African Journal of
Cellular Pathology

OFFICIAL PUBLICATION OF THE SOCIETY FOR CELLULAR PATHOLOGY SCIENTISTS OF NIGERIA
  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 80

AJCPath Articles

Common artifacts and remedies in histopathology (a review)

January 2015

The essence of preparing a biological specimen for microscopic studies is to get adequate and accurate medical information that is a true representation of the specimen, be it for research or diagnostic purposes. An artifact can be defined as unrelated, self-colored artificial feature found in tissue sections. This has been an age long cause of misinterpretation leading to misdiagnosis to microscopists. The processing...

Author(s): Ekundina VO, Eze G

Health point prevalence of helicobacter pylori in central hospital Warri, Nigeria

December 2014

Aim: More than 50% of the world’s population harbor Helicobacter pylori in their upper gastrointestinal tract. Infection is more prevalent in developing countries, and the incidence is decreasing in the West. This study aims to determine the health prevalence rate H. pylori in Central Hospital Warri. Method: All patients suspected of dyspepsia or/and gastritis from 2012 to 2014 were tested for H. pylori....

Author(s): Jemikalajah DJ, Okogun GRA

Effect of Tamoxifen on the histomorphological and biochemical components of the liver of Guinea Pigs

December 2014

Aim: Tamoxifen, once praised for its importance in preventing breast cancer recurrence, is now implicated in dangerous side-effects. The authors are not aware of studies on the effect of tamoxifen on the histomorphological and biochemical components of the liver of guinea pig, hence the present one. Methods: Thirty guinea pigs weighing between 650g and 700g were assigned randomly into 6 groups of five and were...

Author(s): Okolie NJC, Okechi OO, Ofor I, Okorochi EC

Effect of cigarette smoke on some enzymes of the descending aorta of adult wistar rats (rattus norvegicus)

December 2014

Aim: The effect of cigarette smoke on the aorta of Wistar rats was investigated for possible enzymatic destruction. Methods: Thirty six Wistar rats 200±10g were randomly grouped into 3 of 12 rats in each group. One group was exposed to cigarette smoke (Benson and Hedges containing 1.1mg nicotine) once daily at 18.00hours. The second group was exposed to smoke from cotton wool of equal weight as of the...

Author(s): Popoola, NA, Enaibe, BU , Adekomi, DA , Raheem, SA , Olajide, OJ , Mustapha, T  

Phytochemical and trace element analysis of Vernonia Amygdalina (bitter leaf) in different locations in Nigeria

December 2014

Aim: This study was to evaluate the phytochemical and mineral elements of Vernonia amygdalina leaf grown in Anambra, Imo, Delta and Edo States of Nigeria. Methods: Standard methods were used for the phytochemical screening while the elemental analysis was done by the use of Atomic Absorption Spectrophotometer. Results: The results revealed high concentrations in mg/100g of the bioactive constituents; Flavonoids...

Author(s): Mokogwu ATH, Okorie UP, Digban KA, Abubakar A, Mokogwu EE.

Prevalence of parasitic agents associated with diarrhoea in children less than 5 years old in Lagos, Nigeria

December 2014

Aim: Diarrhoea has been a common cause of morbidity and mortality in children less than 5years old. This work was intended to see if the level of hygiene is a reflection of the type of water taken by children. Methods: One hundred and five stool samples were collected from children in two health facilities in Lagos: Ajegunle (52) and Surulere (53) from April to July 2012. The samples from children who had diarrhoea...

Author(s): Ogbonna FN, David AN, Ezeugwu SMC, Onyejepu N, Ajayi MB

The effect of oral administration of the mixture of honey and garcinia kola on the kidney of wistar rats

December 2014

Aim: Honey and Garcinia kola have long been used separately by the traditional medical practitioners as remedies for cough and other ailments. Recently, a combination of both as a remedy for cough is common. This work was intended to see the effect of this synergy on the kidney. Methods: Twenty five Wistar albino rats weighing 180±10g were grouped into 5 (A, B, C, D, E) of 5 rats each. They were fed twice...

Author(s): Avwioro OG , Demehin AO , Onyije FM , Bini N , Oladele AA , Umukoro S

The effect of the mixture of garcinia kola and honey on the liver of wistar rats

December 2014

Aim: A mixture of honey and Garcinia kola has been used for the treatment of certain dry coughs and diseases. The effect of the recommended dosage of the mixture on the liver was investigated. Methods: Twenty five Wistar albino rats weighing between 170g and 190g were grouped into 5. There were 5 rats each group. The rats were fed twice daily at 8.00am and 6.00pm with a mixture of G. kola and honey 0.16g/kg + 0.5ml,...

Author(s): Avwioro OG, Ogunbayo TJ, Ekhueorhan A, Onyije FM, Adedeji TM

Evaluation of serum proteins in pulmonary tuberculosis

November 2014

Aim: Tuberculosis (TB) remains a major public health problem throughout the world, especially in developing countries with its attendant mortality and morbidity. Proteins in plasma or serum are readily accessible and can be analyzed directly to produce diagnostic information on disease states in patients. Methods: 5ml of venous blood was collected from One hundred (100) volunteers which comprised fifty (50)...

Author(s): Jemikalajah JD, Okogun GRA, Adu ME, Okolie GC

The use of arm span to estimate height among the Urhobos in Delta state of Nigeria

October 2014

Aim: The purpose of this study is to determine the accuracy of arm span as a measure of height among the Urhobos in Delta State of Nigeria. Methods: The nature and scope of this study encompassed 401 adults (199 males and 202 females) aged 22 to 65 years from the Urhobo ethnic group in Delta State of Nigeria. Data was collected with subjects in the anatomical position. Height and arm span were measured with a...

Author(s): Anibor E, Ogbor-Omorie E, Nwagbara A

The effect of ascorbic acid on mercury-induced changes on the histomorphology of the cerebellum of adult wistar rats

September 2014

Aim: The present study was aimed at evaluating the effect of ascorbic acid on mercury-induced changes on the cerebellar cortex of adult Wistar rats. Methods: Thirty adult Wistar rats of average weight of 200g were randomly divided into 6 groups of 5 rats each. The animals in Group 1 (control) were administered with distilled water, Groups 2 and 3 were administered with 52mg/kg and 26.25mg/kg body weight of HgCl2...

Author(s): Ibegbu AO, Animoku AA, Ayuba M, Brosu D, Adamu SA, Akpulu P, Hamman WO, Umana UE, Musa SA

Serum lipid abnormalities in type 2 diabetes mellitus

August 2014

Aim: Diabetes mellitus is a clinical syndrome characterized by hyperglycemia due to absolute or relative deficiency of insulin. The present study was conducted to determine the lipid profile of diabetes in Delta State. Methods: Serum total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL) as well as Body mass index (BMI) were...

Author(s): Adu ME

The circumference interorbital index of the Isoko ethnic group in Nigeria

July 2014

Aim: The aim of the study is to determine the circumference interorbital index amongst the Isoko ethnic group of Nigeria. Methods: This study was based on data collected from 600 Isoko subjects between 12–31 years of age in Delta State of Nigeria. Data was collected using a tape rule to measure the head circumference and a non-stretchable transparent centimeter ruler to measure the inner canthal distance....

Author(s): Anibor E, Ogbor-Omorie E, Ogadima PN

TESTICULAR ALTERATION IN OVER DOSAGE OF AZATHIOPRINE: A HISTOLOGICAL AND HISTOCHEMICAL STUDY IN WISTAR RATS

May 2014

Aim: The use of Azathioprine (AZA) in the prevention of organ rejection during transplantation has been documented for different organs of the body. In this study, we investigated the effects of azathioprine on the integrity of the testis of Wistar rats using histological and histochemical techniques. Methods: Eighteen adult male Wistar rats with mean weight 210±2.65 g were randomly assigned into three...

Author(s): Onanuga IO, Ibrahim RB, Amin A, Omotoso GO

The effect of Vernonia Amygdalina and Ocimum Gratissimum on Alloxan-induced diabetic rats

May 2014

Aim: Anti-diabetic evaluation of Vernonia amygdalina and Ocimum gratissimum on alloxan induced diabetic rats was investigated. Methods: Thirty rats were divided into six groups of five per group. The rats were fed with aqueous and ethanolic plant extracts of the plants. Results: On day 2 post induction, fasting blood glucose of all the animals across the groups increased significantly (P<0.05) compared to pre...

Author(s): Adewoga TOS, Sebiomo A, Fagbemi FT

Histomorpohological assessment of the extract of the stalk of sorghum bicolor as a counterstain

May 2014

Aim: The objective of this study was to investigate the staining ability of the extract of the stalk of Sorghum bicolor as a counterstain on Haematoxylin. Methods: Tissue blocks of trachea, oesophagus and ileum were retrieved from the Autopsy Block Archive of the Department of Pathology, University of Ilorin Teaching Hospital Ilorin. Eight (8) serial sections labeled A to H were made from each block and stained...

Author(s): Omoowo BT, Bankole JK, Muhammed AO, Benard SA, Afolabi OO

Evaluation of the lethal dose of the methanol extract of rhizophora racemosa leaf using Karber’s method

May 2014

Aim: To evaluate the median lethal dose (LD50) of the methanol extract of Rhizophora racemosa leaf commonly used for toothache and dysmenorrhoea in the Niger Delta Area of Nigeria. Methods: The modified arithmetic Karber’s method by Aliu and Nwude was used. Various doses of the extract were administered to adult albino rats through intraperitoneal route and the LD50 was calculated. Results: The result...

Author(s): Angalabiri-Owei BE, Isirima JC

The effect of honey and aloe vera extract on aspirin induced liver damage in rats

April 2014

Aim: The aim of this study was to investigate the effect of honey and Aloe vera extract on Aspirin-induced liver damage in albino rats. Methods: A total of twenty four adult male albino rats weighing between 100 and 150g were divided into six groups. (A, B, C, D, E and F) of four rats each in a group, Rats in Group A served as control and were given water and feeds only. Rats in Group B were given 100mg/kg of...

Author(s): Adewoga TOS, Sebiomo A

Histological and Biochemical effects of aqueous extract of ocimum gratissimum on the liver and kidney of adult wistar rats

April 2014

Aim: Ocimum gratissimum is used commonly in traditional medicine to treat certain diseases. This study accessed the histological and biochemical effects of aqueous extract of Ocimum gratissimum leaves on the kidney and liver of adult Wistar rats. Methods: Twenty four adult Wistar rats were assigned into four groups (A, B, C and D) of 6 rats each. Group A was used as control, and B, C, and D were the treatment...

Author(s): Ebeye OA, Ekundina OV, Wilkie IE

Haematologic and biochemical implications of inhalation of fumes of petroleum products

March 2014

Aims: To investigate the Haematologic and biochemical implications of exposure to fumes of petroleum products in human subjects. Methods: A total of 100 subjects (40 males and 60 females) aged between 18-30 years participated in the study. Each gender was further categorized into two groups of 10 controls and 30 tests in males and 20 controls and 40 tests in females. Test Group 1 subjects were exposed to fumes of...

Author(s): Isirima JC, Angalabiri-Owei BE

HIV and HBV coinfection in Niger-Delta, Nigeria

March 2014

Aim: This study was conducted to ascertain the level of coexistence of Hepatitis B virus (HBV) and HIV and to determine their significant association. Both HBV and HIV share the same routes of infection. Methods: The study was conducted on 500 persons consisting 250 subjects who tested positive to HIV and 250 subjects who tested positive to HBV. HIV positive individuals were further tested for HBV. Similarly, HBV...

Author(s): Avwioro OG, Ekene EN, Afadu TE

Serum testosterone level in Nigerian marijuana and cigarette smokers

March 2014

Aim: To evaluate the effects of marijuana and cigarette smoke on serum testosterone level in male marijuana and cigarette smokers. Methods: Testosterone was estimated using enzyme immunoassay on micro plate format in 30 marijuana smokers, 15 cigarette smokers and 25 sex, age matched non-smokers as controls. Body mass index (BMI) of all subjects was also calculated. Results: There was a significant decrease...

Author(s): Adu EM, Popoola OA, Adikema NA

Effect of stress of examination on serum cortisol level and cd4 cell count in male undergraduates at Igbinedion University, Nigeria

February 2014

Aim: To assess the effect of stress of examination on serum cortisol level and CD4 cell count in young male students at Igbinedion University. Methods: A cross sectional laboratory based analysis was adopted for this study. A total of 204 male undergraduate volunteers (age 22 + 1.0 years, body mass index 23 + 0.5 kg/m2) were randomly recruited for the study. Total white blood cell (TWBC) was determined using the...

Author(s): Ehiaghe FA, , , Digban K.A., Ehiaghe IJ, .  

Observations on the quail’s bursa of fabricius under normal and experimental infectious bursal disease conditions

February 2014

AIM: The study involved the evaluation of the bursa of fabricius in healthy and experimentally infected quails with infectious bursal disease virus (IBDV). METHODS: One hundred and fifty days old quail chicks were obtained and divided into two groups. The Group B birds were inoculated with two drops of IBDV antigen while Group A were inoculated with two drops of phosphate buffered saline per os and kept for 14 weeks....

Author(s): Sonfada ML, Kwari HD, Rabo JS, Wiam IM, Hena SA

Micronutrient levels in workers occupationally exposed to formaldehyde

February 2014

Aim: The aim of the work was to determine the levels of some micronutrients in the serum of persons occupationally exposed to formalin in Benin City, Nigeria. Methods: The exposed group (n=36) comprised male embalmers (morticians) who have had occupational exposure for a minimum of five years, while apparently healthy age-matched male subjects (n=34) without considerable exposure to formaldehyde served as control...

Author(s): Igharo OG, Osadolor HB, Odigie BE, Ilyas Y, Idemudia OU, Igharo LE, Airhomwanbor K

Prevalence of squamous intraepithelial lesions of the cervix in Jalingo, Nigeria

November 2013

Aim: Cervical cancer is the second most common cancer among women in Nigeria; fortunately it is preventable through regular screening and management of intraepithelial lesions. This study aims to determine the prevalence of squamous intraepithelial lesions (SIL) of the cervix among women of reproductive age. Methods: All sexually active women between the ages of 16 – 45 years were screened consecutively for...

Author(s): Ahmed SA, Ayuba HU, Maiangwa A, Vakkai VI, Dashe DR, Joel R, Abubakar M, Danga D, Raalueke UA, Kataps HJ

Effect of ascorbic acid on mercuric chloride-induced changes on the cerebral cortex of wistar rats

November 2013

Aim: The present work was aimed at evaluating the effect of ascorbic acid on mercuric chloride induced changes on the cerebrum of Wistar rats. Methods: Thirty Wistar rats of average weight of 200g were divided into 6 groups of 5 rats each. In addition to normal diet, the animals in Group 1 were given distilled water, Groups 2 and 3 were administered 52mg/kg and 26.25mg/kg of mercuric chloride (HgCl) respectively...

Author(s): Ibegbu AO, Animoku AA, Ayuba M, Brosu D, Adamu SA, Akpulu P, Hamman WO, Umana UE, Musa SA

Impact of liver damage on the histoarchitectural profile of the cerebellar cortex in rats

November 2013

Aim: This study described the histopathological profile of the cerebellar cortex and liver of rats with carbon tetrachloride (CCl4)-induced liver damage. Methods: Male Wistar rats weighing about 250 g were divided into 2 groups (A and B). Group A (control) rats were treated with olive oil (OO) solution only while Group B rats were treated with carbon tetrachloride (CCl4) for 8 weeks. Thereafter, the cerebellum and...

Author(s): Adekomi DA, Oyesomi TO, Ajao MS, Ojo OA, Onikanni SA

Histopathological pattern of renal tumours seen in Usmanu Danfodiyo University Teaching Hospital Sokoto, Nigeria

November 2013

Aim: Malignant renal tumour is a relatively rare type of cancer that occurs third in urological tumours after prostate and bladder cancers. Little is known in the literatures about its existence in Sokoto which prompted this research. This study was carried out to determine the prevalence and histopathological pattern of malignant renal tumours in Sokoto, Nigeria. Methods: A total of 11,554 H&E stained sections...

Author(s): Isah RT, Sahabi SM, Adamu SN, Muhammad AT, Mungadi IA

Effect of exercise induced stress on serum cortisol level and cd4 cell count in rats

November 2013

Aim: To evaluate the effect of exercise induced stress on serum cortisol level and CD4 cells in rats. Methods: A total of 21 male albino rats weighing 100±10g were used for the study. The exercise pre-conditioning was in the form of mere swimming. Serum cortisol was evaluated using Enzyme Linked Immunosorbent Assay. CD4 cell counts were estimated using Partec Cyflow counter, Germany for the quantification...

Author(s): Ehiaghe FA,, Agbonlahor DE, Etikerentse SMO, Osadolor HB

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