African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 384

AJBR Articles

December 2009

Anti-inflammatory and anti-ulcerogenic activity of the ethanol extract of ginger (Zingiber officinale)

  The acute toxicity test carried out on the ginger extract gave the LD50 value as 1000 mg/kg. The antiinflammatory and anti-ulcerogenic effects of the ethanol extract of ginger (Zingiber officinale) in adult Wistar rats were studied using values below the lethal dose. Inflammation was induced by injecting 0.1 ml undiluted fresh egg albumin (philogistic agent) into the subplantar surface of the...

Author(s): Chioma A. Anosike, Onyechi Obidoa, Lawrence U. S. Ezeanyika and Meshach M. Nwuba.

  • Article Number: 3FC7A2940810

December 2009

Modulation of melanin synthesis and its gene expression in skin melanocytes by palm tocotrienol rich fraction

  Melanin is the pigment that determines skin color. Melanin synthesis is catalysed by the enzyme tyrosinase and is controlled by TYR, TYRP1 and TYRP2 genes. The objective of this study was to evaluate the anti pigmentation property of palm tocotrienol rich fraction by determining melanin synthesis and expression of genes involved in its regulation in skin melanocytes. Palm tocotrienol...

Author(s):   Suzana Makpol, Nur Nadia Mohd Arifin, Zahariah Ismail, Chua Kien Hui, Yasmin Anum Mohd Yusof and Wan Zurinah Wan Ngah   

  • Article Number: 5C41BB540817

December 2009

Antifeedant and antimicrobial activity of Tylophora indica

  Crude and pure extracts of Tylophora indica were investigated in view of antifeedant, antibacterial and antifungal properties.  Leaf crude extract showed more antifeedant activity than stem and root against Spodoptera litura, a polyphagous pest on wide ranging crops. Among the pure compounds isolated, Tylophorine showed the highest antifeedant activity followed by Septicine, O-Methyl...

Author(s):   B. Krishna Reddy, M. Balaji, P. Uma Reddy, G. Sailaja, K. Vaidyanath and G. Narasimha

  • Article Number: E94389640821

November 2009

Effect of falciparum malaria on some plasma proteins in males: With special reference to the levels of testosterone and cortisol

  Sex-associated hormones were evidenced to modulate immune responses and consequently directly influence the outcome of infection. Testosterone is known to influence both protein metabolism and the level of cortisol which is the hormone of stress. This work was conducted to explore the influence of the degree of parasitemia in Plasmodium falciparum malaria on the male sex hormone testosterone, plasma...

Author(s): Muawia A. Abdagalil and Nabiela M. ElBagir

  • Article Number: 6F15B6311264

November 2009

Immunopurification of a rape (Brassica napus L.) seedling lipase

  Lipase or triacylglycerol acylhydrolase (E.C.3.1.1.3) was purified to homogeneity from rapeseed-germinated cotyledons (Brassica napus L.). The purification scheme involved homogenization, centrifugation, ultracentrifugation and affinity chromatography using polyclonal antibodies raised against porcine pancreatic lipase. The purified rapeseed lipase was homogenous and did not contain...

Author(s): H. Belguith, S. Fattouch, T. Jridi and J. Ben Hamida

  • Article Number: A50B89B11285

November 2009

Effect of Gongronema latifolium crude leaf extract on some cardiac enzymes of alloxan-induced diabetic rats

  The effect of Gongronema latifolium on serum cardiac enzymes in alloxan induced diabetic rat models and normal control rats were determined using graded doses of 80% ethanol extract of G. latifolium leaf. The serum activities of aspartate aminotransferase (AST), creatine kinase (CK), creatine kinase isoenzyme (CKMB) and lactate dehydrogenase (LD) were determined in diabetic Wistar albino...

Author(s): E. E. Edet, M. I. Akpanabiatu A. E. Eno, I. B. Umoh and E. H. Itam

  • Article Number: F19D5FD11291

November 2009

Electrolyte profile and prevalent causes of sickle cell crisis in Enugu, Nigeria

  One hundred sickle cell patients aged between 6 - 25 years in steady state who attended Sickle Cell Clinic at University of Nigeria Teaching Hospital, Enugu, Nigeria were selected for this study. Out of this number, only thirty who were eventually admitted in crisis state within one year of this study were selected for subsequent investigations. They included 20 females and 10 males. We also selected thirty...

Author(s): E. O. Ibe, A. C. J. Ezeoke, I. Emeodi, E. I. Akubugwo, E. Elekwa, M. C. Ugonabo and W. C. Ugbajah

  • Article Number: B0B28D511296

November 2009

The role of ascorbic acid in the treatment of Plasmodium Berghei infected mice

  This work aimed at examining the effect of malaria parasites and ascorbic treatments in mice. The relevance of this research derives from the desire to understand the role of ascorbic acid in malaria infection. In this study design, three groups of ten mice each categorized as non-parasitized-non-treated (control), parasitized-non-treated (PnT) and parasitized ascorbic acid treated (P+asT) were used....

Author(s): H. O. T. Iyawe and A. O. Onigbinde

  • Article Number: CBA24E911303

October 2009

Prevention of cadmium-induced alteration in rat testes and prostate lipid patterns by α-tocopherol

Cadmium induced testicular damage has been investigated in α-tocopherol (Vitamin E) pretreated and non-pretreated male rats exposed to a single sub-lethal dose of cadmium in form of CdCl2. Graded doses of vitamin E (75, 150, and 750 mg kg-1 body wt.) were administered daily to rats in separate groups by gavage for 4 weeks while 3 mg Cd kg-1 body wt was administered subcutaneously, 24 hr to the termination of the...

Author(s): M. A. Adaikpoh and F. O. Obi

  • Article Number: 1E8D95C11224

October 2009

The hormone-emotion-behavioural gene-neuromessenger labyrinth: Pertinent questions

  The discovery of behavioural genes has raised the prospect that behaviour may be governed, in part, by the actions of mutant gene products on the brain. These are mostly enzymes or proteins involved in processes related to neurotransmission. In addition, numerous studies have demonstrated the effects of specific hormones on behaviour. Furthermore, the ability of intense emotions to stimulate or suppress the...

Author(s): N. A. Adamafio

  • Article Number: 8F99C0011232

October 2009

Determination of toxic metal concentrations in flame-treated meat products, ponmo

  Cowhides ‘ponmo’ prepared by various and unknown processing methods were purchased from several markets in Lagos and environs and the contents of lead, cadmium, chromium, zinc, mercury and arsenic were determined before and after boiling. Significantly high levels of these metals except cadmium and zinc were found in all the samples obtained after boiling. The highest levels of Pb (1.54 mg.kg-1),...

Author(s): W. Okiei, M. Ogunlesi, F. Alabi, B. Osiughwu and A. Sojinrin

  • Article Number: A7E23FA11243

October 2009

Studies on separation techniques of pomegranate seeds and their effect on quality of Anardana

  The dehydrated seeds of wild pomegranate fruits (Anardana) are used as acidulent in culinary preparations and in making various medicines. For easy separation of seeds, fruits were subjected to sand roasting, hot water dipping and soaking in cold water. Hot water dip for 2 min saved time required for separation of seeds from fruits (80% excluding treatment time and 74% including treatment time). Due to the...

Author(s): Amit Parashar, S. K. Gupta and Ashok Kumar

  • Article Number: 8112B9B11248

October 2009

Antidermatophytic activities of Ixora brachiata Roxb

  The in vitro antifungal activity of Ixora brachiata Roxb. leaf and root extracts were evaluated against three different genera of dermatophytes viz. Microsporum,Trichophyton and Epidermophyton by Dilution Agar Method. The crude extracts ofIxora brachiata root and leaf showed in-vitro antifungal properties and completely prevented the growth of tested...

Author(s): B. Sadeghi-Nejad and S. S Deokule

  • Article Number: D21A82311257

September 2009

Recent advances in the characterization of peptidyl transferase center: Zero-distance labeling of proteins at or near the catalytic site of human 80S or Escherichia coli 70S ribosomes by means of periodate-oxidized tRNA

  Periodate-oxidized tRNA (tRNAox), the 2’,3’-dialdehyde derivative of tRNA, was used as a zero-length active site-directed affinity labeling reagent, to covalently label proteins at the peptidyl transferase center (PTC), the catalytic site of the large ribosomal subunit. When human 80S or E. coli 70S ribosomes were reacted separately with tRNAox positioned at the P-site, in the...

Author(s): Soria Baouz, Anne Woisard, Lila Chenoune, Gustave Aguié, Gérard Keith, Jean-Marie Schmitter, Jean-Pierre Le Caer and Codjo Hountondji

  • Article Number: 8285D1C11197

September 2009

Haematology, plasma enzymes and organ indices of Clarias gariepinus after intramuscular injection with aqueous leaves extracts of Lepidagathis alopecuroides

  Tank-raised Clarias gariepinus (mean total length, 30.05±4.05cm,SD; mean weights, 250.04±50.22gSD) were injected intra-muscularly with two millilitres per kilogram of each of five concentrations (2.00, 2.00, 6.00, 8.00 and 10.00ppm) of aqueous extracts of leaves of Lepidagathis alopecuroides above the lateral line. The fish in the control group were injected with same dose of...

Author(s): U. U. Gabriel, F. G. Obomanu and O. S. Edori

  • Article Number: 0A69FC111207

September 2009

Levels of cadmium in different brands of cigerettes sold in Abakaliki metropolis of Nigeria

  Cadmium (Cd) is recognized as category 1 carcinogen by the international agency for research on cancer based on its relationship to pulmonary tumors. Cigarette smoking is one major source of Cd in the environment. Levels of Cd in 19 different brands of cigarettes (both local and foreign made) sold in Abakaliki town were determined using atomic absorption spectrophotometer (AAS) (205). The results showed...

Author(s): Augustine A. Uwakwe and Udu Ibiam

  • Article Number: 06A875711212

August 2009

Predicting a-amylase yield and malt quality of some sprouting cereals using 2nd order polynomial model

  Alpha amylase yield in sprouting Maize, Acha, Rice and Sorghum were studied for 180 h. The result was analyzed using 2nd order polynomial model. The result showed that the rate of α- amylase secretion with growth period is significantly high (p < 0.05) and the R2 for each ranged from 67 - 90%, while the R2 for sprouting vigour ranged within 99% for all the cereals studied. The...

Author(s): C. Egwim Evans and O. Adenomon Monday

  • Article Number: 011AD3C11172

August 2009

Asymmetrical dimethylarginine (ADMA) and nitric oxide as potential cardiovascular risk factors in type 2 diabetes mellitus

  Hyperglycemia affects biochemical parameters and influences the progression of coronary heart disease and mortality rates in diabetic patients. L-arginine is the substrate used by NO synthase to produce the vasodilator NO. However, in patients with type 2 diabetes mellitus (T2DM), there is an increase in serum levels of methylated L-arginines, such as ADMA, which is a recently identified potent cardiovascular...

Author(s): Mohamed H. Mahfouz, Ibrahim A. Emara, Mohamed S. Shouman and Magda K. Ezz 

  • Article Number: BBF55A611180

July 2009

Toxicological studies of Ceiba pentandra linn

  The toxicity profile of aqueous methanol extract of Ceiba pentandra leaves was investigated in mice. Two parameters were determined; acute toxicity and chronic toxicity. For acute toxicity test, the LD50 was found to be over 5000 mg/kg. For chronic toxicity test, the mice were injected with graded doses (250 - 500 mg/kg) of the leaves extract daily for 21 days and the effects on body...

Author(s): S, Sarkiyayi, S. Ibrahim and M. S. Abubakar

  • Article Number: 0A858F111147

July 2009

Influence of road transportation during hot summer conditions on oxidative status biomarkers in Iranian dromedary camels (Camelus dromedarius)

  Transportation causes stress in livestock that may alter numerous physiological variables with a negative impact on production and health. The objective of the current study was to investigate the effects of road transport on oxidative stress biomarkers in camels. Ten Iranian dromedary camels were selected and subjected to a journey of approximately 300 km in a truck by road in August 2008. Blood samples were...

Author(s): Saeed Nazifi, Mahdi Saeb, Hasan Baghshani and Saeedeh Saeb

  • Article Number: C99B00511156

June 2009

Comparative methaemoglobin concentrations of three erythrocyte genotypes (HbAA, HbAS and HbSS) of male participants administered with five antimalarial drugs

  In the present in-vivo study, the capacities of five antimalarial drugs (Fansidar, Halfan, Quinine, Coartem and Chloroquine phosphate) to alter/distort methaemoglobin concentrations of three human erythrocyte genotypes (HbAA, HbAS and HbSS) was investigated. Spectrophotometric method was used to ascertain this erythrocyte parameter. The male participants enrolled for this study were grouped...

Author(s): P.C. Chikezie

  • Article Number: 662A21211129

June 2009

Purification of a mannose/glucose-specific lectin with antifungal activity from pepper seeds (Capsicum annuum)

  A lectin was isolated and purified from the pepper seeds Capsicum annuum. The purification procedure involved anionic exchange chromatography on DEAE – Cellulose and QAE – Sephadex columns followed by gel filtration on Sephadex G–100. The heamagglutinating activity of the lectin towards human erythrocytes was sensitive to inhibition by D-mannose and D-glucose; and enhancement by...

Author(s): Adenike Kuku, Oludele Odekanyin, Kemi Adeniran, Mary Adewusi and Toyin Olonade

  • Article Number: A8C28A211135

May 2009

The Hsp40-Hsp70 chaperone machinery of Plasmodium falciparum

  Plasmodium falciparum is the protozoan parasite responsible for the most virulent form of malaria. The majority of the asexual stages of its life cycle occur in the human erythrocyte. Since the infected erythrocytes undergo dramatic structural and functional changes upon parasite infection, malaria research has been focusing on investigating the proteins potentially involved in host cell...

Author(s): Eva-Rachele Pesce and Gregory L. Blatch

  • Article Number: 6E039A710955

May 2009

The use of circular dichroism spectroscopy to study protein folding, form and function

Circular Dichroism (CD) is a spectroscopic technique widely used for the evaluation of the conformation and stability of proteins in several environmental conditions like temperature, ionic strength, and presence of solutes or small molecules. Circular Dichroism spectroscopy is non-destructive, relatively easy to operate, requires small amount of sample and few data collection. Additionally, data analyses are fast....

Author(s): Daniel H. A. Corrêa,  and Carlos H. I. Ramos

  • Article Number: 15798EB10962

May 2009

A novel antifungal phenolic compound from Parrotia persica

  Aqueous and methanol extracts of Parrotia persica leaves were assayed for antifungal activity against phytopathogenic Fusarium oxysporum and human pathogenic Candida albicans by poisoned food technique. Both the aqueous and methanol extracts demonstrated significant antifungal activity. Further fractionation of methanol extract guided by antifungal activity resulted in the...

Author(s): M. Ahanjan, M. P. Raghavendra, and K. A. Raveesha

  • Article Number: F12E68A10998

May 2009

Effects of cinnamon on blood glucose and lipids levels in diabetic patients (Type1)

  The present study was designed to investigate the effects of supplementation of cinnamon on blood glucose and lipids levels among type1 diabetics. The samples consisted of 60 subjects with type1 diabetes and the doses of cinnamon were equally administered orally in the form of capsules with breakfast, lunch and dinner. The doses were given for 4 weeks. Blood samples were taken on the starting day of the...

Author(s): Abdul Rahim Al Jamal

  • Article Number: DF8FCBC11007

May 2009

Salivary amino acids quantification using RP-HPLC during normal menstrual cycle

  The present study was carried out to detect amino acids profile in women saliva in order to establish the qualitative and quantitative differences that might have potential value in detection of ovulation by noninvasive methods. For the collection of sample, the stages of menstrual cycle were decided by the physical and morphological examination of salivary fern pattern. The saliva from various reproductive...

Author(s): S. Alagendran, K. Rameshkumar, K. Palanivelu, N. Puspha, M. Ranjani, N. Arulmozhi and G. Archunan

  • Article Number: F94F5C111015

May 2009

Effects of ivermectin and albendazole on some liver and kidney function indices in rats

  Evaluation of repeated administration of ivermectin and albendazole separately and in combination on some hepatic and renal function indices were examined in albino rats (Rattus novergicus). The experimental animals were randomly divided into four groups: those administered distilled water (control), those administered 0.4 mg/kg bodyweight of ivermectin (Iver), those administered 15 mg/kg body weight...

Author(s): R. O. Arise and S. O. Malomo

  • Article Number: E62326811023

May 2009

Effect of 3-hydroxymethyl xylitol on hepatic and renal functional markers and protein levels in streptozotocin-diabetic rats

  Oral administration of 3-hydroxymethyl xylitol at 40 mg/kg body weight to diabetic rats for 45 days resulted in a significant reduction in blood glucose and significant increase in plasma insulin levels. In addition, the diabetic rats had decreased levels of plasma total protein, albumin, globulin and albumin/globulin ratio as compared to control rats. After treatment with 3-hydroxymethyl xylitol and...

Author(s): Govindasamy Chandramohan, Khalid S. Al-Numair and Kodukkur Viswanathan Pugalendi

  • Article Number: 8557BC011034

May 2009

Lipid composition of microsomal fraction of female rat liver at different stages of growth

  It has been reported that lipids are the only macromolecules which display consistency in their pattern of biosynthesis for all living system. In this study, lipid biosynthesis in the liver microsomes of female Sprague-Dawley rats as they aged (3, 7, 12 , 16 and 20 weeks) was studied. The microsomes were isolated by homogenization and centrifugation. The aliquot of the microsomes and soluble enzymes fraction...

Author(s): Chidozie, V. N., Anekwe, G. E., Chukwu, O. O. C., Olabode, O. A., Igweh, A. C. and Adeyanju, O. N.

  • Article Number: 9356B5D11040

May 2009

Glutathione S-transferase activity of erythrocyte genotypes HbAA, HbAS and HbSS in male volunteers administered with fansidar and quinine

  In vivo investigations were carried out to ascertain the comparative levels of erythrocyte GST activity between non-malarious and malarious male subjects of HbAA, HbAS and HbSS erythrocyte genotypes, administered with fansidar and quinine. The incubation of human erythrocytes with 1-chloro-2,4-dinitrobenzene (CDNB) resulted in almost quantitative conjugation of glutathione (GSH) to form...

Author(s): P. C. Chikezie, A. A. Uwakwe and C. C. Monago

  • Article Number: 0250B9B11051

May 2009

Hepatoprotective potential of crocin and curcumin against iron overload-induced biochemical alterations in rat

  The present study was undertaken to evaluate the possible ameliorating effect of crocin and curcumin on certain biochemical alterations associated with iron overload-induced liver injury in rats. 5 groups of rats were used, a normal control group received daily i.p. injections of saline and 4 groups received daily i.p. injections of ferric nitrilotriacetate (FeNTA) for 8 successive...

Author(s): Shoddy A. EL-Maraghy, Sherine M. Rizk and Maha M. El-Sawalhi

  • Article Number: 27FC7A111058

May 2009

Modulation of di- (2- ethylhexyl) phthalate induced hepatic toxicity by Apium graveolens L. seeds extract in rats

  In the present study, the hepatoprotective activity of methanolic extract of Apiumgraveolens L. (celery) seeds was tested against Di-(2- ethylhexyl) phthalate(DEHP) induced hepatotoxicity in rats. Oral administration of DEHP (1000 mg/kg b.wt/day) for 6 weeks in rats caused a significant increase in the levels of serum marker enzymes like serum glutamate oxaloacetate transaminase (SGOT), serum...

Author(s): G. C. Jain, Hemant Pareek, B. S. Khajja, Kusum Jain, S. Jhalani, S. Agarwal and Sameer Sharma

  • Article Number: D2CA89F11067

May 2009

Direct ex vivo effects of herbal extracts on serum bilirubin in neonatal blood samples

  Herbal drug therapy is a common practice adopted in traditional and alternative medicine and has been used in the treatment of neonatal jaundice or hyperbilirubinemia from ancient times. This is done with the help of different herbal extracts and using different treatment methods. The knowledge of new possibilities and the fact that herbal drugs have been used in some communities for a long time, clarifies...

Author(s): Seyed Hessamedin Nabavizadeh, Ozair-bin Majid and Amir Anushiravani

  • Article Number: B3F00A911074

May 2009

Toxic effects of aqueous stem bark extract of Cassia sieberiana on some biochemical parameters in rats

  The aqueous extract of Cassia sieberiana stem bark was administered to groups of 4 albino rats (160 ± 10 g) at 0, 20, 60 or 180 mg/kg body weight daily by gavages for six weeks. A 7% decrease in mean body weight gain was observed in the group treated with the highest concentration of the extract (180 mg/kg). Groups treated with the extract showed significant (p < 0.05) increase in serum...

Author(s): W. Obidah, U. A. Sa’ad and A. U. Wurochekke

  • Article Number: 5A1773911080

May 2009

Mechanisms of arsenic toxicity and carcinogenesis

  Industrialization has excessively modified the discharge and distribution of arsenic in the environment through natural and anthropogenic activities. Gastrointestinal tract, Lung and Dermal absorptions account for various adverse effects associated with arsenic toxicity. The knowledge of arsenic biotransformation holds the trivalent species (DMA3+ and MMA3+) accountable for most arsenic toxicity with...

Author(s): Obinaju, Blessing Ebele

  • Article Number: 757CFF211086

May 2009

Effects of sodium ion and water hyacinth extract in the production of Curvularia pallescens in culture media

  An investigation was conducted on the pH, nutritional and cost benefit of the use of different substrates for the production of Curvularia pallescens Boedijn. The growth of the organism was examined at pH range between 5.5 and 8.6 and on different growth media, potato carrot agar (PCA), potato dextrose agar (PDA), sabouraud agar (SA), tap water agar (TWA), water hyacinth agar (WHA) and Czapek-Dox...

Author(s): Okunowo Wahab Oluwanisola and Ogunkanmi Liasu Adebayo

  • Article Number: 562E27511092

May 2009

Anti anaemic properties of Scoparia dulcis in Trypanosoma brucei infected rabbits

  A major feature of infection with trypanosomes is the development of anaemia. In this study, the effect of Scoparia dulcis (Atiotiousha in Akoko-Edo) onTrypanosoma brucei induced anaemia was investigated in fifteen rabbits divided into three groups of n = 5 over a period of twenty eight days. Changes in Packed cell volume (PCV), Haemoglobin (Hb) concentration, Red blood cell count (RBC), Mean...

Author(s): Orhue N. E. J. and Nwanze E. A. C.

  • Article Number: 39246CF11098

May 2009

Purification and characterization of a laccase from the basidiomycete Funalia trogii (Berk.) isolated in Tanzania

  A lignolytic basidiomycete fungus, Funalia trogii (Berk.), was isolated from decayed wood in coastal Tanzania and cultivated in submerged culture. Initially screened crude enzyme filtrate showed complete rhemazol brilliant blue - R (RBBR) decolorization 2,2’-azino-bis (3-ethylbenzthiazoline)-6-sulfonate and guaiacol oxidation after 7 days of incubation. The fungal...

Author(s): Ferdinandi Patrick, Godliving Mtui, Anthony Manoni Mshandete, Gunnar Johansson and Amelia Kivaisi

  • Article Number: 2BC0F6F11107

May 2009

Effects of curcumin and tetrahydrocurcumin on diabetes induced endothelial dysfunction

  Diabetes-induced endothelial dysfunction has been well recognized for its underlining causes of oxidative stress. Therefore, several studies have worked on testing active antioxidant agents such as vitamin C and E against diabetes induced oxidative stress to preserve endothelial cells. In the present study, we assessed the effects of plant-derived antioxidant, curcumin and its analog, tetrahydrocurcumin (THC)...

Author(s): Natchaya Wongeakin, Pattarin Sridulyakul, Amporn Jariyapongskul, Apichart Suksamrarn and Suthiluk Patumraj

  • Article Number: AE2AD1E11114

April 2009

Enhancing antioxidant availability in grains of wheat plants grown under seawater-stress in response to microalgae extracts treatments

  This study investigated the antioxidant capacity and the levels of enhanced total carotenoids (TCAR), tocopherols (TOC) and phenolic (TPC) and protein (PC) contents in whole grains of wheat plants irrigated 10 and 20% (v/v) seawater (SW) in response to water extracts of microalgae Spirulina maxima (SME) and Chlorella ellipsoida (CEE) and exogenous plant growth enhancers of ascorbic acid...

Author(s): Hanaa H. Abd El-Baky

  • Article Number: 18AA17B10479

April 2009

Effect of traditionally designed nutraceutical on stress induced immunoglobulin changes at Antarctica

  This study was conducted to establish the effect of a traditionally designed nutraceutical on stress related changes in selected immunoglobulin levels in the body. The nutraceutical was prepared from different potent herbs described in Ayurveda using standard operative procedures and were tested for heavy metal and microbial load. Initially, 21 subjects were selected in addition to 7 volunteers for control...

Author(s): P. Bansal, R. Sannd, N. Srikanth and G. S. Lavekar

  • Article Number: FE2593B10487

April 2009

Fatty acid composition and properties of skin and digestive fat content oils from Rhynchophorus palmarum L. larva

  Skin and digestive fat content (DFC) oils from Rhynchophorus palmarum L. larva (Curculionidae) were extracted and their physicochemical properties were characterized. Water content (0.41 %) of skin oil was higher than the amount of DFC (0.04 %). While, the lipid fraction of the skin (35.16%) was slightly lower than the DFC (49.05%). The fatty acid compositions of the both oils were determined....

Author(s): Edmond Ahipo Dué, Hervé César B. L. Zabri, Jean Parfait E.N. Kouadioand Lucien Patrice Kouamé

  • Article Number: 35F19DB10496

April 2009

Cholesterol concentration in different parts of bovine meat sold in Nsukka, Nigeria: Implications for cardiovascular disease risk

  Cardiovascular disease (CVD) is a leading cause of mortality globally. Reducing dietary fat and cholesterol intake is central to the reduction in the risk of CVD. In Nigeria and other developing countries, meat is a good source of protein and other nutrients, and its consumption is increasing. This study investigates the cholesterol concentration of ten parts of bovine meat – rib muscle, fore-limb...

Author(s): Chukwunonso E. C. C. Ejike and Tufon N. Emmanuel

  • Article Number: A4B63F910504

April 2009

Regenerative action of Cochlospermum tinctorium aqueous root extract on experimentally induced hepatic damage in rats

  The hepatoprotective effect of aqueous root extract of Cochlospermum tinctoriumon carbon tetrachloride (CCl4) – induced hepatic damage in rats was reported. The present study examined the curative action of the plant extract on experimentally induced hepatic damage in rats. Wistar rats were divided into normal control, induction control, extract and prednisolone treated groups. Hepatotoxicity was...

Author(s): Etuk E. U., Francis U. U. and Garba I.

  • Article Number: 0CB9F5C10522

April 2009

Antisickling property of Carica papaya leaf extract

  Sickle cell disease (SCD) results from a mutation in the hemoglobin inside the red blood cells, where a glutamic acid at position 6 is replaced by a valine. Many phytomedicines have been identified as potential antisickling agents, stemming from reported usage as ethnomedicines by the local folk. This research examined methanolic leaf extracts of Carica papaya L. (Caricaceae) for possible in...

Author(s): N. O. A. Imaga, G. O. Gbenle, V. I. Okochi, S. O. Akanbi, S. O. Edeoghon, V. Oigbochie, M. O. Kehinde and S. B. Bamiro

  • Article Number: 499890910533

April 2009

Effect of experimental Schistosomiasis mansoni infection on serum levels of iron, zinc and copper in the olive baboon (Papio anubis)

  Schistosoma mansoniasis is a disease of grave concern due to its high morbidity and mortality in parts of the world. This study aimed at providing insight into the pathogenesis of S. mansoniasis as an aid in the development of effective control methods. Iron, zinc and copper concentrations were spectrophotometrically measured in sequential serum specimens obtained from baboons throughout the...

Author(s): Mungatana N. W. K., Ngure R. M., Shitandi A. A., Mungatana C. K.  and Yole D. S.

  • Article Number: 2CA822810541

April 2009

Epidemiological and biochemical studies of human lymphatic filariasis and associated parasitoses in Oguta, South-Eastern, Nigeria

  Possible organ infections associated with human filariasis, helminthiasis and malaria in Oguta Local Government Area of Imo State, South-Eastern Nigeria were investigated. Blood, urine and stool samples were collected in appropriate containers from 200 male and female respondents aged 31 – 85 years. Parasitological studies were carried out on blood samples for malaria and/or microfilariae parasites...

Author(s): Okey A. Ojiako and G. O. C. Onyeze

  • Article Number: 1CC9C4210548

April 2009

Effect of administration of acetylsalicylic acid on phosphatase enzymes in liver of metabisulphite treated rats

  Membrane stabilization is an established attribute of most anti-inflammatory drugs. In this work the membrane stabilization capability of acetylsalicylic acid (ASA) was investigated in the liver of metabisulphite insulted experimental rats. Previous reports have shown that sodium metabisulphite administered to rats resulted in labilization of plasma membrane of some rat tissues while acetylsalicylic acid, an...

Author(s): J. E. Olajide, M. A. Akanji, J. Omale and N. O. Mohammad

  • Article Number: FB5F3AB10555

April 2009

Purification of human serum paraoxonase: A simple and rapid method

  Paraoxonase/arylesterases (EC.3.1.8.2) is an enzyme found tightly associated with high density lipoprotein particle in serum. Because of its unique enzyme activity, antioxidant property and its role as an anti atherosclerotic molecule, various methods are used for its purification from human serum. Methods involved in its purification are elaborate and complicated. Also the yield and final activity are highly...

Author(s): A.J. Mahadesh Prasad, K. Kemparaju, Elizabeth A Frank and Cletus J.M. D’Souza.

  • Article Number: 6AC98DC10564

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