Chemical characterization of seeds of Amazon fruits as nutritional contribution with functional medicinal potential
May 2020
The fruit seeds of the Northern Amazon Region were evaluated bromatologically and nutritionally in terms of the level of macro- and micro-elements and fatty acids present in them. Bromatologically, the seeds of camu-camu (369.08 kcal 100 g-1) and biribá (364.78 kcal 100 g-1) have the highest energy value. In terms of the macroelements, the highest concentration was potassium (554.23 mg 100 g-1) seen in graviola,...
Comparative effect on liver fibrosis of bicyclol and silymarin
May 2020
Bicyclol and silymarin are widely used in the treatment of various liver diseases; however, there is no report on comparative effect of them on liver fibrosis. To compare their liver protective effect, liver fibrosis rats induced by bile duct ligation (BDL) were orally treated with 100 mg/kg bicyclol and 100 mg/kg silymarin respectively for 4 weeks. Liver index, liver function activities, inflammatory biomarkers,...
Designing polyethylene oxide and hydroxypropyl methylcellulose matrix tablets with comparable dissolution properties
May 2020
PolyoxTM coagulant (molecular weight 5 × 106 Da) and hydroxypropyl methylcellulose (HPMC) K4M (USP substitution type 2208) were used to identify the composition variables that ensure the production of polyethylene oxide (PEO) matrix tablets with the same dissolution characteristics as those containing HPMC. Based on the dissolution results obtained using Apparatus 3, a 53% concentration of PEO polymer in the...
The potential cardioprotective effects of Febuxostat versus Cilostazol on Isoproterenol induced cardiac dysfunction in rats
May 2020
Myocardial infarction causes an acute condition of necrosis of the myocardium resulting in increased production of free radicals and decreased levels of antioxidants. It was proposed that Febuxostat reduced myocardial oxidative stress and suppressed apoptosis. Cilostazol used to treat claudication has a growing evidence, suggesting that Cilostazol could be cardioprotective. This work aims to highlight the potential...
Chemical composition of essential oil of Melissa officinalis L. and antioxidant activity from Boa Vista-RR, Brazil
April 2020
In this work, the chemical composition of the essential oil of lemon balm (Melissa officinalis L.) was determined by CG-FID.In the essential oil of M. officinalis,there area total of 22 chemical constituents, among them are geranial (34.6%), neral (26.0%), γ-caryophyllene (7.5%), caryophyllene oxide (5.3%), -pinene (5.3%) and sabinene (3.6%); it also has antioxidant capacity and total phenolic compounds in vitro....
Biological activities of Bonsupari (Caryota urens L.) fruits
April 2020
In Asian subcontinent, Caryota urens L. plant is well known. Its leaf has antioxidant and antimicrobial properties. The work aims to analyze the composition of the plant’s fruit extract and its aqueous and organic soluble fractions for its cytotoxic, thrombolytic, antioxidant, membrane stabilizing and antimicrobial properties. 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity assay,...
A preliminary study to assess knowledge, preferences, and perception of adult population of Karachi about scored and colored oral solid dosage form
April 2020
Beyond the pharmacological activity, the differences have been observed in the preferences of solid dosage form on the basis of color and swallowing difficulty in the studies conducted by a different researcher. The aim of the study is to insight the perception of the general population of Karachi about the color, scoring and splitting of tablets. A convenience sampling technique was used to collect data. Knowledge,...
Antihyperglycaemic and antioxidant activities of Sansevierialiberica as justification for its antidiabetic claims
April 2020
Diabetes has become a global emergency because of its high prevalence, morbidity and mortality while the available hypoglycaemic drugs possess various adverse effects and are expensive. This has necessitated a continuous search for cheaper antidiabetic agents of plant origin with fewer or no side effects. The study evaluated the antihyperglycaemic activities of the methanol extract of Sansevieria liberica Gerome and...
Antiproliferative and cytotoxic activity of Hematite (α-Fe2O3) nanoparticles from Butea monosperma on MCF-7 Cells
February 2020
Silver nanoparticles (Hematite (α-Fe2O3) have been used as an antimicrobial and as disinfectant. Nevertheless, there is limited data about its antitumor potential. This study focused on investigating the cytotoxic effects of Hematite (α-Fe2O3) from Butea monosperma flower extract on MCF-7 breast cancer cells and its mechanism of action. Green method was created for the synthesis of Hematite...
Formulation and enhancement of dissolution rate of poorly aqueous soluble drug Aceclofenac by solid dispersion method: In vitro study
January 2020
Solid dispersion technique was successfully used to enhance the dissolution of poorly aqueous soluble drugs aceclofenac. Four carriers Hydroxyl propyl methylcellulose (HPMC), polyvinyl alcohol (PVA), Mannitol and Dextrose in two ratios (1:2, 1:3 w/w) were used to prepare solid dispersion. Eight different formulations were designed by the varying carrier and the drug: Carrier ratio and solvent wetting method was used for...
Histopathological and genetic study on the protective role of β-Carotene on testicular tissue of adult male albino rats treated with titanium dioxide nanoparticles
January 2020
Titanium dioxide nanoparticles are one of the famous widely produced nanoparticles in the world that are widely used in paints, cosmetics, plastics, pharmaceutical preparations, water treatment and purification and filtration of air. Beta carotene is provitamin A carotenoid with antioxidant and anti-apoptotic activities. The aim of this study is to evaluate the histopathological changes that occur in the testicular...
Evaluation of pharmaceuticals in household waste in Senador Canedo, State of Goiás, Brazil
January 2020
The disposal of pharmaceuticals has become a problem for society and public health and causes risks to the environment. Therefore, the objective of this work was to evaluate the number of pharmaceuticals and the classes of the most discarded pharmaceuticals in household waste in Senador Canedo, Goiás, Brazil. The study was conducted in Senador Canedo, GO, Brazil (16° 42' 28'' S, 49° 5'...
Anti-inflammatory and analgesic activities of extracts from Balanites aegyptiaca L. Delile (Balanitaceae) root bark: Plant used against liver diseases in Bukina Faso
December 2019
Balanites aegyptiaca (L.) Del has been used in various traditional medicines against inflammation and pain. The aim of this study was to evaluate the enzymatic, anti-oedmeatous and analgesic activities of ethanolic and aqueous extracts of Balanites aegyptiaca (L.) Del root bark in mice. The extracts were tested in vitro for their ability to inhibit the enzymes cyclooxygenase (COX)-1 and COX-2, 15-lipoxygenase (LOX) and...
Non-adherence to statins therapy and its impact on cardiac morbidity and mortality: A metanalysis
December 2019
Dyslipidemia is a major risk factor for cardiovascular disease, the leading cause of death worldwide. Statins have been shown to significantly reduce morbidity and mortality in patients with coronary artery disease and in patients with hyperlipidemia. However, there is a significant gap between expected and actual benefits; this may be attributed to poor adherence to statin therapy. Literature search was conducted by...
Hepatoprotective and antioxidant activities of Pterocarpus santalinoides methanol leaf extract
December 2019
This study evaluated the hepatoprotective and antioxidant activities (AA) of Pterocarpus santalinoides methanol leaf extract (PSMLE) on carbon tetrachloride (CCl4)-induced hepatotoxicity in albino rats. Thirty male albino rats randomly assigned into 6 groups (A – F) of 5 rats each were used for the in vivo study. Hepatotoxicity was induced in groups A – E using CCl4. Group A served as negative control....
Therapeutic effectiveness assessment of antiviral drugs used in chronic hepatitis treatment in three Ivorian university hospitals
December 2019
This work aims to evaluate the effectiveness of drugs used for the management of chronic viral hepatitis in the three major university hospitals in Abidjan. This is a retrospective cross-sectional descriptive study of 203 patients investigated for treatment protocols, patient parameters before and after treatment. It emerged that treatment with pegylated Interferon alpha 2a resulted in a significant decrease in viremia...
Phytochemical analysis and in vitro antibacterial evaluation of leaf and bark extracts of Alstonia boonei
November 2019
The antibacterial effect of the leaf, bark and leaf and bark combined of Alstonia boonei on bacterial pathogens, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumonia, Proteus mirabilis, Klebsiella pneumonia, Shigella dysenteriae and Salmonella typhimurium was determined using agar diffusion technique to investigate their efficacy as anti-bacterial agent. The phytochemical components...
Acquaintance of Botox: A cross-sectional survey among female students in Karachi, Pakistan
November 2019
The cosmetic treatment strategies have been considerably popular over the last few decades among the population with respect to age, gender, and ethnicity. These procedures are easily accessible safer, minimally invasive, and more precise. Botox therapy is one of the most common non-surgical cosmetic treatment. Thus, the current study was accomplished to assess the knowledge of female students towards Botox therapy for...
Evaluation of the immunomodulatory properties and microbial bioburden of three commercial herbal mixtures sold in Awka, Anambra State Nigeria
November 2019
The consumption of herbal medicine and herbal medicinal products has been on the rise lately. This has led to an increase in research on herbal medicine and its different formulations to gain more knowledge in their constituents, therapeutic effects, its mechanism, and their undesired or toxic effects. The purpose of this study was to evaluate toxicity profile, phytochemical constituents, microbial quality and...
Cytotoxic effects on MCF-7 breast cancer cell lines, phenol and flavonoid contents, high performance liquid chromatography (HPLC) analysis and antioxidant activity of Maerua pseudopetalosa (Gilg and Bened) De Wolf fractions
November 2019
Maerua pseudopetalosa (Gilg and Bened.) De Wolf tubers which are used traditionally as antitumor agent in Sudan were subjected to separation by column chromatography technique. Eight fractions were obtained for the ethyl acetate extract and twelve for the ethanolic extract. The ethanolic fractions F8, F9, F11 and F12, with high bioactivity were subjected to further investigations....
Tremendous health benefits and clinical aspects of Smilax china
October 2019
A lot of species of Smilax known as Baqia in China are used in folk medicine for various purposes. Smilax china L., is a small vine that grows in the southern parts of China, known as Jin Gang Ten, which has a long history of indigenous use in China. S. china consists of fat, saponins, glucosides, gum, starch, flavonoids, tannins, and alkaloids. S. china has been used in traditional Chinese medicine because it has...
Effect of the anticancer drug tamoxifen on chronic toxoplasmosis in experimentally infected rats
October 2019
Toxoplasma gondii is an opportunistic parasite that can cause severe disorders in infants and pregnant women and can also be lethal in immunologically compromised individuals. During unfit host immune conditions, and as a consequence to latent stage opportunity, the protozoan stimulates serious infection, and signifies higher morbidity and mortality including humans with Acquired Immuno-Deficiency Syndrome (AIDS) or...
Prevalence and indication of gabapentin and pregabalin prescriptions among adults in King Abdulaziz Hospital in Makkah AL-Mukarramah, KSA
October 2019
Gabapentin and pregabalin prescribing have increased substantially over the recent years. Some evidence supports that gabapentin and pregabalin use in non-neuropathic pain disorders indicates they are less effective than several other licensed non-opioid analgesics. On the other hand, other studies have shown that those drugs are to be beneficial in the treatment of non-neuropathic pain and improves the analgesic...
Pharmaceutical polymorphisms and its influence on the dissolution profile of two pioglitazone brands
October 2019
1Pharmacognosy Laboratory,Faculty of Chemical Sciences, Juarez Durango State University, Mexico. 2Technology and health laboratory, Academic Coordination Altiplano Region, Autonomy University of San Luis, Potosi, Mexico.
Evaluation of hypoglycemic activity and safety of Carica papaya seed extracts in alloxan-induced diabetic mice
October 2019
Carica papaya is used for the treatment of many diseases such as stomach upsets, diarrhoea, bilharzia, diabetes. The study aims to evaluate the safety and hypoglycemic potential effect of Carica papaya seeds on alloxan induced diabetic mice. DCM extracts were examined for the presence of terpenoids, flavonoids, steroids, phenols, tannins and alkaloids. Toxicity profile was established at 5, 50, 200, 300 and 2000 mg/kg...
Canvassing of biological attributes by In vitro screening of Canarium bengalense
September 2019
Various Hoang family remedies known as Dai-Thien-Nuong, utilize Canarium bengalense Roxb. (Family: Burseraceae) as a major component for the treatment of tumor and liver damage. This study was performed using the crude methanol extract of C. bengalense Roxb. bark and its petroleum ether, carbon tetrachloride, dichloromethane and aqueous soluble fractions for antioxidant, cytotoxic, thrombolytic, membrane stabilizing and...
Tolerance and observance of methotrexate in the treatment of rheumatoid arthritis at the university Hospital Bogodogo, Burkina Faso
September 2019
This study is aimed at assessing tolerance and observance of the patients with RA (rheumatoid arthritis) treated by methotrexate at University Hospital Bogodogo, in Burkina Faso. A cross-sectional study was conducted from July to September 2015 in outpatients with rheumatoid arthritis monitored in rheumatology service. Data were obtained from interview, by reviewing medical cards of the patients and consultation report...
Use of medicinal plants for the treatment of gastric ulcer in some parts of Southwestern Nigeria
September 2019
Ulcer is erosion in the lining of the stomach or duodenum. It is caused by disruption of the gastric mucosal defense and repair systems. There has been much interest in natural medicines derived from traditional knowledge of pharmacological properties of plants recently. The major aim of this study was to conduct an ethnobotanical survey of plants used in the treatment of Gastric ulcers in some local government areas of...
Effects of methanolic tuber extract of Cyperus esculentus Linn (tiger nuts) on sub-acute liver damage in albino rats
September 2019
This study evaluated the effects of Cyperus esculentus methanolic tuber extract (CEME) on carbon tetrachloride (CCl4)-induced sub-acute liver damage in albino rats. Dried tubers of C. esculentus were pulverized and extracted by cold maceration, using 80% methanol. Thirty albino rats, randomly assigned to 6 groups (A–F) of 5 each were used for the study. Sub-acute liver damage was induced in Groups A-E rats using...
24 h pre-incubation of EA.hy926 cells with angiotensin II regulates insulin-dependent activation of eNOS in a concentration-dependent manner
September 2019
The rennin-angiotensin II system (RAS) and the insulin-PI3kinase signalling pathways cross-interact with important physiological and pathophysiological consequences for cells and the whole organism. Here, the effect of 24 h pre-incubation of EA.hy926 with two different concentrations of angiotensin II, on insulin-mediated activation of the PI3kinase-AKT-eNOS signalling was investigated. Quiescent EA.hy926 cells were...
Antioxidant and cicatrizing activity of the species Abarema cochliacarpos (Gomes) Barneby & J. W. Grimes
August 2019
In equine clinics, skin injuries are some of the most frequently treated injuries, this research evaluated the healing potential and antioxidant activity of Abarema cochliacarpos in order to develop a pharmaceutical formulation for treating skin lesions in horses. Firstly, the antioxidant activity of several fractions was evaluated using the 2,2-diphenyl-1-picrylhydrazyl radical method and the thiobarbituric acid test....
Acute toxicity evaluation of ethanolic extract of the air parts of Sida rhombifolia L., in wistar rats
August 2019
Sida rhombifolia L., popularly known in Brazil as "SIDA" or "mata-pasto", is considered a weed; a plant of the American continent and widely distributed in North Africa, belongs to the Malvaceae family. In Brazil, S. rhombifolia L. is scattered throughout the national territory, infesting agricultural crops. Certain species of the genus Sida, including S. rhombifolia, are widely used in Indian,...
Efficacy of transurethral resection of prostate in patients of benign prostatic hyperplasia with lower urinary tract symptoms
August 2019
Transurethral resection of the prostate (TURP) has been the prime procedure for decenniums to treat benign prostatic hyperplasia (BPH), but is mainly predicated on historic data that lacks utilization of validated measures. It is noteworthy that TURP done nowadays significantly differs from that performed 30 years ago. Men who had undergone TURP between 2013 and 2018 were reviewed. 50 patients presented in the...
Antibacterial activities of three medicinal plant extracts and their synergistic effect on Staphylococcus aureus isolated from burn wounds
August 2019
This study was undertaken to investigate the antibacterial activities of three medicinal plant extracts and their synergistic effect on Staphylococcus aureus isolated from burn wounds. A total of 50 swab samples of burn wounds were collected from burn wound patients attending Federal Teaching Hospital Abakaliki and screened for S. aureus using standard microbiological techniques. Three plant materials (Cucurbita pepo...
Sciatica: Medical treatment or Physiotherapy?
August 2019
Low back pain is usually self-limiting. It has a sizeable impact on patients, and is associated with high healthcare and societal costs as much as $16 billion each year. Patients are commonly treated in primary care but a small proportion is referred to secondary care and may eventually have surgery. There are numerous treatment approaches for sciatica. Many people receive only medical treatment and are unaware of the...
Phytochemical analysis and investigation of sedative-hypnotic activity of methanolic stem bark extract of Ficus abutilifolia in mice
July 2019
Most of the sedative drugs cause dose-dependent depression of the central nervous system (CNS) leading to hypnosis and possibly anaesthesia, however, these agents are associated with some side effects ranging from digestive, respiratory, immune system dysfunctions, cognitive function deterioration, tolerance, and physical dependence, hence investigations of newer and safer agents is therefore imperative. The current...
Aflatoxin M1 in cheese samples from the Amazon Region
July 2019
Aflatoxin M1 (AFM1) is a mycotoxin that can be found in cheeses and makes the monitoring of this food of public health interesting. In Brazil, the Amazon region has a cattle herd with dairy production of cheese, and an evaluation of the food and its risk to the population is required. The objective of this study was to evaluate the levels of AFM1, moisture content (mc) and water activity (aw) in different cheeses types,...
Evaluation of anthelmintic activity of ethanolic extracts of Carica papaya leaves using Paramphistomum cervi and Haemonchus contortus
July 2019
The aim of this present study is to evaluate the anthelmintic activity of leaves extracts of Carica papaya using Paramphistomum cervi and Haemonchus contortus as the test worms. A range of concentrations (100, 50 and 25%) of ethanolic extracts of C. papaya were tested to assay the procedure. This is mainly applied for the determination of time of death (D) and time of paralysis (P) of the tested worms. After the...
Rational and experiential decision-making preferences of pharmacy students in Karachi, Pakistan
July 2019
This study was conducted to examine the rational (systematic and rule-based) and experiential (fast and intuitive) thinking preferences of pharmacy students. This may assist in formulating learning and teaching tactics for decision-making leading to safe and optimized patient care services. Here, a validated psychometric tool, that is, the Rational Experiential Inventory (REI-40) survey was used. It was distributed to...
Sex differences in the neuroprotective effect of insulin against chemically-induced convulsions in mice
June 2019
Insulin, an important regulator of peripheral metabolism, has been reported to interact with many neurotransmitter systems including those associated with convulsion. The effect of insulin against pentylenetetrazole and strychnine-induced convulsions in mice, as well as possible sex differences, were evaluated in this study. Mice of both sexes weighing between 20 and 25 g were administered insulin intraperitoneally at...
Effect of amodiaquine on the pharmacokinetics of gliclazide in diabetic subjects
June 2019
The study aims at investigating the effect of amodiaquine on the pharmacokinetic profile of gliclazide. It is a one-way single dose cross-over study in two phases. Six freshly diagnosed diabetic volunteers were used. The subjects acted as their own control, and each phase was preceded by an overnight fast. Phase 1 of the study involved the administration of a single oral dose of 80 mg of gliclazide after an overnight...
Nanotechnology: A non-invasive diagnosis and therapeutic tool for brain disorders
June 2019
Presently, nanotechnology appears as a powerful and innovative tool in the medical field. It has various advantages over the conventional drug therapy such as therapeutic specificity, has less side effects, reduces dose of drug, has more precise treatment and can access the inaccessible areas of the body like brain, tumor cells, etc. The human brain is the most complicated part of the body which is highly protected with...
Myorelaxant effect of aqueous root bark extract of Carissa edulis (Forssk.) Vahl. is mediated through activation of nitric oxide synthase
June 2019
Many patients in Africa often utilize herbal medicine for the management of hyperactive gut disorders such as diarrhea and abdominal colic. There is therefore a need to scientifically evaluate efficacy of this herbal remedies. This study investigated the myorelaxant effect of Carissa edulis (Forssk.) Vahl and its possible mechanism of action using isolated rabbit jejunum preparations. Pieces of jejunum were isolated...
Flavonoids in neuropathic pain management: A new player on an old target
May 2019
Neuropathic pain is the consequence of abnormal processing in the peripheral or central nervous system (CNS) elicited by neuronal injury. Due to its heterogeneous nature and important unwanted adverse effects of the commonly prescribed psychoactive drugs like benzodiazepines (BDZ), the treatment of neuropathic pain has remained a challenge for the scientific community. Flavonoids initially isolated from plants and used...
Effects of anti-hyperglicemic of yacon leaf (Smallanthus sonchifolius) ethanolic extracts using zebrafish as a model
May 2019
This study aims to investigate the anti-hyperglicemic effects of yacon leaf (Smallanthus sonchifolius) using zebrafish. In this study, zebrafish is used as a model, with alloxan compounds to induce hyperglicemic. The induction stage consists of 3 phases: in the first the zebra was induced at 0.3% for 30 min, in the second stage, it was transferred to a 3% D-glucose solution for 30 min, and in the last, immersion was...
Effect of Parkia biglobosa extract on open skin wound healing in dexamethasone- induced hyperglycaemia and histological assessment in rats
May 2019
Glucocorticoid-induced diabetes mellitus (GIDM) is an abnormal increase in blood glucose associated with the use of glucocorticoids in a patient with or without a prior history of diabetes mellitus. This is a common and potentially harmful problem in clinical practice, affecting almost all medical specialties, but is often diffi¬cult to detect in clinical settings. The objective of this study was to determine...
Neferine and isoliensinine from Nelumbo nucifera induced reactive oxygen species (ROS)-mediated apoptosis in colorectal cancer HCT-15 cells
May 2019
Several scientific reports documented the potent anti-cancer effect of various natural products such as curcumin, epigallocatechin gallate (EGCG), resveretrol via the rise in reactive oxygen species (ROS) and dysfunction of anti-apoptotic gene expressions. The present study evaluated the anticancer potential of lotus derived alkaloids, neferine and isoliensinine on colorectal cancer HCT-15 (CRCs) cells....
Endopleura uchi (Huber) Cuatrec, a medicinal plant with potential anti-inflammatory activity: A review of its phytochemistry and biological activities
April 2019
Endopleura uchi (Huber) Cuatrec. is a tree found in the Brazilian Amazon, whose barks are used in folk medicine as an alternative treatment for inflammatory-related diseases. This review, performed using current available international scientific literature, aimed to survey biological activities reported from E. uchi, and describes its phytochemistry. In folk medicine, the barks are used to treat a range of conditions...
Medicines prescribing pattern in northern Ghana: does it comply with WHO recommendations for prescribing indicators?
March 2019
The prescribing of medicines is critical in the treatment of diseases in general practice. Inappropriate prescribing can negatively influence the goals of treatment, which makes the assessment of the patterns of prescriptions essential. The objective of this study was to assess the medicines prescribing pattern in health facilities in the Northern Ghana, a developing economy in Africa, using the prescribing indicators...
Effect of Maytenus senegalensis roots on OVA-induced airway inflammation in a mouse asthma model
March 2019
The present work is focused on the evaluation of the Maytenus senegalensis roots effect on bronchial hyperleukocytosis and the search of its antioxidant potential both in vitro and in vivo. The roots of M. senegalensis (Celastraceae) are traditionally used for the treatment of cough and asthma. This study evaluates the effect of the hydroalcoholic extract of the roots of M. senegalensis on the bronchial...
Page 1 of 44, showing 50 records out of 2173 total, starting on record 1, ending on 50
Advertisement
Advertisement
