Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007

JMPR Articles

October 2018

In vivo antitumor effect of the aqueous extract of Punica granatum in the sarcoma 180 murine model

Punica granatum, specifically the fruit, has a long ethno medical history and is a phytochemical reservoir of great medicinal value. The phytochemistry and pharmacological actions of all P. granatum components suggest a wide range of clinical applications. The aim of the present study is to investigate the anticancer potential of aqueous extract of P. granatum (AEPG) in experimental models. The chemical composition of...

Author(s): Talita Santos Bastos, Danilo Barauna Nascimento da Costa, Rafael Barreto Vieira Valois, Sara Maria Thomazzi, Marismar Fernandes do Nascimento, Grace Anne Azevedo Dória, Ricardo Guimarães Amaral, Silvana Vieira Floresta Gomes, Isabel Bezerra Lima-Verde, Cláudia Andréa Lima Cardoso, Francine Ferreira Padilha, Margarete Zanardo Gomes, Juliana Cordeiro Cardoso, Adriana Andrade Carvalho andRicardo Luiz Cavalcanti de Albuquerque-Júnior,   

October 2018

Effects of methanolic calyx extract of Hibiscus sabdariffa on body weight, blood cholesterol and liver marker enzymes in Wistar rats

Eighty male albino rats were used to investigate the effects of methanolic calyx extract of Hibiscus sabdariffa on body weight, blood cholesterol and liver enzymes markers. Twenty-eight days oral administration of 100, 200, 400 and 800 mg/kg body weight of the extract showed a significant (p<0.05) time-dependent decrease in the body weights of all the treated groups when compared with the control, with 100 mg/kg...

Author(s): Emmanuel I. Nnamonu, Vincent C. Ejere, Edmund C. Mbegbu, Chiemekam S. Ezechukwu and Anthony O. Ejim  

October 2018

Knowledge of medicinal plants used by residents in two peripheral districts of Boa Vista, Roraima, Northern Brazilian Amazon: Phytotherapy as a new strategy in collective health

The aim of the study was to describe local knowledge about the use of medicinal plants cited by study participants, as well as to examine how phytotherapy serves as an important strategy of integrative and complementary practice in coping with health problems. The research is characterized as an exploratory study of the descriptive type. Non-probabilistic snowball sampling generated a sample of one hundred and ten...

Author(s): Kristiane Alves Araújo, Ires Paula de Andrade Miranda, Calvino Camargo and Maxim Repetto  

October 2018

Antiviral effect of the seaweed Osmundaria obtusiloba against the Zika virus

Zika virus (ZIKV), a mosquito-borne member of the family Flaviviridae, is a human pathogen of global significance. Recently, ZIKV, has become a public health problem with increases in numbers of cases and a strong association between ZIKV outbreaks and the spread of cases of Guillain-Barré Syndrome and microcephaly. In this study, the extracts of the seaweed Osmundaria obtusiloba (O. obtusiloba) (native to the...

Author(s): Claudio Cesar Cirne-Santos, Caroline de Souza Barros, , Caio Cesar Richter Nogueira, Leonardo dos Santos Corrêa Amorim, Renata de Mendonça Campos, Norman Arthur Ratcliffe, Valeria Laneuville Teixeira, Davis Fernandes Ferreira and Izabel Christina Nunes de Palmer Paixão  

October 2018

Malaria parasite clearance rate of crude methanol extract of Cryptolepis sanguinolenta in mice infected with chloroquine sensitive strain of Plasmodium berghei

This study aims to determine the malaria parasite clearance rate of crude methanol extract of Cryptolepis sanguinolenta in mice infected with chloroquine sensitive strain of Plasmodium berghei. P. berghei was injected in mice and left for 3 days for establishment. Blood sample collected and diluted with phosphate buffer saline was used for infection. Five (5) groups of animals (mice) were used in this study each...

Author(s): Eze, Chinelo C., Attama, Anthony A., Ibezim, Emmanuel C., Berebon, Dinebari P. and Agbo, Martina C.

October 2018

Chemical composition, oviposition deterrent and larvicidal activities of the wood extracts of Tabebuia avellanedae from the Cerrado of Brazil

Tabebuia avellanedae is an important timber source belonging to the family of Bignoniaceae. The latter is known for its richness in terms of variety of bioactive chemical constituents, and it has been used in folk medicine for treatment of various diseases. The aim of this work was to investigate the chemical composition, oviposition deterrent and larvicidal activities of the wood extracts of T. avellanedae from the...

Author(s): Jaqueline Cibene Moreira Borges, Eder Alves Pereira e Silva, Tarcísio Castro Alves de Barros, Ilsamar Mendes Soares, Sérgio Donizeti Ascêncio, Rodrigo Ribeiro Fidelis and Raimundo Wagner de Souza Aguiar  

September 2018

Antioxidant activity of extracts from Schinus molle L. and Gleditsia triacanthos L.

Methanolic and chloroform extracts obtained from various parts of Schinus molle and Gleditsia triacanthos were evaluated by DPPH radical scavenging assay. The methanolic extracts from S. molle showed scavenging activity ranging from 35.97±1.02 to 83.38±2.74%, while the chloroform seed extract showed relatively weak scavenging activity ranging from 8.20±1.02 to 68.82±3.17%. The IC50 values of...

Author(s): Manoharan Karuppiah Pillai, Kemelo Sanett Matela, Mosotho Joseph George and Sibusisiwe Magama  

September 2018

Medicinal plants used for the management of hepatic ailments in Katsina State, Nigeria

People in Katsina State, Nigeria have been using medicinal plants to cure several ailments associated with liver since time immemorial; however the use of such plants was never documented. In this study, an ethnobotanical survey was conducted to document the medicinal plants used for the management of hepatic ailments in Katsina State, Nigeria. A semi-structured questionnaire method was adopted to interview 150...

Author(s): Sulaiman Sani Kankara, Abdulazeez Bashir Isah, Abubakar Bello, Abdulhamid Ahmed and Umar Lawal  

September 2018

Evaluation of anti-Mycobacterium tuberculosis activity of fractions from selected medicinal plants used traditionally for treating cough and respiratory disorders in South West of Nigeria

Tuberculosis is a contagious airborne infection that mostly affects the lungs. The causative agent of tuberculosis in human is Mycobacterium tuberculosis. The emergence and dissemination of M. tuberculosis isolates that are resistant to multiple antimicrobial drugs represent a growing public health threat. Fractions from Alafia barteri, Chasmanthera dependence, Chrysophyllum albidum, Emilia coccinea, Mezoneuron...

Author(s): Morufu Adisa Ademoye, Labunmi Lajide, Bodunde Joseph Owolabi, and Catherine Chizoba Onubogu

September 2018

A comparative study of the histopathological modifications of adrenal gland in STZ-induced diabetic Wistar rats administered with selected herbal plants versus Glimepiride

This study investigated the comparative study of four herbal extract versus Glimepiride on the histomorphological modification of adrenal gland in STZ induced diabetic rats with a view to understanding their antidiabetic properties.  Forty- two healthy adult Wistar rats (Rattus novergicus) with an average weight of 153.4 g were randomly divided into seven groups (n=6). STZ (65 mg/kg) dissolved in citrate buffer was...

Author(s): Komolafe Omobola A., Ofusori David A., Odukoya Samson A., Saka Olusola S. and Arayombo Babatunde E.

September 2018

Anti-oxidant and anti-microbial study of Adiantum capillus veneris and Pteris quadriureta L

Adiantum capillus veneris (ACV) and Pteris quadriureta (PQ), two common ferns belonging to Pteridophyta family, has been used in traditional Ayurvedic and Unani medicine against numerous human ailments since ancient times. This study was designed to analyse the presence of various phytochemicals in the ACV and PQ leaves and their pharmacological activities. The methanol extract of ACV and PQ leaves was screened for the...

Author(s): Satabdi Rautray, Sukanya Panikar, Asaithambi Sofia and A. Usha Rajananthini    

August 2018

Evaluation of antiplasmodial potential of Aloe barbadensis and Allium sativum on plasmodium berghei-infected mice

A significant percentage of the developing countries are living in malaria-endemic communities and are prone to contacting the disease. The fight against malaria is faced with the occurrence of widespread resistance of Plasmodium falciparum to the available anti-malarial drugs. Thus, this study evaluates the anti-malarial activity of extracts of Aloe barbadensis and Allium sativum in Plasmodium berghei infected mice. To...

Author(s): Nassar Sulaiman Adebayo and Oyewole Motunrayo  

August 2018

Medicine bottled (garrafada): Rescue of the popular knowledge

Using plants to treat health problems is an ancient practice that is still practiced today. One way that plants are used to improve health is through medicine bottled (garrafada). A medicine bottled is a homemade mixture of medicinal plants added to a solvent. Medicines bottled are medicinal mixtures that have been widely used, especially by residents of rural areas. Therefore, the goal of this study was to determine...

Author(s): Graciela da Silva Miguéis, Rosa Helena da Silva, Germano Guarim-Neto and Geraldo Alves Damasceno Júnior  

August 2018

Comparison of several hydrophilic extracts of Polypodium leucotomos reveals different antioxidant moieties and photoprotective effects in vitro

Oral photoprotection can be used to prevent photocarcinogenesis and photoaging. It is mainly based on the presence of antioxidant moieties in phytochemical extracts. The appearance of different botanical formulations endowed with apparently similar properties requires their side-by-side examination using an unbiased approach. The objectives of this study were to determine the antioxidant properties of several extracts...

Author(s): Salvador González, Silvia R Lucena, Pablo Delgado and Angeles Juarranz  

August 2018

Ethnobotanical study of medicinal plants used by local people in Menz Gera Midir District, North Shewa Zone, Amhara Regional State, Ethiopia

This study was conducted in Menz Gera Midir (Ethiopia) to document medicinal plants and related indigenous knowledge of local people. Data were collected from 72 (12 of them key) informants using semi-structured interview, group discussion and guided field walk. Priority ranking, paired comparison and direct matrix ranking were used in data analysis. A total of 155 medicinal plant species, 104 (67.1%) from natural...

Author(s): Seble W. Yohannis, Zemede Asfaw and Ensermu Kelbessa  

August 2018

Evaluating the antipyretic activities of aqueous and ethanol extracts of leaves of Artemisia Annua in mice

Phytomedicines obtained from herbal sources are in great demand as they are able to cure many infectious diseases. Artemisia annua is an herbaceous plant that belongs to Composite family. As traditional medicine, it is used for cancer, ulcer, rheumatic pain and other ailments including fever in children. The objective of the present study was to evaluate the antipyretic activities of the aqueous and ethanol extracts of...

Author(s): Kassahun Dires Ayenew and Teklit Baraki Kebede  

July 2018

Medicinal plants used in the treatment of livestock diseases in Berbere district of Bale zone, Oromia region, Ethiopia

An ethnoveterinary study of medicinal plants used by local people of Berbere district was carried out from June 25 to September 5, 2015. The study was focused on utilization of medicinal plants to treat various livestock health problems by people of the study area. The data were gathered using semi-structured interview, participant observation and personal interviews. A total of 69 informants (55 male and 14 female) in...

Author(s): Tilahun Tolossa Jima  

July 2018

Plants and their metabolites against Streptococcus mutans

Oral diseases represent a major public health problem, especially for economically marginalized communities with limited access to health services. In addition, the constant increase in bacterial resistance to many of the antibiotics contributes to worsen the problem. In this context, great importance had been given to natural compounds for the discovery of new drugs that contribute to the prevention and control of oral...

Author(s): Landi B. O., Di Pace B. and Conceição A. O.  

July 2018

Quantitative analyses of phytochemical and trace elements contents of daily detox, herbal tea consumed in Nigeria

Tea is one of the commonest drinks in most homes. Many people consume tea due to its unique taste and associated health benefits. Several medical disorders such as cancer, cardiovascular diseases and diabetes mellitus have been linked to the excessive generation of free radicals and oxidative stress. Studies conducted on Daily Detox, a tea consumed by many Nigerians have been limited to qualitative assessment of...

Author(s): Orimadegun B. E., Bolajoko E. B., Onyeaghala A. A. and Ademola-Aremu O. O.  

July 2018

Evaluation of Procavia capensis hyraceum used in traditional medicine for antioxidant activity

Hyraceum (HM) used in traditional medicine in Southern Africa is produced by the herbivore Procavia capensis. It is fossilized excreta derived from urine, faecal matter and plant material. In this study a qualitative phytochemical screening, determination of the in vitro antioxidant activity using the 1, 1-Diphenyl-2-picrylhydrazyl (DPPH) and hydrogen peroxide scavenging methods, and determination of the total phenolic...

Author(s): Sibusisiwe Magama, Thabang Rants’o, Asita Okorie Asita and Matsepo Taole  

July 2018

Towards accomplishing the roll back malaria initiative: Phytochemical screening and antimalarial activity of ethanolic leaf extract of Ricinus communis L. (Euphorbiaceae)

Malaria is a major debilitating disease caused by Plasmodium species and spread by female Anopheles mosquitoes. This research was conducted to determine the efficacy of ethanolic leaf extracts of Ricinus communis L. against Plasmodium berghei (NK65) infection in mice. Phytochemical components of the extract were analyzed and elucidated in order to reveal the constituents with antimalarial potentials. The safety of the...

Author(s): Abdulhamid Ahmed, Mansur Liadi Yusuf, Sulaiman Sani Kankara and Umar Lawal  

July 2018

Spermostatic activity of Eugenia brejoensis and Myroxylon peruiferum essential oils toward human spermatozoa

In this study, the in vitro spermostatic action, hemolytic action in combination of parabens of two essential oils (EOs) from Eugenia brejoensis Mazin (Myrtaceae, EbEO) and Myroxylon peruiferum L. (Fabaceae, MpEO) is reported, in addition to the first chemical characterization of MpEO. The EOs were obtained by hydrodistillation and characterized by gas chromatography-mass spectrometry (GC-MS). Different concentrations...

Author(s): José Adelson Alves do Nascimento Junior, Clovis Macêdo Bezerra Filho, Thiago Henrique Florencio de Oliveira, Alexandre Gomes da Silva, Patricia Cristina Bezerra-Silva, Patricia Maria Guedes Paiva, Marcia Vanusa da Silva, Daniela Maria do Amaral Ferraz Navarro, Luis Claudio Nascimento da Silva, and Maria Tereza dos Santos Correia,

June 2018

The “Doctrine of Signatures” in herbal prescriptions in Ikale and Ilaje communities of Ondo State, Southwestern Nigeria

The knowledge and application of the notion of “doctrine of signatures or correspondences” was evaluated among the Ikale and Ilaje people of Ondo State, Southwestern Nigeria. Information was solicited by administering questionnaires to one hundred and five (105) informants. Periodic field observations were also made. The research yielded 60 plants belonging to 37 families. The plants have characteristics...

Author(s): Aworinde David Olaniran, Erinoso Sakiru Morenikeji, Ogundele Alimi Adeyemi, Teniola Olasimbo Anuoluwapo and Ojo Samuel Omoniyi

June 2018

Ameliorative effects of glabridin on the structure and function of pancreas in streptozotocin-induced diabetic rats

Several studies highlight beneficial effect of glabridin as an anti-hyperglycemic agent. However, the protective mechanisms of glabridin on improvement of pancreatic islets damage due to streptozotocin (STZ) exposure have not been adequately investigated. In the present study, we aimed to elucidate the effects of glabridin on restoration of pancreatic islet architecture, at least in part by restoring collagen I and...

Author(s): Jongdee Nopparat, Wipapan Khimmaktong, Paweena Sanpradit and Rapeepan Kongnual

June 2018

An ethno-veterinary survey of medicinal plants used to treat bacterial diseases of livestock in three geographical areas of the Eastern Cape Province, South Africa.

An ethno-veterinary survey of plants used to treat certain bacterial diseases of livestock in three geographical areas of the Eastern Cape was conducted during 2013 to 2014. A purposive sampling technique was carried out using a semi-structured questionnaire and field observations to document indigenous knowledge in 48 communal households. From the respondents of the 48 households, 64.6% men and 35.4% women were...

Author(s): S. Mthi, J.M. Rust, T.L. Morgenthal and B. Moyo

June 2018

Evaluation of Procavia capensis hyraceum used in traditional medicine for modulation of mutagen-induced genotoxicity

Hyraceum (HM) is used in traditional medicine in Southern Africa. Three concentrations of HM (mg/ml in distilled water) (0.0156, 0.03125 and 0.0625) were assessed for cytotoxicity (CT), genotoxicity (GT) and modulation of cyclophosphamide (CP)- and ethyl methanesulfonate (EMS)-induced GT using the Allium cepa assay following 24 h treatment.  CP (1.00 mg/ml) and EMS (0.0375 mg/ml) were not cytotoxic but genotoxic....

Author(s): Asita Okorie Asita, Thabang Rants’o, Sibusisiwe Magama and Matsepo Taole  

June 2018

Acute toxicity evaluation of ethanol extract of red algae, Osmundaria obtusiloba, in BALB/c mice

The genus Osmundaria (Rhodophyta, Ceramilaes, Rhodomelaceae) comprises tropical and temperate regions red marine seaweeds species. Osmundaria obtusiloba is distributed from the northeastern coast of Brazil to the state of Rio de Janeiro. Studies with ethanol extract of red seaweed O. obtusiloba showed the antiviral potential of this alga. Hence, this study examined in BALB/c mice the acute toxicity after oral...

Author(s): Caroline de Souza Barros, Max Willian Lisboa Gomes, Rafaela dos Santos Pereira Gomes, Vanessa Melchiades, Caio Cesar Richter Nogueira, Claudio César Cirne-Santos, Valeria Garrido, Carla Eponina Carvalho Pinto, Valeria Laneuville Teixeira and Izabel Christina Nunes de Palmer Paixão  

May 2018

In vitro antioxidant and antimicrobial activities of Pistacia lentiscus, Phyllanthus anderssonii and Cinnamomum verum crude extracts and fractions

In this study, phytochemical screening, antioxidant and antimicrobial activities of ethanolic (80%) extracts from leaf and stem of Pistacia lentiscus and Phyllanthus anderssonii and leaf of Cinnamomum verum and their fractions were evaluated. Antimicrobial activity was performed by disc diffusion method. The antioxidant activity was determined by stable 1, 1-diphenyl-2-picryl hydrazyl (DPPH) free radical method....

Author(s): Emtinan A. Alhadi, Omer A. A. Hamdi, Saad M. H. Ayoub and Sakina Yagi  

May 2018

Indigenous knowledge on medicinal plants used in and around Robe Town, Bale Zone, Oromia Region, Southeast Ethiopia

A study on medicinally important plants in and around Robe town, Southwest Ethiopia was been carried out to document the medicinal plants and the associated knowledge in the area. Thirty informants with age range between 18 and 70 years took part in this study. Semi-structured interview was used to collect the data from the informants. The collected data was then analyzed using micro-soft excel spread sheet 2007 and...

Author(s): Abadi Birhanu and Shimels Ayalew  

May 2018

Phytochemical screening and peroxide value determination of methanolic extract of four traditional medicinal plants from Debre Tabor Town, Ethiopia

Medicinal plants have bioactive compounds which are used for curing of various human diseases and also play an important role in healing of different disease. Terpenoids, flavonoids, alkaloids, tannins are some of bioactive compounds present in different parts of medicinal plants. Qualitative identification of bioactive compounds and antioxidant activity determination of crude extracts of the leaves of four different...

Author(s): Limenew Abate and Tadesse Mengistu

May 2018

Antibacterial activity of endophytic fungi isolated from Croton lechleri (Euphorbiaceae)

Croton lechleri is a native species from the Amazon and used with relative frequency in folk medicine in Brazil and other countries. Diversity and antibacterial activity of endophytic fungi associated with this plant were studied here. Samples of leaves and stems were used and 575 endophytic fungi were isolated (307 from leaves and 268 from stems), comprising 284 morphotypes distributed in 13 genera and unknown. The...

Author(s): Sebastião Luiz Pires Vargas, Erlan Kessyo Braga de Albuquerque; Sandra Albuquerque Lima Ribeiro; Atilon Vasconcelos de Araujo, Renildo Moura da Cunha and Clarice Maia Carvalho  

May 2018

Antibacterial activity of endophytic fungi from the medicinal plant Uncaria tomentosa (Willd.) DC

This study was designed to determine the diversity and antibacterial activity of endophytic fungi isolated from Uncaria tomentosa. Leaf and stem were disinfected superficially and inoculated in PDA and SDA medium, with and without plant extract and incubated at 18 and 28°C for isolation of endophytic fungi. Endophytic fungi were inoculated in BD medium and the metabolites extracted with ethyl acetate. Endophytic...

Author(s): Rodrigo Asfury Rodrigues, Atilon Vasconcelos de Araujo, Renildo Moura da Cunha and Clarice Maia Carvalho  

April 2018

Effect of aqueous leaf extracts of Leptadenia hastata Pers (Decne) on spermiogram and testicular histology in albino rats (Wistar strain)

This study was designed to determine the effects of prolonged oral administration of aqueous leaf extract of Leptadenia hastata Pers (Decne) on sperm concentration, sperm motility and testicular histology in Wistar rats.  Rats were given graded doses (200, 400, 600 and 800 mg kg-1) of aqueous leaf extract of L. hastata orally for 28 days. Weekly changes in sperm concentration and motility as well as testicular...

Author(s): Victoria Adam Maina, Innocent Damudu Peter, Dauda Yahi, Umar Kyari Sandabe and Godwin Onyeamaechi Egwu  

April 2018

Isolation, characterization and biological activity of organic extractives from Calodendrum capense (L.f.) Thunb.(Rutaceae)

A novel prenylfuroquinoline alkaloid capensenin (1), an alkaloid confusameline (2), two furanocoumarins psolaren (3) and bergapten (4), were isolated from hexane and dichloromethane crude extracts of stem bark, leaves and fruit pericarp of Calodendrum capense. Limonin (5) was also isolated from the stem bark, while limonin diosphenol (6) was isolated from the seeds. Capensenin (1) showed weak antimicrobial activity...

Author(s): Okwemba R. I., Tarus P. K., Machocho A. K., Wanyonyi A. W., Waweru, I. M.,  Onyancha J. M., Onani M. O. and Amuka O.

March 2018

Characterization and antioxidant properties of crude water soluble polysaccharides from three edible mushrooms

In the present study three species of mushrooms, Auricularia auricula (AAP), Lentinus edodes (LDP, Shiitake mushroom) and Poria cocos (PCP) were isolated water soluble polysaccharides, and their antioxidant properties and chemical characteristics were evaluated. Fourier Transform-infrared analysis demonstrated that three polysaccharides were composed of β-glycoside linkages 3304 to 1000 cm-1, and continued until...

Author(s): Ashfaque Ahmed Khaskheli, Shahzor Gul Khaskheli, Ying Liu, Saghir Ahmed Sheikh, Yan-Feng Wang, Mamoun A. Homaida, Aijaz Hussain Soomro, Dong Xiao bo, Abdul Ghani Dars, Javaid Ahmed Lakho, Si Hu and Wen Huang

March 2018

Bioefficacy of Duranta erecta leaf extract on yellow fever and dengue vector, Aedes aegypti Linn. in Nigeria

Mosquitoes are considered as a major problem in public health. Control measures mainly by chemical insecticides, have led to several environmental and health problems in addition to development of resistance. The bioefficacy of aqueous extract of leaves of Duranta erecta against the yellow fever and dengue vector, Aedes aegypti was evaluated as a step towards developing a safe and eco-friendly agent to combat the...

Author(s): Agwu Ekenma Julia, Odo Ejikeme Gregory, Ekeh Felicia, Uwagbae Michael, Ngwu Godwin and Ehilegbu Chinelo  

March 2018

In vitro antiviral activity of Brazilian Cerrado plant extracts against animal and human herpesviruses

The Brazilian savanna known as “Cerrado” is very rich in medicinal plants that are used by the local population for treatment of several illnesses. The herpesvirus is a serious problem worldwide, and affects both animal and human health. This work aimed to study the antiviral activity of eight extracts from plants natives of “Cerrado” region against human (HSV-1), equine (EqHV-1) and swine...

Author(s): Marina A. Padilla, Isabela C. Simoni, Verônica Moreira H. Hoe, Maria Judite B. Fernandes, Clarice W. Arns, Juliana R. Brito and João Henrique G. Lago  

March 2018

Pharmaceutical topical gel containing proanthocyanidin polymers-rich fraction from Stryphnodendron adstringens

The stem bark of Stryphnodendron adstringens, popularly known in Brazil as "barbatimão", has many biological activities, including antifungal activity. Considering the increasing interest of using "barbatimão" extract in the treatment of vaginal candidiasis, the aim of this study was to propose a pharmaceutical topical gel containing a proanthocyanidin polymers-rich fraction for use as...

Author(s): Marco Antonio Costa, Andressa Blainski,  Vanessa Kaplum, Marli Miriam de Souza Lima, Tânia Ueda-Nakamura, Benedito Prado Dias Filho, João Carlos Palazzo de Mello and Celso Vataru Nakamura  

March 2018

Acute toxicity and gastric anti-ulcer activity of an aqueous extract of the leaves of Macaranga barteri Müll.Arg (Euphorbiaceae) on rat models

Gastro-duodenal ulcers are diseases that constitute a major public health problem all over the world and particularly in Côte d'Ivoire. The aim of this study was to evaluate the acute toxicity and gastric anti-ulcer activity of an aqueous extract of the leaves of Macaranga barteri (AEMb). Acute toxicity was carried out using the Organization for Economic Co-operation and Development (OECD) Guidelines 420. The...

Author(s): EHILE Ehilé Hervé, GOZE Nomane Bernard, KOUAKOU Kouakou Léandre, YAPO Angoué Paul and EHILE Ehouan Etienne

February 2018

Gas chromatography–mass spectrometry (GC-MS) analysis of the constituents of the fixed oils obtained from the barks, leaves and stems of Spondias tuberosa Arruda (Anacardiaceae)

Spondias tuberosa Arruda (Anacardiaceae) is an endemic tree in the Caatinga Brazilian Biome, known locally as "umbuzeiro" and used for various purposes, especially as food and folk medicine. In this study, it was realized for the first time, the extraction and characterization by gas chromatography-mass spectrometry (GC-MS) of the fixed oils of barks, leaves and stems of S. tuberosa. The constituents of the...

Author(s): Amanda Leite Guimarães, Ana Paula de Oliveira, Geisiane Suila Feitosa dos Santos Silva, Geórgia Sueley Bezerra, Inaiara Sousa, Jackson Roberto Guedes da Silva Almeida, Joana D&#;arc de Sousa Rodrigues, José Marcos Teixeira de Alencar Filho and Edigênia Cavalcante da Cruz Araújo  

February 2018

Quantitative proteomic analysis of Isorhamnetin treatment in human liver cancer cells

Isorhamnetin (Iso) exhibits antitumor effects in promyelotic leukemia and lung cancers. However, its effect in liver cancer is not clear. This study explored the effects of Iso in human liver cancer cells and profiled the differential proteins upon Iso treatment, which contributes to a better understanding of its anticancer mechanisms. Stable isotope labeling with amino acids in cell culture-mass spectrometry:...

Author(s): Runhuan Fei and Haiyan Wei

February 2018

Antibacterial activity of Ethiopian Lepidium sativum L. against pathogenic bacteria

Lepidium sativum is commonly known as “fetto” in Ethiopia, and a popular herbal plant which is widely used in folk medicine. The objective of this study is to investigate the potential of three different crude solvent extracts from seed of Lepidium sativum (ethanol, methanol and chloroform) against human pathogenic bacterial strains: Escherichia coli (ATCC 25922), Klebsiella pneumoniae (ATCC-27736),...

Author(s): Yohannes Besufekad, Senbeto Beri, Tefera Adugnaw and Kibitu Beyene

February 2018

The antiulcer and antioxidant mechanisms of the butanolic fraction extract obtained from Bauhinia forficata leaves: A medicinal plant frequently used in Brazilian folk medicine

The objectives of this work were to evaluate the antiulcer activity, antioxidant mechanisms, phytochemical analysis and ecotoxicological risk of the butanolic fraction (ButFr) obtained from the leaf extracts of Bauhinia forficata. In an ischemia-reperfusion (IR), gastric ulcer model with doses 12.5 and 6.25 mg kg-1 promoted significant decreases in the ulcerative lesion area (ULA) by 50% (p<0.001) and 46%...

Author(s): Bárbara Gomes Del Rey, Luciana Lopes Guimarães, Marcos Sergio de Toledo, Hélio Kiyoshi Takahashi, Anita Hilda Straus, Monike Silva de Freitas, Bruna Hattebberger, Cláudia Maria Moraes Silva, Matheus Roberti de Carvalho and Walber Toma

February 2018

Effect of Combretum molle (Combretaceae) seed extract on hematological and biochemical parameters

Combretum molle (Combretaceae) is widely used traditional medicinal plant for treatment of different illnesses in most parts of Africa. However, its in vivo toxic effect is not evaluated yet. Thus, the aim of this study was to evaluate cytotoxic effect of C. molle seed extract on biochemical and hematological parameters using mice. Accordingly, effect of seed extract of the plant on hematological and biochemical...

Author(s): Merkin Anato, Mesele Bezabih and Tsige Ketema

January 2018

In vitro thrombolytic activity, antioxidant and cytotoxic properties of fruit extracts of Ficus erecta (Thunb.)

The aim of the study was to evaluate different biological properties of fruits extracts of Ficus erecta (Thunb.). The concentrated methanolic extracts and Kupchan partitions were screened for thrombolytic activity, whereas streptokinase was used as standard antioxidant property by evaluating free radical scavenging effect and determining total phenolic content and cytotoxic activity by brine shrimp lethality bioassay....

Author(s): Abullah Al Faysal, Yeunus Mian, Muhammed Mahfuzur Rahman, Mofiza Akter, Mahfuzur Rahman, Tariqul Haque Tuhin and Marzia Bilkiss

January 2018

Evaluation of essential oils from 22 Guatemalan medicinal plants for in vitro activity against cancer and established cell lines

Plant species which produce essential oils are important in the healthcare of rural Guatemalans. Steam distilled essential oils from 22 medicinal plant species were analyzed for activity against tongue, skin, and stomach cancer cell lines using a neutral red assay, Vero C1008 cells to assess cytotoxicity, and [3H]-thymidine incorporation assay to assess inhibition of cancer cell proliferation. IC50, CC50, and...

Author(s): Andrew Byron Miller, Rex Gordon Cates, Kim O’Neill, Juan Alfonso Fuentes Soria, Luis Vicente Espinoza, Ballantines Fabrizio Alegre, Jose Vicente Martinez and  Dany Raul Arbizu  

January 2018

Woody species from the Mozambican Miombo woodlands: A review on their ethnomedicinal uses and pharmacological potential

Miombo woodlands cover about two thirds of Mozambique national territory. They provide a wide collection of goods and services to the formal and informal economies. A review on the traditional uses of 15 Miombo tree species in human and animal health, as well as the status of research towards the identification of bioactive compounds is presented. Among the 15 species selected, 12 have been screened for their biological...

Author(s): Isabel Moura, Jossias Alberto Duvane, Maria José Silva, Natasha Ribeiro and Ana Isabel  Ribeiro-Barros

January 2018

Ethnobotanical study of medicinal plants used to manage HIV/AIDS opportunistic infections in Rungwe, Mbeya Region, Tanzania

The current ethnobotanical study identified medicinal plant species used to manage HIV/AIDS opportunistic infections by the communities in Rungwe District, Tanzania. Data were collected using questionnaires (n=193), interviews (n=9) and field observations. A total of 31 plant species from 23 families are used in managing HIV/AIDS opportunistic infections. Compositae and Rosaceae were predominantly used in disease...

Author(s): Suma F. Kibonde, Suzana Augustino, Faith P. Mabiki and Robinson Mdegela

January 2018

Therapeutic and pharmaceutical benefits of native and modified plant pectin

Plant pectin constitutes an important class of naturally occurring polysaccharides and are widely distributed in various fruits and vegetables consumed on a regular basis. These biomolecules are reported to exhibit a vast array of biological activities including effects on digestive system, chemo-preventive effect in colon cancer, regulation of blood cholesterol level and immune-potentiating effects. However, variation...

Author(s): Sutapa Biswas Majee, Dhruti Avlani, Priyanka Ghosh and Gopa Roy Biswas

January 2018

A novel anti-triple negative breast cancer compound isolated from medicinal herb Myrothamnus flabellifolius

Triple negative breast cancer (TNBC) is a disease that impacts millions of people around the world. There is an urgent need to find new therapies, specific to triple negative cancer cells with minimal effect on normal cells. This study explores the use of Myrothamnus flabellifolius as an anti-TNBC. Using High Performance Liquid Chromatography, the extract was fractionated and each fraction was tested against TNBC cells...

Author(s): Jaspal Brar, Norman Fultang, Kayla Askey, Maria Cristina Tettamanzi and Bela Peethambaran

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