February 2019
Endothelium-independent vasorelaxation by dichloromethanolic fraction from Anogeissus leiocarpa (DC) Guill. Et Perr. (Combretaceae) bark of trunk on porcine coronary artery rings: Involvement of [Ca2+]i decreased and phosphodiesterases inhibition
Anogeissus leiocarpa (DC) Guill. et Perr. belongs to the Combretaceae family and was previously named A. leiocarpa (DC) Guill. Et Perr. It has been widely used in Burkina Faso by traditional medicine for the treatment of hypertension. Previous study showed that the dichloromethanolic fraction from the barks of trunk of A. leiocarpa (ALF) has induced an endothelium-independent and endothelium-dependent vasodilation...
February 2019
Anti-fertility activity of aqueous root bark extracts of Asparagus africanus Lam and Annona senegalensis Pers combination on female Sprague Dawley rats
Many rural and poor women have now resorted to use of potential medicinal plants as a means of fertility control. Asparagus africanus Lam and Annona senegalensis Pers are some of the plants used for this purpose. The efficacy and safety of many of such plants, however, have not been verified. Therefore, screening for anti-fertility activity of potential medicinal plants, would thus provide alternative safe and...
February 2019
Good practice guidance to support safe oral medication preparation and administration through feeding tubes
The objective of this work is to elaborate good practice guidance, aimed at preparing and administering drugs through feeding tube. This study was performed at a secondary level hospital in the interior of São Paulo state, Southeast Region of Brazil. For the first phase, a literature review was carried out in the following databases: LILACS, MEDLINE, Web of Science, and MICROMEDEX® Solutions. A manual search...
January 2019
Modern approach of treatment on destroyable pathogenicity of malaria parasite: A review article
Plasmodium is the malaria parasite that completes the life cycle between two different hosts, such as human and Anopheles mosquito. These parasites go through several developmental stages like exo-erythrocytic stage that is absent in Plasmodium falciparum, so relapses do not occur. The drugs which contain three P’s like proguanil, primaquine, and pyrimethamine kill schizonts in the liver. Due to prolonged...
January 2019
Improving blood pressure control in patients with pseudoresistant hypertension – A pilot randomized trial
This study aims to evaluate the effect of an intervention focused on medication adherence to improve blood at three basic health units in Maceió, Brazil. Patients were followed-up for three months. Primary outcomes were pressure control in patients with pseudoresistant hypertension. A randomized controlled clinical trial was conducted mean values of systolic blood pressure (SBP) and diastolic blood pressure...
December 2018
Evaluation of surgical antimicrobial prophylaxis use in Ethiopia: Prospective study
Appropriate use of surgical antimicrobial prophylaxis can prevent approximately 40 to 60% of surgical site infections. Inappropriate use is associated with emergency of antimicrobial resistance, occurrence of side effects and increased health care cost. We aimed to evaluate surgical antimicrobial prophylaxis use of Hawassa...
December 2018
Preclinical 28 days sub-chronic toxicity study of novel formulation of metoprolol tartrate on albino rats using statistical tool
The experimental study mainly focused on evaluation of sub-chronic oral toxicity of sustained formulation of metoprolol succinate. After the formulation development of multiparticulate sustained release capsules, there was an urgent need to analyze their in vivo bioavailability in healthy normal human volunteers. Prior to use in human population, a subchronic oral toxicity study was performed on Swiss Albino rats, of...
November 2018
A novel green approach for the treatment of immature Schistosoma mansoni infection in mice with; Arabic gum (Acacia senegal); an antischistosomal agent
Praziquantel (PZQ), the only common schistosocidal drug in use, is not efficacious for treatment of immature schistosomiasis infection. Arabic gum (AG) is a complex polysaccharide that acts as an anti-oxidant which modulates the inflammatory and/or immunological processes. This study explores for the first time, the antischistosomal properties of AG in mice infected with the immature stage of Schistosoma mansoni (S....
November 2018
Effects of combination therapy of Bridelia ferruginea stem bark and diminazene aceturate on testicular and haematological changes in Trypanosoma brucei infected male rats
The study was done to assess the ameliorative effects of co-administration of methanol extract of Bridelia ferruginea stem bark and diminazene aceturate on trypanosomosis induced testicular and haematological changes in infected male rat. Twenty five male rats were used in the study and assigned into five groups (n=5). Trypanosoma brucei was inoculated into Groups 1, 2, 3 and 4 rats except Group 5. Diminazene aceturate...
November 2018
The protective effects of Vitamin E and glibenclamide on spermatogenic and haematological changes in alloxan-induced diabetic male rats
This study was designed to evaluate the preventive potentials of vitamin E and glibenclamide on spermatogenic and haematological damages in alloxan-induced diabetic male rats. Thirty mature male albino rats randomly assigned into 5 groups (n=6) were used for the study. Diabetes was experimentally induced in groups 1 to 4 while group 5 rats served as the negative control. Rats in groups 1, 2 and 3 were treated with...
October 2018
Physician prescription practice of antibiotics for upper respiratory tract infection at Kilimanjaro Christian Medical Centre Moshi, Tanzania
Upper respiratory tract infection occurs commonly in both children and adults and is a major cause of morbidity worldwide. Inappropriate antibiotic prescription for upper respiratory tract infections is associated with increasing antibiotic resistance, healthcare costs, adverse events, and poor patient outcomes. The objective of this study was to determine physician prescription practices of antibiotics for upper...
October 2018
Simple bioanalytical method development and validation of micronised Domperidone 20 mg tablets using LCMS-MS and its pharmacokinetic application in Healthy Indian Volunteers
The current investigation deals with an validated Liquid chromatography–mass spectrometry/mass spectrometry (LC-MS/MS) analytical method for the quantification of micronised domperidone in plasma of human volunteers. The validation of LC-MS/MS method was accomplished by evaluating the inter-day and intra-day precision and accuracy in a linear concentration range of 3.33-100 ng/ml. The entire study was an attempt...
October 2018
Synthesis, characterization, and anticancer activity against human breast cancer cell-line T47D studies of metal ion Cu(II) complex with 2,4,5-triphenylimidazole ligand
The complex of metal ion Cu(II) with the ligand 2,4,5-trifenilimidazol has been successfully synthesized with mole ratio of metal and ligand 1:2 in N,N-dimethylformamide as a solvent. Complex synthesis results obtained green light crystalline solid. Complex absorbs UV-Vis light at 529 nm. Fourier transform infrared (FTIR) characterization results indicate occurrence of bonding of metals and ligand that is Cu-N in region...
September 2018
Acute skin irritation, acute and sub-acute oral toxicity studies of Rosmarinus officinalis essential oils in mice and rabbit
In Ankober, Northern Ethiopia, Rosmarinus officinalis has been commonly used for flavoring foods as a condiment; moreover, the plant has also been widely used for different medicinal purposes. The current study was undertaken to provide data on acute and subacute toxicity in mice as well as skin irritation of R. officinalis essential oil in rabbit. Acute dermal and oral toxicity tests were conducted using limited dose of...
September 2018
Healing effect of the microemulsion enriched with hydroalcoholic extract of Abarema cochliacarpa (Gomes) Barneby & J. W. Grimes (Fabaceae)
Abarema cochliocarpa is an endemic plant of Brazil and has been traditionally used as a popular medicine to treat various diseases and mostly as a healing agent. The aim of this study was to evaluate the healing effect of the microemulsion containing hydrometanic fraction of the inner bark (HMF) of the plant, as well as its antioxidant, antitumor and cytotoxic potential. The cytotoxicity of HMF was assessed by the...
September 2018
Hypoglycemic profile and ameliorative potential of aqueous garlic extract on sperm characteristics in glibenclamide treated diabetic male rats
This study was carried out to determine the protective effect of aqueous garlic extract on testicular and spermatogenic changes in glibenclamide treated diabetic male rats. Thirty matured male rats were used in this study and were assigned into five groups of six rats each. Diabetes was induced in groups 1, 2, 3, 5 but not induced in group 4. Rats in group 1 were treated with glibenclamide (0.6 mg/kg) daily for 21 days....
September 2018
Analysis of patient information leaflets on Artemisinin-based combination therapy
The objective of this research was to analyze the various patient information leaflets on Artemisinin-based combination therapy (ACTs) sold in Côte-D’Ivoire. A descriptive cross-sectional study was conducted from January 1st to February 20th, 2016, that included all patient information leaflets relating to ACTs registered and marketed in Côte-d’Ivoire. The leaflets were compared to European...
September 2018
Plasmodium falciparum drug resistance gene status in the Horn of Africa: A systematic review
Antimalarial drug resistance monitoring is the key factor in malaria control policy for early detection and subsequent prevention of drug resistance spread. This review was performed to collate all available data of P. falciparum resistant genes in the Horn of Africa as a baseline for future appraisal of the regional malaria control policy. The search of this review was performed in January 2018 using the scientific...
August 2018
Study on increasing the solubility and dissolution rate of sulfamethoxazole by cyclodextrins
The aim of this study was to enhance the solubility and dissolution rate of sulfamethoxazole (SMZ) by preparing the inclusion complexes with β-cyclodextrin (β-CD), hydroxypropyl-β-cyclodextrin (HPβ-CD) and γ-cyclodextrin (γ-CD). The effect of the type of cyclodextrins used for the preparation of complexes, on the in vitro dissolution profiles and solubilities in different mediums (pH 4.5...
August 2018
Extrapyramidal and purgative effects of fluphenazine in turkeys
Fluphenazine is a typical antipsychotic medicine with extrapyramidal effects. It was tested for purgative and neurological effects in turkeys. The results showed that the drug induced purgation at a dose range of 5 to 200 mg/kg body weight causing highest frequency of fecal droppings (7) at 10 mg/kg in 7 min and lowest frequency of dropping (1) at 50 mg/kg. However, the number of fecal droppings was not linearly...
August 2018
Anti-ulcer and hematological properties of virgin coconut oil (VCO) against indomethacin-induced gastric ulcer in experimental rats
Previous studies have reported various health benefits of virgin coconut oil (VCO) such as weight management, treatment of burns, infections, improve phagocytic activity, etc. The present study was conducted to investigate the anti-ulcer and hematological properties of VCO against indomethacin-induced gastric ulcers using rat model. Twenty-four Wistar albino rats were used for the study and were divided into 6 groups of...
August 2018
Cross-cultural adaptation and validation to Brazil of the “Medication Counseling Behavior Guidelines”
This work aimed to translate cross-culturally adapts, and validate the “Medication Counseling Behavior Guidelines” instrument into Brazilian Portuguese. The process of cross-cultural adaptation was carried out using international recommendations. The generated versions were evaluated for the semantic, idiomatic, cultural, and conceptual equivalences and the pre-test was carried out with undergraduate...
August 2018
Cytotoxic potential of ethanol extract of Parquetina nigrescens on MCF-7, C4-2WT, HT 29 and HTC 116 cell lines
The cytotoxic activity of ethanol extract of Parquetina nigrescen was investigated using a (3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, methylene blue and Trypan Blue exclusion assay on four human cancer cell lines, MCF-7, HT 29, HTC 116 and C4-2WT. A mitochondrial enzyme in living cells, succinate-dehydrogenase cleaves the tetrazolium ring and converts the MTT to an insoluble purple...
July 2018
Assessment of antimalarial activity and proteomics analysis of Dioscorea membranacea Pierre.
Multidrug resistance Plasmodium falciparum remains a significant global health problem worldwide. New alternative antimalarial drugs are urgently needed. Dioscorea membranacea Pierre. is a Thai-medicinal plant that has been shown to exhibit a wide range of pharmacological activities. The study aimed to investigate antimalarial activity and possible protein targets of action of the crude ethanolic extract of the rhizome...
July 2018
Ethnomedicinal plants used for the treatment of gastro-intestinal parasitic diseases in human in Yeki district, Southwest Ethiopia
The use of medicinal plants plays a major role in the primary health care of human beings in Ethiopia. A study was carried out to document ethnomedicinal plants used for the treatment of gastrointestinal parasitic diseases of human in Yeki district, southwest Ethiopia. The key informants were selected using purposive sampling method. The information was obtained from 26 informants and 8 herbalists through the use of a...
July 2018
Antioxidant activity of selenium on bisphenol-induced apoptosis and testicular toxicity of rats
Bisphenol A (BPA) is an industrial chemical widely used to make polycarbonate plastics for packaging and epoxy resins. This study sought to examine how selenium (Se) affects BPA toxicity in terms of albino rats’ histological structure, antioxidant enzymes, sexual hormones, and reproductive organs (seminiferous tubule (coiled tubule) diameter, epithelial height and sperm count). Adult male rats were divided into...
July 2018
Hypoglycemic, hypolipidemic and kidney protective potential of combined formulation of Tribulus terrestris and Andrographis paniculata in alloxan induced mice
The study aims to evaluate the effect of Tribulus terrestris and Andrographis paniculata on body weight, blood glucose, lipid profile and renal protective capability in alloxan induced type-1 diabetic mice. Six groups of five male Swiss Albino mice each, at four weeks of age were used in this experiment. Group-X were fed saline water and Group-Y with combined herbal formulation at a high dose (1 g/kg bwt) to asses...
June 2018
Utility of silver nanoparticles for the analysis of diosmin and rutin in Persicaria salicifolia extract, authentic and pharmaceutical dosage forms monitored with their haemostatic activity
The present work was conducted to evaluate a simple effective technique for spectrophotometric determination of two flavonoids namely diosmin (1) and rutin (2) in the isolated fractions obtained from Persicaria salicifolia, authentic and pharmaceutical dosage forms, the method is based on the reduction of Ag+ cations to silver nanoparticles (Ag-NPs) by the effect of these flavonoids in the presence of...
June 2018
Caffeic acid reduces lipid accumulation and reactive oxygen species production in adipocytes
Caffeic acid (CA) is a hydroxycinnamic acid, a group of natural organic phenolic compounds used in folk medicine and in foods for the prevention and treatment of obesity. CA is present in a variety of plants, as it is an intermediate in secondary metabolism. It is found in coffee, wine and olive oil. The aim of this work was to study the influence of caffeic acid (CA) on the reduction of intracellular lipid...
June 2018
Anti-hyperglycaemic and anti-hyperlipidemic effect of aqueous leaf extract of Vernonia amygdalina in Wistar rats
Diabetes mellitus is a complex metabolic disorder characterised by impaired glucose tolerance and hyperglycemia, which is caused by either lack of or resistance to insulin in tissues; this disease causes significant morbidity and mortality largely due to its end–organ complications. Traditional treatment of diabetes mellitus has involved the use of several plant extracts; in this study the efficacy of aqueous leaf...
June 2018
Neurohistological and immunohistochemical effects of prophylactic ethanolic leaf extract of Nauclea latifolia and Artemether/Lumefantrine on the hippocampus of Plasmodium berghei-infected mice
The prophylactic effect of ethanolic leaf extract of Nauclea latifolia, widely used in herbal malarial treatment, was compared against standard drug Coartem® (Artemether/Lumefantrine) in Plasmodium-infected mice was investigated, and thereafter analysed for organosomatic index, parasitemia, histomorphological and immunohistochemical changes in the hippocampus. Twenty male mice about 6 to 8 weeks weighing 20 to 24 g...
May 2018
Dapsone in topical niosomes for treatment of acne vulgaris
Acne vulgaris is a common inflammatory skin disorder. It affects the pilosebaceous units followed by an overgrowth by Propionibacterium acne bacteria. Dapsone is a sulfone antibiotic with an anti-inflammatory effect, which is considered to be accountable for its effectiveness in the treatment of acne vulgaris. The present study aims to prepare and evaluate the effectiveness of dapsone niosomes for topical application...
May 2018
Safety and toxicity of aqueous leaf extracts of Camellia sinensis, Parquetina nigrescens and Telfairia occidentalis in mice
Plant extracts as potential phytotherapeutic products are supposed to be safe. However, adverse and untoward fatal effects have been reported. Study aimed to evaluate the safety and toxicity of aqueous extracts of Camellia sinensis, Parquetina nigrescens and Telfairia occidentalis leaves. The extracts were subjected to brine shrimp lethality bioassay and toxicities by Lorke’s method. Mice were given oral...
May 2018
Febuxostat in patients with hyperuricemia and severe chronic kidney disease
Febuxostat is a non-purine, selective inhibitor of both isoforms of xanthine oxido-reductase (XOR). Its pharmacokinetics is not dependent on renal clearance, and it may be advantageous in patients with chronic kidney disease (CKD). Although febuxostat is effective in patients with mild-to-moderate CKD, its efficacy and safety in patients with severe CKD remain unclear. This retrospective study included patients with an...
May 2018
Gamma oryzanol loaded microspheres with improved bioavailability
Gamma oryzanol is a phytosterol that is extracted from rice bran oil. It is an antioxidant that possesses a curative effect for many diseases. Gamma oryzanol is a water insoluble compound supporting the idea that it has a low bioavailability due to low intestinal absorption. In this study, γ-oryzanol was loaded in biodegradable microspheres. Intestinal absorption of γ-oryzanol from microspheres was compared...
April 2018
In-vitro membrane stabilizing, thrombolytic, antioxidant and antimicrobial activities of Bangladeshi origin Coccinia indica (Cucurbitaceae)
This study was made to investigate in-vitro membrane stabilizing, thrombolytic, antioxidant and antimicrobial activities of ethanolic leaf extract of Coccinia indica. Different extractives showed significant membrane stabilizing activity. The ethanol soluble fraction showed (45.36±0.45 % and 64.05±0.22 %) of Red blood cells haemolysis inhibition under heat and hypotonic solution induced conditions,...
April 2018
Effect of erythrinaline alkaloids from Erythrina lysistemon on human recombinant caspase-3
Prostate cancer is a leading killer disease among men all over the world. Inducing apoptosis (programmed cell death) is a strategic chemotherapeutic approach. Caspase-3 is a key effector of apoptosis, and its activation promotes apoptosis. It was hypothesized that erythrinaline alkaloids activate caspase-3. The alkaloids were isolated from the flowers and pods of Erythrina lysistemon. Their effect on human recombinant...
April 2018
In vivo assessment of the antipyretic activity of tilmicosin
The aim of the present study was to assess the antipyretic activity of the macrolide antibiotic, tilmicosin, at dose levels of 20 and 40 mg/kg of body weight, subcutaneously, in Brewer's yeast-induced fever model in mice. Pyrexia was induced by subcutaneous injection of 20 mL/kg of 20% (w/v) Brewer’s yeast suspension into the animal’s scruff region. Eighteen hours later, feverish animals were treated...
April 2018
A systematic review: Application of in silico models for antimalarial drug discovery
Malaria remains the global public health problem due to the reemergence of drug resistance. There is an urgent need for development of new antimalarial candidates which are effective against resistant malaria parasite. This systematic review evaluates the published research studies that applied in silico modeling during the discovery process of antimalarial drugs. Literature searches were conducted using PubMed, EBSCO,...
April 2018
In vitro anti-inflammatory activity of Vangueria infausta: An edible wild fruit from Zimbabwe
This study set out to investigate the anti-inflammatory activity of Vangueria infausta, an edible wild fruit from Zimbabwe. The importance lies in the fact that this plant species could be developed as a low cost and effective therapeutic agent, with little or no side effects from natural sources. The fruit pulp of V. infausta was subjected to cold ethanol extraction to get crude extract. Flavonoids were isolated by...
March 2018
Extract and chloroform fraction from Syzygium cumini leaves with vasorelaxant effect mediated by inhibition of calcium channels
Hypertension is associated with endothelial dysfunction characterized by decreased vasorelaxation. Our research group recently demonstrated that hydroalcoholic extract of Syzygium cumini leaves (HESc) reduces the blood pressure in spontaneously hypertensive rats (SHR). This study evaluated the ability of HESc and chloroform fraction (CF) in promoting vasorelaxation on resistance arteries rings. Endothelium-deprived...
March 2018
Antibacterial activity of crude extracts and pure compounds isolated from Vernonia galamensis leaves
The aim of this study was to test the antibacterial property of the extract of the leaves and isolated compounds of Vernonia galamensis that is traditionally claimed to have diverse medicinal use. The disk diffusion method was used to test the successively extracted dried leaves of V. galamensis on Staphylococcus aureus, Escherichia coli, Salmonella typhi and Shigella boydii. Further fractionation of the acetone extract...
March 2018
Characterisation of drug loaded with poly-beta-hydroxyl-butyrate (PHB) nanoparticles onto the cotton gauze for tuberculosis
Nanoparticles are of current interest because of their emerging understanding effects on human health. Many developed nanoparticles were created based upon the current application. The application of nanoparticles in drug delivery of pharmaceuticals offers many advantages on the treatment strategies and therapy outcomes. Poly-beta-hydroxyl-butyrate (PHB) nanoparticles are very versatile and its design could be tailored...
March 2018
In vitro antimicrobial activities of Plocamium rigidum and Plocamium cornutum from the Namibian coast line
The aim of this study was to determine suitable extraction solvents for antimicrobial compounds and the antimicrobial activity of two algal species, Plocamium cornutum and Plocamium rigidum collected from the coastline of Namibia. Samples were collected at low tide from the intertidal area of the coastline at Lüderitz and Henties Bay. The samples were collected about 5 to 10 cm under water by hand and placed in a...
March 2018
A Study on Spurious and Not of Standard Quality Drugs in the State of Andhra Pradesh
Indian Pharmaceutical Industry is the third largest in the world in terms of volume and this industry has a business of about USD 30 billion annually. Availability of quality medical products, especially drugs is important from the perspective of health of the consumers. The manufacture and sale of drugs in India is a licensed activity under Drugs and Cosmetics Act, 1940 and the Drugs and Cosmetics Rules, 1945. The use...
March 2018
Anti-hemolytic and reduction of lipid peroxidation capacities of Detarium microcarpum Guill. and Perr. fruits
This study was designed to investigate the ability of ethanol fruit extract from Detarium microcarpum to protect erythrocytes against hemolysis and lipid peroxidation. To achieve this objective, hemolytic, anti-hemolytic and lipid peroxidation from cell membrane assays were used. Hemolytic and anti-hemolytic activities (regarding H2O2 induced hemolysis) were assessed by determination of free haemoglobin at 540 nm....
March 2018
In vitro evaluation of antiasthmatic activity of ethanol leaf extract of Guiera senegalensis j. F. GMEL (Combretaceae)
Guiera senegalensis is a medicinal plant that is widely used in West Africa against many illnesses. In this work, the antiasthmatic properties of ethanol leaf extract of the G. senegalensis were evaluated by using various in vitro animal models. In vitro models like isolated guinea pig tracheal chain preparation, isolated guinea pig ileum and rabbit jejunum preparations were studied to evaluate possible mechanism by...
February 2018
Anti-respiratory syncytial virus activities of leaf extracts of Alchornea cordifolia and Alchornea floribunda
Respiratory syncytial virus (RSV) causes viral infection of a global proportion. Currently, there is no approved vaccine or useful antiviral drug against it. Natural products hold potential for discovery of anti-RSV agents. The present study assessed the anti-RSV activities of Alchornea cordifolia (AC) (Shumach. and Thonn.) Mϋll. Arg. and Alchornea floribunda (AF) Mϋll. Arg., Antiviral activities of AC and AF leaf...
February 2018
Effects of vanadium on oxidative stress and electrolytes balance of dyslipidemic male rats treated with simvastatin
Dyslipidaemia is characterised by enhanced production of reactive oxygen species and increased oxidative stress, which may affect liver, kidney and heart function. It is considered as a critical risk factor for cardiovascular and liver diseases. The aim of our study was to assess the effect of vanadium chloride on the oxidative stress state of liver, kidney and heart functions along with electrolyte balance during...
February 2018
Isolation, structure elucidation, antioxidant and hepatoprotective effects of petroleum ether extract of Artemisia integrifolia L. against CCl4-induced liver injury in rats
The aim of this study was to investigate the chemical constituents of petroleum ether extract from Artemisia integrifolia L (AIPEE) and to evaluate its hepatoprotective potential and in vivo antioxidant effects. Six compounds, namely eugenol (1), linolenic acid (2), 6,7-epoxy-linolenic acid (3), linoleic acid (4), oleic acid (5) and hexadecanoic acid (6) were isolated from the AIPEE. Oral administration of AIPEE...
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