African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 400

AJBR Articles

Antimalarial pyronaridine resistance may be associated with elevated MDR-1 gene expression profiles but not point mutation in Plasmodium berghei ANKA isolates

October 2020

The selection of resistance is inevitable whenever chemotherapy is necessary for pathogen control. Notably, Plasmodium falciparum has developed multifaceted means to overcome the toxicity of nearly all antimalarial medicines. To bypass this challenge, not only should novel drugs be developed, but the resistance mechanisms to new and existing drugs need should be fully explored. Pyronaridine is a companion drug in...

Author(s): Shadrack Kanyonji Kimani, and Jacob Manyiwa Shume,  

Sub-acute and protective effect of Cymbopogon citratus against carbon tetrachloride-induced liver damage

October 2020

The study evaluates the sub-acute toxicity and antioxidant potential of ethanolic leaf extract of Cymbopogon citratus against CCl4-induced toxicity in Sprague Dawley rats. The ethanolic leaf extract of C. citratus was prepared by solvent maceration method. The phytochemicals present in the extract were determined using standard methods. The potential sub-acute toxicities were evaluated using OECD procedure. The...

Author(s): Momoh Johnson Oshiobugie, Aderele Oluwaseun Raphael and Rasaq Adekunle Kareem

Insulin resistance and specific biomarkers in blood and urine of type 2 diabetic patients with or without nephropathy in Basrah, Iraq

October 2020

Diabetic nephropathy (DN) is a master cause of all surplus death-rate among type 2 diabetes mellitus (T2DM) patients with microalbuminuria. This study aimed to find effective biomarkers for early predicting of DN. Present study included 63 patients with T2DM (31 patients with DN, 32 patients without DN) and 33 healthy controls. These three groups were matched for their glucose, urea, creatinine, insulin, L-Carnitine...

Author(s): Adnan Jassim Mohammed Al-Fartosy, Nadhum Abdulnabi Awad and Sadoun Abbas Alsalimi,  

Correlation between glycated hemoglobin and venous blood sugar in diabetic patients monitored in Abidjan

October 2020

The aim of this study was to determine the correlation between glycated hemoglobin and blood sugar levels in diabetic subjects carried out in Abidjan. This cross-sectional study included 100 patients with diabetes monitored, for three months, for whom glycated blood glucose and hemoglobin were performed, this after informed consent of the patients. Pearson and Spearman correlation tests were used, at the 5% threshold....

Author(s): MONDE Aké Absalome, CAMARA-CISSE Massara, KOFFI Konan Gervais, DIALLO Issiagha, AKE AKE Alexandre, YAPO-AKE Bénédicte, ECRABEY Yann Christian, KOUAKOU Francisk, BENE YAO Roger Espérance and TIAHOU Georges

Evaluation of acute oral toxicity, hemato-biochemical activity and physiological responses of rabbits and rats administered Moringa oleifera leaf extract and meal

October 2020

The present study aims to evaluate acute oral toxicity of leaf extract of Moringa oleifera and determine the effect of the leaf’s meals of this plant on hematological and biochemical parameters of the rabbit. Ten rats weighing 150 ± 200 g were used for the oral acute toxicity study. Five rats received orally a single dose of 2000 mg/kg of weight of aqueous extract and 5 rats used as control....

Author(s): Basile Boni Saka Konmy, Pascal Abiodoun Olounladé, and Sanni-yo Doko-Allou,  

Evaluation of the effects of Azadirachta indica leaf on haematology, lipid profile, body weight and organ-system functions of streptozotocin-induced diabetic male rats

July 2020

This study was carried out to evaluate the effects of ethanol extract of Azadirachta indica leaf on haematological parameters, lipid profile, body weight, organ weight and histopathological functions of streptozotocin-induced diabetic rats. Diabetes was induced by a single intraperitoneal administration of streptozotocin (50 mg/kg bw.). The haematological parameters, lipid profile and histopathological investigations...

Author(s): Ezeigwe Obiajulu Christian, Okani Chukwudi Onyeaghana, Nnadi Naomi Ngozi, Obiukwu Onyinye Olivia, Ekwunoh Peter Okwukwe, Obayuwana Erhunmwense Ann, Okibedi Frances Uchenna and Obi Chioma Henrietta  

Inhibitory potential and antidiabetic activity of leaf extracts of Vitex doniana

July 2020

Pancreatic alpha (α)-amylase and intestinal α-glucosidase involved in the enzymatic breakdown of dietary carbohydrates are implicated in postprandial hyperglycemia. The inhibition of these two enzymes has been exploited in the design of antidiabetic drugs. This study was therefore designed to investigate the ability of the leaf extracts of Vitex doniana to inhibit α-amylase and α-glucosidase as...

Author(s): Ani Onuabuchi Nnenna, Udedi Stanley Chidi, Anajekwu Benedette Azuka, Asogwa Kingsley Kelechi and Ekwealor Kenneth Udeh  

Antibacterial activity of endophytic fungi isolated from leaves of medicinal Plant Leucas martinicensis L. growing in a Kenyan tropical forest

July 2020

Infectious diseases are major threat to public health; a problem that has been exacerbated by emergence of multi-drug resistant (MDR) strains. Finding alternative antimicrobial compounds from natural sources such as fungal endophytes and medicinal plants is crucial for addressing antimicrobial resistance. Thus, in this study search for endophytes with antibacterial activities from leaves of medicinal plant Leucas...

Author(s): Ruth Moraa Obare, Stephen A. Indieka and Josphat Matasyoh  

Study of the nutritional values and sanitary quality of soumbala collected from six regions of Burkina Faso

July 2020

Soumbala is regularly consumed as a condiment in most households in Burkina Faso. The purpose of this study was, therefore, to assess its nutritional and sanitary quality. To achieve this purpose, samples of sombala have been analysed for the determination of pH, water and ash contents, biochemical parameters, mineral elements, and aflatoxin contents. Results showed that Fada N’Gourma soumbala had the highest...

Author(s): Elie Kabré, Raoul Bazié, Moumouni Bandé, Thierry Sanou, Fulbert Nikiéma and Jean Sakandé,  

Vitellaria paradoxa fruit pulp bioethanol production potential: A review

May 2020

In the last decade, bioethanol has become a powerful biofuel for the improvement of environmental pollution such as reduction in greenhouse gas levels. Yet, the source and type of substrate material plays a crucial role in the bioethanol production process due to the different compositional characteristics and availability of monomeric sugars. Different substrates of first, second and third generation fuel sources exist...

Author(s): Abdul-Mumeen Iddrisu, Zakpaa Hilary D., Felix Charles Mills-Robertson and Lowor Samuel T.  

Evaluation of in vivo toxicity of rice husk used as fuel for cooking in households

May 2020

This study aimed to evaluate the toxicological effect of food cooked or water boiled with a fan-assisted top-lit-updraft rice husk fuelled gasifier stove named Paul Olivier 150 (PO150). Distilled water was boiled for 1 h using this stove in an opened pot and closed room. This water was then cooled to room temperature before being administered to rats with body weights ranging from 70 to 110 g. Two types of tests were...

Author(s): Mbassi Josiane Emilie Germaine, Sali Atanga Ndindeng, Achu Mercy Bih Loh, Dimo Théophile and Mbacham Fon Wilfred

The effect of aqueous extract of zest of citrus sinensis (AEZCs) on cadmium chloride induced liver toxicity in wistar rats

January 2020

The potency of the peels of Citrus sinensis against cadmium induced liver damage has not been explored in our environment. 48 wistar rats were used for this study. The animals were randomly divided into eight (8) groups of five (5) rats each. Group A was the positive control and received 5 mg/kg body weight (bw) of cadmium chloride (CdCl2) intraperitoneally as a single dose. Groups B and C received the aqueous extract...

Author(s): Augustine Ndubuisi, Ani Celestine, Eze Wenceslaus, Ugwudike Patrick, Anyaeji Pamela, Ude Victor Chibueze, Agu Francis Uchenna, Nworgu Choice, Ikwuka David, Ugwuishi Emeka and Nwachukwu Daniel

Prevalence of dyslipidemia in a Burkinabe military population

January 2020

The objective of this study was to determine the prevalence of dyslipidemia in soldiers received at the laboratory of the Medical Center Camp General Aboubacar Sangoulé Lamizana (CMCGASL) for a medical visit. This is a prospective study of 224 military personnel assigned to peacekeeping missions outside Burkina Faso. The study was conducted over the period of September 2017 to November 2017. Included in the study...

Author(s): Raoul Karfo, Fabrice Mohamed Kangambega, Elie Kabre, Ouedraogo Paulette, Zakaria Nacro, Zakaria Sanogo, Adama Dao, Jean Sakandé and Lassane Sangaré

Lambda-Cyhalothrin induced hepato-nephro toxicity potentials and post treatment recovery in Clarias garipinus

January 2020

This evaluates the 28-day toxicity and 7-day post treatment effect of LCT on the behaviour, liver and kidney of Clarias gariepinus. Prior to the experiment, fishes were acclimatized for two weeks. 120 fishes of standard length (SL) / weight (W) 10-12 cm, 8 - 17 g were used for median lethal concentration (LC50) test and 120 fishes of SL / W 16 - 40 cm, 200 - 250 g were used for the behavioural, hepato - nephrotoxicity...

Author(s): Samuel Uchenna Ezenwosu, Emmanuel Ikechukwu Nnamonu٭, Gregory Ejikeme Odo, Ogonna Christiana Ani, Obiageli Constance Egilibe, Gladys Ukamaka Ogbodo and John F. Ebe

Study of some biochemical parameters of the seeds of the fruit of the sweet Maniguette (Aframomum alboviolaceum (ridl.) k. Schum.) harvested in the Republic of the Congo

January 2020

Aframomum alboviolaceum is a plant that belongs to the family of Zingiberaceae, genus Aframomum and species of A. alboviolaceum. It is wide spread across tropical Africa and represented about 50 species. Proximate analysis is usually done to determine the values of macronutrients present in plant or food sample; it gives the composition of the biomass in terms of gross components. Proximate analysis includes...

Author(s): Jean Paul Latran Ossoko

Increased levels of mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2-R) found in serum of patients with breast cancer

December 2019

The multifunctional transmembrane mannose-6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2-R) has been proposed as a putative prognostic marker in breast cancer. Loss of heterozygosity (LOH) with mutations in the remaining allele have been described at the gene level. We previously reported significant decrease of M6P/IGF2-R at the protein level in cancer cells than normal peritumoral ducts of breast tumors...

Author(s): Lemamy Guy Joseph, Ndeboko Benedicte, Omouessi Serge Thierry and Mouecoucou Justine

Proximate, mineral and phytochemical compositions of Vernonia amygdalina leaves grown under hot and humid tropical conditions

August 2019

This study was conducted to determine the proximate and phytochemical compositions of Vernonia amygdalina leaves, to ascertain its nutritional potentials. V. amygdalina plants were cultivated, and the leaves were harvested at maturity, cleaned and apportioned into two; one portion was oven dried whilst the other was air-dried- all to a moisture content of about 15%. The dried samples were pulverized and used for...

Author(s): Moses Teye, Victor Y. A. Barku and Faustina F. Yeboah  

Statistical optimization of L–glutaminase production by Trichoderma species under solid state fermentation using African locust beans as substrate

July 2019

Six strains of Trichoderma species isolated from soil and air samples were screened for extracellular L-glutaminase production. The highest enzyme producing isolate, Trichoderma longibrachiatum was subjected to screening and nutrients optimization experiments under solid state fermentation using a constant weight of African locust beans as substrate. A specific activity of 54.96 U/mg was achieved at 1% (w/v) glutamine,...

Author(s): Musa Olatunji Olarewaju and Humphrey Chukwuemeka Nzelibe  

The pro-oxidant effect of dextran sodium sulphate on oxidative stress biomarkers and antioxidant enzymes in Drososphila melanogaster

July 2019

This study sought to evaluate the behavioural and biochemical effects of Dextran Sodium Sulphate (DSS) on the oxidative stress biomarkers and antioxidant enzymes. Drosophila melanogaster (both sexes) of 3 days old were exposed to various DSS incorporated diets at concentrations, 0.5 - 3.0% for a period of 14 days (Survival rate). The second phase comprised of 3 groups; Group I- Control (normal diet), Group II-0.5% DSS,...

Author(s): Augustina O. Akinsanmi, Opeyemi Balogun, Johnson O. Titlayo, Ishaya Y. Longdet and Aguiyi C. John,

Partial purification of invertase from Momordica charantia (bitter melon) by three phase partitioning (TPP) method

June 2019

The single step three-phase partitioning (TPP) method was evaluated for the purification of invertase from Momordica charantia. Optimum conditions for TPP method, that is, 70% ammonium sulfate saturation, 1:0.5 t-butanol ratio and 30 min incubation time lead to 20.28% efficiency and 10.48 fold partial purification. Total protein decreased from 34.86 mg to 0.68 mg in the homogenate, and the specific activity of the...

Author(s): Nihan Kübra Belligün and Burcu Saygıdeğer Demir  

Cadmium-induced toxicity and antioxidant enzyme responses in tissues and organs of African catfish (Clarias gariepinus)

June 2019

Juveniles of Clarias gariepinus were exposed to different concentrations of cadmium chloride for 96 h under laboratory conditions using static bioassays with continuous aeration to determine its mean lethal concentration (LC50), biochemical alterations, bioaccumulation and histological pattern in a sub-lethal toxicity test. The median lethal concentration (LC50) at the end of the acute toxicity was 120.2 mgL-1. Also the...

Author(s): Chisom P. OSISIOGU and Omolara T. ALADESANMI

Immunomodulatory effects of cement in exposed workers

May 2019

This study was conducted to assess the immunomodulatory potentials [immunoglobulin E (IgE), interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α)] of cement dust in individuals occupationally exposed to cement. Potentials of cement particles to modulate immune responses have not been documented in occupationally exposed Nigerians. Twenty-nine male cement loaders who had direct exposure to cement...

Author(s): Moses O. Akiibinu, Taofeeq Oduola and Franklin Akinola  

Phytochemical, acute and subacute toxicity studies of Annona senegalensis Pers. (Annonaceae) root wood extracts

May 2019

Considered safe because being from natural origin, plant products can exhibit toxic effects during their use. To ensure safe use of Annona senegalensis Pers. (Annonaceae), plant widely used for its therapeutic potential, the phytochemical and safety profiles of its root wood were investigated. Standard tube characterization tests were used to highlight phytochemical groups of root wood of the plant. Acute and subacute...

Author(s): Sylvain ILBOUDO, Hortense SOME, Geoffroy G. OUEDRAOGO, Félix B. KINI, Sylvin OUEDRAOGO and Innocent P. GUISSOU,

Problems of interpretation of serum electrophoresis related to the manual phase during its realization with a semi-automatic automaton

April 2019

Manual steps including preparation of samples and gel, and launching of automatic sequences can cause many difficulties in the interpretation of electrophoresis. Three observations of electrophoretic profiles on Hydragel 15β1-β2 agarose gel media led us to look for interference in the manual step of the technique used. After reconsidering all the steps of the manipulation and carefully observing the profiles...

Author(s): Raoul Karfo,, Elie Kabré, Nadia Safir, Mounya Bouabdellah, Laila Benchekroun, Jean Sakandé, and Layachi Chabraoui,

Shea butter extraction technologies: Current status and future perspective

February 2019

Shea butter is a high–value shea nut fat used as an edible oil, antimicrobial and moisturiser in the food, pharmaceutical and cosmetic industries, respectively. The annual worldwide export of shea nut from Africa is 350,000 MT of kernels with a market value of approximately $120 million to producing countries. The multifunctional properties of the shea butter depend strictly on its compositional properties: the...

Author(s): Iddrisu Abdul-Mumeen, Didia Beauty and Abdulai Adam  

Association of metabolic syndrome with the risk of developing liver disease in chronic hepatitis B patients

February 2019

Metabolic syndrome is a constellation of abnormal glucose and lipid metabolic parameter that increases ones risk of developing cardiovascular diseases. Metabolic profiles have been linked to progression of varying stages of liver disease in chronic hepatitis B infection. The main objective of this prospective cross sectional study was to establish a link between metabolic syndrome indicators and markers of progression...

Author(s): Dongsogo Julius and Larbie Christopher

Studies on some physicochemical properties of Rhodanese synthesized by Bacillus cereus isolated from the effluents of iron and steel smelting industry

January 2019

The study purified and investigated the physicochemical properties of rhodanese (a cyanide detoxifying enzyme) synthesized by Bacillus cereus. This was with a view to producing an industrially important enzyme. The bacterial strain was identified as B. cereus by sequencing of its 16SrRNA gene. B. cereus rhodanese was purified with a fold of 3.53, yield of 36.80% and specific activity of 25.30 µmol/min/mg protein....

Author(s): Babamotemi Oluwasola Itakorode, Raphael Emuebie Okonji, Odunayo Adedeji, Nkem Torimiro, Chinwe Onwudiegwu and Ademakinwa Oluwaseyi  

Evaluation of the effect of vitamin C on caspase 9 and oxidative stress in rheumatoid arthritis patients

November 2018

Rheumatoid arthritis (RA) is a chronic and an autoimmune disease of the joints and is widely distributed worldwide. It is characterized by alterations of the antioxidant defense system and increased free radical formation and pro-inflammatory cytokine. The aim of the present study was to evaluate the effect of vitamin C supplementation on oxidative stress biomarkers and caspase 9 level in rheumatoid arthritis patients....

Author(s): Amira M. Elshamy, Nagah K. Gaafar, Nadia E. ElAshwah, Ayman A. Wagih and Abeer A. Shahba  

New insight on premature atherosclerosis in Egyptian children with β-thalassemia major

October 2018

Beta-thalassemia major (β-TM) in children is associated with an increase in the risk of premature cardiovascular complications caused by accelerated atherosclerosis which significantly contributes to morbidity and mortality. The molecular mechanisms underlying β-TM associated atherosclerosis and its relation to biochemical risk factors still remain obscure. We aimed to investigate the association between SIRT1...

Author(s): Hoda Ali Ibrahim, Soha Said Zakaria, Manal Mohamed Elbatch, Mohamed Ramadan Elshanshory and Samia Abd Elhamid Eldardiry  

Lipase in biodiesel production

September 2018

Although fossil fuels have been serving mankind for several centuries, their exploration and use bring about several environmental problems. Besides, fossil fuels are neither renewable nor sustainable. There is therefore a need to search for renewable alternatives which are sustainable and environmentally friendly. Biodiesel, chemically known as methyl ester, is a renewable and sustainable biofuel used to run diesel...

Author(s): Onyinyechukwu J. Chioke, Christiana N. Ogbonna, Chukwudi Onwusi and James C. Ogbonna  

The interplay between paraoxonase-1 and epigenetic changes in colorectal carcinoma

August 2018

Colorectal cancer (CRC) is the third leading cause of cancer-related death. Colorectal mucosa has high levels of oxidative stress (OS) landmarks. OS has deleterious effect on cell structures as lipids, proteins and DNA. Markers of protein oxidation are named as advanced oxidation protein products (AOPPs) which have been considered as novel disease biomarkers. OS may also induce DNA damage which leads to mutation of...

Author(s): El-Tokhy Amira Kamel, Zin El-deen Doaa Hussein, Foda Abd allah Mahmoud, Moussa Gamal Ibrahim and Abo El-Noeman Saad El-Din Abd el-fatah  

Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency (A-376/202) in homozygous sickle cell patients in Senegal and its clinical impact

July 2018

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common worldwide enzymopathy with approximately 400 million individuals affected. This inherited disease is sex-linked recessive inheritance. The high prevalence of certain variants of G6PD in different populations and ethnic groups increases the likelihood of finding associations with other pathologies. Sickle cell disease and thalassemia are the most...

Author(s): Dominique Doupa, Ousseynou Boye, Maguette Ndiaye, Mamadou Djité, Pape Matar Kandji, Sidy Mohamed Seck, Demba Makalou, Aminata Lam, Marie Pierre Diouf, Arame Ndiaye, Blaise Felix Faye, Souleymane Thiam, Abdourahmane Samba, Fatou Diallo, Papa Madieye Gueye, Alassane Diatta, Babacar Faye, Ibrahima Diagne and Saliou Diop  

Bacteriostatic and Bactericidal effects of ethyl acetate root bark extract of Terminalia avicennioides on Methicillin-resistant Staphylococcus aureus

June 2018

Root bark extract of Terminalia avicennioides was obtained by cool maceration with 750 ml n-hexane, chloroform, ethyl acetate and methanol, independently for 48 h using soxhlet extractor. ATCC 33591 standard strains of methicillin-resistant Staphylococcus aureus (MRSA) was used. Strain resistance to methicillin/oxacillin antibiotic was verified by a retest of its sensitivity to oxacillin antibiotic. The antimicrobial...

Author(s): Adim Ekene Ugochukwu, Dingwoke Emeka John, Adamude Fatima Amin, Edenta Chidi, Nwobodo Ndubuisi Nwobodo, Offiah Raymond Ogbonna, Onyeka Ifeanyi Peter and Ezeaku Ikenna Nnamdi

Biochemical characterisation of soybean germplasms with respect to bioavailable iron and zinc, vitamin A and crude protein

May 2018

Soybean germplasms were assessed for bioavailable zinc (Zn) and iron (Fe), vitamin A and crude protein using standard methods. Thirty soybean germplasms were investigated. Results were analysed using analysis of variance (ANOVA) and showed statistically significant differences in their Zn, Fe and vitamin A concentrations, as well as in crude protein content (P < 0.05). The Zn content ranged from 5.74 ± 0.04 to...

Author(s): Titilayo Akande, Francis N. Onyezili and Joseph Ikwebe  

Effects of garden egg, carrot and oat-supplements on biochemical parameters in cadmium exposed rats

March 2018

Cadmium (Cd) toxicity is influenced by dietary components, such as fiber and minerals. Garden egg, carrot and oat are rich sources of fiber. Thus, this study examines the effect of Solanum melongena (garden egg), Daucus carota (carrot) and oat-supplements on selected biochemical parameters in the plasma and tissues of cadmium-exposed rats. Twenty-five healthy male Wistar rats (140±50 g) were distributed into five...

Author(s): Orororo O. Clement, Samuel O. Asagba, Oghri Emus and Egbune E. Oliseneku

Effect of organic acids on the alteration of black rice anthocyanins by Enterobacter aerogenes NBRC 13534

March 2018

In a previous study, it was reported that Enterobacter aerogenes and four organic acids are involved in the alteration of black rice anthocyanins. To investigate the factors involved in altering the coloration of black rice anthocyanins, organic acids (caffeic acid, ferulic acid, malonic acid, and p-hydroxybenzoic acid) were individually added to potato dextrose agar medium containing black rice anthocyanins and...

Author(s): Keiko YAMAMOTO, Noriaki SAIGUSA and Yuji TERAMOTO  

Evaluation of nutritional, anti-nutritional and some biochemical studies on Pleurotus squarrosulus (Mont.) singer using rats

February 2018

Evaluation of nutritional, anti-nutritional and some biochemical studies on Pleurotus squarrosulus (Mont.) Singer using rats was undertaken with standard methods. Results of nutritional contents such as proximate composition revealed moisture (11.67%), crude protein (21.31%) and total carbohydrate (51.58%). Vitamin composition showed the presence of vitamins A (0.17 mg/kg), B2 (0.62 mg/kg), B3 (0.45 mg/kg), B6 (0.84...

Author(s): Duru Majesty, Nwadike Constance, Ezekwe Ahamefula, Nwaogwugwu Caleb, Eboagwu Ijeoma, Odika Prince, Njoku Samuel, and Chukwudoruo Chieme  

Preventive action of zinc against heavy metals toxicity in honeybee

January 2018

A detrimental consequence of industrial growth has been the steady increase in heavy metal pollution which has major, negative impacts on living organisms. Heavy metals still pose a significant health threat, despite the implementation of many strategies to reduce pollution. The aim of this study was to investigate the possible effects of zinc on the accumulation of some heavy metals in honeybees. Groups totalling 15...

Author(s): Cevat Nisbet, Ahmet Güler , Neslihan Ormancı and Sena Cenesiz

Reactive oxygen species (ROS) generation, impacts on tissue oxidation and dietary management of non-communicable diseases: A review

December 2017

Generation of reactive oxygen species (ROS) in biological systems has been reported to be a significant cause of inflammatory and metabolic diseases. More recently, ROS and in a particular ozone has also been implicated in the conversion of cholesterol to atherogenic compounds, secosterol A, and upon aldolization to secosterol-B. Secosterol-A is uniquely produced by cholesterol ozonolysis, while secosterol-B can also be...

Author(s): Wanjala George Wafula, Onyango Arnold, Onyango Calvin and Makayoto Moses

Therapeutic effect of an alkaloid-rich fraction of Abrus precatorius seed methanol extract on paracetamol-induced liver damage in rats

November 2017

The therapeutic effect of an alkaloid-rich fraction of the chloroform-methanol extract of Abrus precatorius seeds on paracetamol-induced hepatotoxicity in rats was investigated in this study. The extract was fractionated in a 17.5 × 2.5 cm Sephadex G15 swollen, packed and eluted with water. The fractions were spotted on F2.54 pre-coated thin layer chromatography (TLC) plates and sprayed with Drangendorff’s...

Author(s): Ukegbu Chimere Young, Parker Elijah Joshua, Okwesili Fred Nwodo C., and Iroha Okechukwu  

Chemical composition, antibiotic promotion and in vivo toxicity of Piper nigrum and Syzygium aromaticum essential oil

October 2017

The antimicrobial activity of spices of human daily diet has been widely demonstrated. Yet, their capacity of promoting antibiotic activity has not been explored adequately. In this work, the chemical composition of essential oils of Piper nigrum and Syzygium aromaticum from Chad were determined and their antimicrobial effect in combination with different antibiotics towards Staphylococcus aureus, Salmonella enteritidis...

Author(s): M. Ismail, G. A. Kemegne, F. N. Njayou, V. Penlap, W. F. Mbacham, and S. L. S. Kamdem,

Haptoglobin polymorphism and cardiovascular risk factors in followed epileptic patients at Fann National University Hospital

August 2017

The aim of our research was to evaluate the cardiovascular risk factors on epileptic patients treated at the Fann University Hospital and to study the influence of haptoglobin (Hp) polymorphism on disease progression. In order to do that, eighty-six (86) patients followed in neurology for at least 2 years were recruited. Each patient was matched to a control according to age and sex. Hp phenotyping was performed by...

Author(s): Papa Madièye GUEYE, Moustapha DJITE, El Hadji Malick NDOUR, Fatou GUEYE-TALL, Néné Oumou Kesso BARRY, Aïssatou SARR, Rokhaya NDIAYE DIALLO, Philomène LOPEZ SALL, Aynina CISSE and Pape Amadou DIOP

Optimization of amylase production by Aspergillus niger cultivated on yam peels in solid state fermentation using response surface methodology

July 2017

The study involved the production of amylase from Aspergillus niger grown on yam peels in solid state fermentation. The process parameters: temperature, pH (initial) and incubation time were optimized for maximum amylase production using central composite design (CCD) of response surface methodology (RSM). Temperature was the most significant (p<0.05) parameter and the maximum interaction occurred between temperature...

Author(s): Samuel Kwatia Victoria Pearl Dzogbefia and Isaac William Ofosu

Effects of ethanol and aqueous leaf extracts of Pterocarpus mildbraedii on hematology parameters and cholesterol in albino rats

June 2017

One of the commonly consumed leafy vegetables in Nigeria is Pterocarpus mildbraedii Harms (Leguminosae) leaf. It has been found that, ethanol and aqueous extracts of the plant leaves exert anti-diabetic effect on rats. This study investigated the effects of ethanol and aqueous leaf extracts of this plant on some hematological parameters and serum cholesterol level in Wistar albino rats. Intraperitoneal administration of...

Author(s): Adegbite A. Victor and Ezekwesili C. Nonyelum

Antimibacterial activity of saponins from Sanseviera trifasciata prain cv. golden hahnii roots on Escherichia coli and Staphylococcus aureus

May 2017

Sansevieria-trifasciata-is commonly known as both in and out door house plant. It is also used in traditional medicine for treatment of influenza, cough and respiratory inflammation. The roots and leaves have secondary metabolites such as saponins that exbihit remedy for cough, snake bite, sprain, bruise, boil, abscess, respiratory inflammation and hair tonic.  The plant sample was collected and dried. The...

Author(s): Whika Febria Dewatisari, Subandi and Desmawati

Effects of date fruit extract on paracetamol induced nephrotoxicity in wistar rats

April 2017

This study was aimed to investigate the protective, ameliorative and preventive effects of aqueous Date fruit extract on paracetamol induced nephrotoxicity in wistar rats. A total of 30 male albino wistar rats were used for this study. Rats were randomly divided into five groups containing 6 animals each. Treatments were given daily for fourteen days. The animals in the control group (Group I) did not receive any...

Author(s): Tijani Idris Ahmad Oseni, Nurah Tijani Oseni, Hauwa Tijani Oseni and Pauline Etuaje Eromon

GC-MS/FT-IR screening of Xylopia aethiopica (Dunal) A. Rich Fruit

March 2017

The present study was aimed at identifying the functional groups and phyto-constituents present in Xylopia aethiopica (Dunal) A Rich fruit using Fourier Transform Infrared Spectrometry (FTIR) and Gas chromatography-mass spectroscopy (GC-MS), spectroscopy. FTIR method was performed using Perkin Elmer Spectrophotometer and the characteristic peaks were detected. The phytochemical constituents were screened by GC-MS method...

Author(s): Okereke S. C., Arunsi U. O. and Nosiri C. I.

Antioxidative activity of Tamarindus indica L. extract and chemical fractions

February 2017

Tamarindus indica L is a tropical plant that is used around the world mainly for medicinal purposes. Yet few scientific studies of its biological potential have been undertaken. The aim of this study was to assess the antioxidative potential of T. indica L leaves. The plant material was harvested and then dried in the absence of direct sunlight. The extraction was done by alcoholic decoction, and the fractions were...

Author(s): Amadou Ibrahima Mbaye, Papa Madieye Gueye, Alioune Dior Fall, Modou Oumy Kane, Kady Diatta Badji, Abdou Sarr, Daouda Diattara and Emmanuel Bassene

Effects of Xylopia aethiopica fruit extract on isolated rabbit ileum

January 2017

In this study, pharmacological reactivity of rabbit ileum to crude extract of fruits of Xylopia aethiopica in the presence of other agonist and antagonist agents was evaluated. The contractility of the isolated rabbit ileum was recorded using kymograph. The effects of the crude extract of X. aethiopica on rabbit ileum were independently determined using a dose range of 10-8 to 10-4 mg/ml. However, to determine the...

Author(s): Okwari O.O, Obembe A.O, Jeje S.O, Honesty E.E and Osim E.E

Extraction, optimization and characterization of crude polysaccharides from Artemesia Mongolica

November 2016

In this study, the extraction conditions of polysaccharides of Artemisia mongolia (PAM) were optimized and their molecular weight, weight distribution, composition and antioxidant activities of the polysaccharides investigated. The degree of polymerization of fructan-oligosaccharides 2-8 was separated by thin layer chromatography (TLC) with good results. Polysaccharides were extracted from the leaves of A. mongolia and...

Author(s): Yahaya Kudush Kawa, Quinck Shang, Shangyi Tian, John Paul Kaisam and Victoria Kabia

Page 1 of 8, showing 50 records out of 400 total, starting on record 1, ending on 50