African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2257

AJPP Articles

Evaluation of the antioxidant activity of the leaves, stem-barks extracts and fractions of Ochna schweinfurthiana F.Hoffm (Ochnaceae)

May 2016

The present study evaluates the in vitro antioxidant activity of the leaves and stem-barks extracts and fractions of Ochna schweinfurthiana. To this effect, the different extracts were obtained by maceration in four solvents namely ethyl acetate, methanol, acetone and water- ethanol mixture (20-80). The methanol extract which exhibited the best antioxidant activity was partitioned in hexane and ethyl acetate. The ethyl...

Author(s): M. A. Nyegue, J. Ngo Mbing, S. V. Djova, A. N. Messi, S. Voundi Olugu, D. E. Pegnyemb, and F. X. Etoa

Larvicidal potential of Mikania glomerata SPRENGEL extract on Ancylostoma caninum larvae

May 2016

Parasitic diseases are seen as indicators of a country’s socioeconomic development, constituting a major public health problem as they cause direct health problems related to the lack of piped water, no sewage system, and lack of orientation. Contamination by the geohelminth Ancylostoma spp, causes the Cutaneous larva migrans (CLM), also known as "sandworms", presenting skin lesions of linear and...

Author(s): Andréia Luiza Araújo, Tracy Lacerda, Emy Hiura, Aline Del Carmen Garcia Lopes, Anderson Rocha Aguiar, Fernando Luiz Tobias, Manuela Colares de Andrade, Fabio Porto Sena, Gracilene Maria Almeida Muniz Braga, Carolina Magri Ferraz, Denise Coutinho Endringer and Fabio Ribeiro Braga

Effect of plants extracts on the growth of Candida albicans and Staphylococcus aureus

April 2016

The purpose of this study was to estimate the effectiveness of cardamom, cinnamon, ginger, cloves and myrrha extracts on the inhibition of Candida albicans and two isolates of Staphylococcus aureus (MRSA) and Staphylococcus aureus (MSSA) and in different concentrations. The results showed that the aqueous extract of spices have no inhibitory effect on the growth of the tested microbes, while, that two types of the...

Author(s): Amira Hassan Abdullah Al-Abdalall

Cytotoxicity, antifungal and antioxidant activities of the essential oil from Eupatorium ballotifolium Kunth (Asteraceae)

April 2016

This study aimed to characterize chemically and evaluate the cytotoxicity and antioxidant, antifungal and modulatory activities of the essential oil of Eupatorium ballotifolium, collected in the mountainous region of Meruoca in the state of Ceará. The antioxidant activity was investigated by the free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay and β-carotene/linoleic-acid oxidation model...

Author(s): Antonio Carlos Nogueira Sobrinho, Elnatan Bezerra de Souza, Marcos Fábio Gadelha Rocha, Maria Rose Jane Ribeiro Albuquerque, Paulo Nogueira Bandera, Hélcio Silva dos Santos, Rafael Pereira, Selene Maia de Morais, Raquel Oliveira dos Santos Fontenelle and Carolina Sidrim de Paula Cavalcante

Therapeutic and preventive effects of Commiphora gileadensis against diethylnitrosamine-induced hepatic injury in albino rats

April 2016

Commiphora gileadensis is a tree in the burseraceae family, cultivated widely in Hadhramaut governorate (Yemen) and known locally as “Besham“ or Balsam” used traditionally for many ailments. The aim of this study was to evaluate the therapeutic and preventive effects of C. gileadensis against diethylnitrosamine (DEN) -induced hepatic injury in albino rats. 40 albino rats were divided randomly into five...

Author(s): Doa’a Anwar, I., Amani, S., Alzoreqy, A., Al-Dbhani, A., Al-Fteih, L., Abu-Al-fatah, T., QojaNazer, H. and Alnoor, E.

Influence of polymorphism of adenosine triphosphate binding cassette on oral drug absorption

April 2016

Administration of drugs via oral route is the most common and convenient. Three major factors can affect drug absorption from this route: physiologic, physicochemical and formulation. Drug absorption mainly takes place in small intestine after oral administration. Within the small intestine, there are 2 major families of proteins involved in transport that have significant roles on drugs absorption:...

Author(s): Muluemebet Fikadu and Tesfaye Gabriel

Antioxidant and antinociceptive effect of the hydroethanolic extract and fractions of the bark of Bowdichia virgilioides in orofacial pain

April 2016

Bowdichia virgilioides is used by the population for treating inflammation in general. This study evaluated the antinociceptive activity and possible mechanisms of action of hydroethanolic extract (HEE) and hexane (HXF), chloroform (CLF), ethyl acetate (EAF) and hydromethanol (HMF) fraction of HEE obtained from the plant stem bark against orofacial pain, as well as in vitro its antioxidant effect on the scavenging of...

Author(s): Andrea Yu Kwan Villar Shan, Elis Cristiane Valença de Almeida, André Luiz Lima Menezes dos Santos, Amanda do Carmo Bion de Lima, Clisiane Carla de Souza Santos, Marília Trindade de Santana Souza, Nicole Prata Damascena, Silvan Silva de Araújo, Jymmys Lopes dos Santos, Monica Silveira Paixão, Anderson Carlos Marçal, Lucindo José Quintans Júnior, Brancilene Santos de Araujo and Charles dos Santos Estevam

Phytochemistry and antibacterial activity of extracts from medicinal plant Olea africana

April 2016

Increase in prevalence of resistant microorganisms especially to synthetic drugs, has necessitated the need to search for new bioactive compounds having natural origin. Phytochemical investigation of Olea africana extracts afforded two triterpenoids namely erythrodiol and uvaol which were obtained through repeated column chromatography. The compounds were characterized using Nuclear Magnetic Resonance (NMR) spectroscopy...

Author(s): Kemboi Douglas, Joyce Jepkorir Kiplimo and Denis Chirchir

Antioxidant properties of antiepileptic drugs levetiracetam and clonazepam in mice brain after in vitro-induced oxidative stress

April 2016

This study aimed to investigate the in vitro antioxidant activity of the novel anticonvulsant levetiracetam and benzodiazepine clonazepam. To do this, the mice brain homogenates were incubated with levetiracetam (50, 100 or 200 g/ml) or clonazepam (50, 100 or 200 g/ml), and then, submitted to heating at 37°C for 1 h. Ascorbic acid (vitamin C, 200 g/ml) was used as reference antioxidant drug. The markers of...

Author(s): Aline de Albuquerque Oliveira, Maria Isabel Linhares, Adriano José Maia Chaves Filho, Emiliano Ricardo Vasconcelos Rios, Camila Nayane de Carvalho Lima, Edith Teles Venancio, Alana Gomes de Souza, Klistenes Alves de Lima, Francisca Cléa Florenço de Sousa, Danielle Macedo Gaspar and Marta Maria de França Fonteles,

Steady-state bioequivalence study of clozapine psychotic patients in Brazil

April 2016

The present work aimed to compare the relative bioavailability of Zolapin with 100 mg tablet Leponex as a reference formulation, through a simple, robust and low-cost bioequivalence assays method. The study design was multiple-dose, randomized, crossover with patients in steady-state, and was performed with 24 schizophrenic male patients. Subjects received 100 mg twice a day of either Leponex or Zolapin for 10 days. At...

Author(s): Margareth de Oliveira Timóteo, Gutemberg Gomes Alves , Gilberto Perez Cardoso, Beni Olej, Mauro Vitor Mendlowicz, Luis Guillermo Coca Velarde and Luiz Querino de Araújo Caldas,

In- vivo and vitro bioactivities of the essential oil of Duguetia lanceolata branches

April 2016

The present study investigated the in- vivo and vitro bioactivities of the essential oil of Duguetia lanceolata branches (EODL) and caryophyllene oxide (CO). The chemical composition of EODL was analyzed by GC and GC/MS. Acetic acid-induced writhing, formalin, hot plate and tail-immersion methods were used to evaluate the antinociceptive effect in mice. Anti-inflammatory activity was tested by carrageenan-induced paw...

Author(s): Orlando Vieira de Sousa, Glauciemar Del-Vechio-Vieira, Bruna Celeida Silva Santos, Célia Hitomi Yamamoto, Ana Lúcia Santos de Matos Araújo, Ailson da Luz André de Araújo, Miriam Aparecida de Oliveira Pinto, Mirian Pereira Rodarte and Maria Silvana Alves

Phytochemical Analysis and Evaluation of Analgesic and Anti-inflammatory Properties of Xanthoxylum fraxineum

April 2016

Purpose of this study was to standardize the drug Xanthoxylum fraxineum by performing chemical analysis including FTIR and to evaluate its analgesic and anti-inflammatory properties as the drug has folkloric uses as an anti- inflammatory, antispasmodic and analgesic agent. Chemical analysis revealed presence of flavonoids, alkaloids, tannins and phytosterols. Mice were employed to determine the analgesic activity by...

Author(s): Mansoor Ahmad, Faheem Ahmed Siddiqui, Mehjabeen and Noor Jahan

In vivo hypoglycemic effect of ethanol extract and its fractions of Rhaphidophora glauca (Wall.) Schott leaves with area under curve (AUC) during oral glucose tolerance test (OGTT)

April 2016

This study was carried out to investigate the hypoglycemic effects of ethanol extract and its chloroform and ethyl acetate fractions of Rhaphidophora glauca (Wall.) Schottleaves in normal and glucose induced hyperglycemic mice (in vivo). Area under curve (AUC) was also calculated during oral glucose tolerance test (OGTT). Ethanol extract and its fractions of R. glauca leaves at 400 and 800 mg/kg doses significantly (P...

Author(s): Mohammad Shah Hafez Kabir, Nishan Chakrabarty, Abul Hasanat, Muhammad Abdulla Al Noman, Fahima Zaheed, Mahmudul Hasan, Syed Md. Abdul Kader, Mohammed Munawar Hossain,Tanvir Ahmad Chowdhury and Shabbir Ahmad

Efficacy and effectiveness of drug treatments in amyotrophic lateral sclerosis: A systematic review with meta-analysis

April 2016

The results of published studies with various neuroprotectors seeking to preserve motor neuron function and improve survival in amyotrophic lateral sclerosis patients have poor evidence in humans, although there are several studies in animal models with positive results. A systematic review and meta-analysis of studies on drug treatment options and survival times in animal models and patients with amyotrophic lateral...

Author(s): Mirian Conceicao Moura, Maria Rita Carvalho Garbi Novaes, Yuri SSP Zago, Emanoel Junio Eduardo and Luiz Augusto Casulari

Impact of cooking and conservation for twelve days on total polyphenols content, antioxidant and anticholinesterase activities of red onion

April 2016

The objective of this work was to determine the impact of three cooking modes (boiling, steaming and microwaving) and the conservation of onion at 4°C for 12 days on total polyphenol, flavonoid, tannins, phenolic acids contents antioxidant and anticholinesterase activity of red onion: Allium cepa. The results showed that the three cooking modes caused an increase of the levels of total polyphenols, flavonoids and...

Author(s): Laib I. and Barkat M.

Evaluation of clinical parameters in people living with HIV undergoing pharmacotherapeutic monitoring: Viral load, CD4+ T lymphocytes and adherence to antiretrovirals

March 2016

The aim of this study was to evaluate the clinical indicators (viral load- VL, CD4 lymphocytes and adherence) of HIV+ patients, at the beginning of treatment with antiretrovirals (ARV), during pharmacotherapeutic monitoring (PTM) in a specialized center in Fortaleza, Ceará. The longitudinal study, according to the Dáder method, was used for patients with HIV (n = 100) from 2008 to 2012, beginning at the...

Author(s): Henry Pablo L. C. Reis, Darlan da S. Cândido, Catarine V. Loureiro, Juliana de O.Carlos, Ana Maria S. de Araújo, Maria Jacqueline Batista and Marta Maria de F. Fonteles,

Anticonvulsant and anxiolytic activity of the leaf aqueous and ethanolic extracts of Melanthera scandens in a rat model

March 2016

Modern drug therapy of epilepsy is complicated by the inability of drugs to control seizures in some patients and side effects that range in severity from minimal impairment of the central nervous system to death from aplastic anemia or hepatic failure. Medicinal plants used in traditional medicine for the treatment of epilepsy have been scientifically shown to possess promising anticonvulsant activities in animal...

Author(s): Silvano S. Twinomujuni , Joseph Oloro and Paul E. Alele

Effects of Hibiscus rosa-sinensis leaf products on haematological indices, lipid profile and hepatic parameters of hyperlipidemic rat

March 2016

Previously, we demonstrated that Hibiscus rosa-sinensis leaf contains various secondary metabolites including saponins, tannins and oxalates, which are known to possess documented pharmacological activities. In this present study, we investigated the effects of the leaf products on haematological indices, lipid profile and hepatic parameters using Wistar albino rat bioassay. Data suggested that though the haemoglobin...

Author(s): Don Daniel Nwibo, Mirabel Ifeyinwa Eze  and Thomas Mmuoemene Okonkwo

Evaluation of the compliance of women with breast cancer to treatment in a reference hospital in a city of North-east, Brazil

March 2016

For the translation, transcultural adaptation and a pilot test of the instrument were done. Also, the compliance of the breast cancer patients to the treatment was measured. The questionnaire “Cancer Patient Self-Report Questionnaire Non-Adherence” was translated and adapted; and a pilot test with 30 patients was performed. For this study, the questionnaire, Morisky-Green test, was also used. A hundred and...

Author(s): Anderson L. Freitas, Wellington B. da Silva, Aline de J. Santos, Wesley M. dos Santos and Allan J. de O. Melo

The prevalence of malaria and its therapeutic implication: A case study of Katcha Community

March 2016

Malaria is highly endemic in tropical and subtropical regions of the world, including Nigeria. In view of this, the prevalence of malaria in Katcha community of Nupeland, was studied. The data presented were collated from Munawwarat Hospital. A total of 6,193 registered cases were treated. The medical cases were registered between January, 2000 and December, 2004 and malaria cases were identified using clinical signs...

Author(s): Saganuwan Alhaji Saganuwan and Mohammed Saganuwan Abdul

Antibacterial and antifungal activities of indican (indoxyl β-D-glucoside)

March 2016

Indican (Indoxyl β-d-glucoside), plant pigments found in true Indigo, are present in Indigofera genus plants, fungi and human urine. This study evaluated the antibacterial and antifungal activities of this pigment using the microdilution method. Antibacterial and antifungal activities were performed against Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Candida albicans, Candida...

Author(s): Ivanise Brito da Silva, Izabela Lima Rangel, Roberta Maria de Leite Lima, Edeltrudes Oliveira Lima, Paloma Lys de Medeiros and Sônia Pereira Leite

Orthogonal test design for optimization of the isolation and purification of total favonoids from Artemisia frigida Willd using macroporous resin chromatography

March 2016

In the present study, the authors aimed to use an orthogonal test design to optimize conditions for isolating and purifying total flavonoids from Artemisia frigida Willd (A. frigida) using macroporous resins. An orthogonal L9(3)4 test design was applied to select the optimum isolation and purification parameters, including the volume of sample solution, flow rate of adsorption and eluent concentration and volume. The...

Author(s): Wang Qing-Hu, Tong Qiang, Han Jing-Jing, Bao Bai-Yin-Mu-Qi-E, Wu Jie-Si, Han Na-Ren-Chao-Ke-Tu, Dai Na-Yin-Tai and Wu Rong-Jun

DPPH radical scavenging and lipoxygenase inhibitory effects in extracts from Erythrina senegalensis (Fabaceae) DC

March 2016

Erythrina senegalensis DC (Fabaceae) is a plant used in traditional medicine in Burkina Faso (West Africa) to cure several diseases such as malaria, rheumatism, abdominal pain, fibroma and infections which are always accompanied by oxidative stress. This study aimed to highlight the antioxidant activities in dichloromethane (DCM) and ethyl acetate (EtOAc) extracts of E. senegalensis stem bark and roots. We used the 1, 1...

Author(s): Fofana Souleymane, Gnoula Charlemagne, Ouédraogo Moussa, Palé Eloi, Nébié Roger HC , Nikiema Jean Baptiste, Guissou Innocent Pierre and  Simpore Jacques,

Antimicrobial activity of essential oil of Cordia globosa

March 2016

Cordia globosa is used to treat gastrointestinal diseases in San Rafael Coxcatlan, Puebla, Mexico; however, its medicinal properties have not been investigated. This study reports the chemical composition and the antimicrobial effect of C. globosa essential oil. The essential oil of aerial parts was obtained by steam distillation and 25 compounds were identified by gas chromatography-mass spectrometry (GC-MS). The major...

Author(s): Miguel Melissa, García-Bores Ana, Meraz Samuel, Piedra Elizabeth, Ávila Marisol, Serrano Rocío, Orozco Julieta, Jiménez-Estrada Manuel, Chavarría Juan Carlos, Peñalosa Ignacio,  Ávila José Guillermo and Hernández Tzasna

Bioinorganic elemental content of the Ghanaian aphrodisiac medicinal plant, Paullina pinnata Linn. (Sapindaceae)

March 2016

Macro and micro element content of dried roots sample of Paullinia pinnata Linn. (Sapindaceae) in Ghana were analyzed using energy-dispersive x-ray fluorescence (ED-XRF) technique. The aim was to study the possible quantitative correlation between the measured elements and the traditional usage of the plant in the treatment of sexual dysfunction or enhancing/sustaining penile erection. The analyses yielded forty-five...

Author(s): Frimpong-Manso Samuel, Magnus-Aryitey George Tetteh, Hevi Daniel, Dombi GyÓ§rgy, Nyarko Alexander Kwadwo, Boamah Daniel and Awan Mohamed

Acceptability of culinary preparations based on different ground beef grades

March 2016

This work aims to evaluate the acceptability of culinary preparations formulated with different ground beef grades. Three standards of ground meat samples offered as special, first and second were purchased from local retail shops in Brazil and had its composition and collagen content determined. Culinary preparations were elaborated as meat sauce (braised); meatloaf (roasted) and hamburger patty (fried) evaluating...

Author(s): Marilice de Andrade Grácia, Vinícius José Bolognesi, Renato João Sossela de Freitas, Cátia Nara Tobaldini Frizon, Rosemary Hoffmann Ribani and Carlos Eduardo Rocha Garcia

Cytotoxic effect of Plectranthus neochilus extracts in head and neck carcinoma cell lines

March 2016

Following a tendency of studying the potential effects of plant extracts to cancer, this study aimed to evaluate in vitro the cytotoxic activity of Plectranthus neochilus (PN) extracts and its fractions in head and neck squamous cell carcinoma (HNSCC) cell lines and assess their tumor specificity. MTT assay was conducted with two HNSCC cell lines, FaDu (hypopharynx carcinoma) and SCC-25 (tongue carcinoma), one...

Author(s): Gabriel Alvares Borges, Juliana Freitas Ferreira, Silvia Taveira Elias, Eliete Neves Silva Guerra, Dâmaris Silveira and Luiz Alberto Simeoni

Design, synthesis and in vitro cytotoxic activity of Delavayin A: A cyclic hexapeptide

March 2016

Synthesis of new drug for anticancer activity has always been fascinating and interesting for researchers. Increase in the demand for new anticancer agents promotes the researchers for synthesizing new molecules with good activity on human cancer cell lines. Here design, synthesis and cytotoxic, antimicrobial activity of delavayin A is described. The structure of this synthesized compound was confirmed by (IR), 1H NMR,...

Author(s): Nirmala Vikram Shinde, Avinash Shridhar Dhake and Kishan Prabhu Haval

Phytochemical screening and haematological studies of Parquetina nigrescens ethanol and chloroform leaves extracts in normal albino rats

March 2016

The effects of crude ethanol-chloroform extract of Parquetina nigrescens leaves on the haematological parameters of normal albino rats were investigated at dose of 50 and 100 mg/kg body weight (b.w). Acute toxicity study (LD50) and phytochemical constituents of the extracts were also evaluated. Thirty (30) male Wistar rats were grouped into five (5) of 6 rats each (n = 6). Group A: Control; administered 2 ml of normal...

Author(s): Omoboyowa D. Alex, Ogunneye A. Lawrence, Igara C. Ephraim and Otuchristian G.

Did drug availability in Malawian central hospitals improve after the conversion of central medical stores to a trust?

March 2016

Malawian public hospitals have reportedly been experiencing a lot of shortages in medicines and medical supplies in recent years. This was at least in part, attributed to the traditional placement of the drug supply system under the Ministry of Health, and therefore a change in the organizational set-up was implemented in 2011. This study aimed at finding out if the availability of medicines in central hospitals in...

Author(s): Felix Khuluza, Precious Kadammanja, Collins Simango and Mirriam Mukhuna

Supercritical fluid and pharmaceutical applications. Part I: Process classification

March 2016

The supercritical fluid technology has been target of many pharmaceuticals investigations in particles production for almost 35 years. This is due to the great advantages it offers over others technologies currently used for the same purpose. A brief history is presented, as well the classification of supercritical technology based on the role that the supercritical fluid (carbon dioxide) performs in the...

Author(s): Valquíria Miwa HanaiYoshida, Victor Manuel Cardoso Figueiredo Balcão, Marta Maria Duarte Carvalho Vila, José Martins Oliveira Júnior, Norberto Aranha, Maria Palmira Daflon Gremião and Marco Vinícius Chaud

Optimizing community effectiveness of antimalarial drugs in malaria-endemic areas of Africa: Issues, challenges, and proposed actions

March 2016

Malaria remains a disease of public health concern, which is associated with high mortality and morbidity, particularly in sub-Saharan Africa. This picture is mainly due to low effectiveness of antimalarials at the community level, a scenario caused by different factors related to the availability, quality, and efficacy of antimalarials as well as the degree of the patients’ and providers’ adherence to...

Author(s): A. Chika and S. O. Bello

Evaluation of the extracts of Morinda lucida and Tridax procumbens for anti-trypanosomal activity in mice

February 2016

A major problem besetting the chemotherapy of African Trypanosomiasis is parasite resistance to the few available drugs, and a known strategy is to use combination of drugs to overcome parasite drug resistance. An attempt has been made in this study to explore the potential of Tridax procumbens and Morinda lucida individually as single therapy and as combination therapy in the treatment of trypanosomiasis. The effective...

Author(s): Abubakar A., Okogun J. I., Gbodi T. A., Kabiru, Y. A, Makun, H. A. and Ogbadoyi E. O.,

Combination of lauric acid and myristic acid prevents benign prostatic hyperplasia (BPH) symptoms in animal model

February 2016

Benign and uncontrolled growth of prostate gland is known as benign prostatic hyperplasia (BPH). It is a common health issue that affects 8% of all men at the age of 40, 60% of men in their 70s, and 90% of those greater than 80 years of age. In this study, we investigated whether a combination of lauric and myristic acid improved BPH in a testosterone propionate (TP)-induced model of BPH in rats. BPH was induced in the...

Author(s): Anup A. Patil, Veeresh, B. and Adikrao Yadav 

Biochemical parameters and Histomorphometric cardicac evaluation among Wistar rats treated with chia seed (Salvia hispânica L.): Experimental model

February 2016

The advance of global economy affects developing countries that are facing a major public health problem. The prevalence of obesity triggers a series of non-communicable chronic diseases (NCDs). Several studies have suggested that the chia seed (Salvia hispânica L.) may be an alternative to combat NCDs, as it is rich in alpha-linolenic acid (ALA). This research is an experimental work in which 24 Wistar rats were...

Author(s): Camila Saran da Silva, Giuliana Kanaguchi, Camila Ribeiro de Arruda Monteiro, David Feder, Ligia Ajaime Azzalis, Fábio Ferreira Perazzo, Laura Beatriz Mesiano Maifrino, Elisabete Ornelas, Paulo César Pires Rosa and Fernando Luiz Affonso Fonseca,

The effect of surfactant above and below the critical micelle concentration (CMC) and the mathematical models used to determine the kinetics of drug release from the matrix system

February 2016

The liberation of propranolol HCl from a controlled release matrix, containing the hydrophilic polymer, sodium carboxymethylcellulose (NaCMC) and the hydrophobic polymer, Eudragit RL 100 (RL 100) as excipients, was studied. The influences of surface active agents on the dissolution rate of the drug were examined. Tablets were made by direct compression methods. The dissolution tests were performed by using the basket...

Author(s): Hassan A. Alhmoud

Medicinal plants used in hepatic dysfunction

February 2016

This study aimed to perform a survey about medicinal plants used in the treatment of the hepatic dysfunction commercialized by healers (salespeople) in the São José Market - Recife/Pernambuco and São Joaquim Street Market in Salvador/Bahia - Brazil. The place to obtain them, preparation methods and used parts of the medicinal plants, knowledge about plants, age and gender of the healers were also...

Author(s): Izabela Rangel Lima, Ivanise Brito da Silva, Mardonny Bruno de Oliveira Chagas, Roberta Maria Pereira Leite de Lima, Luciano Souza de Lima, Maria Bernadete de Souza Maia and Sônia Pereira Leite

Antidiabetic activity of Annona crassiflora (Annonaceae)

February 2016

Researches have shown that marolo (Annona crassiflora Mart.) contains many biologically active phytochemical classes with antidiabetic properties. Therefore, in order to obtain scientific data that contribute to a better insight of the species, integrating both safety and efficacy to the practice of using the plant as medicine, the study of A. crassiflora Mart. leaves was chosen. To evaluate the possible effect of A....

Author(s): Carla Pereira Rosa, Fernanda Borges de Araújo Paula, Bruno Cesar Correa Salles and Marcelo Aparecido da Silva

Evaluation of ethanolic extract of Morinda citrifolia Linn for antitumor activity

February 2016

Given the concern about to the high incidence of cancer and low specificity of available antineoplasic drugs, Morinda citrifolia Linn is a tropical plant species with wide distribution, which had its consumption widely spread both because it is a source of nutrients and its phytotherapic properties as well as for its adaptation. The potential of tumor inhibition was done in vivo against Ehrlich Carcinoma and Sarcoma...

Author(s): Gabriela Cavalcante da Silva, Gibbelly Cavalcante da Silva, Waneska Alves Pereira da Silva, Alisson Macário de Oliveira, Matheus da Silva Mesquita, Maria da Conceição Cavalcanti de Lira, Evandro Valentim da Silva and Ivone Antônia de Souza

Pharmacological evaluation of the aqueous stem bark extract of Bombax buonopozense in the relief of pain and fever

February 2016

Bombax buonopozense is used in traditional medicine in Nigeria for the treatment of pains and feverish conditions. This study was orally carried out to establish the analgesic, anti-inflammatory and antipyretic properties of an aqueous stem bark extract of Bombax buonopozense in experimental animals. The analgesic activity was measured using the acetic acid-induced abdominal constriction and water tail imgmersion tests....

Author(s): Essien, A. D., Essiet, G. A., Akuodor, G. C., Akpan, J. L., Chilaka, K. C., Bassey, A. L., Ezeokpo, B. C. and Nwobodo, N. N.

Preclinical assessment of the acute toxicity and anti-inflammatory activity of Wissadula periplocifolia (L.) C. Presl ("jangadeira")

January 2016

Wissadula periplocifolia (L.) C. Presl is a plant of the Malvaceae family that is popularly known as white velvet leaf (“jangadeira” and “malva-malva” in Brazil). Species of this family are used in folk medicine as diuretic, anti-inflammatory and anti-rheumatic agents. This study evaluated the acute toxicity and anti-inflammatory effects of a crude ethanolic extract of W. periplocifolia. Acute...

Author(s): Edla Julinda Ribeiro Coutinho Espinola Guedes, Josué do Amaral Ramalho, Luciana da Silva Nunes Ramalho, Gilson Espínola Guedes Neto, Andressa Brito Lira, Mateus Feitosa Alves, Guilherme Eduardo Nunes Dias, Yanna Carolina Fereira Teles, Caliandra Maria Bezerra Luna Lima, Maria de Fátima Vanderlei Souza, Margareth de Fátima Formiga Melo Diniz and Reinaldo Nóbrega de Almeida

Effect of propolis on the reproductive toxicity induced by deltamethrin in male albino rats

January 2016

The author has requested the retraction of this article.

Author(s): Wael M. Al-Amoudi

Prophylactic administration of a Propionibacterium acnes-killed preparation increases survival in animals with polymicrobial sepsis via the nitric oxide and TNF-α pathway

January 2016

Propionibacterium acnes (P. acnes) is a gram-positive anaerobic microorganism present in human skin, and has being widely used in clinical trials as a suitable candidate for therapeutic approach to sepsis. A previous study performed by our research group demonstrated that a P. acne killed preparation had an important immunomodulatory role in severe sepsis. Hence, this study we evaluated the...

Author(s): Temístocles I´talo de Santana, Jaciana dos Santos Aguiar, Larissa Cardoso Corrêa de Araújo, Sandrine Maria de Arruda Lima, Bruno Iraquitan Miranda da Silva, Fabiana Oliveira dos Santos Gomes, Christina Alves Peixoto, Paloma Lys de Medeiros and Teresinha Gonçalves da Silva

Preparation of sertraline-loaded chitosan nanoparticles and the pharmacokinetics studies

January 2016

Sertraline is a worldwide used antidepressant for perinatal depression. However, the secreting of sertraline into milk arose the concerns for the potentially negative effects on breastfed infants. The present study aims to alter the biodistribution of sertraline by loading the drug into chitosan-nanoparticles. Our results demonstrated an effective way to load the water-soluble sertraline into nanoparticles, and keep the...

Author(s): Tian-Yuan Zhang, Dan-Qing Chen, Jian-Qing Gao, and Yu-Lan Hu,

Susceptibility of Blastocystis hominis to monolaurine (Lauric acid), lactoferine (Lactobacillus acidophillus) and metronidazole: An in vitro and in vivo studies

January 2016

Blastocystis hominis is an unusual enteric protozoan of human and animals. Natural products are not only the basis for traditional or ethnic medicine, but also provides highly successful new regimen for human welfare. Meronidazole constitutes a mainstay and is also traditionally considered first line therapy for treatment of Blastocystosis. However, the therapy is complicated due to different dosages and regimens...

Author(s): Soad Ismail,  Iman Ali, Neimat Amer, Zeinab Fahmy, Magda Azmy and Mona Magdy

A study on the prescription pattern of drugs in Jazan general hospital, KSA

January 2016

Inappropriate drug prescribing is a global problem affecting the healthcare system. This study was performed to assess the drug prescribing pattern in geriatric, paediatric and obstetrics and gynaecology department. Patient's chances of exposure to poly pharmacy are more, therefore, this study was carried out to find out the rational use of prescribed drugs in Jazan general hospital. A prospective cross sectional...

Author(s): Nakul Gupta, Mohammed M. Safhi, Jameel M. Y. Sumaily, Maryam Nayeem, Syed Mamoon Hussain, Meetu Agarwal and Abdul Hakeem Siddiqui

A review on corrective action and preventive action (CAPA)

January 2016

The primary objective behind corrective action and preventive action (CAPA) in any pharmaceutical or medical device industry is to determine the weakness, deviation or failures and to carry out its investigation with appropriate actions so that such problems are not repeated again. CAPA is also a method in which preventive measures are taken in the beginning itself so that occurrence of any incidence can be prevented....

Author(s): Abhishek Raj

Investigating extemporaneous compounding practices in the Polokwane tertiary hospital pharmacies in South Africa - a pilot study

December 2015

Medicine availability is an important aspect of providing good quality healthcare. Some medicines are available in doses that are not suitable for a specific population group such as children or geriatric patients. Manipulation of the existing medication is undertaken instead. Studies on the practices, frequency and extent of extemporaneous compounding have been undertaken in countries such as New Zealand, Australia,...

Author(s): Euphenia Mathebule Masupye, Fatima Suleman and Thirumala Govender

Efficacy of Tribulus terrestris extract and metformin on fertility indices and oxidative stress of testicular tissue in streptozotocin-induced diabetic male rats

December 2015

The present study aimed at evaluating the effect of Tribulus terrestris on different parameters of oxidative stress and enzymatic/non-enzymatic antioxidant as well as the number, viability and abnormalities of sperm in testis tissues of male rats after induction of diabetes. The animals were divided into six groups; group I (control) was administered vehicle only, group II was treated with metformin (MET) and...

Author(s): Hend M. Tag, Heba M. A. Abdelazek, Yasmen S. Mahoud and Nahla S. EL-Shenawy

Hypolipidemic effect of ethanolic extract from whole plant of Lactuca runcinata (DC.) in atherogenic diet induced hyperlipidemic rats

December 2015

The present study was designed to investigate the hypolipidemic effect of ethanolic extract from whole plant of Lactuca runcinata (DC.) in rats fed with atherogenic diet (AD). The acute toxicity study shows that the ethanolic extract are safe up to 2000 mg/kg, thus one tenth of this dose was consider as evaluation dose. Ethanolic extract of Lactuca runcinata was administered in doses of 200 and 400 mg/kg/day to rats fed...

Author(s): Jeyaraman Amutha Iswarya Devi and Arumugam Kottai Muthu

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