Chloroform and ethyl acetate extracts of Hedysarum alpinum L. mitigate the ketamine-induced behavioral dysfunction and oxidative stress in schizophrenia-like animals
March 2025
The effects of chloroform and ethyl acetate extracts of Hedysarum alpinum L. were investigated through a ketamine-induced schizophrenia-like rat model. The quantitation of the total triterpene saponin content of extracts was determined by using oleanolic acid as standard. The ethyl acetate extract had a total triterpene saponin of 10.02 ± 0.02 mg otoacoustic emission (OAE)/g, while the chloroform extract had 8.50...
Evaluation of phytochemical properties and antifungal activity of Ocimum gratissimum crude leaf extracts towards dermatophytes
February 2025
The increase in antifungal resistance towards dermatophytosis is an emerging concern globally. Consequently, the search for more effective vegetal drugs, easily consumable, less toxic, and available new substances with antifungal activity remains a priority. Therefore, the phytochemical properties and antidermatophytic effect of Ocimum gratissimum by means of broth microdilution technique was investigated. The leaf...
Phytochemical and pharmacology of weed Mexican medicinal flora: State of the art
January 2025
Weeds, often viewed as pests due to their interference with agriculture, are also crucial opportunistic plants that thrive in disturbed environments and secondary successions. They play a vital ecological role and offer numerous benefits, including fodder, green manure, food, and sources of industrial and medicinal chemicals. In Mesoamerican civilizations, weeds serve as a significant medicinal resource. This study...
Development of in vitro protocol for large-scale clonal propagation of Capparis erythrocarpos for the herbal medicine industry and conservation
November 2024
The increased use of Capparis erythrocarpos for treating rheumatoid arthritis and as an appetite stimulant has necessitated the establishment of efficient in vitro propagation protocols for large-scale production of seedlings to ensure its sustainable use in the herbal medicine industry and conservation of the species. In this study, mechanical scarification and priming of seeds with sulfuric and GA3 induced only...
In vitro toxicity, anti-inflammatory and antioxidant activities of ethanolic root extracts of Tanzanian Hydnora abyssinica A. Br. (Aristolochiaceae)
October 2024
Injuries and the effects of diseases, including various types of cancer, are among the sources of inflammation, pain, and discomfort for patients. Hydnora abyssinica, claimed by traditional practitioners in the Eastern Same district to manage inflammation, may contain ingredients with anti-inflammatory activity. This study aimed to evaluate the toxicity and determine the anti-inflammatory and antioxidant activities of...
Assessment of the bioavailability of a natural supplement (Storg-HIMmax) against cyclophosphamide-induced immunosuppression models and its effect on in vivo immunomodulation and in vitro antioxidant capacity
August 2024
Bioavailability is an important concept when evaluating natural products for their bioactivities. Therefore, the demand for foods that improve immunity has increased recently. The use of herbal medicine as immunomodulators is so common that it just requires hard scientific evidence to support its effectiveness. In this study, bioavailability, immunomodulatory, and in vitro antioxidant activity of "Storg-HIM...
Wound healing effects of Commiphora swynnertonii resin formulations using rat as model animal
July 2024
Commiphora swynnertonii (Burceraceae) is commonly used for the treatment of various ailments, including arthritis, wounds, and skin conditions. In this study, the effects of various formulations of the tree resin on wound healing were evaluated in rats through skin contracture and histological changes. Body weights were also monitored during the experiments. Tree resins were prepared at 0, 2.5, 5, 10, 15, and 30% v/v...
Phytochemical profile and quality control of complex herbal mixtures used to prepare slimming drinks, commercialized in Salvador-Bahia, Brazil
May 2024
Traditional herbal products with multiple associated plant species and weight loss claims are widely consumed. The inadequacy of these resources to health standards, the lack of supervision, and the analytical obstacles involved in their investigation are challenges and reasons for this research. In this sense, this study aimed to characterize the profiles: Phytochemical, physical, physicochemical, and microbiological,...
Pollen extracts from the Soconusco region: Chemical profile and effect against methicillin-resistant Staphylococcus aureus
May 2024
Pollen has been widely known to have beneficial properties for humans, including fighting harmful microorganisms. On the other hand, bacterial resistance is an obvious global problem that has increased over the years. For this reason, the study of the antimicrobial properties of substances such as pollen could play an important role in this area. The present work focused on evaluating the antimocrobial effect of pollen...
Antioxidant, urobactericidal, and antibiotic modulating activity of a parasitic medicinal plant: Cuscuta reflexa Roxb.
May 2024
The therapeutic potential of age-old Indian herbal remedies needs immediate scientific validation against urogenital problems. This study investigates the antibacterial efficacy of the methanolic extract of Cuscuta reflexa Roxb. stem through multiple diffusion techniques and the zones of inhibition (ZOIs) are expressed in millimeters. The minimum inhibitory concentration (MIC) is found to be 1.25 mg/mL against...
In vitro cytotoxic activity of forage peanut (Arachis pintoi Krapov. & W.C. Greg.) oil against leukemic and tumor cell lines
April 2024
Arachis pintoi Krapov. and W.C. Greg. is widely used as forage and displays high seed productivity. Its seed oil contains high levels of phytosterols, mainly β-sitosterol, which has been associated with several biological properties, including cytotoxic activity against different types of cancer. In this study, we investigated the cytotoxic activity of its seed oil against five cancer cell lines using the MTT...
Productivity and picroside contents of Picrorhiza kurroa Royle ex Benth. cultivated at multi-locations in Uttarakhand, India
March 2024
Cultivation is cost effective for conservation and sustainable supply of rare and high value medicinal plants. Assessment of productivity and quality testing validates cultivation and improves trade prospective. Picrorhiza kurroa is a recently domesticated Himalayan medicinal herb. Despite, specific habitat preference above 3000 m in natural habitats, P. kurroa is cultivated successfully below 3000 m under diverse...
Phytochemical screening and biological activities of Copaifera langsdorffii Desf. (Fabaceae) organic extracts
March 2024
This study explores the therapeutic potential of Copaifera langsdorffii Desf. (Fabaceae), commonly known as Copaíba, a legume renowned for its oleoresin extraction. The organic extracts from Copaíba's leaves, stem bark, and wood, using n-hexane, ethyl acetate and methanol were investigated for their antimicrobial, antioxidant and anti-inflammatory activities. In vitro assessments included determining...
Comprehensive evaluation of antiacne properties: HPLC analysis of crude extract from Aloe buettneri leaves against Cutibacterium acnes-induced acne
January 2024
The hydroethanolic extract of Aloe buettneri was assessed for its anti-acne activity in a Cutibacterium acnes-induced acne model in rats as part of this study. Conventional therapies for acne often entail serious side effects. Total phenols, quantified using the Folin-Ciocalteu method, were found to be at a concentration of 16 ± 0.3 mg GAE/g, while total flavonoids, determined using the aluminum chloride method,...
Antimicrobial activities of the extract of shea tree (Vitellaria paradoxa Gaertn. F.) leaf and bark on some selected clinical pathogens
December 2023
The use of plants and plant products in the treatment of various ailments has been with humanity since the dawn of time and the potentials of these plants are so enormous that the continuous search for their hidden treasures is more crucial because of the rise in antibiotic resistance. This study was designed to determine the antimicrobial activities of the shea tree (Vitellaria paradoxa) extracts against some selected...
Qualitative, quantitative composition and evaluation of the antioxidant activity of polar extracts of stem bark of Hexalobus crispiflorus A. Rich (Annonaceae family): Central African species
December 2023
Hexalobus crispiflorus A. Rich., synonym Hexalobus grandiflorus Benth, is a plant in the Central African pharmacopoeia, widely used in the treatment of skin diseases and diabetes. The present study is a contribution to the qualitative and quantitative analysis and evaluation of the antioxidant activity of this plant. Preliminary phytochemical tests carried out on the different crude extracts of H. crispiflorus revealed...
Phytochemical compounds present in COVI-MXG herbal preparation inhibits RNA-Dependent RNA polymerase from SARS-CoV-2: A molecular docking study
December 2023
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been identified as the agent responsible for COVID-19 pandemic. Currently, no therapeutic agents have proven effective in combating the virus. Managing the infection is mainly palliative in nature, involving infection prevention strategies and supportive therapy anchored on drugs that practitioners have had previous usage experience. Previously exploited...
Effects of different nitrogen forms and concentration combinations on American ginseng seedling growth
December 2023
This study investigated the impact of various nitrogen forms on American ginseng (Panax quinquefolius) seedling growth. Thirteen treatments of inorganic and organic nitrogen combinations were tested in the first year and growth indicators were measured. In the second year, treatments with significant growth promotion effects were further verified. The results showed improved growth of American ginseng seedlings when the...
Ethnobotanical studies in Iran’s rangelands
November 2023
Iran’s rich plant biodiversity includes over 8,400 species, of which more than 2,300 possess medicinal properties. The research community comprised scientific documents on ethnobotany published between 2010 and 2022. Keywords related to ethnobotany, rangeland, and Iran were searched in the databases of scientific journals. All articles were downloaded and read. The collected data were analyzed using Excel. This...
Phytochemicals properties of Carica papaya Linn seeds’ essential oil and their antifungal and antibacterial activities
November 2023
Carica papaya seeds have been used as traditional medicine. This study aims to determine the phytochemicals of papaya seeds essential oils their antimicrobial properties. Polyphenolic content and antioxidant properties were determined with standard methods. GC-MS was used to analyze chemical compounds. Antimicrobial properties were performed using agar diffusion method. MICs, MBCs and MFCs were established based on...
Medicinal plants diversity at King Salman Bin Abdulaziz Royal Natural Reserve in Saudi Arabia and their conservation management
November 2023
King Salman Bin Abdulaziz Royal Natural Reserve (KSRNR) is the largest protected area in the Middle East. This literature review study considered the primary survey on the native medicinal plant diversity at KSRNR in the Kingdom of Saudi Arabia (KSA). KSRNR flora, until now, has about 260 plant species, representing about 12% of the KSA flora. Information was gathered through an extensive literature survey, which...
Genipa americana fruit ethanolic extract in the control of environmental infecting agents
November 2023
The choice of substances that are not harmful to man and the environment is a priority in the production of sanitizing products. The aim of this study was to evaluate the disinfectant action and biofilm biomass reduction of the ethanolic extract of Genipa americana fruit. The extract disinfectant efficacy was assessed by modified Kelsey-Sykes, solid surface, and use-dilution methods. Also, the ability of the extract to...
Determination of tetrahydrocannabinol and cannabidiol contents in Cannabis sativa L. samples in Togo using gas chromatography-mass spectrometry
October 2023
Cannabis sativa L. is a widely used recreational drug in Togo, especially among young people. However, little is known about its chemical composition in Sub-Saharan Africa, and specifically in Togo. This study aimed to determine the levels of phytocannabinoids, specifically Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), in cannabis samples collected from various towns in Togo using gas chromatography coupled...
Comprehensive liquid chromatography-mass spectrometry-based metabolomic analysis of Moringa oleifera seeds
September 2023
Moringa oleifera seeds which are less explored and nutriment-rich have attracted scientific interest as the seed kernels contain numerous bioactive components with a variety of traditional uses. Besides its medicinal uses, Moringa oleifera biodiesel has shown remarkable potentiality in conducing to the decrease of greenhouse gases and guaranteeing sustainable supply of energy. In this study, the comprehensive analysis...
Effect of Canarium schweinfurthii leaf and pulp extracts on blood glucose levels in oral glucose load - induced hyperglycemia in Wistar albino rats
September 2023
Canarium schweinfurthii is a common medicinal plant used as food and medicine in communities of central Uganda. Local communities and herbalists commonly used it in the management of diabetes mellitus type 2 with limited information on its effectiveness. Study assessed the hypoglycemic effect of C. schweinfurthii aqueous and total crude leaf and pulp extracts on blood glucose levels in Wistar albino rats. An...
Chemical characterization of bottlebrush leaves found in NISLT premises, Samonda, Ibadan, Nigeria.
August 2023
This study investigated the chemical composition of Bottlebrush leaves for its ascribed mythical medicinal uses. Bottlebrush leaves were collected from the Nigerian institute of science laboratory technology premises in Ibadan, Nigeria. Proximate analyses, phytochemical screening, elemental analysis and antioxidant analysis were carried out on the leaves extract. This study has provided a scientific justification that...
Pre-sowing treatments to improve seed germination and seedling growth of Commiphora swynnertonii (Burrt.) and Synadenium glaucescens (Pax.)
July 2023
Medicinal and pesticidal plant propagation is hampered by poor seed germination due to seed dormancy. This study aimed to enhance seed germination and seedling growth using various pre-sowing treatments. A triplicated two-factor experiment in a Randomized Complete Block design was used. Soaking in water at 25°C for 24 h (T1), soaking in 60°C hot water for 10 min (T2), 10 ppm Potassium nitrate (KNO3) treatment...
Inhibition and dissolution of calcium oxalate crystals and kidney stones by the extract of Kalanchoe pinnata
June 2023
Kalanchoe pinnata leaves are used in South Asia as a natural kidney stone treatment. In vitro studies were conducted in supersaturated and artificial urine solutions to evaluate the antiurolithic properties of K. pinnata leaf extract on calcium oxalate monohydrate (COM) and surgically extracted kidney stones. Key organic acids present in the plant extract were also examined in artificial urine to investigate inhibition...
Anti-inflammatory effect of chaya extracts fractions
June 2023
Patients with Type 2 diabetes often experience chronic inflammation due to the overexpression of NF-kB-regulated pro-inflammatory proteins, such as TNF-alpha, IL-6 and IL-1. Chaya (Cnidoscolus aconitifolius) extracts have been reported to decrease this expression, but fractions of these extracts have not been studied. The present work focused on determining the anti-inflammatory effect of fractions of aqueous extracts...
Palyno-morphological assessment of Asteraceae taxa grown in Qarshi Botanical garden at Qarshi Industries (Pvt.) Ltd by using LM and SEM, Pakistan
May 2023
The present study covers the micro-morphological characteristics of 32 taxa of Asteraceae family from Qarshi Botanical Garden at Qarshi Industries (Pvt.) Ltd., Hattar Haripur, Pakistan. The morpho-palynological characters studied were size, shape, polar and equatorial diameter and their exine ornamentation using light microscopy (LM) and scanning electron microscopy (SEM) for its taxonomic significance. In the present...
Evaluation of catechin, lupeol, and betulinic acid as markers for the chromatographic quality Control of Albizia coriaria raw materials; an experimental study
May 2023
Albizia coriaria stembark is among the most common raw materials used to manufacture herbal products in Uganda. While the plant material is sourced from the wild, there are neither monographs nor chemical analytical methods for its standardisation. In addition, good cultivation, harvesting, and manufacturing practices are not mandatory. This leads to inconsistent quality of raw materials and products. This work...
HPLC determination of polyphenols of the flowers of Digitalis lamarckii, Xeranthemum annuum, Epilobium hirsutum and Silene compacta from Bolu (Turkey)
May 2023
There have been a growing interest since decades in the medicinal plants in terms of preventive health care and treatment of various diseases. On the other hand, polyphenolic compounds present in medicinal plants are known to have antioxidant potency. In the current work, the quantitative HPLC analysis of the flowers of four plants grown in Bolu-Turkey, Silene compacta, Digitalis lamarckii, Xeranthemum annuum L., and...
Sedative and hypnotic effects of the compatibility of Schisandra chinensis and Polygala tenuifolia on insomnia mice
May 2023
The objective of this study is to study the sedative and hypnotic effects of the compatibility of Schisandra chinensis (SC) and Polygala tenuifolia (PT) on insomnia mice and its mechanisms. The 160 SPF KM mice were divided into 8 groups with 20 each group (10 female and 10 male mice), including control, model, estazolam, SC, PT, SC-PT 1:1, SC-PT 1:2, and SC-PT 2:1 group. Insomnia mice model was established with...
Citrullus lanatus plant response to irrigation water magnetized in sandy soil
May 2023
In this study, the productivity of the red watermelon (Citrullus lanatus) crop in arid regions with saline water is examined in relation to the effects of magnetic treatment of irrigation water. The greenhouse experiments compared two treatments (magnetic treatment of irrigation water) and (no magnetic treatment of irrigation water). Magnetic treatment device delta water with a power of 14500 gausses (1.45 T) that was...
Phytochemical screening, anti-inflammatory and immunomodulatory activities of Acanthospermum hispidum and Croton zambesicus collected in the Republic of Benin
April 2023
This study aims to characterize chemical groups of metabolites in extracts of Acanthospermum hispidum and Croton zambesicus, and to evaluate their anti-inflammatory activities and their immunomodulatory effect on two pro-inflammatory cytokines (TNFα and IL6). The phytochemical screening was done on the powders of both plants by staining and precipitation reactions. Anti-inflammatory activity was performed in vivo...
Phytochemical screening and gas chromatography-mass spectrometry analysis of Euphorbia ingens organic root extract
March 2023
Euphorbia ingens is a woody, succulent tree with ethnomedicinal applications; however, its chemical constituents are not well documented. This study determined the phytochemical profile of Euphorbia ingens dichloromethane-methanol root bark extract. Following sample collection and preparation, extraction was done using the cold percolation technique. This was followed by qualitative phytochemical screening and gas...
Effects of millet on calcium oxalate crystal growth and dissolution
March 2023
The influence of aqueous extract of millet on the crystallization and the dissolution of calcium oxalate (CaOx) crystals were investigated in detail under supersaturated and artificial urinary circumstances in order to understand the effect of the water-soluble components of millet on CaOx kidney stones in humans. To investigate the inhibition effect, different volumes of millet extract were added separately to the...
In vivo hypotensive activity on the albino’s rat and in vitro antioxidant activities of aqueous extract from Guibourtia tessmannii (Harms) J. Leonard (Cesalpiniaceae) stem barks
March 2023
In Central Africa, stem bark from Guibourtia tessmannii is used in traditional pharmacopeia for the treatment of hypertension. The aim of this study was to scientifically verify the traditional use in the treatment of metabolic pathologies such as arterial hypertension and evaluated its pharmacological potential. Phytochemical tests were evaluated by standard method of laboratory. Antioxidant activities were determined...
Amazonian andiroba oil (Carapa guianensis Aubl.) minimizes the formation of postoperative adhesions in the uterus and ovaries of sheep
March 2023
Postoperative adhesions (POA) are postsurgical fibrinolytic connections that can cause complications, and alternative materials have drawn attention to their prevention. The aim of this study is to evaluate the effect of andiroba oil in preventing POA in the uterus and ovaries of sheep. Sixteen female Santa Inês adult sheep were randomly divided into two groups, a control group (CCG) with eight of them submitted...
Traditional knowledge of plants used against upper respiratory tract affections in the Littoral Region of Cameroon
February 2023
Traditional medicine is used by people as an alternative to orthodox drugs to treat respiratory infections. The aim of this research was to document traditional recipes used in the treatment of upper respiratory tract infections such as pharyngitis, cold, and sinusitis in peri-urban and rural areas of the Littoral Region of Cameroon. Ethnobotanical surveys were carried out using semi-structured interview model in French...
In-vitro assessment of antibacterial effects of combined crude extracts of S. glaucescens and C. swynnertonii with antibiotics
February 2023
Currently, there is an upsurge of bacterial resistance in single-drug treatment regimens. This has stimulated a growing interest in research and development of new antibacterial agents containing several ingredients as one of the means to combat bacterial resistance. Herb-antibiotic combination therapy is one of the reported effective treatment regimens to combat antimicrobial resistance. This study was aimed to assess...
Evaluation of antibiotic efficacy of Ocimum gratissimum L. essential oil against Staphylococcus aureus and Pseudomonas aeruginosa
February 2023
Ocimum gratissimum essential oil (EOGT) has been evaluated for its antibacterial efficacy, and its combinational therapy with antibiotics may enhance the therapeutic efficiency against infection-causing bacteria. Herein, we evaluated the chemical composition of EOGT and its antibiotic efficacy against Staphylococcus aureus and Pseudomonas aeruginosa. GC-MS and GC-FID analyzed EOGT. The antibiotic efficacy was determined...
Pachyrhizus toxicity: Genetic variability of mature and immature seeds and its effects on Sclerotium rolfsii and Ralstonia solanacearum
January 2023
Pachyrhizus seeds-induced toxicity is very well-known to have developed in humans, fishes, insects, and some micro-organisms. Yet, there is a paucity of studies addressing it in their germplasm, as well as its effects on some phytopathogens. This work aimed to assess the Pachyrhizus genetic variability on toxicity and to determine Pachyrhizus extract toxicity on Sclerotium rolfsii and Ralstonia solanacearum in vitro. In...
Medicinal plants for the treatment of malaria and typhoid diseases
January 2023
The review concentrated on current literature on medicinal plants for the treatment of malaria and typhoid related diseases, highlighting information about their ethnobotany. The entire plants reviewed showed strong activities, establishing their different traditional applications and capability to control or eliminate malaria and typhoid diseases. Malaria and typhoid diseases are the most problematic public health...
Bioprospecting of the antifungal activity of Patchouli essential oil (Pogostemon cablin Benth) against strains of the genus Candida
January 2023
The incidence of infections caused by Candida has increased worldwide and these strains are becoming resistant to their respective drugs, requiring the search for new drugs with greater efficacy and safety. Natural products are an alternative means of treatment. The essential oil (EO) stands out among these products, due to some biological activities relevant to human health, including antibiotic and antifungal...
Valuation study on the extracts of Ilex guayusa Loes. as an antioxidant and anti-aging raw material
January 2023
Ilex guayusa Loes. is a medicinal plant used by people of the Ecuadorian Amazon for treating various diseases and for its stimulating properties. In recent years, several studies have shown this plant to possess a high concentration of phenolic compounds and a high antioxidant potential, allowing it to be used as an ingredient for cosmetic formulations. This research confirms the presence of phenolic compounds between...
Antiedematogenic activity of Petiveria alliacea L. in bothropic poisoning
December 2022
The biodiversity of the Brazilian biomes inspires interest in research about the biological activities of the molecules present in the flora. In this line, Petiveria alliacea a common plant species in the savanna of Tocantins, reported in the treatment for snakebites, was studied to analyze the phytochemical profile and evaluate the activity on the edema caused by Bothrops moojeni snake venom. A qualitative...
Determination of total phenolic and flavonoid content, antioxidant and cytotoxic activity of the methanol extract of Acacia nilotica pods
December 2022
Acacia nilotica is a medicinal plant used in Niger republic for the treatment of gastrointestinal diseases. The aim of this study was to investigate total phenolic and flavonoid content, antioxidant and cytotoxic activity of the A. nilotica pods collected from Niger republic. The phytochemical contents were examined by colorimetric methods. Antioxidant activity of the methanol extract was screened using DPPH, ABTS and...
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