African Journal of
Cellular Pathology

OFFICIAL PUBLICATION OF THE SOCIETY FOR CELLULAR PATHOLOGY SCIENTISTS OF NIGERIA
  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 80

AJCPath Articles

The study of attenuating effects of quercetin on spatial memory impairment and degenerative changes in hippocampus of lead exposed rats

May 2021

Lead neurotoxicity has been studied in animal models to induce neurodegeneration. The study was aimed to evaluate the attenuating effects of quercetin on spatial memory impairment and degenerative changes in hippocampus of lead exposed rats. Thirty (30) Wistar rats were randomly divided into six groups of five rats per group (each, n = 5). Groups I (control) and II were administered distilled water and lead,...

Author(s): Musa O. Iliyasu, Sunday A. Musa, Sunday B. Oladele and Ibrahim A. Iliya 

Effect of n-butanol extract of Cannabis sativa L. extract on the cerebral cortex of adult Wistar rats

February 2020

The present study was aimed at investigating the effect of Cannabis sativa L. administration on neurobehavior and histology of the frontal cortex ofadult Wistar rats. Eighteen (18) adult Wistar rats (120 to 140 g) were divided into three (3) groups of six (6) animals per. Animals in group 1 (control) were given 1 ml/kg distilled water, while groups 2 and 3 were administered with 250 and 500 mg/kg of n-Butanol extract of...

Author(s): Zachariah Richard, Adebisi S. Sunday, Uduak E. Umana, Adamu A. Sadeeq and Policy P. Adamu  

Phytochemical and in vitro antioxidant studies on methanol extract of Vernonia calvoana leaf and its polar fractions: Preliminary study

January 2020

This study aims to screen possible antioxidant potentials of methanol extract and polar fractions of Vernonia calvoana leaves and its phytochemical constituents since the leaves are used ethno medically in managing ailments like wounds, blood pressure, inflammation, arthritis, and bone diseases. Dried leaves (900 g) were ground and de-fatted with n-hexane. The dry marc was extracted using 80% methanol and water....

Author(s): Nwaehujor Chinaka O., and Uwagie-Ero Edwin A.  

Assessment of the effect of post-natal lead exposure on the hippocampus of developing Wistar rats

December 2019

This study examined the effect of post-natal lead exposure on the hippocampus of developing Wistar rats. Nine pregnant Wistar rats were randomly distributed into three groups of three rats each, consisting of a control Group 1 which received distilled water and experimental Groups 2 and 3 orally administered with 60 and 90 mg/kg bwt of lead acetate, respectively. The pups of the experimental Groups 2 and 3 were exposed...

Author(s): Oluwasegun Davis Olatomide, Sunday Samuel Adebisi and Sunday Abraham Musa  

A comparative study of cultural and molecular techniques for the identification of bacterial contaminants of cockroaches (Periplaneta americana)

August 2019

The increasing trends of insect associated bacterial infection in humans are severely hampered by disparaging number of bacteria obtained with the culture-based technique. This study therefore determined how the analysis of the 16S rDNA sequences would compare in terms of precision and reliability to the most adoptable culture-based technique. Results obtained depict enhanced accuracy of  molecular technique over...

Author(s): O. D. Popoola, B. T. Thomas and M. O. Efuntoye

Temporal bone histopathology study on cochlear otosclerosis: A memoir for the cochlear implant surgeon

June 2019

The aim of this study was to describe the pathologic changes in temporal bones with cochlear otosclerosis that may have implications for cochlear implantation. Fifteen human temporal bones with otosclerosis were used for this study. In each temporal bone was studied: (1) medial wall of the middle ear and in particular the horizontal segment of the facial nerve canal; (2) the round window niche and the corresponding part...

Author(s): Abdulazeez Ahmed  

Umbilical cord torsion leading to intrauterine fetal death

June 2019

The umbilical cord is the critical organ that links the placenta and fetus. The intrauterine conditions and fetal activity influences the umbilical cord length. The normal umbilical cord is spiraled. By ultrasound, the spiral nature of the umbilical cord can be demonstrated early in the first trimester. Most of the adverse pregnancy and perinatal outcomes are related to abnormal Umbilical Cord coiling Index (UCI). A 23...

Author(s): Mohammed U., Panti A. A., Abdullahi K., Afolabi O. K., Sani H. and Ekochin K. O.  

CD34 positive stem cells recovered from cord blood remain viable after six months of cryoprotective storage process

May 2019

Cord blood can be used as an alternative source for bone marrow transplantation and its use is developing into a new field of treatment for patients presenting with haematological disorders, immunological defects and specific genetic diseases; including haemoglobinopathies. The aim was to assess the viability of frozen cord blood as a source of HSC which may be suitable for transplantation. Blood specimens were obtained...

Author(s): Muhibi M. A., Mabayoje V. O. and Komolafe J. O.  

Effect of formalin fixation on DNA purity and quantity, nucleic acid, and amplicon size in cervical human papilloma virus detection

September 2018

Tissue fixation with 10% formalin and molten paraffin wax embedding (FFPE) is routinely used protocol for tissue preservation in histopathology laboratory. We therefore aimed at comparing the differences in DNA quantity, DNA purity, nucleic acid and its effect on primers (PCR) amplicon (bp) sizes between fresh cervical tissues and formalin fixed paraffin embedded (FFPE). The differences in DNA purity, quantity and...

Author(s): Oboma Y. I. and Ngokere A. A.  

Effect of Theobroma cacao on renal function of wistar albino rats induced with anaemia

August 2018

The study investigated the effect of Theobroma cacao on renal function of phenylhydrazine induced anaemic albino rats. Forty albino rats were divided into 8 groups of five rats each namely control (group A), Phenyl hydrazine (group B) while groups C, D and E were given phenylhydrazine and administered with 100,200 and 500 mg/kg of T. cacao respectively while groups F, G and H were given 200,500 and 1000 mg/kg of T cacao...

Author(s): Adegoke O. Adebayo, Oluwatayo G. Beatrice and Ogbu U. Patience  

Some plasma biochemical changes in layers experimentally infected with Pasteurella multocida

August 2018

The present study was carried out to investigate some biochemical alterations in layers experimentally infected with Pasteurella multocida. A total of 20 eighteen-week old ISA Brown layers were used in the experiment. The birds were randomly assigned to two groups (infected and control) of 10 layers each. To establish infection, each bird in the infected group was challenged by intra nasal (0.1 ml) and intramuscular...

Author(s): Joseph John Gadzama, Balami Arhyel Gana, Mohammed Adam Chiroma, Sani Adamu, Hassan Abdulsalam, Lekko Madaki Yusuf, Idoko Sunday Idoko, Sani Nuhu Abdulazeez, Samson James Enam and King Akpofure Nelson Esievo  

Phenotypic detection of multidrug resistant extended-spectrum beta-lactamase (ESBL) producing Escherichia coli from clinical samples

July 2018

A clinico-laboratory investigation of multidrug resistant (MDR) characteristics of extended spectrum β-lactamase (ESBL) producing Escherichia coli pathotypes from some hospitals in Bauchi metropolis, Nigeria, was carried out. A total of 198 E. coli isolates were recovered from different patients’ age group (0 to above 70 years), comprising of 134 males and 85 females, as both out-patient (126) and in-patient...

Author(s): Iliyasu M. Y., Uba A. and Agbo E. B.  

Comparative study of the effects of aqueous and ethanol fruit extracts of Phoenix dactylifera L. on the cerebellar cortex of Artesunate–Amodiaquine treated adult Wistar rats

July 2018

This study was to evaluate the effects of aqueous and ethanol fruit extracts of Phoenix dactylifera on the cerebellar cortex of Artesunate-Amodiaquine (AS–AQ) treated Wistar rats. Thirty-six adult male Wistar rats were randomly divided into nine groups (n=4). Group 1 served as the control; Group 2 received 2.86/8.75 mg/kg AS–AQ. Group 3 received 2.86/8.75 mg/kg AS–AQ + 100 mg/kg ascorbic acid; Groups...

Author(s): M. N. Budaye, S. S. Adebisi, A. A. Buraimoh, S. S. Lazarus and A. N. Agbon  

Determination of egg production and weight in layers experimentally infected with Salmonella gallinarum

June 2018

The present study was conducted to determine egg production and weight in layers experimentally infected with Salmonella gallinarum. Twenty layers were used for the research. The layers were purchased at the age of 18 weeks from certified commercial poultry farm in Kujama farm, Kaduna State, Nigeria and housed in the Animal Research Unit of the Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Ahmadu Bello...

Author(s): Mohammed Adam Chiroma, Sani Adamu, Joseph John Gadzama, King Akpofure Nelson Esievo, Abdulsalam Hassan, Arhyel Gana Balami, Muhammad Ya’u, Ibrahim Bulama and Lekko Yusuf Madaki

Histological and histochemical assessements on the effect of ethanol fruit extract of Phoenix dactylifera L. (Date Palm) on cerebral cortex of lead acetate treated wistar rats

June 2018

This study histologically and histochemically assess the effect of ethanol fruit extract of Phoenix dactylifera L. (EFPD) on the cerebral cortex of lead acetate exposed Wistar rats. Twenty rats were grouped into five groups (A to E, n=4). Group A (control) was administered distilled water (2 ml/kg), while groups B to E were treatment groups. Cerebral damage was induced in rats by the administration of lead acetate (120...

Author(s): Stephen Samuel Lazarus, Samuel Sunday Adebisi, Yusuf Tanko, Abel Nosereme Agbon and Michael Ndomi Budaye

Some plasma biochemical changes in layers experimentally infected with Salmonella gallinarum

December 2017

Aim: The study was conducted to investigate some plasma biochemical changes in layers experimentally infected with Salmonella Gallinarum Methods: A total of 20 eighteen-week- old ISA Brown layers were used in the experiment. The birds were randomly divided into two groups; infected and control, of 10 birds each. Each bird in the infected group was orally administered 0.5 ml of the inoculum containing...

Author(s): Chiroma Mohammed Adam, Adamu Sani, Gadzama Joseph John, Esievo King Akpofure Nelson, Abdulsalam Hassan, Balami Arhyel Gana, Enam Samson James, Muhammad Ya’u , Atata Abdulhamid Jamila  

Determination of median lethal dose of ethanolic extract of Sesamum Indicum seeds in adult wistar rats

December 2017

The aim of this research was to determine the median lethal dose of sesamum indicum seeds in Wistar rats. Methods: Twelve Wistar rats within the ages of five to six weeks and of weights, ranging from (98-160) g of both sexes were used for the experiment. They were categorized into two phases of I and II. Phase I consisted three (3) groups of three (3) animals each. While phase II consisted three (3) groups...

Author(s): Yusuf M.K, Ibegbu AO,  Agbon AN, Evang A

Ascorbic acid and testosterone efficacy in spermatoxic and histomorphological changes in Corpora cavernosa in priapism induced sprague-dawley rats

August 2017

Aim: The histomorphological changes in the corpora cavernosa following priapism remains an interesting observation due to its pathological and reproductive implications. We investigated the attenuating effect of testosterone and vitamin C on the corpora cavernosa induced fibrosis in priapism of rats. Methods: Twenty-five Sprague – Dawley male rats were randomly allocated into 5 groups of rats each Group 1 served...

Author(s): Igwe O, Aniah J. A, Godam E. T, Yama O, E.

Male breast adenomyoepithelioma- A case report and literature review

June 2017

Adenomyoepithelioma is an uncommon primary breast tumor characterized by a biphasic proliferation of epithelial and myoepithelial cells which was first described by Hampperl in 1970. The largest reported series had been by Tavassoli (1991) who in reported 27 cases. Most of the others have been one or two case reports. Except for two in male patients [Tamura et al., 1993, Berna et al., 1997] all the reported cases have...

Author(s): Wahab TA, Uwakwe H, Gillibrand R, Fafemi O

Haematological changes in layers experimentally infected with salmonella gallinarum

June 2017

Aim: The present study was conducted to investigate the haematological changes in layers experimentally infected with Salmonella gallinarum. Methods: A total of 20 eighteen-week- old ISA Brown layers were used for the experiment. The birds were randomly divided into two groups, infected and control, of 10 birds each. To establish the infection, each bird in the infected group was orally administered 0.5 ml of the...

Author(s): Chiroma Mohammed Adam, Adamu Sani, Gadzama Joseph John, Esievo King Akpofure Nelson, Abdulsalam Hassan, Sani Nuhu Abdulazeez, Joshua Luka, Muhammad Ya’u

Histomorphology of seminal vesicle and testicular tissue of Wistar rats following administration of Carica Papaya

June 2017

Aim:  This  study  was  aimed  at  evaluating  the  effect  of  Carica  papaya  on  male reproductive organs. Methods: Twenty Wistar rats were randomly grouped into 4 of 5 rats each. They were fed with 2.5g/kg, 5g/kg and 7.5g/kg of ethanolic extract of Carica papaya once a day. The first group was given water. The rats were sacrificed on the 14th...

Author(s): Zenebo VC, Eric UC

EVALUATION OF THE TOXICITY OF PHYLLANTHUS AMARUS IN WISTAR ALBINO RATS

May 2017

Aim: The study evaluated the acute and sub acute toxicity of the aqueous leaf extract of Phyllathus amarus Schum. and Thonn using Wistar albino rat. Methods: Sixty-one adult Wistar rats were grouped four groups with ten rats per group for acute study. Rats in group 2, 3 and 4 received 2000mg/kg, 4000mg/kg, and 8000mg/kg of the extract respectively. For sub acute study, rats were divided into three groups with seven...

Author(s): Adomi PO ,Owhe-Ureghe UB , AsagbaSO

A STUDY OF ULCER INDUCED STOMACH OF ALBINO RATS TREATED WITH IDOGU MIXTURE, A POTENT ANTI-ULCER HERBAL DRUG

April 2017

Aim: The aim of this study was to assess the potency of the anti-ulcer drug, Idogun on the stomach of ulcer induced albino rats. Method: Six groups of locally bred albino rats were used. Each group containing five rats of either sex were orally treated respectively with distilled water (ulcer control group), omeprazole 20mg/kg (reference group) and 100, 200, 400 and 800mg/kg extract of Idogun anti –ulcer...

Author(s): Adediran OA , Avwioro OG and Funsho-Agun AG

SEROPREVALENCE AND HAEMATOLOGICAL STUDIES OF SOME WILD AND SEMI-DOMESTICATED BIRDS NATURALLY INFECTED WITH AVIAN POX VIRUS IN ZARIA, NGERIA

March 2017

Aim: To determine seroprevalence and haematological parameters of some wild and semidomesticated birds naturally infected with avian pox virus (APV). Methods: A total of 160 birds belonging to 12 species were used for the study. Serum samples obtained from these birds were analyzed for antibodies to Avian Pox Virus (APV) using agar gel precipitation test. Natt-Herricks methods and thin blood smear technique were...

Author(s): Andamin AD , AkadeFT , Samuel FU , Enam SJ , Aliyu HB , Abdu PA , Oladele SB

EVALUATION OF THE EFFECTS OF AQUEOUS GARLIC EXTRACT ON LEAD-INDUCED CHANGES ON CEREBELLUM OF WISTAR RATS

February 2017

Aims: The effects of aqueous garlic extract on lead-induced changes on the cerebellum of Wistar rats was investigated. Methods: Forty five Wistar rats were randomly divided into nine groups. Group 1 served as Control. Groups 2 and 3 received lead at low and high doses. Group 4 received lead and garlic extract at low doses while Group 5 received lead at high dose and garlic extract at low dose. Group 6 received lead...

Author(s): Hamza GA , Ibegbu AO , Buraimoh AA

PRELIMINARY HISTOLOGICAL STUDIES ON THE EFFECT OF AQUEOUS FRUIT EXTRACT OF PHOENIX DACTYLIFERA L. (DATE PALM) ON LEAD ACETATE-INDUCED CEREBELLAR DAMAGES IN WISTAR RATS

January 2017

Aim: This study was to histologically assess the therapeutic effect of aqueous fruit extract of Phoenix dactylifera (AFEPD) on lead acetate-induced cerebellar damage in Wistar rats. Methods: Twenty four rats were grouped into six (I–VI; n=4). Group I (control) received distilled water (1 ml/kg). Group II received lead acetate (LA, 120mg/kg) only. Groups III and IV received LA (120mg/kg) followed by AFEPD...

Author(s): Yusuf AO , Buraimoh AA , Agbon AN , Raji K B , Akpulu PS

IMMUNOHISTOCHEMICAL EXPRESSION OF p16(INK4A) PROTEIN IN CERVICAL DYSPLASIA AND CARCINOMA IN PATIENTS ATTENDING FEDERAL TEACHING HOSPITAL, GOMBE, NIGERIA

December 2016

Aim: This study was conducted to determine and compare the immunohistochemical expression of p16(INK4a) in cervical dysplasia and carcinoma in Gombe, Nigeria. Materials: Seventy eight cases of cervical neoplasm; comprising 17 cases of cervical intraepithelial neoplasia (CIN), 53 cases of squamous cell carcinoma (SCC), 6 cases of adenocarcinoma and 2 cases of adenosquamous carcinoma. All samples were stained using...

Author(s): Umar A, Avwioro OG, Muhammad AT, Mohammed I, Mohammed MO, Ibrahim KK, Sahabi SM, Abdullahi K, Mohammed SA, and Ajayi AS  

  • Article Number: 1C4D07365710

HIBISCUS EXTACT-IRON-VAN GIESON: A NEW MORPHOLOGICAL STAINING TECHNIQUE IN NEURO-HISTOLOGY

November 2016

Aim: To investigate the suitability of Hibiscus extract mordanted with ferric chloride and counterstained with Van Gieson in the demonstration of brain histomorphology. Method: 10% formol saline fixed brain tissues from cerebellum, cerebrum and basal ganglia were processed by the paraffin wax technique, sectioned and stained with H&E labeled A, Hibiscus/Van Gieson stain labeled B and Weigert’s Van Gieson...

Author(s): Benard SA, Afolabi OO, Olutunde OA  

  • Article Number: 184BA3765708

HEMATOLOGICAL EVALUATION OF ABINO RATS ORALLY ADMINISTERED PYRETHROIDS FORMULATION

July 2016

Aim: This study was carried out to determine the effect of Mortein on some hematological parameters. Methods: Fifty adult Albino rats (150- 200g) were acquired from the animal house of the College of Health Sciences, Delta State University Abraka and placed into four groups. Groups 1- 3 contained 15 rats each, while 4 contained 5 rats. Groups 1-3 were further sub-divided into 3 sub-groups of 5 rats each. The rats in...

Author(s): Iteire AK  

  • Article Number: EA360A965706

EFFECT OF PRENATAL ETHANOL EXPOSURE AND EXTRACT OF TAMARINDUS INDICA PULP ON THE CEREBRAL CORTEX OF WISTAR RATS

July 2016

Aim: The aim of the study was to evaluate the effect of ethanolic pulp extract of Tamarindus indica (EPTI) on the cerebral cortex in prenatal ethanol exposure in Wistar rats. Method: Twenty four pregnant rats were divided into 7 groups. The Control received 1ml of water, Groups 2 and 3 received 200mg/kg and 300mg/kg body weight (bw) of EPTI and Vitamin E respectively, Group 4 received 0.1ml of olive oil, Group 5...

Author(s): Usman IM, Buraimoh AA, Ibegbu AO  

  • Article Number: 284DB8D65704

SEMEN CHARACTERISTICS OF WISTAR RATS TREATED WITH METHANOLIC EXTRACT OF JATROPHA GOSSYPIFOLIA

June 2016

Aim: The study was designed to determine the effect of methanolic leave extract of Jatropha gossypifolia on semen characteristics in Wistar rats. Methods: Twenty-five male Wistar rats were divided into 5 groups (A, B, C, D and E) comprising 5 rats each. Rats in group A served as control, and were administered distilled water per os for 21 days, while rats in groups B, C, D and E were administered oral 100, 300, 500...

Author(s): Ubah SA, Inyang IE, Waziri MA, Ogunbodede MA, Oladele GM, Ode OJ, Adeyeye AA  

  • Article Number: 2850C0A65702

IMPACT OF COPPER, LEAD, IRON AND ZINC ON OCCUPATIONAL PHOTOCOPIER OPERATORS AND REPAIRERS IN THE UNIVERSITY OF BENIN COMMUNITY- A PILOT STUDY

May 2016

Aim: Photocopying serves as a good source of employment to many Nigerian youths and its importance cannot be overemphasized. Photocopiers are used on a regular basis without any protective measure. This study seeks to ascertain the complexity of copper, lead, iron and zinc accumulates in the body of occupational users of photocopiers and their possible health hazards. Methods: Seventy subjects including tests and...

Author(s): Osadolor HB Vittu OD, and  Idemudia UO  

  • Article Number: EF1487E65700

SKELETAL MUSCLE MITOCHONDRIAL ALTERATIONS IN CARBOXYL TERMINUS OF HSC70 INTERACTING PROTEIN (CHIP)-/- MICE

April 2016

Aim: Hereditary ataxias are characterized by a slowly progressive loss of gait, hand, speech, and eye coordination and cerebellar atrophy. A subset of these, including hypogonadism, are inherited as autosomal recessive traits involving coding mutations of genes involved in ubiquitination including RNF216, OTUD4, and STUB1. Cerebellar CHIPopathy (MIM 615768) is a form of autosomal recessive spinocerebellar ataxia...

Author(s): Jonathan C. Schisler, Cam Patterson, Monte S. Willis

  • Article Number: B5DC83765698

COMPARATIVE EVALUATION OF THE EFFECTS OF PALM BUNCH ASH AND TRONA ON THE LIVER OF ALBINO RATS

April 2016

Aim: To evaluate the haematological, biochemical and histological effects of palm bunch ash (PBA) and trona when used as tenderizers. Methods: Thirty male albino rats were randomly grouped into five designated 1(control), 2, 3, 4 and 5, and were orally given 2 ml of distilled water, 486 mg/kg of trona, 972 mg/kg of Trona, 486 mg/kg of PBA, 972 mg/kg of PBA, respectively for 21 days. Results: The study showed...

Author(s): Okoye JO, Oranefo NO, and Okoli AN  

  • Article Number: 4C7993365696

HISTOPATHOLOGICAL PATTERN OF SKIN LESIONS IN USMANU DANFODIYO UNIVERSITY TEACHING HOSPITAL SOKOTO, NIGERIA

March 2016

Aim: Skin diseases are a common and important cause of morbidity globally. However, there is no study on skin lesion available in Sokoto to add to the existing dermatological knowledge in the sub-Saharan region. This research aims to determine the histopathological pattern of skin lesions in Sokoto. Methods: A total of 329 skin samples were thoroughly analysed in the study. 28 had inadequate data ranging from...

Author(s): Abubakar SD, Tangaza AM, Sahabi SM, Legbo JN  

  • Article Number: AA4295F65692

REPRODUCTION AND TRYPANOSOMA CONGOLENSE IN NIGERIAN WEST AFRICAN DWARF EWES: II. GENITAL AND ENDOCRINE LESIONS

March 2016

Aim: The study was designed to determine the effect of Trypanosoma congolense on the genital and endocrine organs of West African Dwarf (WAD) ewes. Methods: Ten WAD ewes obtained for the study were divided into two groups comprising 5ewes each. Group A was infected with Trypanosoma congolense, while group B was uninfected and allowed to run for eight weeks. At the end of the study period, three infected and two...

Author(s): Abubakar YU, Oyedipe EO, , Eduvie LO , Ogwu DO , Adeyeye AA  

  • Article Number: 1FCFBC465694

A COMPARISON OF THE EFFECT OF COMMERCIAL pH BUFFERS ON EPITOPE RETRIEVAL OF ‘HER-2/neu’ PROTEIN

January 2016

Aim: The significance of immunohistochemistry standardization became important with the disclosure of alarmingly high records of inconsistent results in the assessments of HER-2/neu expression status in women with breast cancers. Formalin-Fixed-Paraffin-Embedded tissue usually presents with conformational macromolecular changes, masking the epitope with sub-optimal staining of HER- 2/neu protein. The pH of epitope...

Author(s): Enemari JO, Avwioro OG, Osadolor HB, Idoko J, Yaro JD, and Odigie BE  

  • Article Number: A3FEB8B65690

Effect of a cassava based diet (gari) on some renal function parameters in albino rats

June 2015

Aim: The study was carried out to ascertain the effect of Gari (a cassava based diet) on renal functions in albino rats. Methods: Thirty five Wistar albino rats divided into seven groups were fed Gari mixed with normal rat diet at concentrations of 0, 10, 20, 40, 60, 80, and 100% respectively for 3 weeks and the renal parameters (Creatinine, Urea, Sodium and Potassium) monitored in the animals. Results: There...

Author(s): Adegoke O.A , Bamigbowu E.O , George–Opuda M. I , Awopeju T A , Mbata CA, Braide SA , Ekwusa O. V , Odunfa T

Isolation and serological detection of mycoplasma gallisepticum and mycoplasma synoviae using a combined mg/ms enzyme-linked immunosorbent assay kit in indigenous chickens in Niger State, Nigeria

June 2015

Aim: The present study was undertaken to determine the seroprevalence of mycoplasma infection and possible isolation from local chickens in Niger State, Nigeria. We have looked into this problem using a combined MG/MS ELISA kit and cultural isolation. Methods: A total of 552 blood samples were randomly collected from exanguinated chickens for serology. Tracheal swabs were collected into screwed cap bijou bottles...

Author(s): Ahmed JS, Lawal SM, Fatihu MY, Moses DG, Barde IJ, Kumbish PR, Oladele SB

Evaluation of serum proteins in some immunocompromised patients in Auchi, Edo State, Nigeria

June 2015

Aim: Immuno compromised state is a condition of alteration in the immune status of an individual, thereby promoting progression of a disease. This work investigated serum proteins in immuno compromised individuals. Methods: 5ml venous blood was collected from 120 volunteers which comprised 20 tuberculosis patients, 40 Human immunodeficiency virus patients, 40 pregnant women and 20 age –sex matched apparently...

Author(s): Okogun GRA , Jemikalajah DJ , Adu ME , Saliu R Okogun GRA , Jemikalajah DJ , Adu ME , Saliu R

Serum biochemical changes in Japanese quail (coturnix coturnix japonica) experimentally infected with salmonella enterica serovar gallinarum

May 2015

Aim: To determine the serum biochemical changes in Japanese quail (Coturnix coturnix japonica) experimentally infected with Salmonella enterica serovar Gallinarum Methods: A total of 160 (108 males and 52 females) Japanese quails (Coturnix coturnix japonica) were used for the experiment. Four weeks old quails were randomly selected and assigned into four groups (A, B,C and D) of forty quails each. Groups A, B and C...

Author(s): BardeIJ, Bale JOO, Oladele SB, Fatihu MY, Kumbish PR, Rimfa AG, Ahmed JS,Okewole PA

Selected markers of oxidant challenge in essential hypertensive smokers

May 2015

Aim: The study was set to assess the relationship between antioxidant status, smoking and hypertension, the argument being whether there would be a significant difference in antioxidant status and perhaps, a significant difference in blood pressure. Methods: A total of105 samples were collected. 36 samples were collected from type I hypertensive smokers; 47 from hypertensive non smokers, the remaining 22 were...

Author(s): Odewusi OO, Tope-ajayi AA, Adeshina AA.

Effect of ethanolic extract of ocimum gratissimum on sodium nitrite-induced cerebral cortex toxicity in adult wistar rats

May 2015

Aim: The effect of ethanolic leaf extract of Ocimum gratissimum on sodium nitrite-induced cerebral oxidative stress in adult Wistar rats was evaluated. Methods: Twenty four adult Wistar rats of weight between 150g to 250g were divided into six groups of four rats each. Group I was the Control and received 2ml/kg bwt of distilled water, Group II received 54mg/kg bwt of NaNO2, Group III received 750mg/kg bwt of the...

Author(s): Ibegbu AO, Eze SM, Livinus PP, Adamu SA, Hamman WO, Umana U, Musa SA

Prevalence of mycobacterium tuberculosis in Human immunodeficiency virus patients at art centre Agbor, Nigeria

May 2015

Aim: The prevalence of pulmonary tuberculosis (PTB) in Human immunodeficiency virus (HIV)/Acquired immunodeficiency syndrome (AIDS) patients is a dual epidemic problem of major concern worldwide especially in Africa where there is upsurge of the disease. This study is set to determine the prevalence of PTB among HIV patients. Methods: A total of 489 patients were recruited into the study, 173(35.4%) were males,...

Author(s): Adu ME  , Ezie E  , Isibor CN , Jemikalajah DJ 

Effect of highly active antiretroviral therapy (haart) on cd4+ cell count and liver enzymes in HIV infection at Lokoja, Nigeria

April 2015

Aim: To assess the effect of highly active antiretroviral therapy (HAART) on CD4 + cell count and liver enzymes in HIV-infected patients six month  post-therapy based on age and sex distribution. Methods: A cohort of 200 (66 males, 134 females) consenting HAAR  naïve patients, aged between 16 and 65 years with confirmed cases of HIV infection (by Western blot method) at Lokoja, Nigeria having a...

Author(s): Itodo GE , Enitan SS , Samanu VO , Ehiaghe FA , Akele YR , Olanyanju OA

A study on the stage of presentation of acute kidney injuries to clinics in Western Nigeria

April 2015

Aim: The research was primarily set to assess the stages at which acute kidney injuries (AKI) are presented for clinical appraisal. Methods: The research was carried out in southwest Nigeria. A total of 151 participants were included, 101 were AKI patients. The remaining 50 were apparently healthy individuals who had no history of AKI, who served as control. Estimation of plasma creatinine was carried out on the...

Author(s): Odewusi OO, Oyedeji SO 

Effect of highly active antiretroviral therapy (haart) on cd4+ cell count and liver enzymes in HIV infection at Lokoja, Nigeria

March 2015

Aim: To assess the effect of highly active antiretroviral therapy (HAART) on CD4 + cell count and liver enzymes in HIV-infected patients six months post-therapy based on age and sex distribution. Methods: A cohort of 200 (66 males, 134 females) consenting HAART naïve patients, aged between 16 and 65 years with confirmed cases of HIV infection (by Western blot method) at Lokoja, Nigeria having a baseline CD4 +...

Author(s): Itodo GE , Enitan SS , Samanu VO , Ehiaghe FA , Akele YR , Olanyanju OA ,

A review of global guinea worm eradication: emphasis on the Nigerian situation

February 2015

Aim: The horror and misery of guinea worm with its attendant negative effects on human health and agricultural production is well documented. This study highlights the efforts made so far globally and nationally to eradicate the scourge. Methods: An update on global guinea worm eradication with emphasis on the Nigerian situation was examined. Documented reports by various experts on guinea worm were examined. There...

Author(s): Ezeugwu SMC, Afocha EE, Ajayi MB 

Sorghum bicolor extract: a suitable counter stain in hibiscus extract nuclear staining of liver and kidney

February 2015

Aim: To investigate the suitability of alcoholic extract of Sorghum bicolor stalk as a counter stain for Hibiscus extract stained nuclei. Method: Formalin fixed kidney and liver biopsies were processed by the paraffin wax technique, sectioned, stained with Hibiscus extract solution and counterstained with 10% alcoholic extract of Sorghum bicolor stalk. Parallel sections were stained with H&E as control. Results:...

Author(s): Benard SA , Muhammed AO , Fowotade AA , Afolabi OO, Olutunde OA. 

Plasma urea and electrolytes profile in different stages of hiv infection in Ekpoma, Nigeria

January 2015

Aim: Human Immune Deficiency Virus (HIV) is one of most dreaded diseases today. This study aims at the determination of electrolyte profile (Na+ , K+ , Cland HCO3 - ), urea levels and CD4 count of patients diagnosed with HIV infection in Ekpoma, Nigeria. Methods: Sixty patients and 40 apparently healthy individuals as controls were examined from January 2013- September 2014. Electrolytes were assayed using flame...

Author(s): Eshiet EM, Jemikalajah DJ, Okogun GRA

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