African Journal of
Cellular Pathology

OFFICIAL PUBLICATION OF THE SOCIETY FOR CELLULAR PATHOLOGY SCIENTISTS OF NIGERIA
  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 107

AJCPath Articles

Galinsoga parviflora restored associated motor coordination through increased linear distribution of Purkinje Cells in mercury chloride-induced toxicity of mice’s cerebellum

July 2022

Mercury (Hg) is a poisonous substance associated with diseases, such as ataxia and Joubert syndrome. Therefore, it is important to find a way to disrupt the process of Hg poisoning in the cerebellum, by exploring the medicinal value of local herb such as Galinsoga parviflora (GP). This study examined the effects of aqueous leaf extract of GP in HgCl2-induced cerebellar toxicity in adult male mice. Twenty-five adult male...

Author(s): John Tabakwot Ayuba, Akeem Ayodeji Okesina, Ibe Michael Usman, Michael Kunle Ajenikoko, Theophilus Pius, Nicholas Kusiima, Saidi Odoma, and Mario Fernandez Edgar  

The study of attenuating effects of quercetin on spatial memory impairment and degenerative changes in hippocampus of lead exposed rats

May 2021

Lead neurotoxicity has been studied in animal models to induce neurodegeneration. The study was aimed to evaluate the attenuating effects of quercetin on spatial memory impairment and degenerative changes in hippocampus of lead exposed rats. Thirty (30) Wistar rats were randomly divided into six groups of five rats per group (each, n = 5). Groups I (control) and II were administered distilled water and lead,...

Author(s): Musa O. Iliyasu, Sunday A. Musa, Sunday B. Oladele and Ibrahim A. Iliya 

Effect of n-butanol extract of Cannabis sativa L. extract on the cerebral cortex of adult Wistar rats

February 2020

The present study was aimed at investigating the effect of Cannabis sativa L. administration on neurobehavior and histology of the frontal cortex ofadult Wistar rats. Eighteen (18) adult Wistar rats (120 to 140 g) were divided into three (3) groups of six (6) animals per. Animals in group 1 (control) were given 1 ml/kg distilled water, while groups 2 and 3 were administered with 250 and 500 mg/kg of n-Butanol extract of...

Author(s): Zachariah Richard, Adebisi S. Sunday, Uduak E. Umana, Adamu A. Sadeeq and Policy P. Adamu  

Phytochemical and in vitro antioxidant studies on methanol extract of Vernonia calvoana leaf and its polar fractions: Preliminary study

January 2020

This study aims to screen possible antioxidant potentials of methanol extract and polar fractions of Vernonia calvoana leaves and its phytochemical constituents since the leaves are used ethno medically in managing ailments like wounds, blood pressure, inflammation, arthritis, and bone diseases. Dried leaves (900 g) were ground and de-fatted with n-hexane. The dry marc was extracted using 80% methanol and water....

Author(s): Nwaehujor Chinaka O., and Uwagie-Ero Edwin A.  

Assessment of the effect of post-natal lead exposure on the hippocampus of developing Wistar rats

December 2019

This study examined the effect of post-natal lead exposure on the hippocampus of developing Wistar rats. Nine pregnant Wistar rats were randomly distributed into three groups of three rats each, consisting of a control Group 1 which received distilled water and experimental Groups 2 and 3 orally administered with 60 and 90 mg/kg bwt of lead acetate, respectively. The pups of the experimental Groups 2 and 3 were exposed...

Author(s): Oluwasegun Davis Olatomide, Sunday Samuel Adebisi and Sunday Abraham Musa  

A comparative study of cultural and molecular techniques for the identification of bacterial contaminants of cockroaches (Periplaneta americana)

August 2019

The increasing trends of insect associated bacterial infection in humans are severely hampered by disparaging number of bacteria obtained with the culture-based technique. This study therefore determined how the analysis of the 16S rDNA sequences would compare in terms of precision and reliability to the most adoptable culture-based technique. Results obtained depict enhanced accuracy of  molecular technique over...

Author(s): O. D. Popoola, B. T. Thomas and M. O. Efuntoye

Temporal bone histopathology study on cochlear otosclerosis: A memoir for the cochlear implant surgeon

June 2019

The aim of this study was to describe the pathologic changes in temporal bones with cochlear otosclerosis that may have implications for cochlear implantation. Fifteen human temporal bones with otosclerosis were used for this study. In each temporal bone was studied: (1) medial wall of the middle ear and in particular the horizontal segment of the facial nerve canal; (2) the round window niche and the corresponding part...

Author(s): Abdulazeez Ahmed  

Umbilical cord torsion leading to intrauterine fetal death

June 2019

The umbilical cord is the critical organ that links the placenta and fetus. The intrauterine conditions and fetal activity influences the umbilical cord length. The normal umbilical cord is spiraled. By ultrasound, the spiral nature of the umbilical cord can be demonstrated early in the first trimester. Most of the adverse pregnancy and perinatal outcomes are related to abnormal Umbilical Cord coiling Index (UCI). A 23...

Author(s): Mohammed U., Panti A. A., Abdullahi K., Afolabi O. K., Sani H. and Ekochin K. O.  

CD34 positive stem cells recovered from cord blood remain viable after six months of cryoprotective storage process

May 2019

Cord blood can be used as an alternative source for bone marrow transplantation and its use is developing into a new field of treatment for patients presenting with haematological disorders, immunological defects and specific genetic diseases; including haemoglobinopathies. The aim was to assess the viability of frozen cord blood as a source of HSC which may be suitable for transplantation. Blood specimens were obtained...

Author(s): Muhibi M. A., Mabayoje V. O. and Komolafe J. O.  

Effect of formalin fixation on DNA purity and quantity, nucleic acid, and amplicon size in cervical human papilloma virus detection

September 2018

Tissue fixation with 10% formalin and molten paraffin wax embedding (FFPE) is routinely used protocol for tissue preservation in histopathology laboratory. We therefore aimed at comparing the differences in DNA quantity, DNA purity, nucleic acid and its effect on primers (PCR) amplicon (bp) sizes between fresh cervical tissues and formalin fixed paraffin embedded (FFPE). The differences in DNA purity, quantity and...

Author(s): Oboma Y. I. and Ngokere A. A.  

Effect of Theobroma cacao on renal function of wistar albino rats induced with anaemia

August 2018

The study investigated the effect of Theobroma cacao on renal function of phenylhydrazine induced anaemic albino rats. Forty albino rats were divided into 8 groups of five rats each namely control (group A), Phenyl hydrazine (group B) while groups C, D and E were given phenylhydrazine and administered with 100,200 and 500 mg/kg of T. cacao respectively while groups F, G and H were given 200,500 and 1000 mg/kg of T cacao...

Author(s): Adegoke O. Adebayo, Oluwatayo G. Beatrice and Ogbu U. Patience  

Some plasma biochemical changes in layers experimentally infected with Pasteurella multocida

August 2018

The present study was carried out to investigate some biochemical alterations in layers experimentally infected with Pasteurella multocida. A total of 20 eighteen-week old ISA Brown layers were used in the experiment. The birds were randomly assigned to two groups (infected and control) of 10 layers each. To establish infection, each bird in the infected group was challenged by intra nasal (0.1 ml) and intramuscular...

Author(s): Joseph John Gadzama, Balami Arhyel Gana, Mohammed Adam Chiroma, Sani Adamu, Hassan Abdulsalam, Lekko Madaki Yusuf, Idoko Sunday Idoko, Sani Nuhu Abdulazeez, Samson James Enam and King Akpofure Nelson Esievo  

Phenotypic detection of multidrug resistant extended-spectrum beta-lactamase (ESBL) producing Escherichia coli from clinical samples

July 2018

A clinico-laboratory investigation of multidrug resistant (MDR) characteristics of extended spectrum β-lactamase (ESBL) producing Escherichia coli pathotypes from some hospitals in Bauchi metropolis, Nigeria, was carried out. A total of 198 E. coli isolates were recovered from different patients’ age group (0 to above 70 years), comprising of 134 males and 85 females, as both out-patient (126) and in-patient...

Author(s): Iliyasu M. Y., Uba A. and Agbo E. B.  

Comparative study of the effects of aqueous and ethanol fruit extracts of Phoenix dactylifera L. on the cerebellar cortex of Artesunate–Amodiaquine treated adult Wistar rats

July 2018

This study was to evaluate the effects of aqueous and ethanol fruit extracts of Phoenix dactylifera on the cerebellar cortex of Artesunate-Amodiaquine (AS–AQ) treated Wistar rats. Thirty-six adult male Wistar rats were randomly divided into nine groups (n=4). Group 1 served as the control; Group 2 received 2.86/8.75 mg/kg AS–AQ. Group 3 received 2.86/8.75 mg/kg AS–AQ + 100 mg/kg ascorbic acid; Groups...

Author(s): M. N. Budaye, S. S. Adebisi, A. A. Buraimoh, S. S. Lazarus and A. N. Agbon  

Determination of egg production and weight in layers experimentally infected with Salmonella gallinarum

June 2018

The present study was conducted to determine egg production and weight in layers experimentally infected with Salmonella gallinarum. Twenty layers were used for the research. The layers were purchased at the age of 18 weeks from certified commercial poultry farm in Kujama farm, Kaduna State, Nigeria and housed in the Animal Research Unit of the Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Ahmadu Bello...

Author(s): Mohammed Adam Chiroma, Sani Adamu, Joseph John Gadzama, King Akpofure Nelson Esievo, Abdulsalam Hassan, Arhyel Gana Balami, Muhammad Ya’u, Ibrahim Bulama and Lekko Yusuf Madaki

Histological and histochemical assessements on the effect of ethanol fruit extract of Phoenix dactylifera L. (Date Palm) on cerebral cortex of lead acetate treated wistar rats

June 2018

This study histologically and histochemically assess the effect of ethanol fruit extract of Phoenix dactylifera L. (EFPD) on the cerebral cortex of lead acetate exposed Wistar rats. Twenty rats were grouped into five groups (A to E, n=4). Group A (control) was administered distilled water (2 ml/kg), while groups B to E were treatment groups. Cerebral damage was induced in rats by the administration of lead acetate (120...

Author(s): Stephen Samuel Lazarus, Samuel Sunday Adebisi, Yusuf Tanko, Abel Nosereme Agbon and Michael Ndomi Budaye

Some plasma biochemical changes in layers experimentally infected with Salmonella gallinarum

December 2017

Aim: The study was conducted to investigate some plasma biochemical changes in layers experimentally infected with Salmonella Gallinarum Methods: A total of 20 eighteen-week- old ISA Brown layers were used in the experiment. The birds were randomly divided into two groups; infected and control, of 10 birds each. Each bird in the infected group was orally administered 0.5 ml of the inoculum containing...

Author(s): Chiroma Mohammed Adam, Adamu Sani, Gadzama Joseph John, Esievo King Akpofure Nelson, Abdulsalam Hassan, Balami Arhyel Gana, Enam Samson James, Muhammad Ya’u , Atata Abdulhamid Jamila  

Determination of median lethal dose of ethanolic extract of Sesamum Indicum seeds in adult wistar rats

December 2017

The aim of this research was to determine the median lethal dose of sesamum indicum seeds in Wistar rats. Methods: Twelve Wistar rats within the ages of five to six weeks and of weights, ranging from (98-160) g of both sexes were used for the experiment. They were categorized into two phases of I and II. Phase I consisted three (3) groups of three (3) animals each. While phase II consisted three (3) groups...

Author(s): Yusuf M.K, Ibegbu AO,  Agbon AN, Evang A

ATELECTATIC AND DEGENERATIVE EFFECTS OF DATURA METEL LEAF EXTRACT ON THE MORPHOLOGY OF THE ALVEOLAR AND HEPATIC TISSUES

September 2017

Aim: This study was aimed at investigating the effects of Datura metel (D. metel) on the histology of the lungs and liver in rat models. Methods: Twenty rats were divided into four groups of five each. D. metel extract was administered (50, 100 and 150mg/kg) to the rats through an orogastric tube once daily for 21days. Results: The histomorphological parameters showed thin atrophic and collapsed alveolar sacs...

Author(s): Onyije FM, Ilegbedion IG, Digba KA

  • Article Number: 18FE86269580

PREVALENCE OF MALARIA PARASITES AMONG PREGNANT WOMEN IN UGHELLI, DELTA STATE

September 2017

Aim: A total of 200 pregnant women were prospectively studied for malaria parasitaemia from October, 2016 to June, 2017 at the Central Hospital Ughelli, Delta State, Nigeria Methods: Malaria parasitaemia was determined microscopically using romanoswsky staining technique. Results: Our result shows that the prevalence rate of parasitaemia in 1st, 2nd and 3rdtrimesters was statistically significant (P<0.05)....

Author(s): Jemikalajah DJ

  • Article Number: E1B878A69579

FOOD POISONING ASSOCIATED BACTERIA ON FRUITS IN THE OPEN MARKETS IN LAGOS NIGERIA

September 2017

Aim: To determine the presence of food poisoning bacteria on fruits in the open markets. Method: A total of 1000 assorted fruits consisting 100 each of guava, carrots, oranges, mangoes, African cherry, pear, water melon, cashew, apple and garden eggs were randomly collected from open markets in Lagos, Nigeria. A sterile cotton wool tipped applicator pre-soaked in normal saline was used to rinse the fruits and...

Author(s): Avwioro TO, Ajayi MB, Onyije FM, Onobrudu DA

  • Article Number: 912F75669578

ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF CLINICAL ISOLATES OF SALMONELLA TYPHI ASSOCIATED WITH SEPTICEMIA AMONG CHILDREN AGED 0-5 YEARS IN KANO, NIGERIA

September 2017

Aim: Typhoid fever is a preventable and treatable enteric disease which can be effectively treated when adequately diagnosed and right antibiotic choice made. It is a major cause of morbidity and mortality in 10-18% of affected children aged 0-5 years. The aim of this work was to determine the antibiotic susceptibility pattern of clinical isolates of Salmonella typhi associated with septicaemia among children aged 0-5...

Author(s): Mustapha HM, Mohammed Y, Rogo LD

  • Article Number: E43B7CD69577

SEROBIOCHEMICAL CHANGES ASSOCIATED WITH HIGHLY PATHOGENIC AVIAN INFLUENZA IN LAYER CHICKENS IN JOS, PLATEAU STATE, NIGERIA

September 2017

Aim: To assess some serobiochemical changes in layer chickens affected with H5N1 Highly Pathogenic Avian Influenza (HPAI) virus in Plateau State, Nigeria. Methods: Five sera samples were collected from ten infected commercial farms (fifty from all the infected layer farms). Five sera samples from non-infected chickens (1 from each layer farm that was free from infection) were used as control. Serum Aspartate...

Author(s): Kumbish PR, Esievo KAN, Ibrahim NDG, Anueyiagu DM, Barde IJ, Choji TPP, Rimfa AG, Moses DG, Atam SK, Ahmed JS

  • Article Number: 4F8119169576

COMPARATIVE HAEMATOLOGY OF SOME SPECIES OF APPARENTLY HEALTHY FREE-LIVING WILD BIRDS IN ZARIA, NIGERIA

September 2017

Aim: To determine the baseline haematological parameters for some apparently free-living wild birds in Zaria, Nigeria. Methods: 133 birds from 7 species were used for the study; 20 each of Streptopelia senegalensis (Laughing Dove), Treron waalia (Bruce’s Green Pigeon), Psittacula krameri (Rose-Ringed Parakeet), Poicephalus senegalus (Senegal Parrot), and 19 Columba guinea (Speckled Pigeon), 16 Streptopelia...

Author(s): Enam SJ, Oladele SB, Idris SY, Balami AG, Abdu PA, Gadzama JJ, Orakpoghenor O

  • Article Number: D227EDC69575

BIOCHEMICAL AND HISTOLOGICAL ASSESSMENT OF THE CEREBELLUM IN ADULT WISTAR RATS FOLLOWING THE ADMINISTRATION OF AQUEOUS EXTRACT OF NICOTIANA TABAC

September 2017

Aim: Using an animal model the direct effect of aqueous extract of Nicotiana tabacum (ANT) administration on the biochemical parameters and cerebellum in Wistar rats was investigated. Methods: Twenty four (24) rats were divided into four groups with six rats per group with an average weight of 150 g. Group 1 served as the Control and was administered distilled water (1 ml/kg bw) and Groups 2, 3 & 4 received 1000...

Author(s): Auza M.I., Ibegbu A., Danborno B.

  • Article Number: 40CBCA369574

HIBISCUS-VAN GIESON STAIN FOR COLLAGEN FIBRES

September 2017

Aim: This is an experimental study aimed at exploring the capability of Hibiscus extract-iron solution counterstained with van Gieson stain to demonstrate collagen fibres in skin tissue. Methods: 10% neutral buffered formalin fixed, paraffin embedded tissue blocks of skin were retrieved from the tissue block archive of the Department of Pathology, Unilorin Teaching Hospital, Ilorin, Kwara State, Nigeria. Two blocks...

Author(s): Benard SA, Afolabi OO, Fowotade AA, Okoye JO, Olutunde OA, Bankole JK

  • Article Number: 584884369573

Ascorbic acid and testosterone efficacy in spermatoxic and histomorphological changes in Corpora cavernosa in priapism induced sprague-dawley rats

August 2017

Aim: The histomorphological changes in the corpora cavernosa following priapism remains an interesting observation due to its pathological and reproductive implications. We investigated the attenuating effect of testosterone and vitamin C on the corpora cavernosa induced fibrosis in priapism of rats. Methods: Twenty-five Sprague – Dawley male rats were randomly allocated into 5 groups of rats each Group 1 served...

Author(s): Igwe O, Aniah J. A, Godam E. T, Yama O, E.

Male breast adenomyoepithelioma- A case report and literature review

June 2017

Adenomyoepithelioma is an uncommon primary breast tumor characterized by a biphasic proliferation of epithelial and myoepithelial cells which was first described by Hampperl in 1970. The largest reported series had been by Tavassoli (1991) who in reported 27 cases. Most of the others have been one or two case reports. Except for two in male patients [Tamura et al., 1993, Berna et al., 1997] all the reported cases have...

Author(s): Wahab TA, Uwakwe H, Gillibrand R, Fafemi O

Haematological changes in layers experimentally infected with salmonella gallinarum

June 2017

Aim: The present study was conducted to investigate the haematological changes in layers experimentally infected with Salmonella gallinarum. Methods: A total of 20 eighteen-week- old ISA Brown layers were used for the experiment. The birds were randomly divided into two groups, infected and control, of 10 birds each. To establish the infection, each bird in the infected group was orally administered 0.5 ml of the...

Author(s): Chiroma Mohammed Adam, Adamu Sani, Gadzama Joseph John, Esievo King Akpofure Nelson, Abdulsalam Hassan, Sani Nuhu Abdulazeez, Joshua Luka, Muhammad Ya’u

Histomorphology of seminal vesicle and testicular tissue of Wistar rats following administration of Carica Papaya

June 2017

Aim:  This  study  was  aimed  at  evaluating  the  effect  of  Carica  papaya  on  male reproductive organs. Methods: Twenty Wistar rats were randomly grouped into 4 of 5 rats each. They were fed with 2.5g/kg, 5g/kg and 7.5g/kg of ethanolic extract of Carica papaya once a day. The first group was given water. The rats were sacrificed on the 14th...

Author(s): Zenebo VC, Eric UC

EVALUATION OF THE TOXICITY OF PHYLLANTHUS AMARUS IN WISTAR ALBINO RATS

May 2017

Aim: The study evaluated the acute and sub acute toxicity of the aqueous leaf extract of Phyllathus amarus Schum. and Thonn using Wistar albino rat. Methods: Sixty-one adult Wistar rats were grouped four groups with ten rats per group for acute study. Rats in group 2, 3 and 4 received 2000mg/kg, 4000mg/kg, and 8000mg/kg of the extract respectively. For sub acute study, rats were divided into three groups with seven...

Author(s): Adomi PO ,Owhe-Ureghe UB , AsagbaSO

A STUDY OF ULCER INDUCED STOMACH OF ALBINO RATS TREATED WITH IDOGU MIXTURE, A POTENT ANTI-ULCER HERBAL DRUG

April 2017

Aim: The aim of this study was to assess the potency of the anti-ulcer drug, Idogun on the stomach of ulcer induced albino rats. Method: Six groups of locally bred albino rats were used. Each group containing five rats of either sex were orally treated respectively with distilled water (ulcer control group), omeprazole 20mg/kg (reference group) and 100, 200, 400 and 800mg/kg extract of Idogun anti –ulcer...

Author(s): Adediran OA , Avwioro OG and Funsho-Agun AG

SEROPREVALENCE AND HAEMATOLOGICAL STUDIES OF SOME WILD AND SEMI-DOMESTICATED BIRDS NATURALLY INFECTED WITH AVIAN POX VIRUS IN ZARIA, NGERIA

March 2017

Aim: To determine seroprevalence and haematological parameters of some wild and semidomesticated birds naturally infected with avian pox virus (APV). Methods: A total of 160 birds belonging to 12 species were used for the study. Serum samples obtained from these birds were analyzed for antibodies to Avian Pox Virus (APV) using agar gel precipitation test. Natt-Herricks methods and thin blood smear technique were...

Author(s): Andamin AD , AkadeFT , Samuel FU , Enam SJ , Aliyu HB , Abdu PA , Oladele SB

EVALUATION OF THE EFFECTS OF AQUEOUS GARLIC EXTRACT ON LEAD-INDUCED CHANGES ON CEREBELLUM OF WISTAR RATS

February 2017

Aims: The effects of aqueous garlic extract on lead-induced changes on the cerebellum of Wistar rats was investigated. Methods: Forty five Wistar rats were randomly divided into nine groups. Group 1 served as Control. Groups 2 and 3 received lead at low and high doses. Group 4 received lead and garlic extract at low doses while Group 5 received lead at high dose and garlic extract at low dose. Group 6 received lead...

Author(s): Hamza GA , Ibegbu AO , Buraimoh AA

PRELIMINARY HISTOLOGICAL STUDIES ON THE EFFECT OF AQUEOUS FRUIT EXTRACT OF PHOENIX DACTYLIFERA L. (DATE PALM) ON LEAD ACETATE-INDUCED CEREBELLAR DAMAGES IN WISTAR RATS

January 2017

Aim: This study was to histologically assess the therapeutic effect of aqueous fruit extract of Phoenix dactylifera (AFEPD) on lead acetate-induced cerebellar damage in Wistar rats. Methods: Twenty four rats were grouped into six (I–VI; n=4). Group I (control) received distilled water (1 ml/kg). Group II received lead acetate (LA, 120mg/kg) only. Groups III and IV received LA (120mg/kg) followed by AFEPD...

Author(s): Yusuf AO , Buraimoh AA , Agbon AN , Raji K B , Akpulu PS

IMMUNOHISTOCHEMICAL EXPRESSION OF p16(INK4A) PROTEIN IN CERVICAL DYSPLASIA AND CARCINOMA IN PATIENTS ATTENDING FEDERAL TEACHING HOSPITAL, GOMBE, NIGERIA

December 2016

Aim: This study was conducted to determine and compare the immunohistochemical expression of p16(INK4a) in cervical dysplasia and carcinoma in Gombe, Nigeria. Materials: Seventy eight cases of cervical neoplasm; comprising 17 cases of cervical intraepithelial neoplasia (CIN), 53 cases of squamous cell carcinoma (SCC), 6 cases of adenocarcinoma and 2 cases of adenosquamous carcinoma. All samples were stained using...

Author(s): Umar A, Avwioro OG, Muhammad AT, Mohammed I, Mohammed MO, Ibrahim KK, Sahabi SM, Abdullahi K, Mohammed SA, and Ajayi AS  

  • Article Number: 1C4D07365710

HIBISCUS EXTACT-IRON-VAN GIESON: A NEW MORPHOLOGICAL STAINING TECHNIQUE IN NEURO-HISTOLOGY

November 2016

Aim: To investigate the suitability of Hibiscus extract mordanted with ferric chloride and counterstained with Van Gieson in the demonstration of brain histomorphology. Method: 10% formol saline fixed brain tissues from cerebellum, cerebrum and basal ganglia were processed by the paraffin wax technique, sectioned and stained with H&E labeled A, Hibiscus/Van Gieson stain labeled B and Weigert’s Van Gieson...

Author(s): Benard SA, Afolabi OO, Olutunde OA  

  • Article Number: 184BA3765708

COGNITIVE-ENHANCING AND NEUROTHERAPEUTIC PROSPECTS OF VISCUM ALBUM IN EXPERIMENTAL MODEL OF ALZHEIMER’S DISEASE

July 2016

Aim: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterised by multiple cognitive deficits, behavioural disorders, mood changes and neurohistological alterations including neurofibrillary degeneration, and development of plaques and tangles of fibrous proteins in the brain. Novel natural antioxidants from plants like Viscum album may offer an effective and safe means of bolstering the...

Author(s): Oremosu Ademola, Edem Edem, Dosunmu Olufunke, Kunlere Oladunni

  • Article Number: 18DD94869568

COGNITIVE-ENHANCING AND NEUROTHERAPEUTIC PROSPECTS OF VISCUM ALBUM IN EXPERIMENTAL MODEL OF ALZHEIMER’S DISEASE

July 2016

Aim: Histomorphological effect of ascorbic acid on mercury exposure on temporal lobe of the cerebral cortex of Adult Wistar rats was investigated. Methods: Twenty five adult Wistar rats of average weight of 185 grams were randomly divided into five groups of five rats per group namely; a control group administered with normal saline, a mercuric chloride only group (HgCl2; 49.8mg/kg), HgCl2 with distilled water...

Author(s): Animoku AA, Mesole SB, Yusuf UA, Ayuba M

  • Article Number: ADD179669567

HEMATOLOGICAL EVALUATION OF ABINO RATS ORALLY ADMINISTERED PYRETHROIDS FORMULATION

July 2016

Aim: This study was carried out to determine the effect of Mortein on some hematological parameters. Methods: Fifty adult Albino rats (150- 200g) were acquired from the animal house of the College of Health Sciences, Delta State University Abraka and placed into four groups. Groups 1- 3 contained 15 rats each, while 4 contained 5 rats. Groups 1-3 were further sub-divided into 3 sub-groups of 5 rats each. The rats in...

Author(s): Iteire AK  

  • Article Number: EA360A965706

EFFECT OF PRENATAL ETHANOL EXPOSURE AND EXTRACT OF TAMARINDUS INDICA PULP ON THE CEREBRAL CORTEX OF WISTAR RATS

July 2016

Aim: The aim of the study was to evaluate the effect of ethanolic pulp extract of Tamarindus indica (EPTI) on the cerebral cortex in prenatal ethanol exposure in Wistar rats. Method: Twenty four pregnant rats were divided into 7 groups. The Control received 1ml of water, Groups 2 and 3 received 200mg/kg and 300mg/kg body weight (bw) of EPTI and Vitamin E respectively, Group 4 received 0.1ml of olive oil, Group 5...

Author(s): Usman IM, Buraimoh AA, Ibegbu AO  

  • Article Number: 284DB8D65704

SEMEN CHARACTERISTICS OF WISTAR RATS TREATED WITH METHANOLIC EXTRACT OF JATROPHA GOSSYPIFOLIA

June 2016

Aim: The study was designed to determine the effect of methanolic leave extract of Jatropha gossypifolia on semen characteristics in Wistar rats. Methods: Twenty-five male Wistar rats were divided into 5 groups (A, B, C, D and E) comprising 5 rats each. Rats in group A served as control, and were administered distilled water per os for 21 days, while rats in groups B, C, D and E were administered oral 100, 300, 500...

Author(s): Ubah SA, Inyang IE, Waziri MA, Ogunbodede MA, Oladele GM, Ode OJ, Adeyeye AA  

  • Article Number: 2850C0A65702

BACTERIOLOGICAL EVALUATION OF POULTRY FEEDS IN EKPOMA, NIGERIA

June 2016

Aim: Poultry feed is one of the major vector for the transmission of microbial agents to poultry farms and processing plants. This study aims at the evaluation and identification of bacteria and fungi agents in Ekpoma poultry feed. Methods: Bacteriological investigation was carried out on five different poultry feed samples from poultry farmers in Ekpoma, Edo State from January to June 2015. The samples were...

Author(s): Okogun GRA, Jemikalajah DJ, Ebhohimen EV

  • Article Number: 19B3BE669557

EVALUATION OF LEVELS OF PROSTATE SPECIFIC ANTIGEN AND LIPID LEVELS IN PROSTATE AND NON PROSTATE CANCER PATIENTS IN PORT HARCOURT, NIGERIA

June 2016

Aim: In order to determine possible linkages between the onset of prostate cancer and some lipid characteristics, the levels of Prostate Specific Antigen (PSA) and Lipid characteristics of prostate and non -prostate cancer subjects were evaluated. Methods: Blood samples were collected from 100 subjects; 50 of whom had newly been diagnosed for prostate cancer but had not yet been on medication and the other 50 as non...

Author(s): Obunwo C. C, Andy-Nwokocha M. J

  • Article Number: 2BA91C069558

PREVALENCE OF FACIAL DIMPLES AMONG THE NIGER DELTANS IN NIGERIA

June 2016

Aim: The purpose of this study was to determine the prevalence of facial dimples among the Niger Deltans in Nigeria. Methods: This is a cross sectional type of descriptive study. The nature and scope of this study encompassed 2304 subjects (1147 males and 1157 females) who were observed for the presence of cheek and chin dimples, by means of physical examination and structured questionnaires. The multistage sampling...

Author(s): Anibor Ese

  • Article Number: ECB084169559

AGE PREVALENCE OF UTERINE FIBROID IN SOUTH WESTERN NIGERIA

June 2016

Aim: Fibroid is said to be one of the causes of pain in the pelvic area and infertility amongst women of childbearing ages. The aim of this study was to determine fibroid distribution by age group among women of childbearing age in South Western Nigeria. Methods: A total of 500 uterine samples selected randomly from women of childbearing ages diagnosed with fibroids in some hospitals in South West Nigeria were used...

Author(s): Adedokun IO, Avwioro TO, Ogharanduku TO, Enaohwo TM, Onyije FM, Mokogwu ATH

  • Article Number: 0539C0E69560

EVALUATION OF ISOPROPANOL AS A BETTER ALTERNATIVE TO XYLENE IN TISSUE PROCESSING BY THE PARAFFIN WAX METHOD

June 2016

Aim: The aim of the study was to find a suitable less toxic alternative to xylene in the paraffin wax method of tissue processing. Methods: Twenty albino rats were randomized into two groups of ten animals each. One group was fed with normal diet while the second group received in addition to the normal diet, 20mg/kg of omeprazole for 7days. They all had water freely. The second group was given 2ml ethanol to induce...

Author(s): Adediran OA, Ibikunle DE

  • Article Number: 17C8B0B69564

EVALUATION OF TOOTH LOSS AMONG THE EDOS IN NIGERIA

June 2016

Aim: The aim of this study was to identify the causes and effects of tooth loss among the Edos in Nigeria. Methods: This cross-sectional study was conducted among 384 subjects of various age groups made up of male and female indigenes of Edo State. Data was collected using a self-administered questionnaire containing relevant questions directed to consenting individuals who met the inclusion criteria. Intraoral...

Author(s): Anibor Ese, Ochiagha CS

  • Article Number: B938E2B69563

INTRAORAL DISTRIBUTION OF GINGIVAL RECESSION IN A NIGERIAN POPULATION

June 2016

Aim: This study was designed to determine the intraoral distribution of gingival recession in a Nigerian population. Methods: The study was performed on 153 males and 219 females, aged 15years and above who had gingival recession. Intraoral examination was performed on a cross section of Deltans in Abraka to determine the intraoral distribution of gingival recession in the area. Statistical analysis of the results was...

Author(s): Anibor Ese

  • Article Number: C7CF1E769562

THE EFFECT OF RAUVLFIA VOMITORIA ON MERCURY-INDUCED CHANGES ON THE HISTOLOGY OF THE HIPPOCAMPUS OF ADULT WISTAR RATS

June 2016

Aim: The present study was aimed at evaluating the effect of Rauvlfia vomitoria (RV) on mercury-induced changes on the hippocampus of adult Wistar rats. Methods: Thirty adult Wistar rats were divided into 6 Groups of 5 animals each. The Control was administered with water, Groups 2 and 4 were administered 49.8mg/kg body weight (bwt) of HgCl2 and 250mg/kg bwt RV, Group 3 was administered with 750mg/kg bwt of RV,...

Author(s):

  • Article Number: B7C509669561

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