Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3641

JMPR Articles

December 2019

Recent advances in analytical approaches for the standardization and quality of polyphenols of propolis

Analytical approaches utilized for the characterization of polyphenols from propolis useful for the determination of its quality is investigated in this study. A qualitative and quantitative evaluation of propolis bioactive molecules is of interest in medicine and nutraceuticals. Recent powerful analytical techniques are of great utility to separate and quantify polyphenols in extracts and finished products due to their...

Author(s): Fabio Galeotti, Federica Capitani, Alfredo Fachini and Nicola Volpi  

December 2019

In vitro and in vivo antimalarial activity of Nigella sativa L. extracts

The Arabs, Asians and, Traditional Health Practitioners in Mombasa county found in Kenya have been using Nigella sativa L. seeds to traditionally manage malaria associated symptoms that is, headache, fever, chills, loss of appetite among others. The present study investigated in vitro antiplasmodial, in vivo antimalarial activities and safety of different extracts of N. sativa. Five extracts obtained via aqueous...

Author(s): Job Oyweri, Awadh Mohammed, Rahma Udu, Jeremiah Gathirwa, Edwin Too, Protus Omondi, Francis Kimani, Suhaila Hashim and Laila Abubakar  

December 2019

Preliminary study to identify anti-sickle cell plants in Niger's traditional pharmacopoeia and their phytochemicals

The management of sickle cell disease is a major challenge at the international level. In many African countries, sickle cell anemia is one of the major causes of mortality and is a critical public health problem in Niger. In this part of the continent, the estimated prevalence is around 18 to 22%, which is amongst the highest in Africa. Nowadays, despite the existence of some ways to improve the prognosis of sickle...

Author(s): Amadou Tidjani Ilagouma, Issoufou Amadou, Hamo Issaka, Oumalhéri Amadou Tidjani Ilagouma and Khalid Ikhiri

November 2019

Antioxidant, DNA protective and antibacterial activities of Terminalia bellerica extracts

Terminalia bellerica Roxb., commonly known as Beleric myrobalan, is a well-known large deciduous tree with various pharmaceutical properties. However, scientific information on T. bellerica, growing in India, as regards to its phytochemical constituents and pharmacological properties is very limited. With this in view, this study investigated the antioxidant, DNA protective and antibacterial activities of different...

Author(s): Rasna Gupta, Ram Lakhan Singh and Ankit Gupta  

November 2019

Therapeutic role of chitosan nanoparticles in murine schistosomiasis mansoni

This research evaluates the value of loading Nigella sativa on chitosan nanoparticles (ChNPs) in the treatment of Schistosoma mansoni infection compared to praziquantel. Chitosan has efficient oral administrative capability to penetrate mucosal surface being mucoadhesive and non-toxic, as well as combination with NPs add characters of controlled release and safe serum levels. The study was done on 40 S. mansoni infected...

Author(s): Waleed E. Elawamy, Ahlam F. Mohram, Marwa M. Naguib, Hemat S. Ali, Shereen M. Kishik and Fatam F. Hendawi  

November 2019

The insight and survey on medicinal properties and nutritive components of Shallot

Shallot is a horticultural commodity belonging to spice vegetables. Shallot (Allium ascalonicum L.) is a perennial crop which is grown as an annual for its cluster of small cloves and bulbs. Persian shallot also is native and endemic of Iran and grows as a wild plant across Zagross mountains at high elevations. Shallot is an important source of carbohydrate, vitamin A, B, and C. Phenolic compound in Shallot consist of...

Author(s): Wenli Sun, Mohamad Hesam Shahrajabian, and Qi Cheng,  

November 2019

Menopause disorders and their treatment in traditional medicine in Burkina Faso

A survey was conducted in the central region of Burkina Faso to find out about women's menopause-related disorders and their treatment in traditional medicine. Fifty-six (56) species have been identified to treat different symptoms such as hot flashes, insomnia, nausea, joint and muscle pain, itching, lower abdominal pain, edema, mood disorders, vertigo. Leaves and stem bark were the most recommended in the...

Author(s): Alphonsine Ramde-Tiendrebeogo, Sabine Hien, Hassanata Millogo-Kone, Felix B. Kini, Aristide Traore, Joseph Issaka Boussim and Innocent Pierre Guissou  

November 2019

Effect of Withania somnifera in the treatment of male infertility: A literature review

The high prevalence of male infertility associated with the high costs of its conventional treatment motivated researchers to look for alternative approaches to the treatment of sexual dysfunction. The use of medicinal plants for these fins has been adopted in Withania somnifera which is one of the plants that has been associated with improvements in male fertility. Thus, the aim of this study was to review data...

Author(s): Maria Yasmin Paz Teixeira and Camilla Oliveira Duarte de Araujo  

November 2019

Evaluation of aphrodisiac properties of the aqueous extract of the trunk barks of Spathodea campanulata P. Beauv. (Bignoniaceae) on albino rats (Rattus norvegicus)

Spathodea campanulata P. Beauvois (Bignoniaceae) is a tree from the tropical and subtropical forests of Africa, used in folk medicine for the treatment of several diseases such as gastric pain, rheumatism, lumbago, cataracts and some intestinal parasites. In West Cameroon, traditional healers use a decoction of the bark of the trunk as an aphrodisiac in males. The objective of the present study was to evaluate the...

Author(s): Talla Clovis, Ilyassa Yaya, Nnanga Nga, Dibong Siegfried Didier and Mpondo Mpondo Emmanuel,  

October 2019

Hypoglycemic activity of Antidesma bunius (L.) Spreng and Mollugo oppositifolia L. fresh and alcoholic extracts in the db/db diabetic mouse model

Antidesma bunius (L.) Spreng and Mollugo oppositifolia L., also known as “bignay” and “malagoso” respectively, are commonly used medicinal plants in the Philippines to treat diabetes. However, the hypoglycemic effect of A. bunius (L.) Spreng and M. oppositifolia L. has not been reported to date. Therefore, this study was undertaken to investigate the hypoglycemic effects of the fresh and...

Author(s): N. C. Tanquilut, N. Q. Alonzo, A. E. James, D. K. Rowlands, G. C. Sanchez, R. D. San Jose, E. Yesner, M. R. C. Tanquilut and B. A. S. Reyes,  

October 2019

Chromatography and bioautography of endophytic fungi extracts of Uncaria tomentosa (Willd.) DC with antibacterial activity

Endophytic fungi of different species have already proved their efficacy against a range of pathogenic bacteria. However, the separation of the compounds contained in these extracts that actually have an effective activity is not a constant, but it is essential for the scientific knowledge to formulate a new medication. Thus, this study aimed to separate compounds from two endophytic fungi extracts of Uncaria tomentosa...

Author(s): Fernando Generoso da Silva GONÇALVES, Jonatas Conceição de ARAÚJO, Dionízio da Silva BRASIL, Rodrigo Asfury RODRIGUES and Clarice Maia CARVALHO  

October 2019

Antifungal efficacy of crude extracts of Azadirachta indica and Vernonia amygdalina against pathogenic Aspergillus niger (ATCC 16404)

This research work was conducted to assess the potency of ethanolic and hot water extract of Azadirachta indica and Vernonia amygdalina against pathogenic Aspergillus niger (ATCC 16404). Potato Dextrose Agar was the medium under which the antimicrobial sensitivity test was carried out. Streptomycin solution was also added to the medium to selectively inhibit the growth of bacterial cell. The results showed that, higher...

Author(s): Ninkuu V., Adetunde, L. A., Sackey I., Opoku N. and Diedong P.  

October 2019

Biotechnological potential of the Carapa guianensis, Bertholletia excelsa and Copaifera spp. oils

The use of vegetable species for treatment or prevention of diseases is one of the most ancient medicine techniques in humanity. In Amazon rainforest, there are numerous of plant species that possess biotechnological potential, and due to this, this study aimed at carrying out a bibliographic review describing the biotechnological potential in Carapa guianensis, Bertholletia excels, and Copaifera spp. oils. This study...

Author(s): Naila Fernanda Sbsczk Pereira Meneguetti, Dionatas Ulises de Oliveira Meneguetti,, and Amauri Siviero,  

October 2019

Evaluation of hepatoprotective, antioxidant and cytotoxic properties of aqueous extract of turmeric rhizome (Turmesac®)

In the present study, the hepatoprotective, antioxidant and cytotoxic activities of aqueous extract of turmeric rhizome (Turmesac®) were evaluated. In brief, Turmesac® was extracted from turmeric rhizome. 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay was used to evaluate the hepatoprotective and cytotoxic activities of the Turmesac® against the human liver (HUH-7) and breast cancer...

Author(s): C. T. Sadashiva, H. M. Firoz Hussain and S. Nanjundaiah  

September 2019

DNA methylation as the most important content of epigenetics in traditional Chinese herbal medicine

Traditional Chinese medicine is commonly used in China and so many other Asian and western Countries. Epigenetics relates to heritable alternations in chromatin architecture that do not involve changes in the underlying DNA sequence but profoundly affect gene expression and impact cellular function. Epigenetic regulation is attained by specific mechanisms involving DNA methylation, histone posttranslational...

Author(s): Mohamad Hesam Shahrajabian,#, Wenli Sun,# and Qi Cheng,#  

September 2019

Ethnobotanical studies of medicinal plants used in traditional treatment of malaria by some herbalists in Ghana

The use of medicinal plants for the treatment of diseases including malaria is a common practice in Ghanaian traditional medicine. The objective of this study is to document indigenous knowledge of medicinal plants used for the treatment of malaria through ethno-botanical studies to facilitate the discovery of new sources of drugs. The study was carried out in 2018 at the Centre for Plant Medicine Research (CPMR) among...

Author(s): Tonny Asafo-Agyei, Heron R. Blagogee, Susana Oteng Mintah, Mary-Ann Archer, Frederick Ayertey, Alexis Conrad Sapaty, Peter Atta-Adjei Jnr, Daniel Boamah, Jerry Asiedu-Larbi and Alfred Ampomah Appiah  

September 2019

Chemical composition, in vitro antioxidant and antiparasitic properties of the essential oils of three plants used in traditional medicine in Benin.

Sclerocarya birrea (Sb), Psidium guajava (Pg) and Eucalyptus camaldulensis (Ec) are widely used in traditional medicine for the treatment of many diseases, some of which were related to oxidative stress and parasitic diseases. Their essential oils (EO) were analyzed by GC/MS and FID and tested in vitro for their antioxidant activities (DPPH), their anti-trypanosomal and anti-plasmodial activities against Trypanosoma...

Author(s): Didier Kpadonou, Salomé Kpoviessi,, Joanne Bero, Pierre Agbani, Fernand Gbaguidi, Bénédicta Kpadonou-Kpoviessi, Brice Sinsin, Michel Frédérich and Joëlle Quetin-Leclercq  

August 2019

DPPH radical scavenging activity of extracts from Rhamnus prinoides

Hexane, chloroform, ethyl acetate and methanolic extracts from leaves and stem-bark of Rhamnus prinoides were evaluated for their antioxidant activity by DPPH radical scavenging assay. The leaves extracts showed scavenging activity ranging from 03.33±0.89 to 55.03±3.40 µg mL-1 while the stem-bark extracts showed relatively strong scavenging activity ranging from 03.65±1.02 to 59.55±2.27...

Author(s): Manoharan Karuppiah Pillai, Lehlohonolo Isaac Santi and Sibusisiwe Magama

August 2019

Evaluation of cytotoxic activity of triterpenes from Clusia studartiana

Family Clusiaceae is spread throughout tropical as well as temperate zones, presenting many triterpenes, reported as selective antitumoral agents. The aim of this study is to isolate and identify triterpenes from Clusia studartiana C. M. Vieira & Gomes da Silva and evaluate their cytotoxicity in melanoma (SKMEL 28) and myeloid leukemia (K562) cell lines. Thus, the hexanic extract was processed by phytochemical...

Author(s): Lavínia de C. Brito, Marcia V. de Carvalho, Vagner P. da Silva, Alan P. Heringer, Priscila M. da Silva, Ana Paula G. A. Fontão, Maria R. Figueiredo and André Luiz F. Sampaio  

August 2019

Modulatory effects of Momordica balsamina on Th1/Th2 cytokine profiles in immune-challenged rats

There is an ever-growing interest to identify plants that boost the immune system functions. The objective of the present study was to evaluate the immunomodulatory effects of Momordica balsamina (MB) leaves extract in BCG-immunized rats. Thirty rats were randomly divided into five groups (n = 6). MB extract was suspended in 1% carboxymethyl cellulose (CMC).  Firstly, animals were challenged subcutaneously with...

Author(s): Iman H. Abdoon, Bashier Osman, Maowia M. Mukhtar and Hatim Ali Elsheikh  

August 2019

Comparative study of proximate, mineral and phytochemical analysis of the leaves of Ocimum gratissimum, Vernonia amygdalina and Moringa oleifera

The aim of this study is to make a comparative analysis of the proximate, mineral and phytochemical compositions of the leaves of Ocimum gratissimum, Vernonia amygdalina and Moringa Oleifera plants found within our vicinity in Nigeria. The analyses were investigated in accordance with standard procedures and compared. Of the 3 plants, M. oleifera had highest (P<0.05) crude fat, crude protein and total ash but lowest...

Author(s): M. D. Olumide, O. A. Ajayi and O. E. Akinboye  

July 2019

Phytochemical screening, chromatographic profile and evaluation of antimicrobial and antioxidant activities of three species of the Cyperaceae Juss. Family

Some species of the family Cyperaceae have been studied extensively for presenting bioactive compounds of pharmacological interest. Thus, the present research aimed to investigate the antimicrobial, antioxidant and chemical constituents of Kyllinga odorata Vahl, Oxycaryum cubensis Poepp. & Kunth and Rhynchospora nervosa Boeck. Hydroalcoholic extracts (1:1, v:v) of aerial and underground parts. These species were...

Author(s): José Jailson Lima Bezerra, Ticiano Gomes do Nascimento, Regianne Umeko Kamiya, Ana Paula do Nascimento Prata, Patrícia Muniz de Medeiros, Sâmia Andrícia Souza da Silva and Cecília Nascimento de Mendonça  

July 2019

Evaluation of antidiabetic activity of the ethanol extract of Momordica charantia L. and the identification of charantine by gas chromatography coupled with Mass spectrometry

The aerial parts of Momordica charantia L. are very often used in traditional Congolese medicine for their multiple virtues. Our study focused on the identification of a well-known antidiabetic molecule: the charantine and also the antidiabetic properties of the ethanol extract of M. charantia L. After being treated with MSTFA (N-Methyl-N-(trimethylsilyl) trifluoroacetamide) and using gas chromatography-Mass...

Author(s): Snelle Miakayizila Baonda, Celestine Nkounkou Loumpangou, Raoul Ampa, Arnold Murphy Elouma Ndinga, Longin Justin Clair Bonazaba Milandou, Myriam Bonose  and Jean Maurille Ouamba  

July 2019

Evaluation of acute toxicity and sub-acute toxicity of the methanolic extract of Aloe rabaiensis Rendle in BALB/c mice

This study was undertaken to evaluate preclinical acute and sub-acute toxicity of Aloe rabaiensis leaf methanolic extract (ARLME) on BALB/c mice following OECD guidelines 423 and 407, respectively. In an acute oral toxicity test, ARLME was administered to the mice by oral gavage at a single dose of 1000, 2000, 3000, 4000 and 5000 mg/Kg body weight. The mice were observed for toxic signs for 14 days. In sub-acute oral...

Author(s): Mwanaisha Mkangara, Ernest Mbega and Musa Chacha  

July 2019

In vitro antiproliferative potential of Annona senegalensis Pers. and Allophylus africanus P Beauv. plant extracts against selected cancer cell lines

The medicinal plants Annona senegalensis Pers. and Allophylus africanus P Beauv. are used in Tanzania traditional medicine for the treatment of cancer. However, there is no scientific documentation on their therapeutic effectiveness. The present study evaluated antiproliferative potential as an indicator of anticancer activity of A. senegalensis and A. africanus plant species from Tanzania. A. senegalensis and A....

Author(s): Emiliana Zacharia Biseko, Hulda Shaidi Swai, Regina Wachuka Mbugua, Jecinta Wanjiru Ndung’u, Jean Chepng’etich and Jeremiah Waweru Gathirwa

June 2019

Fungistatic activity of essential oils for the control of bipolaris leaf spot in maize

Research institutions have emphasized alternative disease control agents because they represent a great option with beneficial effects on human and animal health and ecosystem balance. Despite the studies already done on botanical fungicides, their effective use requires knowledge about the applicability of natural products to different production systems. The main objective of this study is to evaluate the efficacy of...

Author(s): Dalmarcia De Souza Carlos Mourão, Micaele Rodrigues De Souza, João Vinícius Lopes Dos Reis, Talita Pereira De Souza Ferreira, Pedro Raymundo Argüelles Osorio, Eduardo Ribeiro Dos Santos, Damiana Beatriz Da Silva, Paulo Henrique Tschoeke, Fabrício Souza Campos and Gil Rodrigues Dos Santos  

June 2019

Evaluation of active phytochemical constituents linked to the analgesic and anti-inflammatory property of Cassia singueana Del. root bark

Cassia singueana is used in ethnomedicine for the management of pain and other related ailments. This study aimed to investigate the phytochemical constituents of the plant’s root bark linked to the therapeutics claims of its analgesic and anti-inflammatory activities. The plant material was obtained and identified, and its phytochemical fingerprint profile was established using GC-MS technique. The plant’s...

Author(s): Michael Sunday Uko, Aliyu Usman, Ibrahim Toma, Samuel E. Okhale, Samuel T. Magili and Bulus Adzu,  

June 2019

In vitro evaluation of fruit extracts of Annona stenophylla diels and Flacourtia indica for incorporation into formulations for management of cancer

There are many reports which show a positive relationship between free radical damage and diseases such as cancer. Free radicals are formed when humans are exposed to ionizing radiation or during oxidation process in human beings can damage tissues and may potentially lead to development of cancers. Since radiation may be used in the management of cancer, there is need for the development of a radioprotective herbal...

Author(s): Cosmas Josiah Musewu and Rudo Fiona Mapanga  

June 2019

Chemical fingerprint of Bacopa monnieri L. and Rosmarinus officinalis L. and their neuroprotective activity against Alzheimer's disease in rat model’s putative modulation via cholinergic and monoaminergic pathways

Alzheimer’s disease is characterized by progressive degeneration of cortical and hippocampal neurons. This study aims to characterize the metabolic profiles of the hydro-ethanolic extracts of Bacopa monnieri L. (BM) and Rosmarinus officinalis L. (RO) cultivated in Egypt via UPLC–ESI/MS analyses and reveal their possible mechanism of the prophylactic effect(s) on neuro-degeneration in rat model of...

Author(s): Nermien E. Waly, Nora M. Aborehab and Mahitab H. El Bishbishy  

June 2019

Evaluation of the in vivo antiplasmodial activity of ethanol leaf extract and fractions of Jatropha gossypifolia in Plasmodium berghei infected mice

The study evaluates the in vivo antiplasmodial activity of ethanol leaf extract and fractions of Jatropha gossypifolia in Plasmodium berghei infected mice. Phytochemical, physicochemical analyses, median lethal dose (LD50), effects on biochemical parameter were evaluated and the schizonticidal effects during early and established infections were investigated. The extract (50-200 mg/kg) was screened for antimalarial...

Author(s): Onyegbule F. A., Bruce S. O., Onyekwe O. N., Onyealisi O. L. and Okoye P. C.  

May 2019

A review of Ginseng species in different regions as a multipurpose herb in traditional Chinese medicine, modern herbology and pharmacological science

Ginseng is the most famous of the Chinese herbs throughout the world, and has been one of the most valued herb in China. Traditional Chinese medicine as an essential element of alternative and complementary medicine, advanced over thousands of years with its own distinctive arrangement of therapies, diagnostics theories and in Asian countries, particularly China. In most parts of the world, especially western countries,...

Author(s): Mohamad Hesam Shahrajabian, Wenli Sun, and Qi Cheng,  

May 2019

In vitro anti-inflammatory activity of ginger (Zingiber officinale Rosc.) rhizome, callus and callus treated with some elicitors

This study evaluated the effect of ginger rhizome and its callus as well as callus elicited by yeast extract, glycine and salicylic acid on the production of pro-inflammatory (TNF-α, IL-1 and IL-6) and anti-inflammatory (IL-10 and TGF-β) cytokines in vitro. Petroleum ether (PE) and chloroform; methanol (1:1) (CM) extracts of rhizome and callus were shown to significantly (P < 0.05) suppress in a...

Author(s): Ammar Mohammed Ahmed Ali, Mawahib ElAmin Mohamed El-Nour, Owais Mohammad and Sakina Mohamed Yagi  

May 2019

Antihistaminic action of Melaleuca armillaris ointment

Melaleuca oil has great medicinal properties. The objective is to develop a product based on Melaleuca armillaris to evaluate its antihistaminic action and to compare the antihistaminic effect and protective effect of M. armillaris oil and ointment. Pruritus intensity was assessed at sensitization points. Eighty volunteers, aged between 21 and 60 years (male and female) participated in the study, without...

Author(s): Kassandra Elfrida Pauliello, Diba Maria Sebba Tosta Souza, Marcos Mesquita Filho, Manoel Araújo Teixeira and Adriana Rodrigues dos Anjos Mendonça  

May 2019

Chemical composition and antimicrobial activity of essential oils from Aframomum citratum, Aframomum daniellii, Piper capense and Monodora myristica

This study was initiated to evaluate the chemical composition and in vitro antimicrobial activity of essential oils from four Cameroonian spices and to determine the therapeutic effect of a cream based on essential oil from Aframomum citratum. Essential oils were extracted from seeds by hydrodistillation and analyzed by gas chromatography coupled with mass spectrometry (GC/MS). The broth microdilution method was used...

Author(s): Sylvie Carolle Meffo Dongmo, Jean-De-Dieu Tamokou#, Guy Sedar Singor Njateng, Pierre Tane and Jules-Roger Kuiate  

May 2019

Cytotoxicity of selected Ethiopian medicinal plants used in traditional breast cancer treatment against breast-derived cell lines

Traditional medicine is widely practiced in Ethiopia. Here we investigate the toxicity of extracts of seven medicinal plants traditionally used to treat breast cancer in Ethiopia. These plants, Sideroxylon oxyacanthum, Zanthoxylum chalybeum, Clematis simensis, Clematis longicauda, Dovyalis abyssinica, Vernonia leopoldi, and Clerodendrum myricoides, were selected based on recommendations by traditional healers and on the...

Author(s): Nigatu Tuasha,, Daniel Seifu, Endalamaw Gadisa, Beyene Petros and Stina Oredsson  

May 2019

Ethnobotanical survey and phytogeographical study of plants species from genus Acacia in Bénin

The genus Acacia, mainly distributed in the tropical and subtropical regions, has been used in traditional medicines for the treatment of microbial infections, malaria, diarrhea, oedema and inflammation. The present study aims to provide a comprehensive data on the distribution and medicinal use of Acacia species. Ethnobotanical survey and phytogeographical study were undertook using field interviews. Informant...

Author(s): Mounirou Tchatchedre, Abdou Madjid Amoussa, Marcel Houinato, Hounnankpon Yedomonhan and Latifou Lagnika  

April 2019

Isolation and identification of compounds with dioxin-induced AhR transformation inhibitory activity from the leaves of Mallotus japonicus (Thunb.) Muell. Arg.

The solvent extracts of 368 plant parts from 191 different species cultivated in Tsukuba (Ibaraki Prefecture, Japan) were previously screened for aryl hydrocarbon receptor (AhR) transformation inhibitory activity. It was observed that the leaf extract of Mallotus japonicus had strong activity. To clarify the antidioxin phytochemical, a 70% acetone extraction from the leaves was fractionated with three kinds of solvent...

Author(s): Keizo Hosokawa, Atsuyuki Hishida, Shin Nishiumi, Eri Fukushi, Jun Kawabata and Hitoshi Ashida  

April 2019

Genus Etlingera - A review on chemical composition and antimicrobial activity of essential oils

Essential oil from plants belonging to several species has been extensively used as natural resources in the prevention and treatment of a large number of diseases. The medicinal and aromatic plants of genus Etlingera produces high percentages of essential oil from its every organ and is recommended for a variety of health problems by traditional systems of medicine in south-east Asia. Essential oils from this genus...

Author(s): A. F. M. Shahid Ud-Daula and Mohammad A. Basher

April 2019

Cytotoxic potential of 14 Passiflora species against cancer cells

This work aimed to evaluate the cytotoxic potential against cancer cells of Passiflora genus plant species cultivated in Brazil and identify the mechanism of cytotoxicity induced by the most promising extract. Ethanolic extracts from the leaves of 14 Passiflora species were obtained by accelerated solvent extraction and in vitro cytotoxicity evaluated against cancer cell lines using MTT assay at a single concentration...

Author(s): Ricardo Guimarães Amaral, Silvana Vieira Floresta Gomes, Maria Claudia dos Santos Luciano, Cláudia do Ó Pessoa, Luciana Nalone Andrade, Patrícia Severino, Geraldo Célio Brandão, Larissa Mendes Bomfim, Milena Botelho Pereira Soares, Daniel Pereira Bezerra, Jorge Maurício David and Adriana Andrade Carvalho  

March 2019

Bio-guided identification of antiglycative constituents from the leaves of Mangifera indica L.

Advanced glycation end-products (AGEs) have been shown to be implicated in many degenerative disorders as well as diabetic pathology. Of interest, several natural compounds including phenolic constituents are capable of inhibiting the formation of AGEs. Bio-guided fractionation of a methanol extract from Mangifera indica leaves led to the characterization of six antiglycative constituents including gallic acid (1),...

Author(s): Samba Fama Ndoye, Didier Fraisse, Blandine Akendengué, Rokhaya Sylla Gueye, Cheikh Sall, Mael Gainche, Insa Seck, Catherine Felgines, Matar Seck and François Senejoux  

March 2019

Edraianthus pumilio (Schult.) A. DC.: Phytochemical and biological profile

Edraianthus pumilio is stenoendemic plant native to Dalmatia, Croatia. This paper deals with its phytochemical and biological profile. Phytochemical profile of volatile oil was performed by the gas chromatography–mass spectrometry (GC/MS), while total phenolic content of its aqueous extract was performed by Folin-Ciocalteu method. The phytochemical analysis showed that the main volatile oil compounds were nonanal...

Author(s): Olivera Politeo, Stanislava Talic  and Mirko Ruscic  

March 2019

Protective effects of Pleurotus ostreatus in ameliorating carbon tetrachloride (ccl4) induced liver injury in Wistar rats

Since oxidative stress is implicated in the pathogenesis of liver diseases, this study was carried out to evaluate the hepatoprotective, hematoprotective and hypolipidemic effects of Pleurotus ostreatus (Oyster mushroom) in Carbon Tetrachloride (CCl4) induced liver injury in wistar rats. Thirty rats were used for this study. The rats were divided into five groups of six rats per cage. Group I that served as the normal...

Author(s): Ubhenin, A. E., Adamude F. A., Nweze,C.C., and Dingwoke, E.J.  

March 2019

Identification of annotated metabolites in the extract of Centella asiatica

Plants contribute to 75% of molecular medicines (MM) either directly or indirectly. Centella asiatica (CA) is being extensively used in experimental and clinical studies. However, its scientific approval is not forthcoming. It is well known that every plant contains useful as well as some harmful compounds. Subjecting whole plant extracts containing harmful compounds to modern pharmacological methods will only...

Author(s): Komal Rani, Mitali Tyagi, Akanksha Singh, Vairamani Shanmugam, Annaian Shanmugam, Manoj Pillai and Alagiri Srinivasan,  

February 2019

Essential oil composition, antifungal activity and leaf anatomy of Lippia alba (Verbenaceae) from Brazilian Chaco

This study aims to determine the essential oil chemical composition of Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson collected in the Brazilian Chaco where plants grow in conditions of high temperatures in the summer, periodic flood, low temperatures and air humidity in the winter. We also evaluate the oil antifungal activity against the animal and plant pathogenic fungi Aspergillus flavus, A. fumigatus, A....

Author(s): Rosani do Carmo de Oliveira Arruda⊃, Cristiane Pimentel Victório⊃, Amanda Galdi Boaretto⊃, Carlos Alexandre Carollo⊃, Cariolando da Silva Farias, Clarice Rossato Marchetti, Ronaldo José dos Santos⊃, Giovana Cristina Giannesi and Denise Brentan Silva⊃  

February 2019

Determination of concentration of some essential and heavy metals in roots of Moringa stenopetala using flame atomic absorption spectroscopy

This study is aimed at determination of concentration of essential (Ca, K, Na and Mg) and heavy (Cd, Cr, Pb, Hg, Cu and Zn) metals using Flame Atomic Absorption Spectroscopy (FAAS) of samples taken from fresh roots of Moringa stenopetala. A wet digestion method involving use of mixture of (HCl and HNO3, ratio 3:1) and 10 ml of 30% H2O2 at an optimum temperature and time duration was deployed during sample preparations....

Author(s): Tsegaye Mega Kaba and Kusse Gudishe Goroya  

February 2019

Aristolochic acids in herbal medicine: Public health concerns for consumption and poor regulation of botanical products in Nigeria and West Africa

Aristolochic acids are naturally occurring biomolecules found in plants of the genus Aristolochia and Asarum belonging to the family Aristolochiaceae. They are reported to be carcinogenic and nephrotoxic; and are implicated in kidney diseases, aristolochic acid nephropathy (AAN) which may result in kidney failure, other health complications and possibly death. Aristolochic acids are highly genotoxic and are linked to...

Author(s): Okhale S. E., Egharevba H. O., Okpara O. J., Ugbabe G. E., Ibrahim J. A., Fatokum O. T., Sulyman A. O.  and Igoli J. O.  

February 2019

In vitro effect and scanning electron microscopic changes of Nigella sativa loaded chitosan nanoparticles on Schistosoma mansoni adult

Nanoparticles can act as drug carriers that can modulate pharmacokinetics, increase bioavailability and target release with minimal toxic effects. The present work aimed to assess the therapeutic effect and electron microscopic changes of Nigella sativa loaded Chitosan Nanoparticles (NSLCN) on adult Schistosoma mansoni in vitro. Adult worms were removed from the portal and mesenteric veins of infected mice after 90...

Author(s): Shereen Magdy Kishik, Ahlam Farag Mohram, Marwa Mohamed Nagib, Hemat Salah Ali and Fatma Fawzi Hendawy  

February 2019

Effect of hormones on the seed germination of Bupleurum species

In Asia, Radix Bupleuri (Bupleurum spp. root) is an important medicine used for treating many diseases over the past 2000 years. However, its cultivation is difficult due to poor germination rates and loss of seedling viability shortly after seeding. In the present study, the effect of 6-benzyl aminopurine (6-BA), daminozide, gibberellin (GA3), paclobutrazol, uniconazole, and mepiquat chloride (MC) on the germination of...

Author(s): Ma Yu, Guihua Lv, Hongzhang, Yuchan Li, Cheng Yuan, Zhikang Tang, Xiaoyan Shu, Chun Sui, Dabin Hou and Jian-He Wei  

January 2019

Exploring the anticoagulant and antiplatelet effect of the extracts of the red marine alga Acanthophora spicifera

Cardiovascular diseases represent the major cause of death and morbidity in the world. An uncontrolled activation of the coagulation cascade and platelet aggregation may lead to the formation of thrombi. Antithrombotic drugs have limitations and may produce side effects, and consequently, alternative therapies have been extensively investigated. Thus, the aim of this work was to evaluate anticoagulant and antiplatelet...

Author(s): Vivian Rodrigues de Souza, Laura de Andrade Moura, Ana Cláudia Rodrigues da Silva, Kelly Ketely Granja Pereira, Caio Cesar Richter Nogueira, Diana Negrão Cavalcanti, Valéria Laneuville Teixeira and André Lopes Fuly  

January 2019

Antibacterial potential of extracts of the roots of Zingiber officinale against bacterial strains commonly associated with nosocomial infections

Zingiber officinale, commonly known as ginger, has been used as a medicinal plant for decades for medical and culinary purposes. This study aimed to determine the antimicrobial potential of ginger root extracts using the Kirby-Bayer agar diffusion method to compare the zones of inhibition of the extracts to those of synthetic antibiotics against five clinical bacterial pathogens (Escherichia coli, Pseudomonas...

Author(s): Hannaty Abuga and Goabaone Gaobotse  

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