African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2213

AJPP Articles

Quality assessment of frequently available mother tinctures in the market by employing standard values

April 2021

As general awareness for using herbal drugs in today’s health practice is increasing, the world is endorsing extraordinary increase in the consumption of herbal products. This increase in the demand has led to consumers’ dissatisfaction due to substandard products, making the herbal market risky. There is need to set standard that will help to evaluate herbal drugs to ensure formulation of high quality...

Author(s): Mahrukh Malik, Shahzad Hussain, Javeria Arshad Malik, Asia Adil, Sara Nazir and Muhammad Usman Gondal  

Knowledge of hypertension and diabetes comorbid patients about their medication in a municipal hospital in Ghana

April 2021

Patients with hypertension and diabetes co-morbidity may have medication knowledge and therapy challenges that could impact on patients’ outcomes. The study examines knowledge of medication and therapy among hypertension and Type-2- diabetes mellitus co-morbid patients at a Municipal hospital in Ghana. This study was conducted at the medical outpatient department (OPD) of the Municipal Hospital in Tema (a Harbour...

Author(s): Kwakye, A. O., Buabeng, K. O., Opare-Addo, N. A. M. and Owusu-Dabo, E.  

Effect of Cov-Pla1 and Cov-Pla3 extract on some pulmonary function parameters in rabbits

March 2021

Transmission of COVID-19 is facilitated by uptake of droplets containing coronavirus from the breath, sneeze or cough of infected persons. This represents the commonest mode of coronavirus infection and spread to mucous membranes of the respiratory system. The virus rapidly replicates in alveolar cells, triggering a strong immune response, resulting in cytokine storm syndromes and pulmonary tissue damage. These...

Author(s): Kakjing D. Falang, Kennedy I. Amagon, Bukata B. Bukar, Ajima Ukpe, Noel N. Wannang, Jacob A. Kolawole, James G. Damen, Yusuf Agabi, Richard J. Kutshik, Ishaya Y. Longdet, Simji S. Gomerep, Ismaila Shittu, and Stephen D. Davou,  

Evaluation of hematological and biochemical activity of Bauhinia strychnifolia Craib leaves ethanol extracts in normal albino rats

March 2021

The aim of this research is to evaluate the hematological and biochemical activity of Bauhinia strychnifolia Craib leaf ethanol extracts in normal albino rats. Thirty-two male and female rats were divided into four groups, each with equal numbers of male (n=4), female (n=4). The control group was administered 1 ml of 10% tween 80. The experimental groups were administered ethanol with concentrations of 125, 250 and 500...

Author(s): Juthaporn Kwansang, Watchara Damjuti and Natnaree Siriwon  

Novelty-induced behavior and memory enhancing activities of aqueous and ethanol extracts of Solanum incanum Linn. fruits in mice

February 2021

The present study investigated novelty-induced behavior, learning and memory enhancing activities of aqueous and ethanol fruit extracts of Solanum incanum Linn. using mice models. The mice were divided into sixteen (16) groups of five (5) mice each and treated with distilled water (10 ml/kg, i.p); 7.5, 15, 30 mg/kg (i.p) of both aqueous and ethanol fruit extracts; scopolamine (0.4 mg/kg) and scopolamine (0.4 mg/kg, i.p)...

Author(s): Akanmu A. O., Sodipo O. A., Sandabe U. K., Shamaki B. U., Balogun S. T. and Jubrin J.  

Reflection on medicinal plants, especially antivirals and how to reconsider ethnobotany as an interesting way for health preservation

January 2021

The medicinal plants, which are at the origin of the medical sciences, are gradually passing from the apothecary vials, from the handmade bags of the tradipraticians to the laboratories to provide countless new medicines synthesis models. Today, chemical drugs have replaced most herbal drugs in pharmacies. Empirical knowledge has been neglected as chemistry progressed. Yet 80% of the world’s population is still...

Author(s): Fatiha El Babili, VM Lamade, Hugo Fabre and Daniel Charlot  

Therapeutic potential of Annona senegalensis Pers (Annonaceae), a plant used in traditional medicine for the treatment of epilepsy in Burkina Faso

January 2021

Annona senegalensis Pers. is a plant used in Burkina folkloric medicine for the treatment of epilepsy. The stem-bark, roots and leaves of A. senegalensis are used for an array of human disorders, including epilepsy. Previous studies have demonstrated some genuine effects of A. senegalensis fractions in vivo models of temporal lobe epilepsy. In the present work, we have compared the pharmacological profile of the most...

Author(s): Almamy Konate,, Franck Dubruc, Richard W. Sawadogo, Lotfi Ferhat, Norah Boumedine, Valérie Mahiou, Evelyne Ollivier, Pierre I. Guissou, and Olivier Caillard,  

Patterns of prescription and inappropriate medications use in elderly patients of Makkah community in Saudi Arabia

December 2020

Polypharmacy and the prescription of inappropriate medications are common in elderly patients due to the high rate of morbidity in this population. However, this information is scarce about patients in this age group in Saudi Arabia. In general, this study was conducted to investigate the drug prescriptions in elderly patients in Makkah city of Saudi Arabia. This topic threw light mainly on the pattern of drug...

Author(s): Ghazi A. Bamagous  

Evaluation of the elemental, nutritional and antioxidant properties of Cov-Pla herbal preparations

November 2020

The outbreak of the Covid-19 pandemic has had a dramatic effect on human existence and still shows no sign of abating. Scientists worldwide are therefore working assiduously to get new drug treatments to help mitigate the crisis. Some of those efforts involve research to obtain Covid-19 treatments from natural sources. The present study is aimed at evaluating the elemental, nutritional and antioxidant properties of...

Author(s): Ukpe Ajima, Jacob Adegboyega Kolawole, Kakjing Dadul Falang, Bukata Bayero Bukar, Kennedy Iliya Amagon, James Garba Damen, Yusuf Amuda Agabi, Richard Joseph Kutshik, Ishaya Yohanna Longdet, Simji Samuel Gomerep, Ismaila Shittu,  Stephen Daniel Davou, and Noel Nen’man Wannang,  

Notice of Retraction: Preparation and characterization of crosslinked and non-crosslinked polycaprolactone fumarate (PCLF) NPs as carriers for doxorubicin HCl

November 2020

The editors of the African Journal of Pharmacy and Pharmacology (AJPP) are retracting the article, “Preparation and characterization of crosslinked and non-crosslinked polycaprolactone fumarate (PCLF) NPs as carriers for doxorubicin HCl” published in 2011 (Vol. 5(7), pp. 797-805, July 2011). This is based on evidences of text overlap (in figures and tables) between the article and those published in two...

Author(s): Narges Shokri, Hamid Akbari Javar, Shamileh Fouladdel, Ali Khalaj, Rasoul Dinarvand, and Ebrahim Azizi

Determinants of asthma disease control in Ambo University Referral Hospital: Observational cross-sectional study

November 2020

Over a decade, different stakeholders have engaged concerted efforts to reduce morbidity and mortality related to asthma. Despite all these efforts, substantial proportions of asthmatic patients do not achieve proper asthma control. The aim of this study was to evaluate the level of asthma control and to assess the factors that might influence control of the disease. The study was conducted at the Ambo University...

Author(s): Worku Degefa, Endalkachew Mekonnen Eticha and Gurmu Tsfaye Umeta

Wrong time medication administration errors: Frequency and their causes at Adult University Teaching Hospitals in Zambia

November 2020

Wrong-time medication administration errors (WTMAEs) can have serious consequences for medication safety. The study was a cross-sectional study that employed a prospective observation technique and was conducted from 4th June to 20th July 2018 at Adult University Teaching Hospital (AUTH) in the Internal Medicine and Surgery departments. A total of 1749 doses were observed being administered to 325 inpatients and the...

Author(s): Martin Kampamba, Tilolele Mwanza, Kennedy Saini, Hanzooma Hatwiko, Luke Biete and Christabel Nangandu Hikaambo  

Hypoglycemic and antihyperglycemic activities of the aqueous ethanolic extracts of Gymnema sylvestre (RETZ) R. Br. Ex SCHULT and Sclerocarya birrea (A RICH) HOCHST

October 2020

Gymnema sylvestre (Retz.) R. Br. ex Schult (Asclepiadaceae) and Sclerocarya birrea (A. Rich) Hochst (Anacardiaceae) are two plants used in Burkina Faso in traditional medicine and in the form of phytomedicine in the treatment of diabetes. This study evaluated the effect of aqueous ethanolic extracts of leaves of Gymnema sylvestre and Sclerocarya birrea on glycemia. A phytochemical screening of the extracts obtained by...

Author(s): Estelle N. H. Youl, Sonia Nassouri, Sonia Ilboudo, Moussa Ouédraogo, Charles B. Sombié, Sylvain Ilboudo, Zéphirin P. Dakuyo and Innocent P. Guissou  

A review for selecting medicinal plants commonly used for malaria in Uganda

October 2020

The menace of current cases of parasite resistance to antimalarial drugs, non- availability and accessibility, and the high costs of pharmaceutical products contribute to the high rate of medicinal plants consumption in the treatment of malaria in Uganda. Different ethnobotanical surveys on medicinal plants with antimalarial properties have been conducted across different geographical regions in Uganda in order to...

Author(s): Clement O. Ajayi, Anthony A. Elujoba, Félicien M. Kasali, Mercy G. Tenywa, Hedmon Okella, Anke Weisheit, Casim U. Tolo and Patrick E. Ogwang  

Development and validation of UV- Spectrophotometric and RP-HPLC method for the analysis of raw material and formulations of Aceclofenac

September 2020

The purpose of the study is to develop and validate method for assay of Aceclofenac in tablet dosage forms using ultra violet spectrophotometry (UV) and high performance liquid chromatography (HPLC) techniques. A method was developed and validated for analysis of Aceclofenac using UV technique with methanol and phosphate buffer 7.4 as solvent. The HPLC analysis was conducted using two mobile phases, that is,...

Author(s): Tahir Jamshaid, Syed Saeed ul Hassan, Hammad Ahmed, and Muhammad Khalil ur Rehman

Hepatoprotective and free radical scavenging activities of methanol extract fractions of Capparis decidua Edgew (Forssk.) (Capparidaceae)

September 2020

The main objective of the study is to evaluate the hepatoprotective and antioxidant activities of different extracts and fractions of a Sudanese traditionally used plant, Capparis decidua Edgwe (Forssk.) (Capparidaceae). Carbon tetrachloride (CCl4) induced hepatotoxicity in rats, and DPPH radical scavenging activity (RSA) were the methods used to evaluate the hepatoprotective and antioxidant activities of this plant...

Author(s): Mohamed Mirghani, Hassan S. Khalid, Mona S. Mohammed, Ahmed Babiker Mohamed, Amna Ali, Wadah Osman, Waleed A Alobaid and Ramzi A. Mothana  

Cardioprotective effects of animal grade piperazine citrate on isoproterenol induced myocardial infarction in wistar rats: Biochemical and histopathological evaluation

September 2020

The present study was designed to investigate the cardioprotective effect of animal grade piperazine citrate on isoproterenol-induced myocardial infarction in rats by studying cardiac marker enzymes and histopathological changes of the cardiac muscle. Isoproterenol administration showed significant (P<0.001) increase in the serum levels of cardiac injury markers (creatine kinase-MB and troponin-I), 358.98 ±...

Author(s): Ghasi, S. I., Umana, I. K., Ogbonna, A. O., Nwokike, M. O. and Ufelle, S.  

Investigation of hemotoxicologic potential of an ayurvedic preparation “Kutajarista” used in Sprue syndrome after chronic administration to male Sprague-Dawley rats

September 2020

The ayurvedic medicinal system is the world’s most primitive medical systems which were originated in India. For the treatment of Sprue syndrome, a very well-known ayurvedic preparation named Kutajarista (KTJ) is used in the south Asian region. This study aimed to detect the impact of chronic administration of KTJ on hematological parameters. The experimental animals were subdivided into two groups. A high dose...

Author(s): Mohammad Tohidul Amin, Kaniz Fatema, Palash karmakar, Md. Abdur Rahman, Tazmel Haque and M. Shahabuddin Kabir Choudhuri  

Neuroprotective effects of methanol extract of Terminalia macroptera leaf in mice

September 2020

The plant Terminalia macroptera has been reported to possess many pharmacological activities. The aim of the present study was to screen the effect of the methanol extract of T. macroptera against ketamine-induced mice model of psychosis and the apomorphine climbing test. The behavioural studies entailed an evaluation of locomotor activity, stereotypic behaviours in the open field and stereotypic climbing behaviour,...

Author(s): Lydia Doosuur Ior, Sunday Oritsetimenyin Otimenyin and John Stephen Gushit  

Cytotoxic, antimicrobial and antioxidant activities and phytochemical analysis of Artemisia judaica and A. sieberi in Saudi Arabia

September 2020

Cancer and microbial infectious diseases are considered a global threat. Plants have been investigated across the world to exploit their potential anticancer and antimicrobial effective agents. In this study, two medicinal plant species native to Saudi Arabia, namely; Artemisia judaica and Artemisia sieberi were screened to assess their antioxidant, anticancer and antimicrobial potential activities as well as...

Author(s): Fahd A. Nasr, Omar M. Noman, Ramzi A. Mothana, Ali S. Alqahtani and Abdullah A. Al-Mishari  

Assessment of the antioxidant and antimicrobial activities of Caralluma deflersiana growing in the South of Saudi Arabia

September 2020

Reactive oxygen species and oxidative stress are related to a large number of human degenerative diseases. Consequently, plants have been investigated across the world to exploit their potential antioxidant and antimicrobial activities. In the current study, Caralluma deflersiana is native to Saudi Arabia and was screened to assess its antioxidant and antimicrobial potential activities as well as the phenolic...

Author(s): Mona Nasser BinMowyna and Muneer Mohammed Alsayadi  

Assessment of anti-hepatitis B virus activity of endemic medicinal plants from Socotra Island

September 2020

Hepatitis B virus (HBV) is a leading cause of liver disease and a possible worldwide source of severe morbidity and mortality. The current standard therapy using interferons or antiviral agents is not successful in all cases and is associated with severe side effects. Consequently, the development of new medicines for the treatment of HBV is still relevant. This experimental study was therefore performed to assess the...

Author(s): Ramzi A. Mothana, Ahmed H. Arbab, Mohammad K. Parvez and Mohammed S. Al-Dosari  

Assessment of acute and sub-chronic toxicity of Camellia hakodae Ninh leaves aqueous extracts in experimental animals

August 2020

Camellia hakodae Ninh (CHN) is an ornamental plant of Vietnam, whose extracts is used as a potential phytotherapeutic beverage due to its good improvement in the immune system, reduction of inflammation and assisting the treatment of some chronic diseases. CHN production may be useful for health during this coronavirus epidemic period. This study aimed to evaluate the safety, acute and sub-chronic toxicity of aqueous...

Author(s): Hong Hanh Nguyen, Hoang Ngan Nguyen and Van Cuong Truong  

Pharmacognostic and toxicological evaluation of the leaves of Piper guineense Schum. and Thonn (Piperaceae)

August 2020

The leaves of Piper guineense Schum. and Thonn (Piperaceae) are used in ethnomedicine for the management/treatment of various diseases. The objective of this study was to establish the pharmacognostic and toxicological profiles of P. guineense to help practitioners in making choices, and to assist scientists involved in the research of the Piper genus. The fresh leaves were examined for their macroscopic and microscopic...

Author(s): Tavs A. Abere ⃰, Mumuni Sumaila and Obi Ifeoma Stephanie  

Assessment of household knowledge, attitude and practices on disposal methods of expired and unused medicines among residents of Lusaka City, Zambia

August 2020

Medicines play an important role in treating different diseases and conditions, but when left unused or to expire at home and improperly disposed, they may cause environmental pollution and can be hazardous to health. In this study, assessment of household knowledge attitude and practices on disposal methods of expired and unused medicines among residents was done in selected areas of Lusaka City, Zambia. This was...

Author(s): Martin Kampamba, Martin Nyirenda, Hanzooma Hatwiko, Davies Kampamba and Christabel Nangandu Hikaambo  

Prevalence and gene sequencing of extended spectrum β-lactamases producing Salmonella enterica serovar. Typhi from South-East Nigeria

August 2020

Enteric fever is a systemic disease classified into typhoid and paratyphoid fever. Fluoroquinolones and third generation cephalosporins are usually the drugs of choice in the management of Salmonella infections. Previous reports have indicated common occurrence of multi-drug resistance (MDR) including resistance to β-lactams and fluoroquinolones. However, there is paucity of information on the genetic determinants...

Author(s): Nathaniel Ejikeme Onyenwe, Nnabuike Didacus Nnamani, Jude Chidi Okoro, Chioma Nnenna Nwofor and Christiana Jesumirhewe  

Toxicological potential of ethanol extract of stem bark and Croton heliotropiifolius (Euphorbiaceae)

August 2020

Croton heliotropiifolius is an endemic specie in northeast of Brazil. It is renowned for its medicinal properties, larvicidal, insecticidal and cytotoxic activity. This study evaluated the phytochemical screening of ethanolic extract stem bark of C. heliotropiifolius (EECroton) and the toxicological potential in Swiss albino mice. Phytochemical analysis were performed by thin-layer chromatography. The EECroton at 2000...

Author(s): Willams Alves da Silva, Kristiana Cerqueira Mousinho, Mary Anne Medeiros Bandeira, Marcos Aurélio Santos da Costa, Renatha Claudia Barros Sobreira, Tainá Maria Santos Silva, José Gildo da Silva, Sandrine Maria de Arruda Lima, Luciano Souza de Lima, Roberta M Leite Lima and Sônia Pereira Leite  

Prescribing pattern of medications prescribed to outpatients based on WHO prescribing indicators in Ethiopia: A systematic review and meta-analysis of observational studies

August 2020

Poor prescribing pattern is observed and become a serious problem in the world including developing countries. In Ethiopia, several studies showed that health care institutions did not meet WHO prescribing indicators and the prescribing pattern is not satisfactory in the health care institutions. This study aimsto review the prescribing pattern of medications prescribed to outpatients based on WHO prescribing indicators...

Author(s): Wondim Ayenew, Getahun Asmamaw and Atsede Getaneh  

Comparative analysis of biopharmaceutic classification system (BCS) based biowaiver protocols to validate equivalence of a multisource product

August 2020

Biopharmaceutic classification system (BCS) is a substantial part of drug designing and generic product development and has been accepted as a technique to renounce in-vivo pharmacokinetic evaluation (biowaiver). It appeared to be worthwhile and time-saving by means of in-vitro studies in the presence of biorelevant physiological mediums that mimic not only the predictable solubility but also permeability of the...

Author(s): Farah Khalid, Syed Muhammad Farid Hassan, Madiha Mushtaque, Rabia Noor, Sana Ghayas, Iyad Naeem Muhammad and Fouzia Hassan  

Antibacterial activities of Camellia sinensis plant extracts against uropathogenic E. coli in vitro and in vivo

July 2020

This study evaluated the in vitro and in vivo antibacterial activities of methanol and ethyl acetate extracts of Camellia sinensis (Green tea) against Escherichia coli implicated in urinary tract infections. Antibacterial activities of these plant extracts were tested against 10 multi-drug resistant E. coli isolates obtained from clinical specimens of UTI patients. Forty-five (45) Wister albino rats were used for this...

Author(s): Agbom J. N., Ogbu O., Iroha I. R., Moses I. B., Onuora A. L., Kalu A. C., Nwakaeze E. A., Mohammed D. I., Oke B., Egwu I. H., Ajah P. M.,  Okorie C. C. and Okata-Nwali O. D.  

Levels of red blood cells derived microparticles in stored erythrocyte concentrate

July 2020

There is increasing evidence of the clinical importance of microparticles (MPs) and their role in blood transfusion-related side effects and the transmission of pathogens. The study aims to examine the red blood cell-derived MPs in blood bags during storage under standardized blood bank conditions. The samples were tested at various times to demonstrate the presence of RBC-derived MPs by flow cytometry. The quantitative...

Author(s): Maheen Rana, Yasir Arfat, Omar Naseem, Nazish Mazari, Navida Manzoor, Rao Salman Aziz, Muhammad Rashid and Shahida Mohsin

Morbidity rate of drug-susceptible tuberculosis and its medico-economic impact

July 2020

This assessment aims to identify the increasing number of morbidity of drug susceptible tuberculosis (TB) and its treatment outcomes, government cost of medicines as well as the economic impact on society. A retrospective observational study had been conducted in a government hospital using a patient’s record from 2013 to 2017, treated under the Direct Observed Therapy Short Course (DOTS) program in Karachi,...

Author(s): Rida Masood, Iyad Naeem Muhammad, Sidra Kanwal Ali, Madiha Mushtaque, Tuba Siddiqui, Farah Khalid and Aatka Ali,  

Jatropha dioica, an Aztec plant with promising pharmacological properties: A systematic review

July 2020

Few pharmacological and toxicological studies have been conducted to demonstrate the usefulness and safety of using the Jatropha dioica extract. The aim of this study was to update the state of the art on the chemical composition, pharmacology, and toxicology of the species J. dioica, to find new possible applications. A search of different databases was carried out on the internet, specifically in Science Direct,...

Author(s): Agustina Ramírez-Moreno,, Dealmy Delgadillo-Guzmán, Verónica Bautista-Robles, Jolanta E Marszalek, Hady Keita,, Ansoumane Kourouma, Sergio Alberto Ramírez García, Jesús Rafael Rodríguez Amado, and José Carlos Tavares-Carvalho  

Prescribing errors among family and community medicine center in Riyadh, Saudi Arabia

July 2020

Prescribing errors are common. Available data on these errors, particularly in family community centers in Saudi Arabia, presents a problem that must be addressed. The aim of this study is to investigate the rate and types of prescribing errors at an ambulatory care setting in Riyadh, Saudi Arabia. Data were collected to cover a 12-month period. A prospective review of hand-written prescriptions was made by a trained...

Author(s): Norah Abanmy, Fatimah Alrowibah, Lobna Al Juffali, Ebrahim Assiri and Mostafa Kofi  

Bioactivities of stem bark of Albizia chinensis Osbeck. Merr., Chakua Koroi of Bangladesh

July 2020

Albizia chinensis Osbeck. Merr. (Family: Fabaceae) is quite abundant in Bangladesh. The plant has a history of its traditional use in scorpion and snake bite. This investigation was designed to analyze the analgesic, anti-diarrheal and anti-inflammatory potentials along with sleep inducing property of the crude methanol extract of stem bark of Albizia chinensis Osbeck. Merr. Peripheral analgesic activity was evaluated...

Author(s): Tasnuva Sharmin and Mohammad A. Rashid  

Phytochemical screening and toxicological effects of Amblygonocarpus andongensis aqueous stem bark extract in wistar albino rat

June 2020

Amblygonocarpus andongenesis is being used as antipsychotic. Hence, it may portend high risk of toxicosis. In view of this, phytochemical screening and toxicological effects of aqueous stem bark extract of the plant was studied in wistar albino rats. Qualitative screening of the stem bark extract revealed the presence of alkaloid, hydrolysable tannin, saponin, glycoside, cardiac glycoside, saponin glycoside and...

Author(s): Abdullahi Aliyu Ebbo, Abdullahi Teleh Elsa, Emmanuel Udok Etuk, Muhammad Jengebe Ladan and Saganuwan Alhaji Saganuwan

Nutrients in Amazonian fruit pulps with functional and pharmacological interest

June 2020

In this research, nine fruits cultivated in Northern Amazon were studied: Abiu, acerola, araçá, bacupari, biribá, camu-camu, fruta-do-conde, graviola and taperebá, with the objective of carrying out a proximate and nutritional study of the pulps of the Northern Amazon fruits. They were graviola (76.83 ± 0.02 Kcal 100 g-1), bacupari (53.15 ± 0.02 Kcal 100 g-1) and fruta-do-conde...

Author(s): Montero I. F., Saravia S. A. M., Santos R. A., dos Santos R. C., Marcía J. A. F. and da Costa H. N. R.  

Nutritional characterization pulp of Chrysobalanus icaco L.

June 2020

After Southeast Asia, Brazil is the second largest producer of tropical fruits having more than 500 species, and many of these have high potential regarding nutritional content that can be marketed. Among them, Chrysobalanus icaco L., which can be found in abundance in several countries of South America stands out. Among its nutritional profile, it had low value of titratable acidity (0.41 ± 0.02%) and lipid...

Author(s): Selvin Antonio Saravia Maldonado, Ismael Montero Fernández, Luis Antonio Beltrán Alemán, Ricardo Santos Alemán and Jhunior Abrahan Marcia Fuentes  

Prevalence and the level of evidences supporting off-label prescribing of antidepressant, antipsychotic and antiepileptic drugs in Makkah Almukarramah: A case sectional study

June 2020

Off-label prescribing is very common among physicians, particularly among psychiatrists and there is limited information regarding the extent of the unapproved drug use in Makkah city. The objective of this study was to assess the prevalence of off-label indications for antidepressant, antipsychotic and antiepileptic and the strength of evidence supporting use of the prescribed drug for the respective indication. A case...

Author(s): Yosra Al-Hindi, Amal Al-sulami, Aseel Al-ghamdi, Nuha Al-Harbi, Huda Hamdi , Shooq Al-moqati, Yara Abualkair and Arwa Fairaq  

Haematology, serum biochemistry and histopathological findings associated with sub-chronic administration of methanol leaf extract of Pterocarpus santalinoides DC in albino rats

June 2020

The effects of sub-chronic administration of Pterocarpus santalinoides methanol leaf extract (PSME) on haematology, serum biochemistry and histology of albino rats were evaluated. Twenty female albino rats, randomly assigned into four groups (A-D) of five rats each, were used for the study. Groups A-C were treated orally with 500, 250 and 50 mg/kg PSME, respectively, while Group D was given distilled water as placebo at...

Author(s): Thelma Ebele Ihedioha, Isaac Uzoma Asuzu, Aruh Ottah Anaga and John Ikechukwu Ihedioha

Designing polyethylene oxide and hydroxypropyl methylcellulose matrix tablets with comparable dissolution properties

May 2020

PolyoxTM coagulant (molecular weight 5 × 106 Da) and hydroxypropyl methylcellulose (HPMC) K4M (USP substitution type 2208) were used to identify the composition variables that ensure the production of polyethylene oxide (PEO) matrix tablets with the same dissolution characteristics as those containing HPMC. Based on the dissolution results obtained using Apparatus 3, a 53% concentration of PEO polymer in the...

Author(s): Petra Draksler, and Biljana Janković,  

Comparative effect on liver fibrosis of bicyclol and silymarin

May 2020

Bicyclol and silymarin are widely used in the treatment of various liver diseases; however, there is no report on comparative effect of them on liver fibrosis. To compare their liver protective effect, liver fibrosis rats induced by bile duct ligation (BDL) were orally treated with 100 mg/kg bicyclol and 100 mg/kg silymarin respectively for 4 weeks. Liver index, liver function activities, inflammatory biomarkers,...

Author(s): Liping Wang, Li Zhang, Kelan Gan, Xiaoping Hua, Ying Xiao, Yikun Shi and Zhenghuai Tan  

Chemical characterization of seeds of Amazon fruits as nutritional contribution with functional medicinal potential

May 2020

The fruit seeds of the Northern Amazon Region were evaluated bromatologically and nutritionally in terms of the level of macro- and micro-elements and fatty acids present in them. Bromatologically, the seeds of camu-camu (369.08 kcal 100 g-1) and biribá (364.78 kcal 100 g-1) have the highest energy value. In terms of the macroelements, the highest concentration was potassium (554.23 mg 100 g-1) seen in graviola,...

Author(s): Ismael Montero Fernández, Selvin Antonio Saravia Maldonado, Vany Perpetua Ferraz, Ricardo Santos Alemán, Jhunior Abrahan Marcia Fuentes and Antonio Alves de Melo Filho

The potential cardioprotective effects of Febuxostat versus Cilostazol on Isoproterenol induced cardiac dysfunction in rats

May 2020

Myocardial infarction causes an acute condition of necrosis of the myocardium resulting in increased production of free radicals and decreased levels of antioxidants. It was proposed that Febuxostat reduced myocardial oxidative stress and suppressed apoptosis. Cilostazol used to treat claudication has a growing evidence, suggesting that Cilostazol could be cardioprotective. This work aims to highlight the potential...

Author(s): Ayman Helal, Sawsan Sadik and Eman Hussein  

Biological activities of Bonsupari (Caryota urens L.) fruits

April 2020

In Asian subcontinent, Caryota urens L. plant is well known. Its leaf has antioxidant and antimicrobial properties. The work aims to analyze the composition of the plant’s fruit extract and its aqueous and organic soluble fractions for its cytotoxic, thrombolytic, antioxidant, membrane stabilizing and antimicrobial properties. 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity assay,...

Author(s): Tasnuva Sharmin, Md Shahidur Rahman, Sirajis Salekin and Kamrun Nahar  

Chemical composition of essential oil of Melissa officinalis L. and antioxidant activity from Boa Vista-RR, Brazil

April 2020

In this work, the chemical composition of the essential oil of lemon balm (Melissa officinalis L.) was determined by CG-FID.In the essential oil of M. officinalis,there area total of 22 chemical constituents, among them are geranial (34.6%), neral (26.0%), γ-caryophyllene (7.5%), caryophyllene oxide (5.3%), -pinene (5.3%) and sabinene (3.6%); it also has antioxidant capacity and total phenolic compounds in...

Author(s): Ismael Montero Fernández,  Pedro Rômulo Estevam Ribeiro,  Selvin Antonio Saravia Maldonado, Vany Perpetua Ferraz, Ricardo Santos Alemán, Jhunior Abrahan Marcia Fuentes and Luis Antonio Beltrán Alemán  

A preliminary study to assess knowledge, preferences, and perception of adult population of Karachi about scored and colored oral solid dosage form

April 2020

Beyond the pharmacological activity, the differences have been observed in the preferences of solid dosage form on the basis of color and swallowing difficulty in the studies conducted by a different researcher. The aim of the study is to insight the perception of the general population of Karachi about the color, scoring and splitting of tablets. A convenience sampling technique was used to collect data. Knowledge,...

Author(s): Aatka Ali, Madiha Mushtaque, Sarah Jameel Khan, Sidra Kanwal Ali, Tahmina Maqbool, and Rida Masood  

Antihyperglycaemic and antioxidant activities of Sansevierialiberica as justification for its antidiabetic claims

April 2020

Diabetes has become a global emergency because of its high prevalence, morbidity and mortality while the available hypoglycaemic drugs possess various adverse effects and are expensive. This has necessitated a continuous search for cheaper antidiabetic agents of plant origin with fewer or no side effects. The study evaluated the antihyperglycaemic activities of the methanol extract of Sansevieria liberica Gerome and...

Author(s): Aanuolu Jesudunni Ajileye, Marcus Durojaye Ayoola, Anthony Adebolu Elujoba and Kemi Feyisayo Akinwunmi  

Antiproliferative and cytotoxic activity of Hematite (α-Fe2O3) nanoparticles from Butea monosperma on MCF-7 Cells

February 2020

Silver nanoparticles (Hematite (α-Fe2O3) have been used as an antimicrobial and as disinfectant. Nevertheless, there is limited data about its antitumor potential. This study focused on investigating the cytotoxic effects of Hematite (α-Fe2O3) from Butea monosperma flower extract on MCF-7 breast cancer cells and its mechanism of action.  Green method was created for the synthesis of Hematite...

Author(s): B. Behera, S. Pradhan, A. Samantaray and D. Pradhan  

Histopathological and genetic study on the protective role of β-Carotene on testicular tissue of adult male albino rats treated with titanium dioxide nanoparticles

January 2020

Titanium dioxide nanoparticles are one of the famous widely produced nanoparticles in the world that are widely used in paints, cosmetics, plastics, pharmaceutical preparations, water treatment and purification and filtration of air. Beta carotene is provitamin A carotenoid with antioxidant and anti-apoptotic activities. The aim of this study is to evaluate the histopathological changes that occur in the testicular...

Author(s): Amira Hamed Mohamed Soliman, Ibrahim Amin Ibrahim, Mohammed Ahmed Shehata and Heba Osama Mohammed  

Page 1 of 45, showing 50 records out of 2213 total, starting on record 1, ending on 50