African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2173

AJPP Articles

Chemical characterization of seeds of Amazon fruits as nutritional contribution with functional medicinal potential

May 2020

The fruit seeds of the Northern Amazon Region were evaluated bromatologically and nutritionally in terms of the level of macro- and micro-elements and fatty acids present in them. Bromatologically, the seeds of camu-camu (369.08 kcal 100 g-1) and biribá (364.78 kcal 100 g-1) have the highest energy value. In terms of the macroelements, the highest concentration was potassium (554.23 mg 100 g-1) seen in graviola,...

Author(s): Ismael Montero Fernández, Selvin Antonio Saravia Maldonado, Vany Perpetua Ferraz, Ricardo Santos Alemán, Jhunior Abrahan Marcia Fuentes and Antonio Alves de Melo Filho

Comparative effect on liver fibrosis of bicyclol and silymarin

May 2020

Bicyclol and silymarin are widely used in the treatment of various liver diseases; however, there is no report on comparative effect of them on liver fibrosis. To compare their liver protective effect, liver fibrosis rats induced by bile duct ligation (BDL) were orally treated with 100 mg/kg bicyclol and 100 mg/kg silymarin respectively for 4 weeks. Liver index, liver function activities, inflammatory biomarkers,...

Author(s): Liping Wang, Li Zhang, Kelan Gan, Xiaoping Hua, Ying Xiao, Yikun Shi and Zhenghuai Tan  

Designing polyethylene oxide and hydroxypropyl methylcellulose matrix tablets with comparable dissolution properties

May 2020

PolyoxTM coagulant (molecular weight 5 × 106 Da) and hydroxypropyl methylcellulose (HPMC) K4M (USP substitution type 2208) were used to identify the composition variables that ensure the production of polyethylene oxide (PEO) matrix tablets with the same dissolution characteristics as those containing HPMC. Based on the dissolution results obtained using Apparatus 3, a 53% concentration of PEO polymer in the...

Author(s): Petra Draksler, and Biljana Janković,  

The potential cardioprotective effects of Febuxostat versus Cilostazol on Isoproterenol induced cardiac dysfunction in rats

May 2020

Myocardial infarction causes an acute condition of necrosis of the myocardium resulting in increased production of free radicals and decreased levels of antioxidants. It was proposed that Febuxostat reduced myocardial oxidative stress and suppressed apoptosis. Cilostazol used to treat claudication has a growing evidence, suggesting that Cilostazol could be cardioprotective. This work aims to highlight the potential...

Author(s): Ayman Helal, Sawsan Sadik and Eman Hussein  

Chemical composition of essential oil of Melissa officinalis L. and antioxidant activity from Boa Vista-RR, Brazil

April 2020

In this work, the chemical composition of the essential oil of lemon balm (Melissa officinalis L.) was determined by CG-FID.In the essential oil of M. officinalis,there area total of 22 chemical constituents, among them are geranial (34.6%), neral (26.0%), γ-caryophyllene (7.5%), caryophyllene oxide (5.3%), -pinene (5.3%) and sabinene (3.6%); it also has antioxidant capacity and total phenolic compounds in vitro....

Author(s): Ismael Montero Fernández,  Pedro Rômulo Estevam Ribeiro,  Selvin Antonio Saravia Maldonado, Vany Perpetua Ferraz, Ricardo Santos Alemán, Jhunior Abrahan Marcia Fuentes and Luis Antonio Beltrán Alemán  

Biological activities of Bonsupari (Caryota urens L.) fruits

April 2020

In Asian subcontinent, Caryota urens L. plant is well known. Its leaf has antioxidant and antimicrobial properties. The work aims to analyze the composition of the plant’s fruit extract and its aqueous and organic soluble fractions for its cytotoxic, thrombolytic, antioxidant, membrane stabilizing and antimicrobial properties. 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity assay,...

Author(s): Tasnuva Sharmin, Md Shahidur Rahman, Sirajis Salekin and Kamrun Nahar  

A preliminary study to assess knowledge, preferences, and perception of adult population of Karachi about scored and colored oral solid dosage form

April 2020

Beyond the pharmacological activity, the differences have been observed in the preferences of solid dosage form on the basis of color and swallowing difficulty in the studies conducted by a different researcher. The aim of the study is to insight the perception of the general population of Karachi about the color, scoring and splitting of tablets. A convenience sampling technique was used to collect data. Knowledge,...

Author(s): Aatka Ali, Madiha Mushtaque, Sarah Jameel Khan, Sidra Kanwal Ali, Tahmina Maqbool, and Rida Masood  

Antihyperglycaemic and antioxidant activities of Sansevierialiberica as justification for its antidiabetic claims

April 2020

Diabetes has become a global emergency because of its high prevalence, morbidity and mortality while the available hypoglycaemic drugs possess various adverse effects and are expensive. This has necessitated a continuous search for cheaper antidiabetic agents of plant origin with fewer or no side effects. The study evaluated the antihyperglycaemic activities of the methanol extract of Sansevieria liberica Gerome and...

Author(s): Aanuolu Jesudunni Ajileye, Marcus Durojaye Ayoola, Anthony Adebolu Elujoba and Kemi Feyisayo Akinwunmi  

Antiproliferative and cytotoxic activity of Hematite (α-Fe2O3) nanoparticles from Butea monosperma on MCF-7 Cells

February 2020

Silver nanoparticles (Hematite (α-Fe2O3) have been used as an antimicrobial and as disinfectant. Nevertheless, there is limited data about its antitumor potential. This study focused on investigating the cytotoxic effects of Hematite (α-Fe2O3) from Butea monosperma flower extract on MCF-7 breast cancer cells and its mechanism of action.  Green method was created for the synthesis of Hematite...

Author(s): B. Behera, S. Pradhan, A. Samantaray and D. Pradhan  

Formulation and enhancement of dissolution rate of poorly aqueous soluble drug Aceclofenac by solid dispersion method: In vitro study

January 2020

Solid dispersion technique was successfully used to enhance the dissolution of poorly aqueous soluble drugs aceclofenac. Four carriers Hydroxyl propyl methylcellulose (HPMC), polyvinyl alcohol (PVA), Mannitol and Dextrose in two ratios (1:2, 1:3 w/w) were used to prepare solid dispersion. Eight different formulations were designed by the varying carrier and the drug: Carrier ratio and solvent wetting method was used for...

Author(s): Sumana Neupane and Chhitij Thapa  

Histopathological and genetic study on the protective role of β-Carotene on testicular tissue of adult male albino rats treated with titanium dioxide nanoparticles

January 2020

Titanium dioxide nanoparticles are one of the famous widely produced nanoparticles in the world that are widely used in paints, cosmetics, plastics, pharmaceutical preparations, water treatment and purification and filtration of air. Beta carotene is provitamin A carotenoid with antioxidant and anti-apoptotic activities. The aim of this study is to evaluate the histopathological changes that occur in the testicular...

Author(s): Amira Hamed Mohamed Soliman, Ibrahim Amin Ibrahim, Mohammed Ahmed Shehata and Heba Osama Mohammed  

Evaluation of pharmaceuticals in household waste in Senador Canedo, State of Goiás, Brazil

January 2020

The disposal of pharmaceuticals has become a problem for society and public health and causes risks to the environment. Therefore, the objective of this work was to evaluate the number of pharmaceuticals and the classes of the most discarded pharmaceuticals in household waste in Senador Canedo, Goiás, Brazil. The study was conducted in Senador Canedo, GO, Brazil (16° 42' 28'' S, 49° 5'...

Author(s): Pollyana Dalenogari Costa and Lúcia Maria Moraes  

Anti-inflammatory and analgesic activities of extracts from Balanites aegyptiaca L. Delile (Balanitaceae) root bark: Plant used against liver diseases in Bukina Faso

December 2019

Balanites aegyptiaca (L.) Del has been used in various traditional medicines against inflammation and pain. The aim of this study was to evaluate the enzymatic, anti-oedmeatous and analgesic activities of ethanolic and aqueous extracts of Balanites aegyptiaca (L.) Del root bark in mice. The extracts were tested in vitro for their ability to inhibit the enzymes cyclooxygenase (COX)-1 and COX-2, 15-lipoxygenase (LOX) and...

Author(s): Kadiatou Tata Traoré, Noufou Ouédraogo, Lazare Belemnaba, Gilchrist Abdoul Laurent Boly, Leïla Marie Esther W. Kabré, Constantin B. Atchadé, Mohamed B. Belemlilga, Sylvain Ilboudo, Marius Lompo, Sylvin Ouédraogo, André Tibiri and Innocent Pierre Guissou,  

Non-adherence to statins therapy and its impact on cardiac morbidity and mortality: A metanalysis

December 2019

Dyslipidemia is a major risk factor for cardiovascular disease, the leading cause of death worldwide. Statins have been shown to significantly reduce morbidity and mortality in patients with coronary artery disease and in patients with hyperlipidemia. However, there is a significant gap between expected and actual benefits; this may be attributed to poor adherence to statin therapy. Literature search was conducted by...

Author(s): Zelalem Gebretsadik Anebo and Nurettin Abacioglu  

Hepatoprotective and antioxidant activities of Pterocarpus santalinoides methanol leaf extract

December 2019

This study evaluated the hepatoprotective and antioxidant activities (AA) of Pterocarpus santalinoides methanol leaf extract (PSMLE) on carbon tetrachloride (CCl4)-induced hepatotoxicity in albino rats. Thirty male albino rats randomly assigned into 6 groups (A – F) of 5 rats each were used for the in vivo study. Hepatotoxicity was induced in groups A – E using CCl4. Group A served as negative control....

Author(s): Thelma Ebele Ihedioha, Isaac Uzoma Asuzu, Aruh Ottah Anaga and John Ikechukwu Ihedioha  

Therapeutic effectiveness assessment of antiviral drugs used in chronic hepatitis treatment in three Ivorian university hospitals

December 2019

This work aims to evaluate the effectiveness of drugs used for the management of chronic viral hepatitis in the three major university hospitals in Abidjan. This is a retrospective cross-sectional descriptive study of 203 patients investigated for treatment protocols, patient parameters before and after treatment. It emerged that treatment with pegylated Interferon alpha 2a resulted in a significant decrease in viremia...

Author(s): Geneviève Amenan N’guessan-Irié, Emile Allah-Kouadio, Christiane Ella Kogbahonon Allouka, Steven Driga Tchekpa Paul Kohi, Bienvenu Oko Gnépéhi and  Gisèle N’doua Siransy-Kouakou,  

Phytochemical analysis and in vitro antibacterial evaluation of leaf and bark extracts of Alstonia boonei

November 2019

The antibacterial effect of the leaf, bark and leaf and bark combined of Alstonia boonei on bacterial pathogens, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumonia, Proteus mirabilis, Klebsiella pneumonia, Shigella dysenteriae and Salmonella typhimurium was determined using agar diffusion technique to investigate their efficacy as anti-bacterial agent. The phytochemical components...

Author(s): D. J. Ajose, O. F. Onifade and I. I. Wemambu  

Acquaintance of Botox: A cross-sectional survey among female students in Karachi, Pakistan

November 2019

The cosmetic treatment strategies have been considerably popular over the last few decades among the population with respect to age, gender, and ethnicity. These procedures are easily accessible safer, minimally invasive, and more precise. Botox therapy is one of the most common non-surgical cosmetic treatment. Thus, the current study was accomplished to assess the knowledge of female students towards Botox therapy for...

Author(s): Shahlla Imam, Wajiha Iffat, Sadia Shakeel, Ambreen Qamar Najaf Usman, Nuzhat Sultana and Faisal Muhammad Khan  

Evaluation of the immunomodulatory properties and microbial bioburden of three commercial herbal mixtures sold in Awka, Anambra State Nigeria

November 2019

The consumption of herbal medicine and herbal medicinal products has been on the rise lately. This has led to an increase in research on herbal medicine and its different formulations to gain more knowledge in their constituents, therapeutic effects, its mechanism, and their undesired or toxic effects. The purpose of this study was to evaluate toxicity profile, phytochemical constituents, microbial quality and...

Author(s): Christopher E. Enemor, Malachy Ugwu and Chukwuemeka Nworu  

Cytotoxic effects on MCF-7 breast cancer cell lines, phenol and flavonoid contents, high performance liquid chromatography (HPLC) analysis and antioxidant activity of Maerua pseudopetalosa (Gilg and Bened) De Wolf fractions

November 2019

Maerua pseudopetalosa (Gilg and Bened.) De Wolf tubers which are used traditionally as antitumor agent in Sudan were subjected to separation by column chromatography technique. Eight fractions were obtained for the ethyl acetate extract and twelve for the ethanolic extract. The ethanolic fractions F8, F9, F11 and F12, with high bioactivity were subjected to further investigations....

Author(s): Manal A Ibrahim and Manal M Ramadan

Tremendous health benefits and clinical aspects of Smilax china

October 2019

A lot of species of Smilax known as Baqia in China are used in folk medicine for various purposes. Smilax china L., is a small vine that grows in the southern parts of China, known as Jin Gang Ten, which has a long history of indigenous use in China. S. china consists of fat, saponins, glucosides, gum, starch, flavonoids, tannins, and alkaloids. S. china has been used in traditional Chinese medicine because it has...

Author(s): Mohamad Hesam Shahrajabian, Wenli Sun, and Qi Cheng,  

Effect of the anticancer drug tamoxifen on chronic toxoplasmosis in experimentally infected rats

October 2019

Toxoplasma gondii is an opportunistic parasite that can cause severe disorders in infants and pregnant women and can also be lethal in immunologically compromised individuals. During unfit host immune conditions, and as a consequence to latent stage opportunity, the protozoan stimulates serious infection, and signifies higher morbidity and mortality including humans with Acquired Immuno-Deficiency Syndrome (AIDS) or...

Author(s): Rabab Fawzy Selem, Gehan Abdel Rahman Rashed, Ashraf Mohamed Abdel Khalek Barakat, Hasan Mohamed Ali Elfadaly, Boshra EL-sayed Talha Hussien, Hemat Salah Mohamed, Marwa Mohamed Nageeb and Ahlam Farag Moharm  

Prevalence and indication of gabapentin and pregabalin prescriptions among adults in King Abdulaziz Hospital in Makkah AL-Mukarramah, KSA

October 2019

Gabapentin and pregabalin prescribing have increased substantially over the recent years. Some evidence supports that gabapentin and pregabalin use in non-neuropathic pain disorders indicates they are less effective than several other licensed non-opioid analgesics. On the other hand, other studies have shown that those drugs are to be beneficial in the treatment of non-neuropathic pain and improves the analgesic...

Author(s): Salma Alotaibi, Arwa Alotaibi, Ashwaq Almqati, Khloud Alotaibi, Atyaf Bogar and Yosra Alhindi  

Pharmaceutical polymorphisms and its influence on the dissolution profile of two pioglitazone brands

October 2019

1Pharmacognosy Laboratory,Faculty of Chemical Sciences, Juarez Durango State University, Mexico. 2Technology and health laboratory, Academic Coordination Altiplano Region, Autonomy University of San Luis, Potosi, Mexico.  

Author(s): Eduardo Lozano Guzmán, Saúl Alejandro Aguirre Rentería, María Guadalupe Nieto Pescador, Maribel Cervantes Flores, Ángel Antonio Vértiz Hernández and  Francisco Javier Moreno Cruz  

Evaluation of hypoglycemic activity and safety of Carica papaya seed extracts in alloxan-induced diabetic mice

October 2019

Carica papaya is used for the treatment of many diseases such as stomach upsets, diarrhoea, bilharzia, diabetes. The study aims to evaluate the safety and hypoglycemic potential effect of Carica papaya seeds on alloxan induced diabetic mice. DCM extracts were examined for the presence of terpenoids, flavonoids, steroids, phenols, tannins and alkaloids. Toxicity profile was established at 5, 50, 200, 300 and 2000 mg/kg...

Author(s): Samuel P. Kagame, , Nicholas Mwikwabe, Peter Mwitari and Moses Gichua  

Canvassing of biological attributes by In vitro screening of Canarium bengalense

September 2019

Various Hoang family remedies known as Dai-Thien-Nuong, utilize Canarium bengalense Roxb. (Family: Burseraceae) as a major component for the treatment of tumor and liver damage. This study was performed using the crude methanol extract of C. bengalense Roxb. bark and its petroleum ether, carbon tetrachloride, dichloromethane and aqueous soluble fractions for antioxidant, cytotoxic, thrombolytic, membrane stabilizing and...

Author(s):  Sanjina Saif Karim, Quazi Sufia Islam and Tasnuva Sharmin  

Tolerance and observance of methotrexate in the treatment of rheumatoid arthritis at the university Hospital Bogodogo, Burkina Faso

September 2019

This study is aimed at assessing tolerance and observance of the patients with RA (rheumatoid arthritis) treated by methotrexate at University Hospital Bogodogo, in Burkina Faso. A cross-sectional study was conducted from July to September 2015 in outpatients with rheumatoid arthritis monitored in rheumatology service. Data were obtained from interview, by reviewing medical cards of the patients and consultation report...

Author(s): R. Frank E. Zongo, Joelle S. Zabsonré, Aminata Nacoulma, Souleymane Fofana, Moise W. Sawadogo, Estelle Noella Youl, Moussa Ouédraogo, and Dieu-Donné Ouédraogo,  

Use of medicinal plants for the treatment of gastric ulcer in some parts of Southwestern Nigeria

September 2019

Ulcer is erosion in the lining of the stomach or duodenum. It is caused by disruption of the gastric mucosal defense and repair systems. There has been much interest in natural medicines derived from traditional knowledge of pharmacological properties of plants recently. The major aim of this study was to conduct an ethnobotanical survey of plants used in the treatment of Gastric ulcers in some local government areas of...

Author(s): Idayat A. Akinwumi and Mubo A. Sonibare  

Effects of methanolic tuber extract of Cyperus esculentus Linn (tiger nuts) on sub-acute liver damage in albino rats

September 2019

This study evaluated the effects of Cyperus esculentus methanolic tuber extract (CEME) on carbon tetrachloride (CCl4)-induced sub-acute liver damage in albino rats. Dried tubers of C. esculentus were pulverized and extracted by cold maceration, using 80% methanol. Thirty albino rats, randomly assigned to 6 groups (A–F) of 5 each were used for the study. Sub-acute liver damage was induced in Groups A-E rats using...

Author(s): Thelma Ebele Ihedioha, Rita Ifeoma Odo, Uwakwe Simon Onoja, Chinweike Emmanuel Chiwetalu and John Ikechukwu Ihedioha  

24 h pre-incubation of EA.hy926 cells with angiotensin II regulates insulin-dependent activation of eNOS in a concentration-dependent manner

September 2019

The rennin-angiotensin II system (RAS) and the insulin-PI3kinase signalling pathways cross-interact with important physiological and pathophysiological consequences for cells and the whole organism. Here, the effect of 24 h pre-incubation of EA.hy926 with two different concentrations of angiotensin II, on insulin-mediated activation of the PI3kinase-AKT-eNOS signalling was investigated. Quiescent EA.hy926 cells were...

Author(s): Ejebe D. E.  

Antioxidant and cicatrizing activity of the species Abarema cochliacarpos (Gomes) Barneby & J. W. Grimes

August 2019

In equine clinics, skin injuries are some of the most frequently treated injuries, this research evaluated the healing potential and antioxidant activity of Abarema cochliacarpos in order to develop a pharmaceutical formulation for treating skin lesions in horses. Firstly, the antioxidant activity of several fractions was evaluated using the 2,2-diphenyl-1-picrylhydrazyl radical method and the thiobarbituric acid test....

Author(s): Saskya Araújo Fonseca, J. R. M. Costa, N. R. S. Gomes, Amanda Lima Cunha, João Gomes da Costa, Thiago José Matos-Rocha, Karwhory Wallas Lins da Silva, Paulo Henrique Barcellos França, Francisco Feliciano da Silva Júnior, Antônio Euzébio Goulart Sant’Ana and Aldenir Feitosa dos Santos,  

Acute toxicity evaluation of ethanolic extract of the air parts of Sida rhombifolia L., in wistar rats

August 2019

Sida rhombifolia L., popularly known in Brazil as "SIDA" or "mata-pasto", is considered a weed; a plant of the American continent and widely distributed in North Africa, belongs to the Malvaceae family. In Brazil, S. rhombifolia L. is scattered throughout the national territory, infesting agricultural crops. Certain species of the genus Sida, including S. rhombifolia, are widely used in Indian,...

Author(s): Luciana da Silva Nunes Ramalho, Gabriela Tafaela Dias, Edla Julinda Ribeiro Coutinho Espinola Guedes, Micaelly da Silva Oliveira, Andressa Brito Lira, Kardilândia Mendes de Oliveira, Otemberg Souza Chaves, Josué do Amaral Ramalho, Alexandre Rolim da Paz , Janine Agra Padilha, Hilzeth de Luna Freire Pessoa, Maria de Fátima Vanderlei de Souza, Caliandra Maria Bezerra Luna Lima and Margareth de Fátima Formiga Melo Diniz  

Efficacy of transurethral resection of prostate in patients of benign prostatic hyperplasia with lower urinary tract symptoms

August 2019

Transurethral resection of the prostate (TURP) has been the prime procedure for decenniums to treat benign prostatic hyperplasia (BPH), but is mainly predicated on historic data that lacks utilization of validated measures. It is noteworthy that TURP done nowadays significantly differs from that performed 30 years ago. Men who had undergone TURP between 2013 and 2018 were reviewed. 50 patients presented in the...

Author(s): Shahjahan Ur Rehman, Salman Iftikhar, Kamran Zaidi, Rao Salman Aziz, Yasir Arfat and Muhammad Sohail  

Antibacterial activities of three medicinal plant extracts and their synergistic effect on Staphylococcus aureus isolated from burn wounds

August 2019

This study was undertaken to investigate the antibacterial activities of three medicinal plant extracts and their synergistic effect on Staphylococcus aureus isolated from burn wounds. A total of 50 swab samples of burn wounds were collected from burn wound patients attending Federal Teaching Hospital Abakaliki and screened for S. aureus using standard microbiological techniques. Three plant materials (Cucurbita pepo...

Author(s): Nwuna E. N., Nwuzo A. C., Afiukwa F. N., Oke Boniface,  Udu-iIbiam E. O., Moses I. B., Ilang D. C. and Aondaackaa A. D.  

Sciatica: Medical treatment or Physiotherapy?

August 2019

Low back pain is usually self-limiting. It has a sizeable impact on patients, and is associated with high healthcare and societal costs as much as $16 billion each year. Patients are commonly treated in primary care but a small proportion is referred to secondary care and may eventually have surgery. There are numerous treatment approaches for sciatica. Many people receive only medical treatment and are unaware of the...

Author(s): Mehreen Saleem, Salman Iftikhar, Ramsha Javaid,Tayyaba Rana, Maheen Rana and Yasir Arfat  

Phytochemical analysis and investigation of sedative-hypnotic activity of methanolic stem bark extract of Ficus abutilifolia in mice

July 2019

Most of the sedative drugs cause dose-dependent depression of the central nervous system (CNS) leading to hypnosis and possibly anaesthesia, however, these agents are associated with some side effects ranging from digestive, respiratory, immune system dysfunctions, cognitive function deterioration, tolerance, and physical dependence, hence investigations of newer and safer agents is therefore imperative. The current...

Author(s): Mikail, H. G., Akumka, D. D., Adamu, M., Zaifada, A. U.  

Aflatoxin M1 in cheese samples from the Amazon Region

July 2019

Aflatoxin M1 (AFM1) is a mycotoxin that can be found in cheeses and makes the monitoring of this food of public health interesting. In Brazil, the Amazon region has a cattle herd with dairy production of cheese, and an evaluation of the food and its risk to the population is required. The objective of this study was to evaluate the levels of AFM1, moisture content (mc) and water activity (aw) in different cheeses types,...

Author(s): Janaína Santos Barroncas, Ariane Mendonça Kluczkovski, Emerson Silva Lima, Pedro Henrique Campelo Felix, Cibele de Souza Viana, Lawrence Ramos Xavier, Samir de Carvalho Buzaglo Pinto and Augusto Kluczkovski Kunior  

Evaluation of anthelmintic activity of ethanolic extracts of Carica papaya leaves using Paramphistomum cervi and Haemonchus contortus

July 2019

The aim of this present study is to evaluate the anthelmintic activity of leaves extracts of Carica papaya using Paramphistomum cervi and Haemonchus contortus as the test worms. A range of concentrations (100, 50 and 25%) of ethanolic extracts of C. papaya were tested to assay the procedure. This is mainly applied for the determination of time of death (D) and time of paralysis (P) of the tested worms. After the...

Author(s): Md. Rabiul Islam, Syeda Fatema Tuz Zahra, S. M. Ibrahim Sumon, Shahnaj Parvin, Kamrul Hasan, Moudud Ahmed, Md. Abu Talha Siddique and Tazmel Haque    

Rational and experiential decision-making preferences of pharmacy students in Karachi, Pakistan

July 2019

This study was conducted to examine the rational (systematic and rule-based) and experiential (fast and intuitive) thinking preferences of pharmacy students. This may assist in formulating learning and teaching tactics for decision-making leading to safe and optimized patient care services. Here, a validated psychometric tool, that is, the Rational Experiential Inventory (REI-40) survey was used. It was distributed to...

Author(s): Wajiha Iffat, Sadia Shakeel, Atta Abbas Naqvi, Shehlla Imam, Tariq Ali, Shagufta Nesar, Riffat Yasmin, Faaiza Qazi Muhammad Faisal Khan and Madeeha Khan  

Sex differences in the neuroprotective effect of insulin against chemically-induced convulsions in mice

June 2019

Insulin, an important regulator of peripheral metabolism, has been reported to interact with many neurotransmitter systems including those associated with convulsion. The effect of insulin against pentylenetetrazole and strychnine-induced convulsions in mice, as well as possible sex differences, were evaluated in this study. Mice of both sexes weighing between 20 and 25 g were administered insulin intraperitoneally at...

Author(s): Susanna Adeola Adebayo, Oluwole Isaac Adeyemi, Adegbenga Rotimi Owolabi and Moses Atanda Akanmu

Effect of amodiaquine on the pharmacokinetics of gliclazide in diabetic subjects

June 2019

The study aims at investigating the effect of amodiaquine on the pharmacokinetic profile of gliclazide. It is a one-way single dose cross-over study in two phases. Six freshly diagnosed diabetic volunteers were used. The subjects acted as their own control, and each phase was preceded by an overnight fast. Phase 1 of the study involved the administration of a single oral dose of 80 mg of gliclazide after an overnight...

Author(s): Sambo Godwin Ishaku, Mojirade Taibat Bakare-Odunola, Aminu Musa, Ibrahim Adamu Yakasai, Magaji Garba and Bulus Adzu  

Nanotechnology: A non-invasive diagnosis and therapeutic tool for brain disorders

June 2019

Presently, nanotechnology appears as a powerful and innovative tool in the medical field. It has various advantages over the conventional drug therapy such as therapeutic specificity, has less side effects, reduces dose of drug, has more precise treatment and can access the inaccessible areas of the body like brain, tumor cells, etc. The human brain is the most complicated part of the body which is highly protected with...

Author(s): Amit Alexander, Sabahuddin Siddique, Mukta Agrawal, Ajazuddin, Ahmed M. Shehata, Mahmoud A. Shaker,  Syed Ata Ur Rahman, Mohi Iqbal M Abdul and Mohamed A. Shaker,  

Myorelaxant effect of aqueous root bark extract of Carissa edulis (Forssk.) Vahl. is mediated through activation of nitric oxide synthase

June 2019

Many patients in Africa often utilize herbal medicine for the management of hyperactive gut disorders such as diarrhea and abdominal colic. There is therefore a need to scientifically evaluate efficacy of this herbal remedies. This study investigated the myorelaxant effect of Carissa edulis (Forssk.) Vahl and its possible mechanism of action using isolated rabbit jejunum preparations. Pieces of jejunum were isolated...

Author(s): Oluoch Linus Lincone, Mbugua Paul Mungai, Muriithi Anne Wangechi, Siringo Cyril George, Wafula David Kayaja and Boniface Mwangi Chege  

Flavonoids in neuropathic pain management: A new player on an old target

May 2019

Neuropathic pain is the consequence of abnormal processing in the peripheral or central nervous system (CNS) elicited by neuronal injury. Due to its heterogeneous nature and important unwanted adverse effects of the commonly prescribed psychoactive drugs like benzodiazepines (BDZ), the treatment of neuropathic pain has remained a challenge for the scientific community. Flavonoids initially isolated from plants and used...

Author(s): Shehla Akbar  

Effects of anti-hyperglicemic of yacon leaf (Smallanthus sonchifolius) ethanolic extracts using zebrafish as a model

May 2019

This study aims to investigate the anti-hyperglicemic effects of yacon leaf (Smallanthus sonchifolius) using zebrafish. In this study, zebrafish is used as a model, with alloxan compounds to induce hyperglicemic. The induction stage consists of 3 phases: in the first the zebra was induced at 0.3% for 30 min, in the second stage, it was transferred to a 3% D-glucose solution for 30 min, and in the last, immersion was...

Author(s): Zuhelmi Aziz, Nanda Tamara, Rahmi Three Wahyuni, Inawati and Syamsudin Abdillah  

Effect of Parkia biglobosa extract on open skin wound healing in dexamethasone- induced hyperglycaemia and histological assessment in rats

May 2019

Glucocorticoid-induced diabetes mellitus (GIDM) is an abnormal increase in blood glucose associated with the use of glucocorticoids in a patient with or without a prior history of diabetes mellitus. This is a common and potentially harmful problem in clinical practice, affecting almost all medical specialties, but is often diffi¬cult to detect in clinical settings.  The objective of this study was to determine...

Author(s): Modupe Iretiola Builders, Oyepata Simeon Joseph and Akpobome Raymond Vhriterhire  

Neferine and isoliensinine from Nelumbo nucifera induced reactive oxygen species (ROS)-mediated apoptosis in colorectal cancer HCT-15 cells

May 2019

Several scientific reports documented the potent anti-cancer effect of various natural products  such as curcumin, epigallocatechin gallate (EGCG), resveretrol via the rise in reactive oxygen species (ROS) and dysfunction of anti-apoptotic gene expressions. The present study evaluated the anticancer potential of lotus derived alkaloids, neferine and isoliensinine on colorectal cancer HCT-15 (CRCs) cells....

Author(s): Prasath Manogaran, Narasimha Murthy Beeraka, Chih-Yang Huang, Viswanadha Vijaya Padma,  

Endopleura uchi (Huber) Cuatrec, a medicinal plant with potential anti-inflammatory activity: A review of its phytochemistry and biological activities

April 2019

Endopleura uchi (Huber) Cuatrec. is a tree found in the Brazilian Amazon, whose barks are used in folk medicine as an alternative treatment for inflammatory-related diseases. This review, performed using current available international scientific literature, aimed to survey biological activities reported from E. uchi, and describes its phytochemistry. In folk medicine, the barks are used to treat a range of conditions...

Author(s): Beatriz Martins de Sá Hyacienth, Brenda Sánchez Ortiz , Arlindo César Matias Pereira, Danilo Cabral de Sá Hyacienth, Josué Arturo Velázquez Moyado, Glória Melisa Gonzales Aduanga, Andrés Navarrete and José Carlos Tavares Carvalho,  

Medicines prescribing pattern in northern Ghana: does it comply with WHO recommendations for prescribing indicators?

March 2019

The prescribing of medicines is critical in the treatment of diseases in general practice. Inappropriate prescribing can negatively influence the goals of treatment, which makes the assessment of the patterns of prescriptions essential. The objective of this study was to assess the medicines prescribing pattern in health facilities in the Northern Ghana, a developing economy in Africa, using the prescribing indicators...

Author(s): Baba Sulemana Mohammed and Salifu Alhassan Tiah  

Effect of Maytenus senegalensis roots on OVA-induced airway inflammation in a mouse asthma model

March 2019

The present work is focused on the evaluation of the Maytenus senegalensis roots effect on bronchial hyperleukocytosis and the search of its antioxidant potential both in vitro and in vivo. The roots of M. senegalensis (Celastraceae) are traditionally used for the treatment of cough and asthma. This study evaluates the effect of the hydroalcoholic extract of the roots of M. senegalensis on the bronchial...

Author(s): Pascaline K. Kpoyizoun, Kossi Metowogo, Afiwa Missebukpo, Kwashie Eklu-Gadegbeku, Kodjo A. Aklikokou and Messanvi Gbeassor  

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