African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2152

AJPP Articles

October 2019

Tremendous health benefits and clinical aspects of Smilax china

A lot of species of Smilax known as Baqia in China are used in folk medicine for various purposes. Smilax china L., is a small vine that grows in the southern parts of China, known as Jin Gang Ten, which has a long history of indigenous use in China. S. china consists of fat, saponins, glucosides, gum, starch, flavonoids, tannins, and alkaloids. S. china has been used in traditional Chinese medicine because it has...

Author(s): Mohamad Hesam Shahrajabian, Wenli Sun, and Qi Cheng,  

October 2019

Effect of the anticancer drug tamoxifen on chronic toxoplasmosis in experimentally infected rats

Toxoplasma gondii is an opportunistic parasite that can cause severe disorders in infants and pregnant women and can also be lethal in immunologically compromised individuals. During unfit host immune conditions, and as a consequence to latent stage opportunity, the protozoan stimulates serious infection, and signifies higher morbidity and mortality including humans with Acquired Immuno-Deficiency Syndrome (AIDS) or...

Author(s): Rabab Fawzy Selem, Gehan Abdel Rahman Rashed, Ashraf Mohamed Abdel Khalek Barakat, Hasan Mohamed Ali Elfadaly, Boshra EL-sayed Talha Hussien, Hemat Salah Mohamed, Marwa Mohamed Nageeb and Ahlam Farag Moharm  

October 2019

Prevalence and indication of gabapentin and pregabalin prescriptions among adults in King Abdulaziz Hospital in Makkah AL-Mukarramah, KSA

Gabapentin and pregabalin prescribing have increased substantially over the recent years. Some evidence supports that gabapentin and pregabalin use in non-neuropathic pain disorders indicates they are less effective than several other licensed non-opioid analgesics. On the other hand, other studies have shown that those drugs are to be beneficial in the treatment of non-neuropathic pain and improves the analgesic...

Author(s): Salma Alotaibi, Arwa Alotaibi, Ashwaq Almqati, Khloud Alotaibi, Atyaf Bogar and Yosra Alhindi  

October 2019

Pharmaceutical polymorphisms and its influence on the dissolution profile of two pioglitazone brands

1Pharmacognosy Laboratory,Faculty of Chemical Sciences, Juarez Durango State University, Mexico. 2Technology and health laboratory, Academic Coordination Altiplano Region, Autonomy University of San Luis, Potosi, Mexico.  

Author(s): Eduardo Lozano Guzmán, Saúl Alejandro Aguirre Rentería, María Guadalupe Nieto Pescador, Maribel Cervantes Flores, Ángel Antonio Vértiz Hernández and  Francisco Javier Moreno Cruz  

September 2019

Canvassing of biological attributes by In vitro screening of Canarium bengalense

Various Hoang family remedies known as Dai-Thien-Nuong, utilize Canarium bengalense Roxb. (Family: Burseraceae) as a major component for the treatment of tumor and liver damage. This study was performed using the crude methanol extract of C. bengalense Roxb. bark and its petroleum ether, carbon tetrachloride, dichloromethane and aqueous soluble fractions for antioxidant, cytotoxic, thrombolytic, membrane stabilizing and...

Author(s):  Sanjina Saif Karim, Quazi Sufia Islam and Tasnuva Sharmin  

September 2019

Tolerance and observance of methotrexate in the treatment of rheumatoid arthritis at the university Hospital Bogodogo, Burkina Faso

This study is aimed at assessing tolerance and observance of the patients with RA (rheumatoid arthritis) treated by methotrexate at University Hospital Bogodogo, in Burkina Faso. A cross-sectional study was conducted from July to September 2015 in outpatients with rheumatoid arthritis monitored in rheumatology service. Data were obtained from interview, by reviewing medical cards of the patients and consultation report...

Author(s): R. Frank E. Zongo, Joelle S. Zabsonré, Aminata Nacoulma, Souleymane Fofana, Moise W. Sawadogo, Estelle Noella Youl, Moussa Ouédraogo, and Dieu-Donné Ouédraogo,  

September 2019

Use of medicinal plants for the treatment of gastric ulcer in some parts of Southwestern Nigeria

Ulcer is erosion in the lining of the stomach or duodenum. It is caused by disruption of the gastric mucosal defense and repair systems. There has been much interest in natural medicines derived from traditional knowledge of pharmacological properties of plants recently. The major aim of this study was to conduct an ethnobotanical survey of plants used in the treatment of Gastric ulcers in some local government areas of...

Author(s): Idayat A. Akinwumi and Mubo A. Sonibare  

September 2019

Effects of methanolic tuber extract of Cyperus esculentus Linn (tiger nuts) on sub-acute liver damage in albino rats

This study evaluated the effects of Cyperus esculentus methanolic tuber extract (CEME) on carbon tetrachloride (CCl4)-induced sub-acute liver damage in albino rats. Dried tubers of C. esculentus were pulverized and extracted by cold maceration, using 80% methanol. Thirty albino rats, randomly assigned to 6 groups (A–F) of 5 each were used for the study. Sub-acute liver damage was induced in Groups A-E rats using...

Author(s): Thelma Ebele Ihedioha, Rita Ifeoma Odo, Uwakwe Simon Onoja, Chinweike Emmanuel Chiwetalu and John Ikechukwu Ihedioha  

September 2019

24 h pre-incubation of EA.hy926 cells with angiotensin II regulates insulin-dependent activation of eNOS in a concentration-dependent manner

The rennin-angiotensin II system (RAS) and the insulin-PI3kinase signalling pathways cross-interact with important physiological and pathophysiological consequences for cells and the whole organism. Here, the effect of 24 h pre-incubation of EA.hy926 with two different concentrations of angiotensin II, on insulin-mediated activation of the PI3kinase-AKT-eNOS signalling was investigated. Quiescent EA.hy926 cells were...

Author(s): Ejebe D. E.  

August 2019

Antioxidant and cicatrizing activity of the species Abarema cochliacarpos (Gomes) Barneby & J. W. Grimes

In equine clinics, skin injuries are some of the most frequently treated injuries, this research evaluated the healing potential and antioxidant activity of Abarema cochliacarpos in order to develop a pharmaceutical formulation for treating skin lesions in horses. Firstly, the antioxidant activity of several fractions was evaluated using the 2,2-diphenyl-1-picrylhydrazyl radical method and the thiobarbituric acid test....

Author(s): Saskya Araújo Fonseca, J. R. M. Costa, N. R. S. Gomes, Amanda Lima Cunha, João Gomes da Costa, Thiago José Matos-Rocha, Karwhory Wallas Lins da Silva, Paulo Henrique Barcellos França, Francisco Feliciano da Silva Júnior, Antônio Euzébio Goulart Sant’Ana and Aldenir Feitosa dos Santos,  

August 2019

Acute toxicity evaluation of ethanolic extract of the air parts of Sida rhombifolia L., in wistar rats

Sida rhombifolia L., popularly known in Brazil as "SIDA" or "mata-pasto", is considered a weed; a plant of the American continent and widely distributed in North Africa, belongs to the Malvaceae family. In Brazil, S. rhombifolia L. is scattered throughout the national territory, infesting agricultural crops. Certain species of the genus Sida, including S. rhombifolia, are widely used in Indian,...

Author(s): Luciana da Silva Nunes Ramalho, Gabriela Tafaela Dias, Edla Julinda Ribeiro Coutinho Espinola Guedes, Micaelly da Silva Oliveira, Andressa Brito Lira, Kardilândia Mendes de Oliveira, Otemberg Souza Chaves, Josué do Amaral Ramalho, Alexandre Rolim da Paz , Janine Agra Padilha, Hilzeth de Luna Freire Pessoa, Maria de Fátima Vanderlei de Souza, Caliandra Maria Bezerra Luna Lima and Margareth de Fátima Formiga Melo Diniz  

August 2019

Efficacy of transurethral resection of prostate in patients of benign prostatic hyperplasia with lower urinary tract symptoms

Transurethral resection of the prostate (TURP) has been the prime procedure for decenniums to treat benign prostatic hyperplasia (BPH), but is mainly predicated on historic data that lacks utilization of validated measures. It is noteworthy that TURP done nowadays significantly differs from that performed 30 years ago. Men who had undergone TURP between 2013 and 2018 were reviewed. 50 patients presented in the...

Author(s): Shahjahan Ur Rehman, Salman Iftikhar, Kamran Zaidi, Rao Salman Aziz, Yasir Arfat and Muhammad Sohail  

August 2019

Antibacterial activities of three medicinal plant extracts and their synergistic effect on Staphylococcus aureus isolated from burn wounds

This study was undertaken to investigate the antibacterial activities of three medicinal plant extracts and their synergistic effect on Staphylococcus aureus isolated from burn wounds. A total of 50 swab samples of burn wounds were collected from burn wound patients attending Federal Teaching Hospital Abakaliki and screened for S. aureus using standard microbiological techniques. Three plant materials (Cucurbita pepo...

Author(s): Nwuna E. N., Nwuzo A. C., Afiukwa F. N., Oke Boniface,  Udu-iIbiam E. O., Moses I. B., Ilang D. C. and Aondaackaa A. D.  

August 2019

Sciatica: Medical treatment or Physiotherapy?

Low back pain is usually self-limiting. It has a sizeable impact on patients, and is associated with high healthcare and societal costs as much as $16 billion each year. Patients are commonly treated in primary care but a small proportion is referred to secondary care and may eventually have surgery. There are numerous treatment approaches for sciatica. Many people receive only medical treatment and are unaware of the...

Author(s): Mehreen Saleem, Salman Iftikhar, Ramsha Javaid,Tayyaba Rana, Maheen Rana and Yasir Arfat  

July 2019

Phytochemical analysis and investigation of sedative-hypnotic activity of methanolic stem bark extract of Ficus abutilifolia in mice

Most of the sedative drugs cause dose-dependent depression of the central nervous system (CNS) leading to hypnosis and possibly anaesthesia, however, these agents are associated with some side effects ranging from digestive, respiratory, immune system dysfunctions, cognitive function deterioration, tolerance, and physical dependence, hence investigations of newer and safer agents is therefore imperative. The current...

Author(s): Mikail, H. G., Akumka, D. D., Adamu, M., Zaifada, A. U.  

July 2019

Aflatoxin M1 in cheese samples from the Amazon Region

Aflatoxin M1 (AFM1) is a mycotoxin that can be found in cheeses and makes the monitoring of this food of public health interesting. In Brazil, the Amazon region has a cattle herd with dairy production of cheese, and an evaluation of the food and its risk to the population is required. The objective of this study was to evaluate the levels of AFM1, moisture content (mc) and water activity (aw) in different cheeses types,...

Author(s): Janaína Santos Barroncas, Ariane Mendonça Kluczkovski, Emerson Silva Lima, Pedro Henrique Campelo Felix, Cibele de Souza Viana, Lawrence Ramos Xavier, Samir de Carvalho Buzaglo Pinto and Augusto Kluczkovski Kunior  

July 2019

Evaluation of anthelmintic activity of ethanolic extracts of Carica papaya leaves using Paramphistomum cervi and Haemonchus contortus

The aim of this present study is to evaluate the anthelmintic activity of leaves extracts of Carica papaya using Paramphistomum cervi and Haemonchus contortus as the test worms. A range of concentrations (100, 50 and 25%) of ethanolic extracts of C. papaya were tested to assay the procedure. This is mainly applied for the determination of time of death (D) and time of paralysis (P) of the tested worms. After the...

Author(s): Md. Rabiul Islam, Syeda Fatema Tuz Zahra, S. M. Ibrahim Sumon, Shahnaj Parvin, Kamrul Hasan, Moudud Ahmed, Md. Abu Talha Siddique and Tazmel Haque    

July 2019

Rational and experiential decision-making preferences of pharmacy students in Karachi, Pakistan

This study was conducted to examine the rational (systematic and rule-based) and experiential (fast and intuitive) thinking preferences of pharmacy students. This may assist in formulating learning and teaching tactics for decision-making leading to safe and optimized patient care services. Here, a validated psychometric tool, that is, the Rational Experiential Inventory (REI-40) survey was used. It was distributed to...

Author(s): Wajiha Iffat, Sadia Shakeel, Atta Abbas Naqvi, Shehlla Imam, Tariq Ali, Shagufta Nesar, Riffat Yasmin, Faaiza Qazi Muhammad Faisal Khan and Madeeha Khan  

June 2019

Sex differences in the neuroprotective effect of insulin against chemically-induced convulsions in mice

Insulin, an important regulator of peripheral metabolism, has been reported to interact with many neurotransmitter systems including those associated with convulsion. The effect of insulin against pentylenetetrazole and strychnine-induced convulsions in mice, as well as possible sex differences, were evaluated in this study. Mice of both sexes weighing between 20 and 25 g were administered insulin intraperitoneally at...

Author(s): Susanna Adeola Adebayo, Oluwole Isaac Adeyemi, Adegbenga Rotimi Owolabi and Moses Atanda Akanmu

June 2019

Effect of amodiaquine on the pharmacokinetics of gliclazide in diabetic subjects

The study aims at investigating the effect of amodiaquine on the pharmacokinetic profile of gliclazide. It is a one-way single dose cross-over study in two phases. Six freshly diagnosed diabetic volunteers were used. The subjects acted as their own control, and each phase was preceded by an overnight fast. Phase 1 of the study involved the administration of a single oral dose of 80 mg of gliclazide after an overnight...

Author(s): Sambo Godwin Ishaku, Mojirade Taibat Bakare-Odunola, Aminu Musa, Ibrahim Adamu Yakasai, Magaji Garba and Bulus Adzu  

June 2019

Nanotechnology: A non-invasive diagnosis and therapeutic tool for brain disorders

Presently, nanotechnology appears as a powerful and innovative tool in the medical field. It has various advantages over the conventional drug therapy such as therapeutic specificity, has less side effects, reduces dose of drug, has more precise treatment and can access the inaccessible areas of the body like brain, tumor cells, etc. The human brain is the most complicated part of the body which is highly protected with...

Author(s): Amit Alexander, Sabahuddin Siddique, Mukta Agrawal, Ajazuddin, Ahmed M. Shehata, Mahmoud A. Shaker,  Syed Ata Ur Rahman, Mohi Iqbal M Abdul and Mohamed A. Shaker,  

June 2019

Myorelaxant effect of aqueous root bark extract of Carissa edulis (Forssk.) Vahl. is mediated through activation of nitric oxide synthase

Many patients in Africa often utilize herbal medicine for the management of hyperactive gut disorders such as diarrhea and abdominal colic. There is therefore a need to scientifically evaluate efficacy of this herbal remedies. This study investigated the myorelaxant effect of Carissa edulis (Forssk.) Vahl and its possible mechanism of action using isolated rabbit jejunum preparations. Pieces of jejunum were isolated...

Author(s): Oluoch Linus Lincone, Mbugua Paul Mungai, Muriithi Anne Wangechi, Siringo Cyril George, Wafula David Kayaja and Boniface Mwangi Chege  

May 2019

Flavonoids in neuropathic pain management: A new player on an old target

Neuropathic pain is the consequence of abnormal processing in the peripheral or central nervous system (CNS) elicited by neuronal injury. Due to its heterogeneous nature and important unwanted adverse effects of the commonly prescribed psychoactive drugs like benzodiazepines (BDZ), the treatment of neuropathic pain has remained a challenge for the scientific community. Flavonoids initially isolated from plants and used...

Author(s): Shehla Akbar  

May 2019

Effects of anti-hyperglicemic of yacon leaf (Smallanthus sonchifolius) ethanolic extracts using zebrafish as a model

This study aims to investigate the anti-hyperglicemic effects of yacon leaf (Smallanthus sonchifolius) using zebrafish. In this study, zebrafish is used as a model, with alloxan compounds to induce hyperglicemic. The induction stage consists of 3 phases: in the first the zebra was induced at 0.3% for 30 min, in the second stage, it was transferred to a 3% D-glucose solution for 30 min, and in the last, immersion was...

Author(s): Zuhelmi Aziz, Nanda Tamara, Rahmi Three Wahyuni, Inawati and Syamsudin Abdillah  

May 2019

Effect of Parkia biglobosa extract on open skin wound healing in dexamethasone- induced hyperglycaemia and histological assessment in rats

Glucocorticoid-induced diabetes mellitus (GIDM) is an abnormal increase in blood glucose associated with the use of glucocorticoids in a patient with or without a prior history of diabetes mellitus. This is a common and potentially harmful problem in clinical practice, affecting almost all medical specialties, but is often diffi¬cult to detect in clinical settings.  The objective of this study was to determine...

Author(s): Modupe Iretiola Builders, Oyepata Simeon Joseph and Akpobome Raymond Vhriterhire  

May 2019

Neferine and isoliensinine from Nelumbo nucifera induced reactive oxygen species (ROS)-mediated apoptosis in colorectal cancer HCT-15 cells

Several scientific reports documented the potent anti-cancer effect of various natural products  such as curcumin, epigallocatechin gallate (EGCG), resveretrol via the rise in reactive oxygen species (ROS) and dysfunction of anti-apoptotic gene expressions. The present study evaluated the anticancer potential of lotus derived alkaloids, neferine and isoliensinine on colorectal cancer HCT-15 (CRCs) cells....

Author(s): Prasath Manogaran, Narasimha Murthy Beeraka, Chih-Yang Huang, Viswanadha Vijaya Padma,  

April 2019

Endopleura uchi (Huber) Cuatrec, a medicinal plant with potential anti-inflammatory activity: A review of its phytochemistry and biological activities

Endopleura uchi (Huber) Cuatrec. is a tree found in the Brazilian Amazon, whose barks are used in folk medicine as an alternative treatment for inflammatory-related diseases. This review, performed using current available international scientific literature, aimed to survey biological activities reported from E. uchi, and describes its phytochemistry. In folk medicine, the barks are used to treat a range of conditions...

Author(s): Beatriz Martins de Sá Hyacienth, Brenda Sánchez Ortiz , Arlindo César Matias Pereira, Danilo Cabral de Sá Hyacienth, Josué Arturo Velázquez Moyado, Glória Melisa Gonzales Aduanga, Andrés Navarrete and José Carlos Tavares Carvalho,  

March 2019

Medicines prescribing pattern in northern Ghana: does it comply with WHO recommendations for prescribing indicators?

The prescribing of medicines is critical in the treatment of diseases in general practice. Inappropriate prescribing can negatively influence the goals of treatment, which makes the assessment of the patterns of prescriptions essential. The objective of this study was to assess the medicines prescribing pattern in health facilities in the Northern Ghana, a developing economy in Africa, using the prescribing indicators...

Author(s): Baba Sulemana Mohammed and Salifu Alhassan Tiah  

March 2019

Effect of Maytenus senegalensis roots on OVA-induced airway inflammation in a mouse asthma model

The present work is focused on the evaluation of the Maytenus senegalensis roots effect on bronchial hyperleukocytosis and the search of its antioxidant potential both in vitro and in vivo. The roots of M. senegalensis (Celastraceae) are traditionally used for the treatment of cough and asthma. This study evaluates the effect of the hydroalcoholic extract of the roots of M. senegalensis on the bronchial...

Author(s): Pascaline K. Kpoyizoun, Kossi Metowogo, Afiwa Missebukpo, Kwashie Eklu-Gadegbeku, Kodjo A. Aklikokou and Messanvi Gbeassor  

March 2019

Antibacterial resistance modulatory properties of selected medicinal plants from Ghana

Bacterial resistance to antibiotics is a serious challenge to human and animal health and all efforts are being put together to resolve the menace. In this study the antibiotic resistance modifying activity of ten plants was established by determination of the minimum inhibitory concentrations (MICs) of the plant extracts, the MICs of the antibiotics alone (amoxicillin, ciprofloxacin, erythromycin and tetracycline) and...

Author(s): Francis Adu, Yaw Duah Boakye, Christian Agyare, George Henry Sam, Vivian Etsiapa Boamah and Frank Boateng Osei  

February 2019

Endothelium-independent vasorelaxation by dichloromethanolic fraction from Anogeissus leiocarpa (DC) Guill. Et Perr. (Combretaceae) bark of trunk on porcine coronary artery rings: Involvement of [Ca2+]i decreased and phosphodiesterases inhibition

Anogeissus leiocarpa (DC) Guill. et Perr. belongs to the Combretaceae family and was previously named A. leiocarpa (DC) Guill. Et Perr. It has been widely used in Burkina Faso by traditional medicine for the treatment of hypertension. Previous study showed that the dichloromethanolic fraction from the barks of trunk of A. leiocarpa (ALF) has induced an endothelium-independent and endothelium-dependent vasodilation...

Author(s): Belemnaba Lazare, Nitiéma Mathieu, Ouédraogo Sylvin, Auger Cyril, Schini-Kerth Valérie B. and Bernard Bucher  

February 2019

Rats cholestasis instigated by 𝛼-Naphthylisothiocyanate and the impacts of green tea (Camellia sinensis) antioxidant

𝛼-Naphthylisothiocyanate (ANIT) is known to provoke liver damage with intrahepatic cholestasis. This ANIT is accepted to be important for assessing the effect of medicine instigated cholestasis. This assessment investigated the effect of green tea (Camellia sinensis) in contrast to that of Vitamin C (VC) against the hepatotoxicity of ANIT. Rats were orally treated with green tea portion (GT50, 75, 100 mg/kg) and CV (250...

Author(s): Wael M. Al-Amoudi  

February 2019

Anti-fertility activity of aqueous root bark extracts of Asparagus africanus Lam and Annona senegalensis Pers combination on female Sprague Dawley rats

Many rural and poor women have now resorted to use of potential medicinal plants as a means of fertility control. Asparagus africanus Lam and Annona senegalensis Pers are some of the plants used for this purpose. The efficacy and safety of many of such plants, however, have not been verified. Therefore, screening for anti-fertility activity of potential medicinal plants, would thus provide alternative safe and...

Author(s): Okidi Oscar P. Okello, Nkwangu David and Joseph Oloro  

February 2019

Good practice guidance to support safe oral medication preparation and administration through feeding tubes

The objective of this work is to elaborate good practice guidance, aimed at preparing and administering drugs through feeding tube. This study was performed at a secondary level hospital in the interior of São Paulo state, Southeast Region of Brazil. For the first phase, a literature review was carried out in the following databases: LILACS, MEDLINE, Web of Science, and MICROMEDEX® Solutions. A manual search...

Author(s): Rosana Aparecida Pereira, Adriano Max Reis, André Aparecido Ramos, Raquel Fernandes, Adriana Cristina Bentlin Canalli, Mayara Carvalho Godinho Rigobello, Ana Paula Gobbo Motta, Fabiana Bolela de Souza and Fernanda Raphael Escobar Gimenes  

January 2019

Modern approach of treatment on destroyable pathogenicity of malaria parasite: A review article

Plasmodium is the malaria parasite that completes the life cycle between two different hosts, such as human and Anopheles mosquito. These parasites go through several developmental stages like exo-erythrocytic stage that is absent in Plasmodium falciparum, so relapses do not occur. The drugs which contain three P’s like proguanil, primaquine, and pyrimethamine kill schizonts in the liver. Due to prolonged...

Author(s): Sourav Das, Sabahuddin Siddique, Ahmed  M Shehata, Mohamed A. Shaker, Mohi Iqbal Mohammed Abdul,  Asis Bala, ,Pallab Mandal, Shubhasis Dan and Anirbandeep Bose  

January 2019

Improving blood pressure control in patients with pseudoresistant hypertension – A pilot randomized trial

This study aims to evaluate the effect of an intervention focused on medication adherence to improve blood at three basic health units in Maceió, Brazil. Patients were followed-up for three months. Primary outcomes were pressure control in patients with pseudoresistant hypertension. A randomized controlled clinical trial was conducted mean values of systolic blood pressure (SBP) and diastolic blood pressure...

Author(s): Dilcy Morgana Barros Maciel Cabral Davino, Rosileide Zeferino Da Silva, Francisco de Assis Costa, Sabrina Joany Felizardo Neves and Alfredo Dias de Oliveira-Filho  

December 2018

Evaluation of surgical antimicrobial prophylaxis use in Ethiopia: Prospective study

Appropriate use of surgical antimicrobial prophylaxis can prevent approximately 40 to 60% of surgical site infections. Inappropriate  use  is  associated  with  emergency  of antimicrobial resistance,  occurrence  of  side  effects  and  increased  health  care  cost.  We aimed to evaluate surgical antimicrobial prophylaxis use of Hawassa...

Author(s): Tamrat Legesse, Desta Hiko, Eneb Khelifa Ismael and Sadikalmahdi Hussen Abdella  

December 2018

Preclinical 28 days sub-chronic toxicity study of novel formulation of metoprolol tartrate on albino rats using statistical tool

The experimental study mainly focused on evaluation of sub-chronic oral toxicity of sustained formulation of metoprolol succinate. After the formulation development of multiparticulate sustained release capsules, there was an urgent need to analyze their in vivo bioavailability in healthy normal human volunteers. Prior to use in human population, a subchronic oral toxicity study was performed on Swiss Albino rats, of...

Author(s): Sabahuddin Siddique, Sourav Das, Mohi Iqbal Mohammed Abdul, Syed Ata Ur Rahman, Durdana Lateef, Shubhasis Dan and Anirbandeep Bose  

November 2018

A novel green approach for the treatment of immature Schistosoma mansoni infection in mice with; Arabic gum (Acacia senegal); an antischistosomal agent

Praziquantel (PZQ), the only common schistosocidal drug in use, is not efficacious for treatment of immature schistosomiasis infection. Arabic gum (AG) is a complex polysaccharide that acts as an anti-oxidant which modulates the inflammatory and/or immunological processes. This study explores for the first time, the antischistosomal properties of AG in mice infected with the immature stage of Schistosoma mansoni (S....

Author(s): Rabab Selem, Samia Rashed, Mohammad Younis, Boshra Hussien, Fatma Mohamed, Awatif Edrees, Asmaa EL-kholy, Gehan Rashed, Shereen Kishik, Ahlam Moharm, Marwa Nageeb and Manal Kardoush  

November 2018

Effects of combination therapy of Bridelia ferruginea stem bark and diminazene aceturate on testicular and haematological changes in Trypanosoma brucei infected male rats

The study was done to assess the ameliorative effects of co-administration of methanol extract of Bridelia ferruginea stem bark and diminazene aceturate on trypanosomosis induced testicular and haematological changes in infected male rat. Twenty five male rats were used in the study and assigned into five groups (n=5). Trypanosoma brucei was inoculated into Groups 1, 2, 3 and 4 rats except Group 5. Diminazene aceturate...

Author(s): Odo Rita Ifeoma, Ihedioha Thelma Ebele and Ukpai Ebubechi Emmanuel  

November 2018

The protective effects of Vitamin E and glibenclamide on spermatogenic and haematological changes in alloxan-induced diabetic male rats

This study was designed to evaluate the preventive potentials of vitamin E and glibenclamide on spermatogenic and haematological damages in alloxan-induced diabetic male rats. Thirty mature male albino rats randomly assigned into 5 groups (n=6) were used for the study. Diabetes was experimentally induced in groups 1 to 4 while group 5 rats served as the negative control. Rats in groups 1, 2 and 3 were treated with...

Author(s): R. I. Odo, N. E. Ugwu and S. Akusu  

October 2018

Physician prescription practice of antibiotics for upper respiratory tract infection at Kilimanjaro Christian Medical Centre Moshi, Tanzania

Upper respiratory tract infection occurs commonly in both children and adults and is a major cause of morbidity worldwide. Inappropriate antibiotic prescription for upper respiratory tract infections is associated with increasing antibiotic resistance, healthcare costs, adverse events, and poor patient outcomes. The objective of this study was to determine physician prescription practices of antibiotics for upper...

Author(s): Aisha Mavura, Geofrey N Sigalla, Florida Muro, Rosemary Malya,, Petro P. Nambunga, Noel Sam and Debora C. Kajeguka  

October 2018

Simple bioanalytical method development and validation of micronised Domperidone 20 mg tablets using LCMS-MS and its pharmacokinetic application in Healthy Indian Volunteers

The current investigation deals with an validated Liquid chromatography–mass spectrometry/mass spectrometry (LC-MS/MS) analytical method for the quantification of micronised domperidone in plasma of human volunteers. The validation of LC-MS/MS method was accomplished by evaluating the inter-day and intra-day precision and accuracy in a linear concentration range of 3.33-100 ng/ml. The entire study was an attempt...

Author(s): Mohi Iqbal Mohammed Abdul, Sabahuddin Siddique, Syed Ata Ur Rahman, Durdana Lateef, Shubhasis Dan and Anirbandeep Bose  

October 2018

Synthesis, characterization, and anticancer activity against human breast cancer cell-line T47D studies of metal ion Cu(II) complex with 2,4,5-triphenylimidazole ligand

The complex of metal ion Cu(II) with the ligand 2,4,5-trifenilimidazol has been successfully synthesized with mole ratio of metal and ligand 1:2 in N,N-dimethylformamide as a solvent. Complex synthesis results obtained green light crystalline solid. Complex absorbs UV-Vis light at 529 nm. Fourier transform infrared (FTIR) characterization results indicate occurrence of bonding of metals and ligand that is Cu-N in region...

Author(s): Teguh Hari Sucipto, Harsasi Setyawati, Irmina Kris Murwani and Fahimah Martak  

September 2018

Acute skin irritation, acute and sub-acute oral toxicity studies of Rosmarinus officinalis essential oils in mice and rabbit

In Ankober, Northern Ethiopia, Rosmarinus officinalis has been commonly used for flavoring foods as a condiment; moreover, the plant has also been widely used for different medicinal purposes. The current study was undertaken to provide data on acute and subacute toxicity in mice as well as skin irritation of R. officinalis essential oil in rabbit. Acute dermal and oral toxicity tests were conducted using limited dose of...

Author(s): Berhan Mengiste, Kassahun Dires, Ermias Lulekal,  Mahlet Arayaselassie, Tizazu Zenebe, Gezu Feleke, Eyasu Makonnen and Awol Mekonnen  

September 2018

Healing effect of the microemulsion enriched with hydroalcoholic extract of Abarema cochliacarpa (Gomes) Barneby & J. W. Grimes (Fabaceae)

Abarema cochliocarpa is an endemic plant of Brazil and has been traditionally used as a popular medicine to treat various diseases and mostly as a healing agent. The aim of this study was to evaluate the healing effect of the microemulsion containing hydrometanic fraction of the inner bark (HMF) of the plant, as well as its antioxidant, antitumor and cytotoxic potential. The cytotoxicity of HMF was assessed by the...

Author(s): Antônio Santos Dias, Clívia Rolemberg Andrade, André Luiz Lima Meneses Santos, Sabrina Zelice de Moraes, Jymmys Lopes dos Santos, Silvan Silva de Araújo, Andrea Yu Kwan Villar Shan, Jamylle Nunes de Souza Ferro, Marcelo Cavalcante Duarte, Emiliano de Oliveira Barreto, Anderson Carlos Marçal, Ricardo Luiz Cavalcante Albuquerque Júnior, Antonio Euzebio Goulart Santana, Brancilene Santos de Araújo  and Charles dos Santos Estevam

September 2018

Hypoglycemic profile and ameliorative potential of aqueous garlic extract on sperm characteristics in glibenclamide treated diabetic male rats

This study was carried out to determine the protective effect of aqueous garlic extract on testicular and spermatogenic changes in glibenclamide treated diabetic male rats. Thirty matured male rats were used in this study and were assigned into five groups of six rats each. Diabetes was induced in groups 1, 2, 3, 5 but not induced in group 4. Rats in group 1 were treated with glibenclamide (0.6 mg/kg) daily for 21 days....

Author(s): Odo Rita Ifeoma, Mbegbu Edmund, Samuel Okezie Ekere and C.F. Amaeze      

September 2018

Analysis of patient information leaflets on Artemisinin-based combination therapy

The objective of this research was to analyze the various patient information leaflets on Artemisinin-based combination therapy (ACTs) sold in Côte-D’Ivoire. A descriptive cross-sectional study was conducted from January 1st to February 20th, 2016, that included all patient information leaflets relating to ACTs registered and marketed in Côte-d’Ivoire. The leaflets were compared to European...

Author(s): Thérèse Daubrey-Potey, Mamadou Kamagaté and Henri Die-Kacou  

September 2018

Plasmodium falciparum drug resistance gene status in the Horn of Africa: A systematic review

Antimalarial drug resistance monitoring is the key factor in malaria control policy for early detection and subsequent prevention of drug resistance spread. This review was performed to collate all available data of P. falciparum resistant genes in the Horn of Africa as a baseline for future appraisal of the regional malaria control policy. The search of this review was performed in January 2018 using the scientific...

Author(s): Abdifatah Abdullahi Jalei, Wanna Chaijaroenkul and Kesara Na-Bangchang,  

August 2018

Study on increasing the solubility and dissolution rate of sulfamethoxazole by cyclodextrins

The aim of this study was to enhance the solubility and dissolution rate of sulfamethoxazole (SMZ) by preparing the inclusion complexes with β-cyclodextrin (β-CD), hydroxypropyl-β-cyclodextrin (HPβ-CD) and γ-cyclodextrin (γ-CD). The effect of the type of cyclodextrins used for the preparation of complexes, on the in vitro dissolution profiles and solubilities in different mediums (pH 4.5...

Author(s): Jülide Şahin and Nurten Özdemir  

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