African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2281

AJPP Articles

Levels of red blood cells derived microparticles in stored erythrocyte concentrate

July 2020

There is increasing evidence of the clinical importance of microparticles (MPs) and their role in blood transfusion-related side effects and the transmission of pathogens. The study aims to examine the red blood cell-derived MPs in blood bags during storage under standardized blood bank conditions. The samples were tested at various times to demonstrate the presence of RBC-derived MPs by flow cytometry. The quantitative...

Author(s): Maheen Rana, Yasir Arfat, Omar Naseem, Nazish Mazari, Navida Manzoor, Rao Salman Aziz, Muhammad Rashid and Shahida Mohsin

Bioactivities of stem bark of Albizia chinensis Osbeck. Merr., Chakua Koroi of Bangladesh

July 2020

Albizia chinensis Osbeck. Merr. (Family: Fabaceae) is quite abundant in Bangladesh. The plant has a history of its traditional use in scorpion and snake bite. This investigation was designed to analyze the analgesic, anti-diarrheal and anti-inflammatory potentials along with sleep inducing property of the crude methanol extract of stem bark of Albizia chinensis Osbeck. Merr. Peripheral analgesic activity was evaluated...

Author(s): Tasnuva Sharmin and Mohammad A. Rashid  

Morbidity rate of drug-susceptible tuberculosis and its medico-economic impact

July 2020

This assessment aims to identify the increasing number of morbidity of drug susceptible tuberculosis (TB) and its treatment outcomes, government cost of medicines as well as the economic impact on society. A retrospective observational study had been conducted in a government hospital using a patient’s record from 2013 to 2017, treated under the Direct Observed Therapy Short Course (DOTS) program in Karachi,...

Author(s): Rida Masood, Iyad Naeem Muhammad, Sidra Kanwal Ali, Madiha Mushtaque, Tuba Siddiqui, Farah Khalid and Aatka Ali,  

Phytochemical screening and toxicological effects of Amblygonocarpus andongensis aqueous stem bark extract in wistar albino rat

June 2020

Amblygonocarpus andongenesis is being used as antipsychotic. Hence, it may portend high risk of toxicosis. In view of this, phytochemical screening and toxicological effects of aqueous stem bark extract of the plant was studied in wistar albino rats. Qualitative screening of the stem bark extract revealed the presence of alkaloid, hydrolysable tannin, saponin, glycoside, cardiac glycoside, saponin glycoside and...

Author(s): Abdullahi Aliyu Ebbo, Abdullahi Teleh Elsa, Emmanuel Udok Etuk, Muhammad Jengebe Ladan and Saganuwan Alhaji Saganuwan

Nutrients in Amazonian fruit pulps with functional and pharmacological interest

June 2020

In this research, nine fruits cultivated in Northern Amazon were studied: Abiu, acerola, araçá, bacupari, biribá, camu-camu, fruta-do-conde, graviola and taperebá, with the objective of carrying out a proximate and nutritional study of the pulps of the Northern Amazon fruits. They were graviola (76.83 ± 0.02 Kcal 100 g-1), bacupari (53.15 ± 0.02 Kcal 100 g-1) and fruta-do-conde...

Author(s): Montero I. F., Saravia S. A. M., Santos R. A., dos Santos R. C., Marcía J. A. F. and da Costa H. N. R.  

Haematology, serum biochemistry and histopathological findings associated with sub-chronic administration of methanol leaf extract of Pterocarpus santalinoides DC in albino rats

June 2020

The effects of sub-chronic administration of Pterocarpus santalinoides methanol leaf extract (PSME) on haematology, serum biochemistry and histology of albino rats were evaluated. Twenty female albino rats, randomly assigned into four groups (A-D) of five rats each, were used for the study. Groups A-C were treated orally with 500, 250 and 50 mg/kg PSME, respectively, while Group D was given distilled water as placebo at...

Author(s): Thelma Ebele Ihedioha, Isaac Uzoma Asuzu, Aruh Ottah Anaga and John Ikechukwu Ihedioha

Nutritional characterization pulp of Chrysobalanus icaco L.

June 2020

After Southeast Asia, Brazil is the second largest producer of tropical fruits having more than 500 species, and many of these have high potential regarding nutritional content that can be marketed. Among them, Chrysobalanus icaco L., which can be found in abundance in several countries of South America stands out. Among its nutritional profile, it had low value of titratable acidity (0.41 ± 0.02%) and lipid...

Author(s): Selvin Antonio Saravia Maldonado, Ismael Montero Fernández, Luis Antonio Beltrán Alemán, Ricardo Santos Alemán and Jhunior Abrahan Marcia Fuentes  

Prevalence and the level of evidences supporting off-label prescribing of antidepressant, antipsychotic and antiepileptic drugs in Makkah Almukarramah: A case sectional study

June 2020

Off-label prescribing is very common among physicians, particularly among psychiatrists and there is limited information regarding the extent of the unapproved drug use in Makkah city. The objective of this study was to assess the prevalence of off-label indications for antidepressant, antipsychotic and antiepileptic and the strength of evidence supporting use of the prescribed drug for the respective indication. A case...

Author(s): Yosra Al-Hindi, Amal Al-sulami, Aseel Al-ghamdi, Nuha Al-Harbi, Huda Hamdi , Shooq Al-moqati, Yara Abualkair and Arwa Fairaq  

The potential cardioprotective effects of Febuxostat versus Cilostazol on Isoproterenol induced cardiac dysfunction in rats

May 2020

Myocardial infarction causes an acute condition of necrosis of the myocardium resulting in increased production of free radicals and decreased levels of antioxidants. It was proposed that Febuxostat reduced myocardial oxidative stress and suppressed apoptosis. Cilostazol used to treat claudication has a growing evidence, suggesting that Cilostazol could be cardioprotective. This work aims to highlight the potential...

Author(s): Ayman Helal, Sawsan Sadik and Eman Hussein  

Comparative effect on liver fibrosis of bicyclol and silymarin

May 2020

Bicyclol and silymarin are widely used in the treatment of various liver diseases; however, there is no report on comparative effect of them on liver fibrosis. To compare their liver protective effect, liver fibrosis rats induced by bile duct ligation (BDL) were orally treated with 100 mg/kg bicyclol and 100 mg/kg silymarin respectively for 4 weeks. Liver index, liver function activities, inflammatory biomarkers,...

Author(s): Liping Wang, Li Zhang, Kelan Gan, Xiaoping Hua, Ying Xiao, Yikun Shi and Zhenghuai Tan  

Designing polyethylene oxide and hydroxypropyl methylcellulose matrix tablets with comparable dissolution properties

May 2020

PolyoxTM coagulant (molecular weight 5 × 106 Da) and hydroxypropyl methylcellulose (HPMC) K4M (USP substitution type 2208) were used to identify the composition variables that ensure the production of polyethylene oxide (PEO) matrix tablets with the same dissolution characteristics as those containing HPMC. Based on the dissolution results obtained using Apparatus 3, a 53% concentration of PEO polymer in the...

Author(s): Petra Draksler, and Biljana Janković,  

Chemical characterization of seeds of Amazon fruits as nutritional contribution with functional medicinal potential

May 2020

The fruit seeds of the Northern Amazon Region were evaluated bromatologically and nutritionally in terms of the level of macro- and micro-elements and fatty acids present in them. Bromatologically, the seeds of camu-camu (369.08 kcal 100 g-1) and biribá (364.78 kcal 100 g-1) have the highest energy value. In terms of the macroelements, the highest concentration was potassium (554.23 mg 100 g-1) seen in graviola,...

Author(s): Ismael Montero Fernández, Selvin Antonio Saravia Maldonado, Vany Perpetua Ferraz, Ricardo Santos Alemán, Jhunior Abrahan Marcia Fuentes and Antonio Alves de Melo Filho

Antihyperglycaemic and antioxidant activities of Sansevierialiberica as justification for its antidiabetic claims

April 2020

Diabetes has become a global emergency because of its high prevalence, morbidity and mortality while the available hypoglycaemic drugs possess various adverse effects and are expensive. This has necessitated a continuous search for cheaper antidiabetic agents of plant origin with fewer or no side effects. The study evaluated the antihyperglycaemic activities of the methanol extract of Sansevieria liberica Gerome and...

Author(s): Aanuolu Jesudunni Ajileye, Marcus Durojaye Ayoola, Anthony Adebolu Elujoba and Kemi Feyisayo Akinwunmi  

A preliminary study to assess knowledge, preferences, and perception of adult population of Karachi about scored and colored oral solid dosage form

April 2020

Beyond the pharmacological activity, the differences have been observed in the preferences of solid dosage form on the basis of color and swallowing difficulty in the studies conducted by a different researcher. The aim of the study is to insight the perception of the general population of Karachi about the color, scoring and splitting of tablets. A convenience sampling technique was used to collect data. Knowledge,...

Author(s): Aatka Ali, Madiha Mushtaque, Sarah Jameel Khan, Sidra Kanwal Ali, Tahmina Maqbool, and Rida Masood  

Biological activities of Bonsupari (Caryota urens L.) fruits

April 2020

In Asian subcontinent, Caryota urens L. plant is well known. Its leaf has antioxidant and antimicrobial properties. The work aims to analyze the composition of the plant’s fruit extract and its aqueous and organic soluble fractions for its cytotoxic, thrombolytic, antioxidant, membrane stabilizing and antimicrobial properties. 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity assay,...

Author(s): Tasnuva Sharmin, Md Shahidur Rahman, Sirajis Salekin and Kamrun Nahar  

Chemical composition of essential oil of Melissa officinalis L. and antioxidant activity from Boa Vista-RR, Brazil

April 2020

In this work, the chemical composition of the essential oil of lemon balm (Melissa officinalis L.) was determined by CG-FID.In the essential oil of M. officinalis,there area total of 22 chemical constituents, among them are geranial (34.6%), neral (26.0%), γ-caryophyllene (7.5%), caryophyllene oxide (5.3%), -pinene (5.3%) and sabinene (3.6%); it also has antioxidant capacity and total phenolic compounds in...

Author(s): Ismael Montero Fernández,  Pedro Rômulo Estevam Ribeiro,  Selvin Antonio Saravia Maldonado, Vany Perpetua Ferraz, Ricardo Santos Alemán, Jhunior Abrahan Marcia Fuentes and Luis Antonio Beltrán Alemán  

Antiproliferative and cytotoxic activity of Hematite (α-Fe2O3) nanoparticles from Butea monosperma on MCF-7 Cells

February 2020

Silver nanoparticles (Hematite (α-Fe2O3) have been used as an antimicrobial and as disinfectant. Nevertheless, there is limited data about its antitumor potential. This study focused on investigating the cytotoxic effects of Hematite (α-Fe2O3) from Butea monosperma flower extract on MCF-7 breast cancer cells and its mechanism of action.  Green method was created for the synthesis of Hematite...

Author(s): B. Behera, S. Pradhan, A. Samantaray and D. Pradhan  

Evaluation of pharmaceuticals in household waste in Senador Canedo, State of Goiás, Brazil

January 2020

The disposal of pharmaceuticals has become a problem for society and public health and causes risks to the environment. Therefore, the objective of this work was to evaluate the number of pharmaceuticals and the classes of the most discarded pharmaceuticals in household waste in Senador Canedo, Goiás, Brazil. The study was conducted in Senador Canedo, GO, Brazil (16° 42' 28'' S, 49° 5'...

Author(s): Pollyana Dalenogari Costa and Lúcia Maria Moraes  

Histopathological and genetic study on the protective role of β-Carotene on testicular tissue of adult male albino rats treated with titanium dioxide nanoparticles

January 2020

Titanium dioxide nanoparticles are one of the famous widely produced nanoparticles in the world that are widely used in paints, cosmetics, plastics, pharmaceutical preparations, water treatment and purification and filtration of air. Beta carotene is provitamin A carotenoid with antioxidant and anti-apoptotic activities. The aim of this study is to evaluate the histopathological changes that occur in the testicular...

Author(s): Amira Hamed Mohamed Soliman, Ibrahim Amin Ibrahim, Mohammed Ahmed Shehata and Heba Osama Mohammed  

Formulation and enhancement of dissolution rate of poorly aqueous soluble drug Aceclofenac by solid dispersion method: In vitro study

January 2020

Solid dispersion technique was successfully used to enhance the dissolution of poorly aqueous soluble drugs aceclofenac. Four carriers Hydroxyl propyl methylcellulose (HPMC), polyvinyl alcohol (PVA), Mannitol and Dextrose in two ratios (1:2, 1:3 w/w) were used to prepare solid dispersion. Eight different formulations were designed by the varying carrier and the drug: Carrier ratio and solvent wetting method was used for...

Author(s): Sumana Neupane and Chhitij Thapa  

Therapeutic effectiveness assessment of antiviral drugs used in chronic hepatitis treatment in three Ivorian university hospitals

December 2019

This work aims to evaluate the effectiveness of drugs used for the management of chronic viral hepatitis in the three major university hospitals in Abidjan. This is a retrospective cross-sectional descriptive study of 203 patients investigated for treatment protocols, patient parameters before and after treatment. It emerged that treatment with pegylated Interferon alpha 2a resulted in a significant decrease in viremia...

Author(s): Geneviève Amenan N’guessan-Irié, Emile Allah-Kouadio, Christiane Ella Kogbahonon Allouka, Steven Driga Tchekpa Paul Kohi, Bienvenu Oko Gnépéhi and  Gisèle N’doua Siransy-Kouakou,  

Non-adherence to statins therapy and its impact on cardiac morbidity and mortality: A metanalysis

December 2019

Dyslipidemia is a major risk factor for cardiovascular disease, the leading cause of death worldwide. Statins have been shown to significantly reduce morbidity and mortality in patients with coronary artery disease and in patients with hyperlipidemia. However, there is a significant gap between expected and actual benefits; this may be attributed to poor adherence to statin therapy. Literature search was conducted by...

Author(s): Zelalem Gebretsadik Anebo and Nurettin Abacioglu  

Hepatoprotective and antioxidant activities of Pterocarpus santalinoides methanol leaf extract

December 2019

This study evaluated the hepatoprotective and antioxidant activities (AA) of Pterocarpus santalinoides methanol leaf extract (PSMLE) on carbon tetrachloride (CCl4)-induced hepatotoxicity in albino rats. Thirty male albino rats randomly assigned into 6 groups (A – F) of 5 rats each were used for the in vivo study. Hepatotoxicity was induced in groups A – E using CCl4. Group A served as negative control....

Author(s): Thelma Ebele Ihedioha, Isaac Uzoma Asuzu, Aruh Ottah Anaga and John Ikechukwu Ihedioha  

Anti-inflammatory and analgesic activities of extracts from Balanites aegyptiaca L. Delile (Balanitaceae) root bark: Plant used against liver diseases in Bukina Faso

December 2019

Balanites aegyptiaca (L.) Del has been used in various traditional medicines against inflammation and pain. The aim of this study was to evaluate the enzymatic, anti-oedmeatous and analgesic activities of ethanolic and aqueous extracts of Balanites aegyptiaca (L.) Del root bark in mice. The extracts were tested in vitro for their ability to inhibit the enzymes cyclooxygenase (COX)-1 and COX-2, 15-lipoxygenase (LOX) and...

Author(s): Kadiatou Tata Traoré, Noufou Ouédraogo, Lazare Belemnaba, Gilchrist Abdoul Laurent Boly, Leïla Marie Esther W. Kabré, Constantin B. Atchadé, Mohamed B. Belemlilga, Sylvain Ilboudo, Marius Lompo, Sylvin Ouédraogo, André Tibiri and Innocent Pierre Guissou,  

Cytotoxic effects on MCF-7 breast cancer cell lines, phenol and flavonoid contents, high performance liquid chromatography (HPLC) analysis and antioxidant activity of Maerua pseudopetalosa (Gilg and Bened) De Wolf fractions

November 2019

Maerua pseudopetalosa (Gilg and Bened.) De Wolf tubers which are used traditionally as antitumor agent in Sudan were subjected to separation by column chromatography technique. Eight fractions were obtained for the ethyl acetate extract and twelve for the ethanolic extract. The ethanolic fractions F8, F9, F11 and F12, with high bioactivity were subjected to further investigations....

Author(s): Manal A Ibrahim and Manal M Ramadan

Evaluation of the immunomodulatory properties and microbial bioburden of three commercial herbal mixtures sold in Awka, Anambra State Nigeria

November 2019

The consumption of herbal medicine and herbal medicinal products has been on the rise lately. This has led to an increase in research on herbal medicine and its different formulations to gain more knowledge in their constituents, therapeutic effects, its mechanism, and their undesired or toxic effects. The purpose of this study was to evaluate toxicity profile, phytochemical constituents, microbial quality and...

Author(s): Christopher E. Enemor, Malachy Ugwu and Chukwuemeka Nworu  

Phytochemical analysis and in vitro antibacterial evaluation of leaf and bark extracts of Alstonia boonei

November 2019

The antibacterial effect of the leaf, bark and leaf and bark combined of Alstonia boonei on bacterial pathogens, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumonia, Proteus mirabilis, Klebsiella pneumonia, Shigella dysenteriae and Salmonella typhimurium was determined using agar diffusion technique to investigate their efficacy as anti-bacterial agent. The phytochemical components...

Author(s): D. J. Ajose, O. F. Onifade and I. I. Wemambu  

Acquaintance of Botox: A cross-sectional survey among female students in Karachi, Pakistan

November 2019

The cosmetic treatment strategies have been considerably popular over the last few decades among the population with respect to age, gender, and ethnicity. These procedures are easily accessible safer, minimally invasive, and more precise. Botox therapy is one of the most common non-surgical cosmetic treatment. Thus, the current study was accomplished to assess the knowledge of female students towards Botox therapy for...

Author(s): Shahlla Imam, Wajiha Iffat, Sadia Shakeel, Ambreen Qamar Najaf Usman, Nuzhat Sultana and Faisal Muhammad Khan  

Effect of the anticancer drug tamoxifen on chronic toxoplasmosis in experimentally infected rats

October 2019

Toxoplasma gondii is an opportunistic parasite that can cause severe disorders in infants and pregnant women and can also be lethal in immunologically compromised individuals. During unfit host immune conditions, and as a consequence to latent stage opportunity, the protozoan stimulates serious infection, and signifies higher morbidity and mortality including humans with Acquired Immuno-Deficiency Syndrome (AIDS) or...

Author(s): Rabab Fawzy Selem, Gehan Abdel Rahman Rashed, Ashraf Mohamed Abdel Khalek Barakat, Hasan Mohamed Ali Elfadaly, Boshra EL-sayed Talha Hussien, Hemat Salah Mohamed, Marwa Mohamed Nageeb and Ahlam Farag Moharm  

Pharmaceutical polymorphisms and its influence on the dissolution profile of two pioglitazone brands

October 2019

1Pharmacognosy Laboratory,Faculty of Chemical Sciences, Juarez Durango State University, Mexico. 2Technology and health laboratory, Academic Coordination Altiplano Region, Autonomy University of San Luis, Potosi, Mexico.  

Author(s): Eduardo Lozano Guzmán, Saúl Alejandro Aguirre Rentería, María Guadalupe Nieto Pescador, Maribel Cervantes Flores, Ángel Antonio Vértiz Hernández and  Francisco Javier Moreno Cruz  

Tremendous health benefits and clinical aspects of Smilax china

October 2019

A lot of species of Smilax known as Baqia in China are used in folk medicine for various purposes. Smilax china L., is a small vine that grows in the southern parts of China, known as Jin Gang Ten, which has a long history of indigenous use in China. S. china consists of fat, saponins, glucosides, gum, starch, flavonoids, tannins, and alkaloids. S. china has been used in traditional Chinese medicine because it has...

Author(s): Mohamad Hesam Shahrajabian, Wenli Sun, and Qi Cheng,  

Prevalence and indication of gabapentin and pregabalin prescriptions among adults in King Abdulaziz Hospital in Makkah AL-Mukarramah, KSA

October 2019

Gabapentin and pregabalin prescribing have increased substantially over the recent years. Some evidence supports that gabapentin and pregabalin use in non-neuropathic pain disorders indicates they are less effective than several other licensed non-opioid analgesics. On the other hand, other studies have shown that those drugs are to be beneficial in the treatment of non-neuropathic pain and improves the analgesic...

Author(s): Salma Alotaibi, Arwa Alotaibi, Ashwaq Almqati, Khloud Alotaibi, Atyaf Bogar and Yosra Alhindi  

Evaluation of hypoglycemic activity and safety of Carica papaya seed extracts in alloxan-induced diabetic mice

October 2019

Carica papaya is used for the treatment of many diseases such as stomach upsets, diarrhoea, bilharzia, diabetes. The study aims to evaluate the safety and hypoglycemic potential effect of Carica papaya seeds on alloxan induced diabetic mice. DCM extracts were examined for the presence of terpenoids, flavonoids, steroids, phenols, tannins and alkaloids. Toxicity profile was established at 5, 50, 200, 300 and 2000 mg/kg...

Author(s): Samuel P. Kagame, , Nicholas Mwikwabe, Peter Mwitari and Moses Gichua  

Tolerance and observance of methotrexate in the treatment of rheumatoid arthritis at the university Hospital Bogodogo, Burkina Faso

September 2019

This study is aimed at assessing tolerance and observance of the patients with RA (rheumatoid arthritis) treated by methotrexate at University Hospital Bogodogo, in Burkina Faso. A cross-sectional study was conducted from July to September 2015 in outpatients with rheumatoid arthritis monitored in rheumatology service. Data were obtained from interview, by reviewing medical cards of the patients and consultation report...

Author(s): R. Frank E. Zongo, Joelle S. Zabsonré, Aminata Nacoulma, Souleymane Fofana, Moise W. Sawadogo, Estelle Noella Youl, Moussa Ouédraogo, and Dieu-Donné Ouédraogo,  

Effects of methanolic tuber extract of Cyperus esculentus Linn (tiger nuts) on sub-acute liver damage in albino rats

September 2019

This study evaluated the effects of Cyperus esculentus methanolic tuber extract (CEME) on carbon tetrachloride (CCl4)-induced sub-acute liver damage in albino rats. Dried tubers of C. esculentus were pulverized and extracted by cold maceration, using 80% methanol. Thirty albino rats, randomly assigned to 6 groups (A–F) of 5 each were used for the study. Sub-acute liver damage was induced in Groups A-E rats using...

Author(s): Thelma Ebele Ihedioha, Rita Ifeoma Odo, Uwakwe Simon Onoja, Chinweike Emmanuel Chiwetalu and John Ikechukwu Ihedioha  

Canvassing of biological attributes by In vitro screening of Canarium bengalense

September 2019

Various Hoang family remedies known as Dai-Thien-Nuong, utilize Canarium bengalense Roxb. (Family: Burseraceae) as a major component for the treatment of tumor and liver damage. This study was performed using the crude methanol extract of C. bengalense Roxb. bark and its petroleum ether, carbon tetrachloride, dichloromethane and aqueous soluble fractions for antioxidant, cytotoxic, thrombolytic, membrane stabilizing and...

Author(s):  Sanjina Saif Karim, Quazi Sufia Islam and Tasnuva Sharmin  

24 h pre-incubation of EA.hy926 cells with angiotensin II regulates insulin-dependent activation of eNOS in a concentration-dependent manner

September 2019

The rennin-angiotensin II system (RAS) and the insulin-PI3kinase signalling pathways cross-interact with important physiological and pathophysiological consequences for cells and the whole organism. Here, the effect of 24 h pre-incubation of EA.hy926 with two different concentrations of angiotensin II, on insulin-mediated activation of the PI3kinase-AKT-eNOS signalling was investigated. Quiescent EA.hy926 cells were...

Author(s): Ejebe D. E.  

Use of medicinal plants for the treatment of gastric ulcer in some parts of Southwestern Nigeria

September 2019

Ulcer is erosion in the lining of the stomach or duodenum. It is caused by disruption of the gastric mucosal defense and repair systems. There has been much interest in natural medicines derived from traditional knowledge of pharmacological properties of plants recently. The major aim of this study was to conduct an ethnobotanical survey of plants used in the treatment of Gastric ulcers in some local government areas of...

Author(s): Idayat A. Akinwumi and Mubo A. Sonibare  

Sciatica: Medical treatment or Physiotherapy?

August 2019

Low back pain is usually self-limiting. It has a sizeable impact on patients, and is associated with high healthcare and societal costs as much as $16 billion each year. Patients are commonly treated in primary care but a small proportion is referred to secondary care and may eventually have surgery. There are numerous treatment approaches for sciatica. Many people receive only medical treatment and are unaware of the...

Author(s): Mehreen Saleem, Salman Iftikhar, Ramsha Javaid,Tayyaba Rana, Maheen Rana and Yasir Arfat  

Antibacterial activities of three medicinal plant extracts and their synergistic effect on Staphylococcus aureus isolated from burn wounds

August 2019

This study was undertaken to investigate the antibacterial activities of three medicinal plant extracts and their synergistic effect on Staphylococcus aureus isolated from burn wounds. A total of 50 swab samples of burn wounds were collected from burn wound patients attending Federal Teaching Hospital Abakaliki and screened for S. aureus using standard microbiological techniques. Three plant materials (Cucurbita pepo...

Author(s): Nwuna E. N., Nwuzo A. C., Afiukwa F. N., Oke Boniface,  Udu-iIbiam E. O., Moses I. B., Ilang D. C. and Aondaackaa A. D.  

Efficacy of transurethral resection of prostate in patients of benign prostatic hyperplasia with lower urinary tract symptoms

August 2019

Transurethral resection of the prostate (TURP) has been the prime procedure for decenniums to treat benign prostatic hyperplasia (BPH), but is mainly predicated on historic data that lacks utilization of validated measures. It is noteworthy that TURP done nowadays significantly differs from that performed 30 years ago. Men who had undergone TURP between 2013 and 2018 were reviewed. 50 patients presented in the...

Author(s): Shahjahan Ur Rehman, Salman Iftikhar, Kamran Zaidi, Rao Salman Aziz, Yasir Arfat and Muhammad Sohail  

Acute toxicity evaluation of ethanolic extract of the air parts of Sida rhombifolia L., in wistar rats

August 2019

Sida rhombifolia L., popularly known in Brazil as "SIDA" or "mata-pasto", is considered a weed; a plant of the American continent and widely distributed in North Africa, belongs to the Malvaceae family. In Brazil, S. rhombifolia L. is scattered throughout the national territory, infesting agricultural crops. Certain species of the genus Sida, including S. rhombifolia, are widely used in Indian,...

Author(s): Luciana da Silva Nunes Ramalho, Gabriela Tafaela Dias, Edla Julinda Ribeiro Coutinho Espinola Guedes, Micaelly da Silva Oliveira, Andressa Brito Lira, Kardilândia Mendes de Oliveira, Otemberg Souza Chaves, Josué do Amaral Ramalho, Alexandre Rolim da Paz , Janine Agra Padilha, Hilzeth de Luna Freire Pessoa, Maria de Fátima Vanderlei de Souza, Caliandra Maria Bezerra Luna Lima and Margareth de Fátima Formiga Melo Diniz  

Antioxidant and cicatrizing activity of the species Abarema cochliacarpos (Gomes) Barneby & J. W. Grimes

August 2019

In equine clinics, skin injuries are some of the most frequently treated injuries, this research evaluated the healing potential and antioxidant activity of Abarema cochliacarpos in order to develop a pharmaceutical formulation for treating skin lesions in horses. Firstly, the antioxidant activity of several fractions was evaluated using the 2,2-diphenyl-1-picrylhydrazyl radical method and the thiobarbituric acid test....

Author(s): Saskya Araújo Fonseca, J. R. M. Costa, N. R. S. Gomes, Amanda Lima Cunha, João Gomes da Costa, Thiago José Matos-Rocha, Karwhory Wallas Lins da Silva, Paulo Henrique Barcellos França, Francisco Feliciano da Silva Júnior, Antônio Euzébio Goulart Sant’Ana and Aldenir Feitosa dos Santos,  

Phytochemical analysis and investigation of sedative-hypnotic activity of methanolic stem bark extract of Ficus abutilifolia in mice

July 2019

Most of the sedative drugs cause dose-dependent depression of the central nervous system (CNS) leading to hypnosis and possibly anaesthesia, however, these agents are associated with some side effects ranging from digestive, respiratory, immune system dysfunctions, cognitive function deterioration, tolerance, and physical dependence, hence investigations of newer and safer agents is therefore imperative. The current...

Author(s): Mikail, H. G., Akumka, D. D., Adamu, M., Zaifada, A. U.  

Aflatoxin M1 in cheese samples from the Amazon Region

July 2019

Aflatoxin M1 (AFM1) is a mycotoxin that can be found in cheeses and makes the monitoring of this food of public health interesting. In Brazil, the Amazon region has a cattle herd with dairy production of cheese, and an evaluation of the food and its risk to the population is required. The objective of this study was to evaluate the levels of AFM1, moisture content (mc) and water activity (aw) in different cheeses types,...

Author(s): Janaína Santos Barroncas, Ariane Mendonça Kluczkovski, Emerson Silva Lima, Pedro Henrique Campelo Felix, Cibele de Souza Viana, Lawrence Ramos Xavier, Samir de Carvalho Buzaglo Pinto and Augusto Kluczkovski Kunior  

Evaluation of anthelmintic activity of ethanolic extracts of Carica papaya leaves using Paramphistomum cervi and Haemonchus contortus

July 2019

The aim of this present study is to evaluate the anthelmintic activity of leaves extracts of Carica papaya using Paramphistomum cervi and Haemonchus contortus as the test worms. A range of concentrations (100, 50 and 25%) of ethanolic extracts of C. papaya were tested to assay the procedure. This is mainly applied for the determination of time of death (D) and time of paralysis (P) of the tested worms. After the...

Author(s): Md. Rabiul Islam, Syeda Fatema Tuz Zahra, S. M. Ibrahim Sumon, Shahnaj Parvin, Kamrul Hasan, Moudud Ahmed, Md. Abu Talha Siddique and Tazmel Haque    

Rational and experiential decision-making preferences of pharmacy students in Karachi, Pakistan

July 2019

This study was conducted to examine the rational (systematic and rule-based) and experiential (fast and intuitive) thinking preferences of pharmacy students. This may assist in formulating learning and teaching tactics for decision-making leading to safe and optimized patient care services. Here, a validated psychometric tool, that is, the Rational Experiential Inventory (REI-40) survey was used. It was distributed to...

Author(s): Wajiha Iffat, Sadia Shakeel, Atta Abbas Naqvi, Shehlla Imam, Tariq Ali, Shagufta Nesar, Riffat Yasmin, Faaiza Qazi Muhammad Faisal Khan and Madeeha Khan  

Sex differences in the neuroprotective effect of insulin against chemically-induced convulsions in mice

June 2019

Insulin, an important regulator of peripheral metabolism, has been reported to interact with many neurotransmitter systems including those associated with convulsion. The effect of insulin against pentylenetetrazole and strychnine-induced convulsions in mice, as well as possible sex differences, were evaluated in this study. Mice of both sexes weighing between 20 and 25 g were administered insulin intraperitoneally at...

Author(s): Susanna Adeola Adebayo, Oluwole Isaac Adeyemi, Adegbenga Rotimi Owolabi and Moses Atanda Akanmu

Effect of amodiaquine on the pharmacokinetics of gliclazide in diabetic subjects

June 2019

The study aims at investigating the effect of amodiaquine on the pharmacokinetic profile of gliclazide. It is a one-way single dose cross-over study in two phases. Six freshly diagnosed diabetic volunteers were used. The subjects acted as their own control, and each phase was preceded by an overnight fast. Phase 1 of the study involved the administration of a single oral dose of 80 mg of gliclazide after an overnight...

Author(s): Sambo Godwin Ishaku, Mojirade Taibat Bakare-Odunola, Aminu Musa, Ibrahim Adamu Yakasai, Magaji Garba and Bulus Adzu  

Myorelaxant effect of aqueous root bark extract of Carissa edulis (Forssk.) Vahl. is mediated through activation of nitric oxide synthase

June 2019

Many patients in Africa often utilize herbal medicine for the management of hyperactive gut disorders such as diarrhea and abdominal colic. There is therefore a need to scientifically evaluate efficacy of this herbal remedies. This study investigated the myorelaxant effect of Carissa edulis (Forssk.) Vahl and its possible mechanism of action using isolated rabbit jejunum preparations. Pieces of jejunum were isolated...

Author(s): Oluoch Linus Lincone, Mbugua Paul Mungai, Muriithi Anne Wangechi, Siringo Cyril George, Wafula David Kayaja and Boniface Mwangi Chege  

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