African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2258

AJPP Articles

In vitro antibacterial and antioxidant activities of alcoholic extract from the leaves of Podocarpus neriifolius D. Don

October 2016

In the present investigation, the methanol leaves extract of Podocarpus neriifolius D. Don was assessed for antibacterial and antioxidant activities. The antibacterial action was evaluated through agar disc diffusion method against seven pathogenic and non-pathogenic bacterial strains at various concentrations and compared against the standard (kanamycin 30 µg/disc). The antioxidant activity of the extract was...

Author(s): Rashaduz Zaman, Mohammad Parvez, Md. Jakaria, Minhajul Islam, Md. Sekendar Ali and Md. Aslam Hossain

Phytochemical and efficacy study on four herbs used in erectile dysfunction: Mondia whiteii, Cola acuminata, Urtica massaica, and Tarenna graveolens

October 2016

There is a resurgence in the use of herbal medicine in the developed countries, with even much more in low developed Countries and especially for conditions such as erectile dysfunction. Studies thus need to be conducted to scientifically validate claims on certain medicinal plants reported to be efficacious in traditional medicine. This current study was conducted to determine the phytochemical composition and efficacy...

Author(s): Joseph Oloro, Tanayen Julius Kihdze, Barbra Katusiime, Lawrence Imanirampa, Paul Waako, Francis Bajunirwe and Amon Agaba Ganafa

Analysis on effects of diets on antiretroviral therapy (ART) immune response among HIV/AIDS Patients in Eastern Ethiopia: Particular emphasis to camel dairy consumption

September 2016

Diets and nutrition have critical effect on immune status of human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) patients and on recovery of immune competence after antiretroviral therapy (ART). A pilot study was conducted to explore associations between the dietary pattern of HIV/AIDS patients and their immune (CD4+ cell recovery) response following ART. A recall interview survey...

Author(s): Befikadu Urga Wakayo, Fentabil Getnet and Teka Feyera

In vitro acaricidal activity of crude extracts of Schinus molle (L.) leaves against field population of Bophilus decoloratus and Rhipicephalus pulchellus ticks

September 2016

Plant products are a rich source of bioactive organic chemicals and offer an advantage over synthetic pesticides as these are less toxic, less prone to development of resistance and easily biodegradable. The present study aimed at screening the acaricidal potential of crude methanolic and aqueous extracts of Schinus molle (L.) leaves on the adult Bophilus decoloratus and Rhipicephalus pulchellus cattle ticks, using in...

Author(s): Teka Feyera and Edilu Abdisa

Activity of red wine polyphenols on endothelial no-synthase (eNOS)

September 2016

Polyphenols (PPH) represent a group of chemical substances found in plants, characterized by the presence of more than one phenol unit. The largest and best studied polyphenols are the flavonoids. Polyphenols contained in red wine have beneficial effects on cardiovascular health. The aim of our research was a comparative and interactive study of four red wine polyphenols - resveratrol (R), quercetin (Q), kaempferol (K)...

Author(s): Naguibou Djibril, Eugene Selidji Attakpa, Habib Ganfon, Victor Bruno Omoregbe

Involvement of pro-inflammatory cytokines and nociceptive pathways on the pharmacological activity of hydantoin derivative 5-(4-isopropylphenyl)-3-phenyl-imidazolidine-2,4-dione

September 2016

Hydantoins are often reported as potent anticonvulsant drugs; however, recent studies have highlighted their antinociceptive potential. Based on these reports, this study investigated the antinociceptive and anti-inflammatory activities of the hydantoin derivative 5-(4-isopropylphenyl)-3-phenyl-imidazolidine-2,4-dione (IM-7) using animal models. Treated mice submitted to the acetic acid-induced writhing test showed...

Author(s): Fabíola Lélis de Carvalho, Diogo Vilar da Fonsêca, Antônia Rosangela Soares Penha, Mirian Graciela da Silva Stiebbe Salvadori, Paula Regina Rodrigues Salgado, Charlane Kelly Souto Pereira, Fagner Carvalho Leite, Márcia Regina Piuvezam, Severino Araújo de Sousa, Petrônio Filgueiras de Athayde-Filho, Liana Clébia de Morais Pordeus and Reinaldo Nóbrega de Almeida

Synthesis and characterization of Cu(II) and Fe(II) metal complexes of oxazepine derivative via Schiff base [Fe(HPOHBOT)Cl2] and [Cu(HPOHBOT)Cl2]

September 2016

A Schiff base and its derivative (oxazepine) have been synthesized by the reaction between thio-semicarbazide and aromatic aldehyde 4-hydroxybenzaldehyde in ethanol in the presence of acetic acids to yield the Schiff base. This Schiff base on treatment with phthalic anhydride to give seven-member heterocyclic ring called oxazepine. Oxazepineas di-dentate ligand treated with hydrated metal chlorides CuCl2 and FeCl2 in...

Author(s): Najim abbas Jabir Al awwadi Bassam Abdulhussein Hasan Alsafee, and Maitham Mohamed Abdulridha

Long term treatment of fluexotine and buspirone on gastric mucosal integrity in rats

September 2016

The highly selective serotonin reuptake inhibitors are successful in the treatment of depression mood and anxiety disorders. The objective of this study is to investigate the effect of fluexotine and buspirone when given orally in three dose levels (5, 10 and 15 mg/ kg) not only for eight weeks on gastric lesions and oxidative markers in normal rats' mucosal integrity, but also for four weeks on gastric mucosal...

Author(s): Gehad A. Abdel-Jaleel, Nawal S. Gomaa, Azza A. Ali, Enaiat Omara and Ola A. Sharaf

Ocular effects of oral acetazolamide on visual functions of normotensive individuals

September 2016

Acetazolamide is a carbonic anhydrase inhibitor which is on World Health Organization’s list of essential medicines, a list of most important medications needed in a basic health system. The ocular effects of acetazolamide was studied in 30 normotensive volunteers. Each volunteer received a loading dose of 500 mg at 0700 h followed by a maintenance dose of 250 mg at 1300 and 1800 h, respectively on day one. From...

Author(s): Igwe S. A., Nwobodo N., Nwadike K., Agbata E. and Aneke B. N.

Ameliorative effect of grape seed extract on metabolic disorders caused by high fat diet induced obesity in rats by reversing the increase in hepatic miR-33a and miR-122

September 2016

MiR-33a and miR-122 are major regulators of lipid metabolism in the liver and their deregulation has been linked to the development of metabolic diseases such as obesity and metabolic syndrome. The aim of this study was to evaluate whether the level of miR-33a and miR-122 in rat liver correlate with obesity and potential anti-obesity effect of grape seed extract (GSE) and calorie restricted diet with special emphasis on...

Author(s): Hoda E. Mohamed, Dina M. Abo-ELmatty, Same M Saleh and Amr T. Sakr

Toxicological assessment of the aqueous dried leaf extracts of Senna alata L. in wistar rats

September 2016

Senna alata is a medicinal plant that belongs to Leguminosae family. Different parts of the plant are used in folklore medicine for curing skin infections, abdominal pain, and gonorrhoea. Despite the use of S. alata in the treatment of various ailments, there is limited or no comprehensive scientific information on the toxicological evaluation of the dried leaf extract in the folklore medicine in Africa. This study...

Author(s): Eziuche Amadike Ugbogu, Emmanuel Okezie, Iheanyichukwu Elekwa, Friday Uhegbu, Emmanuel Akubugwo, Chinyere Godwin Chinyere, Faith Ewuzie and Chizoba Jennifer Ugorji

In vitro and in vivo assessment of genotoxic activity of Petiveria alliacea

September 2016

Petiveria alliacea L. (Phytolaccaceae) is an Amazonian shrub used in traditional medicine for many purposes. This study investigated the genotoxicity of the hydroalcoholic extract of P. alliacea (EHPa). In addition, we conducted pharmacognostic characterization and phytochemical investigation. Phytochemical screening and thin layer chromatography (TLC) were used to determine the chemical composition of the extract....

Author(s): João Paulo Bastos Silva, Fábio Rodrigues de Oliveira, Thiago Portal da Paixão, Nívea Silva Malcher, Patrícia Carara dos Santos, Ana Cristina Baetas, Maria do Carmo Pimentel Batitucci, Marta Chagas Monteiro, and Marcieni Ataíde de Andrade,

Synthesis of 2-(benzylthio)benzimidazole, 2-[(benzimidazol-2-yl)methylthio]benzimidazole and structural analogues against Haemoncus contortus

September 2016

The coupling of the derivatives of the 2-mercaptobenzimidazole 1 with the derivatives of the (chloromethyl)benzene 2 gives 2-(benzylthio)benzimidazole 4a-k on the one hand, and with the 2-(chlorométhyl)benzimidazole 3 on the other the 2-(benzimidazolyl methylthio) benzimidazole and analogues 5a-k. We determined the structures of all synthesized compounds by Nuclear Magnetic Resonance (NMR) and Mass Spectrometry...

Author(s): Sagne Jacques Akpa, Martial Venance Say, Roger Simplice Pépin Zoakouma, Bamba Fanté, Drissa Sissouma and Ané Adjou

The effectiveness of dear healthcare professional letters as a risk minimization tool in Ghana

September 2016

Dear Healthcare Professional (DHP) letter is a risk minimization tool used to inform health workers about new and emerging safety information during the marketing period of medicinal products. DHP letters in some cases may not be effective because targeted audience may not be aware of these letters or even understand them. The objectives of this study were to assess the effectiveness and relevance of DHP letters as...

Author(s): George Tsey Sabblah, Delese Mimi Darko, Abena Asamoa-Amoakohene and Adela Ashie

Acute toxicity and hypoglycaemic activity of the leaf extracts of Persea americana Mill. (Lauraceae) in Wistar rats

September 2016

Persea americana Mill. or avocado plant tree is well-known to people from the sub-Saharan part of Africa. Studies carried out earlier reported on the use of leaf extracts of the named plant to cure diabetes and other diseases in the south of Côte d’Ivoire. This study aimed to assess both acute toxicity and hypoglyceamic activity together with performing a comparative study. The acute toxicity was determined...

Author(s): Mamadou Kamagate, N’Goran Mathieu Kouame, Eugène Koffi, Amani Brice Kadja, Koffi Camille, N’Guessan Alain Roland Yao, Eric Balayssac, Therèse Daubrey-Potey, Kanga Sita N&#;zoue and Henri Maxime Die-Kacou

Study of antidiarrheal and anthelmintic activity methanol extract of Commelina benghalensis leaves

August 2016

The objective of this study was to examine the restorative effects of methanol extract of Commelina benghalensis leaves in antidiarrheal activity in Swiss albino mice model and anthelmintic activity in Tubifex tubifex. Antidiarrheal activity study in Swiss albino mice were divided into four groups. Group I was treated as the control group and received 10 ml/kg of 2% Tween-80 orally; Group II served as a positive control...

Author(s): Mohammad Shah Hafez Kabir, Abul Hasanat, Tanvir Ahmad Chowdhury, Mohammad Mamun Ur Rashid, Mohammed Munawar Hossain and Shabbir Ahmed

Potential impact of urocortin I on sperm count, motility and sex hormone profiles in normal adult rats

August 2016

Urocortin I (Ucn I), Ucn II and Ucn III are corticotropin-releasing factor (CRF) - like peptides. Ucn I has a high affinity for CRF1 and CRF2 receptors. The function of Ucn in male reproduction has not yet been elucidated. Ucn I is present in rat testis with lower levels of Ucn II and III mRNA gene expressions. Therefore, it is suggested that Ucn I may play a role in the regulation of male reproductive action. This...

Author(s): Hany A. El kattawy, Mahmoud A. Naga, Ahmed Shata and Mohamed A. Elbaky

Assessment of the anti-allergenic effects of Scoparia dulcis in asthma management

August 2016

Anti-allergics, including mast cell stabilizers, are used together with other anti-inflammatory drugs in the management of asthma, so as to prevent the release of pre-formed inflammatory mediators upon allergen exposure. This study was aimed at investigating the mast cell stabilizing and anti-anaphylactic effects of a 70% hydro-ethanolic extract of Scoparia dulcis (SDE) in murine models upon exposure to a known...

Author(s): Jones Ofori-Amoah, George Asumeng Koffuor, Emmanuel Akomanin Asiamah, Hope Yao Agbemenyah and Albert Kumi Awuku

Toxicogenetic and antioxidant activities of isopentyl ferulate

August 2016

This study aims to determine the toxicity, genotoxicity and antioxidative defense capacities of isopentanyl ferulate (IF), an ester derivative of ferulic acid (FA). Therefore, albino mice (25-30 g) were treated with 1000 to 3000 mg/kg orally (p.o.) and intraperitoneally (i.p.) to determine median lethal dose (LD50), biochemical and hematological parameters, motor coordination and genotoxic activity by comet assay. In...

Author(s): Marcela Rosado Drumond Taimo, Adailson Almeida Araruna Júnior, Antonio Luiz Gomes Júnior,, Ana Maria Oliveira Ferreira da Mata, Marcus Vinícius Oliveira Barros de Alencar,, Md. Torequl Islam,, Márcia Fernanda Correia Jardim Paz, Hercília Maria Lins Rolim, Maria das Graças Freire de Medeiros, Ana Amélia de Carvalho Melo-Cavalcante,

Peptide hydroxamate derivatives as regulators for insulin receptor signaling and its degradation by zinc metalloprotease in diabetic rats

August 2016

Insulin-degrading enzyme (IDE) is the major zinc-metalloprotease involved in the cleavage of insulin, β-amyloid protein and mainly contributes to the pathophysiology of type 2 diabetes and Alzheimer’s disease. Therefore, this enzyme is expressed as candidate target for drugs used in the management of diabetes and peptide hydroxamates have been reported recently as inhibitors for IDE. Novel synthesized peptide...

Author(s): Mohamed Mahmoud Elseweidy, Rawia Sarhan Amin, Hebatallah Husseini Atteia, Maha Abdo Ali, Nader E. Abo-Dya and Khaled A. Agha

GC-MS analysis of esterified fatty acids obtained from leaves and seeds of Triplaris gardneriana Wedd.

August 2016

Triplaris gardneriana Wedd. belongs to the family Polygonaceae. In Brazil, the plant is known as "Pajéu". The plant has a traditional use in folk medicine for the treatment of some human diseases. In this study, it was realized for first time, the extraction and characterization by gas chromatography–mass spectrometry (GC-MS) of the fixed oils from the leaves and seeds of T. gardneriana collected...

Author(s): Sandra Kelle Souza Macêdo, Anderson Lucas de Lavor, Naiane Darklei dos Santos Silva, Tamires dos Santos Almeida, Iza Miranda Melo Paulo, Georgia Sueley Bezerra, Flávia Keile Souza Macedo, Victor Hugo Almeida dos Anjos, José Alves de Siqueira Filho, Jackson Roberto Guedes da Silva Almeida and Xirley Pereira Nunes

Phytochemical and pharmacological screenings of organic crude fractions of Maesa acuminata

August 2016

The present study is aimed to investigate phytochemical and pharmacological activities of crude organic fractional extracts of Maesa acuminata (MA). Preliminary test for phytoconstituents shows the presence of alkaloid, glycoside, steroids, tannins, saponins and reducing sugars. Fractionation was done by ethanol (leaf: ELMA), chloroform (bark: CBMA) and n-hexane (leaf: HLMA). The crude fractions were then subjected for...

Author(s): Thoufiqul Alam Riaz, Mohammed Ibrahim, Jannatul Ferdous, Md. Torequl Islam,, Atiqur Rahaman, Effat Ara Naznin, Nasreen Sultana, Márcia Fernanda Correia Jardim Paz, Marcus Vinicius Oliveira Barros de Alencar, João Marcelo de Castro e Sousa, Sandra Maria Mendes de Moura Dantas, and Ana Amélia de Carvalho Melo-Cavalcante,

Eye drops prescription pattern in patients with glaucoma

August 2016

Glaucoma is a major public health problem, being the leading cause of irreversible visual impairment worldwide. In most cases, glaucoma is associated with intraocular pressure (IOP) levels that are above those considered normal (IOP ≥ 21 mmHg). The aim of the present work is to describe the pattern of eye drops prescription in patients with glaucoma in the state of Sergipe, Brazil. A descriptive cross-sectional study...

Author(s): Carlos Adriano Santos Souza, Caique Brito Rezende, Chiara Erminia da Rocha, Vinicius Cunha Gois, Divaldo Pereira de Lyra Júnior and Francilene Amaral da Silva

Preclinical evaluation of repeated dose toxicity and anxiolytic activity of monoterpene R - (+) – limonene via inhalation

August 2016

R - (+) - limonene is a monoterpene found in several plant species. Studies have shown that plants that have this compound has anxiolytic activity. This study aimed to investigate the anxiolytic and toxicological activity in rats after inhalation of R - (+) - limonene for 30 min. For the anxiety tests using Elevated Plus Maze (EPM), concentrations of 1.0, 2.5 and 5.0% were determined. From the results, it was observed...

Author(s): Mateus Feitosa Alves, Vanessa Feitosa Alves, Josué do Amaral Ramalho, Guilherme Eduardo Nunes Dias, Kardilândia Mendes de Oliveira, Andressa Brito Lira, Sócrates Golzio dos Santos, Reinaldo Nóbrega de Almeida and Margareth de Fátima Formiga Melo Diniz

Toxicogenetic biomonitoring of workers to the ionizing radiation

August 2016

Occupational exposure to ionizing radiation (IR) can cause systemic acute and chronic effects on human health, including genetic instability that may be etiology of various diseases, including cancer. The aim of this study was to evaluate the possible toxicogenetic  changes in haematological and biochemical parameters, and cytogenetic biomarkers (micronuclei and nuclear abnormalities) indicators of mutagenicity and...

Author(s): Ronald Gerard Silva, Md. Torequl Islam, Ricardo Melo de Carvalho, Marcus Vinícius Oliveira Barros Alencar, Antonio Luiz Gomes Júnior, Rai Pablo Sousa de Aguiar, Ana Maria Oliveira Ferreira da Mata, João Marcelo de Castro e Sousa, Márcia Fernanda Correia Jardim Paz, Paulo Michel Pinheiro Ferreira, Sandra Maria Mendes de Moura Dantas, Ana Amélia de Carvalho Melo-Cavalcante, and Jaqueline Nascimento Picada

A simple and sensitive method for the detection of “Oxytetracycine” levels in ready-to-eat beef by liquid chromatography-mass spectrometry

July 2016

Antimicrobial drug residues have emerged as one of the public health problems worldwide. In this study, a modified sensitive liquid chromatography mass spectrometry (LC-MS) method to detect the “Oxytetracycine” (OTC) levels in ready-to-eat beef meat in Tanzania was evaluated. Beef samples were extracted in acetonitrile in ethylenediaminetetraacetic acid (EDTA) buffer (pH 4), followed by cleaning up with...

Author(s): Frida Mgonja, Resto Mosha, Faith Mabiki and Kennedy Choongo

Antimicrobial potential evaluation of hydroethanolic extracts of the species Anacardium occidentale Linn.

July 2016

The species Staphylococcus aureus and Escherichia coli have shown increased antimicrobial resistance, which can be overcome with plant extracts, in view of their molecular complexity, for example extracts of Anacardium occidentale Linn (cashew). The objective was to evaluate the in vitro antimicrobial activity of cashew stem bark extract. Samples were collected in Santa Cruz / RN / Brazil, and after dried and crushed,...

Author(s): Edilane Rodrigues Dantas Araujo, Silvana Maria Zucolotto Langassner, Geraldo Barroso Cavalcanti Júnior and Dany Gerard Kramer

Evaluation of antidiabetic effect and hematotological profile of methanol extract of Ceiba pentandra G (Malvaceae) stem bark on alloxan-induced diabetic rats

July 2016

The anti-diabetic effect of methanol extract of stem bark of Ceiba pentandra and its beneficial/ toxicological effect on hematological parameters in normal and alloxan-induced-diabetic rats were studied. The acute toxicity (LD50­) test and phytochemical analysis were also carried studied. The diabetic rats were divided into five groups of 5 animals each given oral administration of the extract daily for 14 days. The...

Author(s): Odoh, U. E., Onugha, V. O. and Chukwube, V. O.

A review of twenty ethnobotanicals used in the management of breast cancer in Abeokuta, Ogun State, Nigeria

July 2016

Ethnobotanical investigation revealed the use of Alafia barteri Oliv., Allium ascalonicum L., Alstonia congensis Engl., Anthocleista djalonensis A. Chev., Calliandra portoricensis (Jacq.) Benth., Capsicum frutescens L., Clausena anisata (Willd.) Hook f. ex Benth., Erythophleum suaveolens (Guill. & Perr.) Brenan, Grewia flavescens Juss., Khaya ivorensis A. Chev., Kigelia africana (Lam.) Benth., Lophira alata Banks ex...

Author(s): Gbadamosi, Idayat Titilayo and Erinoso, Sakiru Morenikeji

Antinociceptive and healing activity of the methanolic and hydroethanolic extracts of Caulerpa taxifolia

July 2016

This study aimed to evaluate the healing and analgesic action of methanolic extract and hydroalcoholic of C. taxifolia, and check the percentage of soluble proteins available in the extract of this vegetable. The collection of C. taxifolia occurred on the beach of Barra do Sirinhaém - PE, processed for testing. The animals used in the test were Swiss mice, and Mus musculus of species. For healing activity and...

Author(s): Evandro Valentim da Silva, Gabriela Cavalcanti da Silva, Carla Andrea de Moura, Jefferson de Lima, Marcia Raquel Cedrin Vieira, Laureana de Andrade Lima, Danielle Maria Bastos de Souza, José Ferreira Silva Neto, George Chaves Jimenez, Fálba Bernadete Ramos dos Anjos and Ivone Antonia de Souza

Fixed and volatile constituents of Croton heliotropiifolius Kunth from Bahia-Brazil

July 2016

Essential oils from Croton heliotropiifolius Kunth roots and stems, popularly known in Bahia (Brazil) as velame or cassutinga, were obtained by hydro distillation. Fixed oil from the roots of this species was obtained by maceration in hexane. The oils were analyzed by nuclear magnetic resonance (NMR) and gas chromatography coupled with mass spectrometry (GCMS). 46 compounds were identified in the stems and 35 substances...

Author(s): Douglas Dourado Oliveira, Cinara Vasconcelos da Silva, Maria Lenise Silva Guedes and Eudes da Silva Velozo

Centratherum anthelminticum seeds reverse the carbon tetrachloride-induced hepatotoxicity in rats

July 2016

The present study is the first attempt to evaluate the hepatoprotective effect of ethanolic seeds extract (ESEt) of Centratherum anthelminticum (black cumin) in carbon tetrachloride (CCl4)-induced liver injury. The test doses (600 and 800 mg/kg) of same extract were found effective in their respective test groups by improving the body and liver weights, serum alanine and aspartate transaminases,...

Author(s): Shamim A. Qureshi, Sumera Rais, Rabbiya Usmani, Syed Shabib M. Zaidi, Musarat Jehan, Tooba Lateef and Muhammad Bilal Azmi

Cubebin and semisynthetic dibenzyl butyrolactone derivatives: Biological activities

July 2016

Lignans are a group of secondary metabolites with a wide variety of chemical structures, formed by coupling two phenylpropanoid units.  Currently, there is great interest in lignan due to the wide range of biological activities this class of compounds has demonstrated. This review describes the biological activities of cubebin and semi-synthetic derivatives, focusing primarily on Piper cubeba and Zantoxyllum...

Author(s): Pereira C.C. S. S., Perazzo, F. F., Souza G. H. B., Fonseca, F. L. A., and Rosa P. C. P

Pattern of drugs prescribed for treatment of hypertensive patients: Bangladesh

July 2016

The exponential increase in patients with hypertension puts an enormous burden on healthcare providers. To describe the trends in the prescription of antihypertensive medication in a tertiary care hospital, Bangladesh is the objective of the study. This is a hospital based descriptive cross sectional study conducted at the Medicine outpatient Department in Dhaka Medical College Hospital. Patients more than 20 years of...

Author(s): Md. Jahid Hasan

Medication use history in patients admitted to a teaching hospital: A cross-sectional study

June 2016

Although the literature shows several studies on medication safety, there are few Latin American studies describing aspects in the practice of medication reconciliation carried out by pharmacists in the admission process. This study aimed to describe the acquisition of medication use history of patients during admission, and to characterize the unintentional discrepancies in their pharmacotherapy in a Brazilian teaching...

Author(s): Carina Carvalho Silvestre, Lincoln Marques Cavalcante Santos, Rafaella de Oliveira Santos Silva, Genival Araújo dos Santos Júnior, Alfredo Dias Oliveira-Filho, Iza Maria Fraga Lobo and Divaldo Pereira de Lyra Júnior

Difficulties in antifungal therapy with amphotericin B and the continuous search for new formulations: A literature review

June 2016

Despite advances in the research on new antifungal agents, Amphotericin B (AmB) is still considered as the antifungal of choice for treating most systemic mycoses due to its potency and broad-spectrum action. However, this drug has limited use because of its toxic effects on kidneys, liver and blood. The search for new and safe formulations of AmB is essential because of the emergence of antifungal resistance to other...

Author(s): Ketllyn S. Voncik, Bárbara Luisa Fermino, Nathália C. S. Cardoso, Raissa H. de Mattos, Eliz C. P. Pinto, Jheneffer Deydre Ignachewski, Emerson Carraro, Guilherme B. L. de Freitas, Weber C. F. N.da Silva and Juliana S. Bonini

In vitro antioxidant activity and phenolic contents of different fractions of ethanolic extract from Khaya senegalensis A. Juss. (Meliaceae) stem barks

June 2016

Khaya senegalensis A. Juss (Meliaceae) is a medicinal plant used in folk medicine of Burkina Faso. Its stem barks are used to treat several diseases such as inflammation, arthritis, infections, ulcer, malaria, fever and dermatosis. The antioxidant activity of aqueous ethanol extract and fractions of Khaya senegalensis stem bark was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH•), 2,2'-azino-bis...

Author(s): Lompo Marius, Traoré Rakiatou, Ouédraogo Noufou, Kini Félix, Tibiri André, Duez Pierre and Guissou I. Pierre,

GC-MS analysis and in vitro bioactivity of fixed oil and fatty acid fraction obtained from seeds of Simira gardneriana, a Rubiaceae from Brazilian Caatinga Biome

June 2016

Rubiaceae family includes many species with biological activity, highlighting the genus Simira. In the Caatinga, this genus is represented by six species, and among them, Simira gardneriana is the only endemic species. Previous studies with this plant have shown that extracts from the aerial parts have antioxidant and antimicrobial activity. Thus, the aim of this study was to investigate the chemical composition,...

Author(s): Christiane Adrielly Alves Ferraz, Raimundo Gonçalves de Oliveira-Júnior, Érica Martins de Lavor, Mariana Gama e Silva, Ana Paula de Oliveira, Amanda Leite Guimarães, Izabel Cristina Casanova Turatti, Norberto Peporine Lopes, Rosemairy Luciane Mendes, José Alves de Siqueira-Filho, Jackson Roberto Guedes da Silva Almeida and Xirley Pereira Nunes

Neuropharmacological profile of ethanolic dried seed extract of Persea americana in mice

June 2016

Persea americana Mill (Lauraceae) is a medicinal plant used traditionally in Nigeria to treat several diseases including malaria, hypertension and febrile convulsions among others. Some of these indications are related to central activity but have not been systematically evaluated. This study investigated the neuropharmacological effects and the acute toxicity profile of the ethanolic dried seed extract of P. americana...

Author(s): Idris Ajayi Oyemitan,, Emmanuel Ojo and Adebola Omowumi Oyedeji

Omega 3-fatty acids, atorvastatin as modulators for inflammatory pattern versus diclofenac in osteoarthritis induced in experimental rats

June 2016

Antiinflammatory properties of statins and omega-3 fatty acids are well known and documented before. Present work aimed mainly to demonstrate their effects on inflammatory pattern of osteoarthritis (OA) induced in rats. Osteoarthritis was induced by single intraarticular injection of monosodium iodoacetate (MIA) in the right knee joints in a dose level of 24.6 mg/kg body weight. Omega 3 fatty acids and atorvastatin were...

Author(s): Mohammad M. El-Seweidy, Sousou I. A., Sahar E. Elswefy and Mai M. Mashhour

In vitro anthelmintic activity of Allium sativum, Allium cepa and Jatropha curcas against Toxocara canis and Ancylostoma caninum

June 2016

Prevalence of animal diseases is one of the major livestock production constraints in Kenya with high impacts on livelihoods due to related economic losses affecting food security in the country. The use of synthetic drugs for disease management has challenges. This makes the use of medicinal plants for treatment a rational alternative. Ascarids, Toxocara canis and Ancylostoma caninum are among the most frequently...

Author(s): Orengo, K. O., Maitho T., Mbaria J. M., Maingi N. and Kitaa J. M.

Serum levels of oxytocin in pregnancy, parturition and postpartum for Nigerian females in Zaria, Nigeria

June 2016

Oxytocin is a hormone involved with adjustment of pregnancy, the process of delivery, breastfeeding, social recognition and bonding. This study aimed at determining the serum levels of oxytocin in pregnancy, during labour, and in the puerperium for Nigerian females in Zaria. It was a cross-sectional study of one hundred and twenty women aged 18 to 45 years from four hospitals in Zaria. The women were grouped into four...

Author(s): Achie L. N., Ibrahim G., Olorunshola, K. V., Ayegbusi F. O. and Toryila, J. E.

In vivo anti-inflammatory and in vitro antioxidant properties of Hilleria latifolia and Laportea ovalifolia

May 2016

Inflammation which is a normal phenomenon involved in healing of injurious tissue can be complicated with reactive oxygen resulting in chronic inflammatory state and subsequent tissue damage. Since there are reports on severe side effects associated with the use of synthetic anti-inflammatory medications, there is the need to search for new medications with milder side effects. The study, therefore, investigated the...

Author(s): Susana Oteng Dapaah, Christian Agyare, David Darko Obiri, Yaw Duah Boakye and Newman Osafo

Studies on gastrointestinal properties of ethanolic leaf extract of Salacia lehmbachii in Wistar rats

May 2016

Salacia lehmbachii Loes, is used traditionally in Nigeria for the treatment of gastrointestinal disorders. The aim of this study was to investigate the anti-ulcer and anti-diarrhoeal activities of the ethanolic leaf extract of S. lehmbachii. The ethanolic leaf extract was evaluated for castor oil-induced diarrhoeal, intestinal transit as well as intestinal fluid accumulation in rats, while indomethacin, water immersion...

Author(s): Essien, A. D., Essiet Grace A., Akuodor, G. C., Aja, D. O. J., Thomas Edidara E., Nwadike, K. I., Nwachukwu, D. C. and Chilaka, K. C.

Development of a strategic model of customer relationship management for the pharmaceutical industry of Bangladesh

May 2016

Recent academic and practitioner studies have implied that customer relationship management (CRM) provided improved business opportunity yet it has received sundry performance reviews in the present literature. The pharmaceutical industry, in Bangladesh, is in the midst of fundamental changes. Situational regulations have been placed for decades that minimize pressure from competitor companies, and application of modern...

Author(s): Majedul Islam and Eva Rahman Kabir

Evaluation of Hepatic activity of various morphological parts of Musa paradisiaca L.

May 2016

The objective of present study was to investigate the hepatic activity of methanolic extract of various morphological parts (bract, flower, trachea and tracheal fluid) of Musa paradisiaca L. for their effect on liver of experimental mice. The methanolic extract of morphological parts of Musa paradisiaca (bract, flower, trachea and tracheal fluid) at the dose of (100, 250 and 500 mg/kg b.w) and silymarin (25 mg/kg) was...

Author(s): Khizar Abbas, Ghazala H. Rizwani, Hina Zahid and Tariq M. Javed

Thirst perception in mild to moderate hypertensive Nigerians treated with aqueous extract of Hibiscus sabdariffa L.

May 2016

Aqueous extract of Hibiscus sabdariffa L. is widely consumed in Nigeria as a local beverage used to quench thirst and also because of its antihypertensive action. The present study investigated the effect of consumption of aqueous extract of H. sabdariffa on thirst perception (TP) in mild to moderate hypertensive Nigerians. Fifty mild to moderate hypertensive patients attending medical out-patients clinic of Enugu State...

Author(s): Nwachukwu Daniel C., Aneke Eddy I., Nwachukwu Nkiru Z., Azubike Nkiru, Obika Leonard F.O.

Development of Pharmacy Education in Kenya Universities to date

May 2016

The purpose of this paper was to examine the development of pharmacy education in Kenya since independence. Websites of the Pharmacy and Poison Board of Kenya and the Commission for University Education as well as those of the universities offering pharmacy education were used to obtain information such as the framework for establishment of programmes in higher institutions, curriculum, regulation of pharmacy practice...

Author(s): Ikoni J. Ogaji, Titus M. Kahiga Onesmus W. Gachuno and Julius W. Mwangi

Biotransformation of coumarins by Cunninghamella elegans

May 2016

Microbial biotransformation of coumarin (I) was undertaken using a battery of twenty five microorganisms. Among them, the fungus Cunninghamella elegans NRRL 1392 was the sole microbe that efficiently metabolized coumarin (I) into umbelliferone (II), 3, 4-dihydrocoumarin (V) and transcinnamic acid (VI). Umbelliferone was also biotransformed into 6, 7-dihydroxycoumarin (aesculetin, VII) and p-coumaric acid (VIII). On the...

Author(s): Ghadai A. Attia, Kamillia A. Abou-El-Seoud and Abdel-Rahim S. Ibrahim

Study of the self-association of amoxicillin, thiamine and the hetero-association with biologically active compound chlorgenic acid

May 2016

The self-association of amoxicillin (AMX) and its hetero-association with biologically active compound, chlorogenic acid (CGA) were investigated at room temperature (295°K). The dimerization constant of amoxicillin and thiamine (THIA) analyzed using the dimer model at the wavelength of 278 and 256 nm were found to be  and , respectively. The hetero-association constant of amoxicillin and chlorogenic acid...

Author(s): Ataklti Abraha, Alemu Kebede and Abebe Belay

Page 7 of 46, showing 50 records out of 2258 total, starting on record 301, ending on 350