African Journal of
Cellular Pathology

  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 65

AJCPath Articles

May 2014

The effect of Vernonia Amygdalina and Ocimum Gratissimum on Alloxan-induced diabetic rats

Aim: Anti-diabetic evaluation of Vernonia amygdalina and Ocimum gratissimum on alloxan induced diabetic rats was investigated. Methods: Thirty rats were divided into six groups of five per group. The rats were fed with aqueous and ethanolic plant extracts of the plants. Results: On day 2 post induction, fasting blood glucose of all the animals across the groups increased significantly (P<0.05) compared to pre...

Author(s): Adewoga TOS, Sebiomo A, Fagbemi FT

May 2014


Aim: The use of Azathioprine (AZA) in the prevention of organ rejection during transplantation has been documented for different organs of the body. In this study, we investigated the effects of azathioprine on the integrity of the testis of Wistar rats using histological and histochemical techniques. Methods: Eighteen adult male Wistar rats with mean weight 210±2.65 g were randomly assigned into three...

Author(s): Onanuga IO, Ibrahim RB, Amin A, Omotoso GO

April 2014

The effect of honey and aloe vera extract on aspirin induced liver damage in rats

Aim: The aim of this study was to investigate the effect of honey and Aloe vera extract on Aspirin-induced liver damage in albino rats. Methods: A total of twenty four adult male albino rats weighing between 100 and 150g were divided into six groups. (A, B, C, D, E and F) of four rats each in a group, Rats in Group A served as control and were given water and feeds only. Rats in Group B were given 100mg/kg of...

Author(s): Adewoga TOS, Sebiomo A

April 2014

Histological and Biochemical effects of aqueous extract of ocimum gratissimum on the liver and kidney of adult wistar rats

Aim: Ocimum gratissimum is used commonly in traditional medicine to treat certain diseases. This study accessed the histological and biochemical effects of aqueous extract of Ocimum gratissimum leaves on the kidney and liver of adult Wistar rats. Methods: Twenty four adult Wistar rats were assigned into four groups (A, B, C and D) of 6 rats each. Group A was used as control, and B, C, and D were the treatment...

Author(s): Ebeye OA, Ekundina OV, Wilkie IE

March 2014

Serum testosterone level in Nigerian marijuana and cigarette smokers

Aim: To evaluate the effects of marijuana and cigarette smoke on serum testosterone level in male marijuana and cigarette smokers. Methods: Testosterone was estimated using enzyme immunoassay on micro plate format in 30 marijuana smokers, 15 cigarette smokers and 25 sex, age matched non-smokers as controls. Body mass index (BMI) of all subjects was also calculated. Results: There was a significant decrease...

Author(s): Adu EM, Popoola OA, Adikema NA

March 2014

HIV and HBV coinfection in Niger-Delta, Nigeria

Aim: This study was conducted to ascertain the level of coexistence of Hepatitis B virus (HBV) and HIV and to determine their significant association. Both HBV and HIV share the same routes of infection. Methods: The study was conducted on 500 persons consisting 250 subjects who tested positive to HIV and 250 subjects who tested positive to HBV. HIV positive individuals were further tested for HBV. Similarly, HBV...

Author(s): Avwioro OG, Ekene EN, Afadu TE

March 2014

Haematologic and biochemical implications of inhalation of fumes of petroleum products

Aims: To investigate the Haematologic and biochemical implications of exposure to fumes of petroleum products in human subjects. Methods: A total of 100 subjects (40 males and 60 females) aged between 18-30 years participated in the study. Each gender was further categorized into two groups of 10 controls and 30 tests in males and 20 controls and 40 tests in females. Test Group 1 subjects were exposed to fumes of...

Author(s): Isirima JC, Angalabiri-Owei BE

February 2014

Effect of stress of examination on serum cortisol level and cd4 cell count in male undergraduates at Igbinedion University, Nigeria

Aim: To assess the effect of stress of examination on serum cortisol level and CD4 cell count in young male students at Igbinedion University. Methods: A cross sectional laboratory based analysis was adopted for this study. A total of 204 male undergraduate volunteers (age 22 + 1.0 years, body mass index 23 + 0.5 kg/m2) were randomly recruited for the study. Total white blood cell (TWBC) was determined using the...

Author(s): Ehiaghe FA, , , Digban K.A., Ehiaghe IJ, .  

February 2014

Micronutrient levels in workers occupationally exposed to formaldehyde

Aim: The aim of the work was to determine the levels of some micronutrients in the serum of persons occupationally exposed to formalin in Benin City, Nigeria. Methods: The exposed group (n=36) comprised male embalmers (morticians) who have had occupational exposure for a minimum of five years, while apparently healthy age-matched male subjects (n=34) without considerable exposure to formaldehyde served as control...

Author(s): Igharo OG, Osadolor HB, Odigie BE, Ilyas Y, Idemudia OU, Igharo LE, Airhomwanbor K

February 2014

Observations on the quail’s bursa of fabricius under normal and experimental infectious bursal disease conditions

AIM: The study involved the evaluation of the bursa of fabricius in healthy and experimentally infected quails with infectious bursal disease virus (IBDV). METHODS: One hundred and fifty days old quail chicks were obtained and divided into two groups. The Group B birds were inoculated with two drops of IBDV antigen while Group A were inoculated with two drops of phosphate buffered saline per os and kept for 14 weeks....

Author(s): Sonfada ML, Kwari HD, Rabo JS, Wiam IM, Hena SA

November 2013

Effect of ascorbic acid on mercuric chloride-induced changes on the cerebral cortex of wistar rats

Aim: The present work was aimed at evaluating the effect of ascorbic acid on mercuric chloride induced changes on the cerebrum of Wistar rats. Methods: Thirty Wistar rats of average weight of 200g were divided into 6 groups of 5 rats each. In addition to normal diet, the animals in Group 1 were given distilled water, Groups 2 and 3 were administered 52mg/kg and 26.25mg/kg of mercuric chloride (HgCl) respectively...

Author(s): Ibegbu AO, Animoku AA, Ayuba M, Brosu D, Adamu SA, Akpulu P, Hamman WO, Umana UE, Musa SA

November 2013

Prevalence of squamous intraepithelial lesions of the cervix in Jalingo, Nigeria

Aim: Cervical cancer is the second most common cancer among women in Nigeria; fortunately it is preventable through regular screening and management of intraepithelial lesions. This study aims to determine the prevalence of squamous intraepithelial lesions (SIL) of the cervix among women of reproductive age. Methods: All sexually active women between the ages of 16 – 45 years were screened consecutively for...

Author(s): Ahmed SA, Ayuba HU, Maiangwa A, Vakkai VI, Dashe DR, Joel R, Abubakar M, Danga D, Raalueke UA, Kataps HJ

November 2013

Effect of exercise induced stress on serum cortisol level and cd4 cell count in rats

Aim: To evaluate the effect of exercise induced stress on serum cortisol level and CD4 cells in rats. Methods: A total of 21 male albino rats weighing 100±10g were used for the study. The exercise pre-conditioning was in the form of mere swimming. Serum cortisol was evaluated using Enzyme Linked Immunosorbent Assay. CD4 cell counts were estimated using Partec Cyflow counter, Germany for the quantification...

Author(s): Ehiaghe FA,, Agbonlahor DE, Etikerentse SMO, Osadolor HB

November 2013

Histopathological pattern of renal tumours seen in Usmanu Danfodiyo University Teaching Hospital Sokoto, Nigeria

Aim: Malignant renal tumour is a relatively rare type of cancer that occurs third in urological tumours after prostate and bladder cancers. Little is known in the literatures about its existence in Sokoto which prompted this research. This study was carried out to determine the prevalence and histopathological pattern of malignant renal tumours in Sokoto, Nigeria. Methods: A total of 11,554 H&E stained sections...

Author(s): Isah RT, Sahabi SM, Adamu SN, Muhammad AT, Mungadi IA

November 2013

Impact of liver damage on the histoarchitectural profile of the cerebellar cortex in rats

Aim: This study described the histopathological profile of the cerebellar cortex and liver of rats with carbon tetrachloride (CCl4)-induced liver damage. Methods: Male Wistar rats weighing about 250 g were divided into 2 groups (A and B). Group A (control) rats were treated with olive oil (OO) solution only while Group B rats were treated with carbon tetrachloride (CCl4) for 8 weeks. Thereafter, the cerebellum and...

Author(s): Adekomi DA, Oyesomi TO, Ajao MS, Ojo OA, Onikanni SA

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