Obaineh and Abatan, Oluwole Matthew

Degradation of pyrimidine ribonucleosides by extracts of Aspergillus terreus

March 2009

  Cell-free extracts of nitrate-grown mycelia of Aspergillus terreus could catalyze the hydrolytic deamination of cytidine to uridine and ammonia followed by the hydrolytic cleavage of the N-glycosidic bond of the produced uridine to the corresponding base (uracil) and ribose. The same extracts could not catalyze the hydrolytic deamination of cytosine. Addition of inorganic arsenate to the reaction...

Author(s): Osama M. Abdel-Fatah, Maysa A. Elsayed and Ali M. Elshafei

Effect of 50 Hz electromagnetic fields on acid phosphatase activity

March 2009

  The effect of extremely low frequency (ELF) electromagnetic field (EMF) (50 Hz 0.5 mT) on the activity of acid phosphatase (EC was studied. In addition the factors affecting the enzyme activity such as the temperature, pH and substrate concentration were also investigated. The results show that ELF EMF have significant influence on enzyme activity. Upon EMF...

Author(s): K. S. Prashanth, T. R. S. Chouhan and Snehalatha Nadiger

Lipid profile of a population of diabetic patients attending Nigerian National Petroleum Corporation Clinic, Abuja

March 2009

  This study was conducted to compare the lipid profile of diabetic patients and healthy controls. The lipid profiles and lipoprotein levels of 50 known diabetic patients and 50 healthy subjects were studied. Total cholesterol (TC), Triacylglycerols (TG), Low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) levels were assayed for each group using standard biochemical...

Author(s): Ugwu, C. E. , Ezeanyika, L. U. S., Daikwo, M. A. and Amana, R.

The effect of allelic variation on forage quality of brown midrib sorghum mutants with reduced caffeic acid O-methyl transferase activity

March 2009

  Sorghum brown midrib (bmr) mutants have reddish-brown vascular tissues in their leaves and stems as a result of changes in lignin content and subunit composition. Past research at Purdue University has generated a set of bmr sorghum mutants via chemical mutagenesis and established some to be allelic to each other. More recently, we identified additional spontaneous mutants in true breeding lines with...

Author(s):   R. K. Vogler, T. T. Tesso, K. D. Johnson and G. Ejeta  

Isolation and preliminary characterization of conophor nut (Tetracarpidium conophorum) lipase

February 2009

  Lipase in oilseeds helps to hydrolyze the ester bonds of storage triacylglycerols. The crude lipase from the conophor nut (Tetracarpidium conophorum) was isolated and assayed via quantification of the free fatty acids liberated by the hydrolysis of the oilseed triacylglycerols. Optimum pH and temperature for the enzyme activity of the conophor nut lipase was pH 8.0 and at 30°C with substantial lipolysis...

Author(s): Victor N. Enujiugha

A study on the combined administration of chloroquine and insulin effect on serum transferases and phosphatases activity during increased dietary fat and calcium consumption

February 2009

  Previous studies reported on relationship between chloroquine administration, insulin and glucose homeostasis, but the role of dietary fat and the combined effect of the drugs on liver function have not been exploited. The present study was set up to investigate the effect of combined administration of insulin and chloroquine on serum transferase and phosphates activity during increased dietary fat and...

Author(s): Ajani E. O., Salau B. A., Ezima E. N. , Oyefuga O. H. and Osineye P. O.

Antinociceptive properties of Trigonella foenumgreacum seeds extracts

February 2009

  Trigonella foenum-graecum L. (Leguminosae), known in Morocco as “Helba”, is used in folk medicine for its anti-ulcer, anti-inflammatory, cicatrizing activities and to treat various pain-related physiological conditions. In the present study, we attempted to verify the possible antinociceptive action of different extracts obtained from the seeds of this plant. Three experimental models...

Author(s): A. Laroubi, L. Farouk, R. Aboufatima, A. Benharref , A. Bagri and A. Chait

Toxicological assessment of oral administration of some antisickling agents in rats

February 2009

  This study investigated the toxicological effects of oral administration of hydroxyurea, tellurite and thiocyanate on some biochemical parameters in rats. The drugs were administered orally to rats daily at their therapeutic dose for 28 days after which some biochemical parameters were measured. All the drugs caused growth depression and significant elevation (P < 0.05) of serum alkaline...

Author(s): Oyewole, O. I. and Malomo, S. O.

Regenerative action of Cochlospermum tinctorium aqueous root extract on experimentally induced hepatic damage in rats

January 2009

  The hepatoprotective effect of aqueous root extract of Cochlospermum tinctoriumon carbon tetrachloride (CCl4) on induced hepatic damage in rats was reported. The present study examined the curative action of the plant extract on experimentally induced hepatic damage in rats. Wistar rats were divided into normal control, induction control, extract and prednisolone treated groups. Hepatotoxicity was...

Author(s): Etuk E. U., Francis U. U. and Garba I.

Efficacy of Dissotis rotundifolia on Trypanosoma brucei brucei infection in rats

January 2009

  The therapeutic potential of the crude extract of Dissotis rotundifolia was   investigated in rats infected with Trypanosoma b. brucei. Animals were treated orally or intraperitoneally at 200, 600 and 800 mg/kg body weight. At 800 mg/kg, parasitemia was reduced by 66.7 and 78.4% after oral and intraperitoneal administration respectively. In vitro exposure of blood forms to...

Author(s): Abdullahi Mann, Evans C. Egwim, Barnabas Banji, Nda-Umar Abdukadir, Mohammed Gbate and J. T. Ekanem

Lipid peroxidation and tyrosinase inhibition by lichen symbionts grown in vitro

December 2008

  The symbionts of lichen species Arthothelium awasthii, Heterodermia podocarpa, and Parmotrema tinctorum were isolated and cultured on various nutrient media incubated in a growth chamber. Methanolic extracts of one year old symbiont cultures were taken for evaluating their potential to inhibit lipid peroxidation and tyrosinase enzyme activity. The extracts of all cultured...

Author(s): Neeraj Verma, Bhaskar C. Behera, Anjali Sonone and Urmila Makhija

Maytenus ilicifolia as source of antioxidants and anti-radicals agents and its action on neutrophils peroxidase (myeloperoxidase)

December 2008

  Maytenus ilicifolia is an important plant with a great potential for cancer treatment and has a popular and diffused use, as tea, in Brazil and in other countries against gastric ulcers, dyspepsia and others gastric problems. In this paper, the antioxidant and anti-radical activities of this plant were compared with trolox and uric acid by their abilities as scavengers of DPPH·, ABTS·+,...

Author(s): J. C. R. Vellosa, O. A. K. Khalil, N. M. Khalil, V. A. F. F. M. Santos, R. A.  Hakime -Silva, M. Furlan, I. L. Brunetti and O. M. M. F. Oliveira

Effects of Landolphia owariensis leaf extract on the liver function profile and haemoglobin concentration of albino rats

December 2008

  The effects of aqueous extract of Landolphia owariensis leaves on the biochemical indices of liver function were investigated in Wister strain of albino rats. Preliminary phytochemical analysis of the plant leaves showed the presence of tannins, alkaloids, flavonoids and saponins. Acute toxicity tests of the extract gave an LD50of 3370 mg/kg. Liver function tests revealed that the serum...

Author(s): L. A. Nwogu, C. U. Igwe and A. A. Emejulu

Two-stage anaerobic digestion of aerobic pre-treated sisal leaf decortications residues: hydrolases activities and biogas production profile

November 2008

  A two-stage system was investigated for anaerobic digestion (AD) of aerobically pre-treated sisal leaf decortication residue (SLDR) with regard to hydrolytic enzymes and biogas production. The system consisted of a solid-bed bioreactor for hydrolysis connected to methanogenic bioreactor packed with sisal fibre decortication residues (SFDR) as biofilm carriers. Some of the enzymes produced by microorganisms to...

Author(s): Anthony Manoni Mshandete, Lovisa Björnsson, Amelia Kajumulo Kivaisi, Mugassa Steven Thomas Rubindamayugi and Bo Mattiasson

Study of sensitivity and ability of adenosine deaminase in response to pre-unfolding and especially pathological temperatures via changing the enzyme structure and activity

November 2008

    Adenosine deaminase (ADA) is an important enzyme of the purine metabolic pathway, which catalyzes the conversion of adenosine and deoxyadenosine to their respective inosine derivatives plus ammonia, in a rapid and irreversible reaction. In this work, we studied the structural and kinetic properties of bovine ADA as a function of temperature in the range, 20 - 80°C by circular dichroism (CD) and...

Author(s): Mostafa Rezaei-Tavirani, Saeed Hesami-Takallu, Seyed Hassan Moghaddamnia, Shiva Kalantari, Bijan Ranjbar,  Seyedeh Zahra Moosavi-Nejad, Sayed-Amir Marashi, Mohammad Rahmati Roodsari and Farhad Malekzad

Attenuation of N-nitrosodiethylamine-induced liver carcinogenesis in rats by naturally occurring diallyl sulfide

October 2008

  The present study was aimed to investigate the chemopreventive effects of diallyl sulfide (DAS),  organosulfur compounds present in high amounts in garlic, against N-nitrosodiethylamine (NDEA) induced  hepatocarcinogenesis in rats. NDEA treatment to rats resulted in significantly elevated levels of serum  aspartate transaminase, alkaline phosphatase, lactate dehydrogenase and...

Author(s): Sherine M. Rizk and Safinaz S. Ibrahim

Some properties of extracellular protease from Bacillus licheniformis LBBL-11 isolated from “iru”, a traditionally fermented African locust bean condiment

October 2008

  Twelve strains of Bacillus licheniformis isolated from traditionally fermented African locust bean (iru) were evaluated in respect to production of protease on skim milk agar. B. licheniformis LBBL-11 exhibited the highest proteolytic activity with a diameter of clear zone measuring 35.0 mm. Production of protease from B. licheniformis LBBL-11 was further studied by growing...

Author(s): Folasade M.  Olajuyigbe and Joshua O. Ajele

Protein profiles of adrenal gland of neonatal rat treated with monosodium glutamate

September 2008

  Exposure to excessive monosodium glutamate (MSG) during neonatal life has been correlated with loss of function in stress response that might be involved in changes of adrenal activity. This study was designed to investigate the protein pattern and examine the mRNA level of proteins in the adrenal glands following MSG stimulation. Neonatal rats were subcutaneously administered with MSG at a concentration of 4...

Author(s): Anuwat Wanthong, Sompong Thammasirirak and Khomsorn Lomthaisong

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