Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3626

JMPR Articles

September 2019

DNA methylation as the most important content of epigenetics in traditional Chinese herbal medicine

Traditional Chinese medicine is commonly used in China and so many other Asian and western Countries. Epigenetics relates to heritable alternations in chromatin architecture that do not involve changes in the underlying DNA sequence but profoundly affect gene expression and impact cellular function. Epigenetic regulation is attained by specific mechanisms involving DNA methylation, histone posttranslational...

Author(s): Mohamad Hesam Shahrajabian,#, Wenli Sun,# and Qi Cheng,#  

September 2019

Ethnobotanical studies of medicinal plants used in traditional treatment of malaria by some herbalists in Ghana

The use of medicinal plants for the treatment of diseases including malaria is a common practice in Ghanaian traditional medicine. The objective of this study is to document indigenous knowledge of medicinal plants used for the treatment of malaria through ethno-botanical studies to facilitate the discovery of new sources of drugs. The study was carried out in 2018 at the Centre for Plant Medicine Research (CPMR) among...

Author(s): Tonny Asafo-Agyei, Heron R. Blagogee, Susana Oteng Mintah, Mary-Ann Archer, Frederick Ayertey, Alexis Conrad Sapaty, Peter Atta-Adjei Jnr, Daniel Boamah, Jerry Asiedu-Larbi and Alfred Ampomah Appiah  

August 2019

DPPH radical scavenging activity of extracts from Rhamnus prinoides

Hexane, chloroform, ethyl acetate and methanolic extracts from leaves and stem-bark of Rhamnus prinoides were evaluated for their antioxidant activity by DPPH radical scavenging assay. The leaves extracts showed scavenging activity ranging from 03.33±0.89 to 55.03±3.40 µg mL-1 while the stem-bark extracts showed relatively strong scavenging activity ranging from 03.65±1.02 to 59.55±2.27...

Author(s): Manoharan Karuppiah Pillai, Lehlohonolo Isaac Santi and Sibusisiwe Magama

August 2019

Evaluation of cytotoxic activity of triterpenes from Clusia studartiana

Family Clusiaceae is spread throughout tropical as well as temperate zones, presenting many triterpenes, reported as selective antitumoral agents. The aim of this study is to isolate and identify triterpenes from Clusia studartiana C. M. Vieira & Gomes da Silva and evaluate their cytotoxicity in melanoma (SKMEL 28) and myeloid leukemia (K562) cell lines. Thus, the hexanic extract was processed by phytochemical...

Author(s): Lavínia de C. Brito, Marcia V. de Carvalho, Vagner P. da Silva, Alan P. Heringer, Priscila M. da Silva, Ana Paula G. A. Fontão, Maria R. Figueiredo and André Luiz F. Sampaio  

August 2019

Modulatory effects of Momordica balsamina on Th1/Th2 cytokine profiles in immune-challenged rats

There is an ever-growing interest to identify plants that boost the immune system functions. The objective of the present study was to evaluate the immunomodulatory effects of Momordica balsamina (MB) leaves extract in BCG-immunized rats. Thirty rats were randomly divided into five groups (n = 6). MB extract was suspended in 1% carboxymethyl cellulose (CMC).  Firstly, animals were challenged subcutaneously with...

Author(s): Iman H. Abdoon, Bashier Osman, Maowia M. Mukhtar and Hatim Ali Elsheikh  

August 2019

Comparative study of proximate, mineral and phytochemical analysis of the leaves of Ocimum gratissimum, Vernonia amygdalina and Moringa oleifera

The aim of this study is to make a comparative analysis of the proximate, mineral and phytochemical compositions of the leaves of Ocimum gratissimum, Vernonia amygdalina and Moringa Oleifera plants found within our vicinity in Nigeria. The analyses were investigated in accordance with standard procedures and compared. Of the 3 plants, M. oleifera had highest (P<0.05) crude fat, crude protein and total ash but lowest...

Author(s): M. D. Olumide, O. A. Ajayi and O. E. Akinboye  

July 2019

Phytochemical screening, chromatographic profile and evaluation of antimicrobial and antioxidant activities of three species of the Cyperaceae Juss. Family

Some species of the family Cyperaceae have been studied extensively for presenting bioactive compounds of pharmacological interest. Thus, the present research aimed to investigate the antimicrobial, antioxidant and chemical constituents of Kyllinga odorata Vahl, Oxycaryum cubensis Poepp. & Kunth and Rhynchospora nervosa Boeck. Hydroalcoholic extracts (1:1, v:v) of aerial and underground parts. These species were...

Author(s): José Jailson Lima Bezerra, Ticiano Gomes do Nascimento, Regianne Umeko Kamiya, Ana Paula do Nascimento Prata, Patrícia Muniz de Medeiros, Sâmia Andrícia Souza da Silva and Cecília Nascimento de Mendonça  

July 2019

Evaluation of antidiabetic activity of the ethanol extract of Momordica charantia L. and the identification of charantine by gas chromatography coupled with Mass spectrometry

The aerial parts of Momordica charantia L. are very often used in traditional Congolese medicine for their multiple virtues. Our study focused on the identification of a well-known antidiabetic molecule: the charantine and also the antidiabetic properties of the ethanol extract of M. charantia L. After being treated with MSTFA (N-Methyl-N-(trimethylsilyl) trifluoroacetamide) and using gas chromatography-Mass...

Author(s): Snelle Miakayizila Baonda, Celestine Nkounkou Loumpangou, Raoul Ampa, Arnold Murphy Elouma Ndinga, Longin Justin Clair Bonazaba Milandou, Myriam Bonose  and Jean Maurille Ouamba  

July 2019

Evaluation of acute toxicity and sub-acute toxicity of the methanolic extract of Aloe rabaiensis Rendle in BALB/c mice

This study was undertaken to evaluate preclinical acute and sub-acute toxicity of Aloe rabaiensis leaf methanolic extract (ARLME) on BALB/c mice following OECD guidelines 423 and 407, respectively. In an acute oral toxicity test, ARLME was administered to the mice by oral gavage at a single dose of 1000, 2000, 3000, 4000 and 5000 mg/Kg body weight. The mice were observed for toxic signs for 14 days. In sub-acute oral...

Author(s): Mwanaisha Mkangara, Ernest Mbega and Musa Chacha  

July 2019

In vitro antiproliferative potential of Annona senegalensis Pers. and Allophylus africanus P Beauv. plant extracts against selected cancer cell lines

The medicinal plants Annona senegalensis Pers. and Allophylus africanus P Beauv. are used in Tanzania traditional medicine for the treatment of cancer. However, there is no scientific documentation on their therapeutic effectiveness. The present study evaluated antiproliferative potential as an indicator of anticancer activity of A. senegalensis and A. africanus plant species from Tanzania. A. senegalensis and A....

Author(s): Emiliana Zacharia Biseko, Hulda Shaidi Swai, Regina Wachuka Mbugua, Jecinta Wanjiru Ndung’u, Jean Chepng’etich and Jeremiah Waweru Gathirwa

June 2019

Fungistatic activity of essential oils for the control of bipolaris leaf spot in maize

Research institutions have emphasized alternative disease control agents because they represent a great option with beneficial effects on human and animal health and ecosystem balance. Despite the studies already done on botanical fungicides, their effective use requires knowledge about the applicability of natural products to different production systems. The main objective of this study is to evaluate the efficacy of...

Author(s): Dalmarcia De Souza Carlos Mourão, Micaele Rodrigues De Souza, João Vinícius Lopes Dos Reis, Talita Pereira De Souza Ferreira, Pedro Raymundo Argüelles Osorio, Eduardo Ribeiro Dos Santos, Damiana Beatriz Da Silva, Paulo Henrique Tschoeke, Fabrício Souza Campos and Gil Rodrigues Dos Santos  

June 2019

Evaluation of active phytochemical constituents linked to the analgesic and anti-inflammatory property of Cassia singueana Del. root bark

Cassia singueana is used in ethnomedicine for the management of pain and other related ailments. This study aimed to investigate the phytochemical constituents of the plant’s root bark linked to the therapeutics claims of its analgesic and anti-inflammatory activities. The plant material was obtained and identified, and its phytochemical fingerprint profile was established using GC-MS technique. The plant’s...

Author(s): Michael Sunday Uko, Aliyu Usman, Ibrahim Toma, Samuel E. Okhale, Samuel T. Magili and Bulus Adzu,  

June 2019

In vitro evaluation of fruit extracts of Annona stenophylla diels and Flacourtia indica for incorporation into formulations for management of cancer

There are many reports which show a positive relationship between free radical damage and diseases such as cancer. Free radicals are formed when humans are exposed to ionizing radiation or during oxidation process in human beings can damage tissues and may potentially lead to development of cancers. Since radiation may be used in the management of cancer, there is need for the development of a radioprotective herbal...

Author(s): Cosmas Josiah Musewu and Rudo Fiona Mapanga  

June 2019

Chemical fingerprint of Bacopa monnieri L. and Rosmarinus officinalis L. and their neuroprotective activity against Alzheimer's disease in rat model’s putative modulation via cholinergic and monoaminergic pathways

Alzheimer’s disease is characterized by progressive degeneration of cortical and hippocampal neurons. This study aims to characterize the metabolic profiles of the hydro-ethanolic extracts of Bacopa monnieri L. (BM) and Rosmarinus officinalis L. (RO) cultivated in Egypt via UPLC–ESI/MS analyses and reveal their possible mechanism of the prophylactic effect(s) on neuro-degeneration in rat model of...

Author(s): Nermien E. Waly, Nora M. Aborehab and Mahitab H. El Bishbishy  

June 2019

Evaluation of the in vivo antiplasmodial activity of ethanol leaf extract and fractions of Jatropha gossypifolia in Plasmodium berghei infected mice

The study evaluates the in vivo antiplasmodial activity of ethanol leaf extract and fractions of Jatropha gossypifolia in Plasmodium berghei infected mice. Phytochemical, physicochemical analyses, median lethal dose (LD50), effects on biochemical parameter were evaluated and the schizonticidal effects during early and established infections were investigated. The extract (50-200 mg/kg) was screened for antimalarial...

Author(s): Onyegbule F. A., Bruce S. O., Onyekwe O. N., Onyealisi O. L. and Okoye P. C.  

May 2019

A review of Ginseng species in different regions as a multipurpose herb in traditional Chinese medicine, modern herbology and pharmacological science

Ginseng is the most famous of the Chinese herbs throughout the world, and has been one of the most valued herb in China. Traditional Chinese medicine as an essential element of alternative and complementary medicine, advanced over thousands of years with its own distinctive arrangement of therapies, diagnostics theories and in Asian countries, particularly China. In most parts of the world, especially western countries,...

Author(s): Mohamad Hesam Shahrajabian, Wenli Sun, and Qi Cheng,  

May 2019

In vitro anti-inflammatory activity of ginger (Zingiber officinale Rosc.) rhizome, callus and callus treated with some elicitors

This study evaluated the effect of ginger rhizome and its callus as well as callus elicited by yeast extract, glycine and salicylic acid on the production of pro-inflammatory (TNF-α, IL-1 and IL-6) and anti-inflammatory (IL-10 and TGF-β) cytokines in vitro. Petroleum ether (PE) and chloroform; methanol (1:1) (CM) extracts of rhizome and callus were shown to significantly (P < 0.05) suppress in a...

Author(s): Ammar Mohammed Ahmed Ali, Mawahib ElAmin Mohamed El-Nour, Owais Mohammad and Sakina Mohamed Yagi  

May 2019

Antihistaminic action of Melaleuca armillaris ointment

Melaleuca oil has great medicinal properties. The objective is to develop a product based on Melaleuca armillaris to evaluate its antihistaminic action and to compare the antihistaminic effect and protective effect of M. armillaris oil and ointment. Pruritus intensity was assessed at sensitization points. Eighty volunteers, aged between 21 and 60 years (male and female) participated in the study, without...

Author(s): Kassandra Elfrida Pauliello, Diba Maria Sebba Tosta Souza, Marcos Mesquita Filho, Manoel Araújo Teixeira and Adriana Rodrigues dos Anjos Mendonça  

May 2019

Chemical composition and antimicrobial activity of essential oils from Aframomum citratum, Aframomum daniellii, Piper capense and Monodora myristica

This study was initiated to evaluate the chemical composition and in vitro antimicrobial activity of essential oils from four Cameroonian spices and to determine the therapeutic effect of a cream based on essential oil from Aframomum citratum. Essential oils were extracted from seeds by hydrodistillation and analyzed by gas chromatography coupled with mass spectrometry (GC/MS). The broth microdilution method was used...

Author(s): Sylvie Carolle Meffo Dongmo, Jean-De-Dieu Tamokou#, Guy Sedar Singor Njateng, Pierre Tane and Jules-Roger Kuiate  

May 2019

Cytotoxicity of selected Ethiopian medicinal plants used in traditional breast cancer treatment against breast-derived cell lines

Traditional medicine is widely practiced in Ethiopia. Here we investigate the toxicity of extracts of seven medicinal plants traditionally used to treat breast cancer in Ethiopia. These plants, Sideroxylon oxyacanthum, Zanthoxylum chalybeum, Clematis simensis, Clematis longicauda, Dovyalis abyssinica, Vernonia leopoldi, and Clerodendrum myricoides, were selected based on recommendations by traditional healers and on the...

Author(s): Nigatu Tuasha,, Daniel Seifu, Endalamaw Gadisa, Beyene Petros and Stina Oredsson  

May 2019

Ethnobotanical survey and phytogeographical study of plants species from genus Acacia in Bénin

The genus Acacia, mainly distributed in the tropical and subtropical regions, has been used in traditional medicines for the treatment of microbial infections, malaria, diarrhea, oedema and inflammation. The present study aims to provide a comprehensive data on the distribution and medicinal use of Acacia species. Ethnobotanical survey and phytogeographical study were undertook using field interviews. Informant...

Author(s): Mounirou Tchatchedre, Abdou Madjid Amoussa, Marcel Houinato, Hounnankpon Yedomonhan and Latifou Lagnika  

April 2019

Isolation and identification of compounds with dioxin-induced AhR transformation inhibitory activity from the leaves of Mallotus japonicus (Thunb.) Muell. Arg.

The solvent extracts of 368 plant parts from 191 different species cultivated in Tsukuba (Ibaraki Prefecture, Japan) were previously screened for aryl hydrocarbon receptor (AhR) transformation inhibitory activity. It was observed that the leaf extract of Mallotus japonicus had strong activity. To clarify the antidioxin phytochemical, a 70% acetone extraction from the leaves was fractionated with three kinds of solvent...

Author(s): Keizo Hosokawa, Atsuyuki Hishida, Shin Nishiumi, Eri Fukushi, Jun Kawabata and Hitoshi Ashida  

April 2019

Genus Etlingera - A review on chemical composition and antimicrobial activity of essential oils

Essential oil from plants belonging to several species has been extensively used as natural resources in the prevention and treatment of a large number of diseases. The medicinal and aromatic plants of genus Etlingera produces high percentages of essential oil from its every organ and is recommended for a variety of health problems by traditional systems of medicine in south-east Asia. Essential oils from this genus...

Author(s): A. F. M. Shahid Ud-Daula and Mohammad A. Basher

April 2019

Cytotoxic potential of 14 Passiflora species against cancer cells

This work aimed to evaluate the cytotoxic potential against cancer cells of Passiflora genus plant species cultivated in Brazil and identify the mechanism of cytotoxicity induced by the most promising extract. Ethanolic extracts from the leaves of 14 Passiflora species were obtained by accelerated solvent extraction and in vitro cytotoxicity evaluated against cancer cell lines using MTT assay at a single concentration...

Author(s): Ricardo Guimarães Amaral, Silvana Vieira Floresta Gomes, Maria Claudia dos Santos Luciano, Cláudia do Ó Pessoa, Luciana Nalone Andrade, Patrícia Severino, Geraldo Célio Brandão, Larissa Mendes Bomfim, Milena Botelho Pereira Soares, Daniel Pereira Bezerra, Jorge Maurício David and Adriana Andrade Carvalho  

March 2019

Bio-guided identification of antiglycative constituents from the leaves of Mangifera indica L.

Advanced glycation end-products (AGEs) have been shown to be implicated in many degenerative disorders as well as diabetic pathology. Of interest, several natural compounds including phenolic constituents are capable of inhibiting the formation of AGEs. Bio-guided fractionation of a methanol extract from Mangifera indica leaves led to the characterization of six antiglycative constituents including gallic acid (1),...

Author(s): Samba Fama Ndoye, Didier Fraisse, Blandine Akendengué, Rokhaya Sylla Gueye, Cheikh Sall, Mael Gainche, Insa Seck, Catherine Felgines, Matar Seck and François Senejoux  

March 2019

Edraianthus pumilio (Schult.) A. DC.: Phytochemical and biological profile

Edraianthus pumilio is stenoendemic plant native to Dalmatia, Croatia. This paper deals with its phytochemical and biological profile. Phytochemical profile of volatile oil was performed by the gas chromatography–mass spectrometry (GC/MS), while total phenolic content of its aqueous extract was performed by Folin-Ciocalteu method. The phytochemical analysis showed that the main volatile oil compounds were nonanal...

Author(s): Olivera Politeo, Stanislava Talic  and Mirko Ruscic  

March 2019

Protective effects of Pleurotus ostreatus in ameliorating carbon tetrachloride (ccl4) induced liver injury in Wistar rats

Since oxidative stress is implicated in the pathogenesis of liver diseases, this study was carried out to evaluate the hepatoprotective, hematoprotective and hypolipidemic effects of Pleurotus ostreatus (Oyster mushroom) in Carbon Tetrachloride (CCl4) induced liver injury in wistar rats. Thirty rats were used for this study. The rats were divided into five groups of six rats per cage. Group I that served as the normal...

Author(s): Ubhenin, A. E., Adamude F. A., Nweze,C.C., and Dingwoke, E.J.  

March 2019

Identification of annotated metabolites in the extract of Centella asiatica

Plants contribute to 75% of molecular medicines (MM) either directly or indirectly. Centella asiatica (CA) is being extensively used in experimental and clinical studies. However, its scientific approval is not forthcoming. It is well known that every plant contains useful as well as some harmful compounds. Subjecting whole plant extracts containing harmful compounds to modern pharmacological methods will only...

Author(s): Komal Rani, Mitali Tyagi, Akanksha Singh, Vairamani Shanmugam, Annaian Shanmugam, Manoj Pillai and Alagiri Srinivasan,  

February 2019

Essential oil composition, antifungal activity and leaf anatomy of Lippia alba (Verbenaceae) from Brazilian Chaco

This study aims to determine the essential oil chemical composition of Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson collected in the Brazilian Chaco where plants grow in conditions of high temperatures in the summer, periodic flood, low temperatures and air humidity in the winter. We also evaluate the oil antifungal activity against the animal and plant pathogenic fungi Aspergillus flavus, A. fumigatus, A....

Author(s): Rosani do Carmo de Oliveira Arruda⊃, Cristiane Pimentel Victório⊃, Amanda Galdi Boaretto⊃, Carlos Alexandre Carollo⊃, Cariolando da Silva Farias, Clarice Rossato Marchetti, Ronaldo José dos Santos⊃, Giovana Cristina Giannesi and Denise Brentan Silva⊃  

February 2019

Determination of concentration of some essential and heavy metals in roots of Moringa stenopetala using flame atomic absorption spectroscopy

This study is aimed at determination of concentration of essential (Ca, K, Na and Mg) and heavy (Cd, Cr, Pb, Hg, Cu and Zn) metals using Flame Atomic Absorption Spectroscopy (FAAS) of samples taken from fresh roots of Moringa stenopetala. A wet digestion method involving use of mixture of (HCl and HNO3, ratio 3:1) and 10 ml of 30% H2O2 at an optimum temperature and time duration was deployed during sample preparations....

Author(s): Tsegaye Mega Kaba and Kusse Gudishe Goroya  

February 2019

Aristolochic acids in herbal medicine: Public health concerns for consumption and poor regulation of botanical products in Nigeria and West Africa

Aristolochic acids are naturally occurring biomolecules found in plants of the genus Aristolochia and Asarum belonging to the family Aristolochiaceae. They are reported to be carcinogenic and nephrotoxic; and are implicated in kidney diseases, aristolochic acid nephropathy (AAN) which may result in kidney failure, other health complications and possibly death. Aristolochic acids are highly genotoxic and are linked to...

Author(s): Okhale S. E., Egharevba H. O., Okpara O. J., Ugbabe G. E., Ibrahim J. A., Fatokum O. T., Sulyman A. O.  and Igoli J. O.  

February 2019

In vitro effect and scanning electron microscopic changes of Nigella sativa loaded chitosan nanoparticles on Schistosoma mansoni adult

Nanoparticles can act as drug carriers that can modulate pharmacokinetics, increase bioavailability and target release with minimal toxic effects. The present work aimed to assess the therapeutic effect and electron microscopic changes of Nigella sativa loaded Chitosan Nanoparticles (NSLCN) on adult Schistosoma mansoni in vitro. Adult worms were removed from the portal and mesenteric veins of infected mice after 90...

Author(s): Shereen Magdy Kishik, Ahlam Farag Mohram, Marwa Mohamed Nagib, Hemat Salah Ali and Fatma Fawzi Hendawy  

February 2019

Effect of hormones on the seed germination of Bupleurum species

In Asia, Radix Bupleuri (Bupleurum spp. root) is an important medicine used for treating many diseases over the past 2000 years. However, its cultivation is difficult due to poor germination rates and loss of seedling viability shortly after seeding. In the present study, the effect of 6-benzyl aminopurine (6-BA), daminozide, gibberellin (GA3), paclobutrazol, uniconazole, and mepiquat chloride (MC) on the germination of...

Author(s): Ma Yu, Guihua Lv, Hongzhang, Yuchan Li, Cheng Yuan, Zhikang Tang, Xiaoyan Shu, Chun Sui, Dabin Hou and Jian-He Wei  

January 2019

Exploring the anticoagulant and antiplatelet effect of the extracts of the red marine alga Acanthophora spicifera

Cardiovascular diseases represent the major cause of death and morbidity in the world. An uncontrolled activation of the coagulation cascade and platelet aggregation may lead to the formation of thrombi. Antithrombotic drugs have limitations and may produce side effects, and consequently, alternative therapies have been extensively investigated. Thus, the aim of this work was to evaluate anticoagulant and antiplatelet...

Author(s): Vivian Rodrigues de Souza, Laura de Andrade Moura, Ana Cláudia Rodrigues da Silva, Kelly Ketely Granja Pereira, Caio Cesar Richter Nogueira, Diana Negrão Cavalcanti, Valéria Laneuville Teixeira and André Lopes Fuly  

January 2019

Antibacterial potential of extracts of the roots of Zingiber officinale against bacterial strains commonly associated with nosocomial infections

Zingiber officinale, commonly known as ginger, has been used as a medicinal plant for decades for medical and culinary purposes. This study aimed to determine the antimicrobial potential of ginger root extracts using the Kirby-Bayer agar diffusion method to compare the zones of inhibition of the extracts to those of synthetic antibiotics against five clinical bacterial pathogens (Escherichia coli, Pseudomonas...

Author(s): Hannaty Abuga and Goabaone Gaobotse  

January 2019

Ethnobotanical study on medicinal plants used by indigenous people in Tenta District, South Wollo, Ethiopia

Ethnobotanical study on medicinal plants was conducted in Tenta District, South Wollo, Ethiopia from December 2016 to May 2017. Data were collected using guided field walk, semi-structured interview, group discussion and direct field observation. Data were analysed using descriptive statistics and response compared with chi-square test. The results documented 121 species of medicinal plants under 98 genera and 53...

Author(s): Tibebu Tefera and Mesele Yihune  

January 2019

Protective potential of Avena sativa seed mucilaginous extract against hyperlipidemia indicated by improved biomarkers and histopathology

Hyperlipidemia is one of the major health concerns worldwide. The present study aimed at utilizing clinicopathological tools to investigate the possible improving effect of Avena sativa mucilaginous extract (ASE) on lipid metabolic and liver function profiles in albino rats. The rats were rendered hyperlipidemic by 6-week supplementation of high-fat diet ad libitum. The rats were grouped into seven groups; with...

Author(s): Ibtsam M. Gheith, and Abubakr M. El-Mahmoudy  

January 2019

Assessment of antioxidant and antidiabetic properties of Picralima nitida seed extracts

The study investigated the antioxidant potential as well as the inhibitory potential of the seed extracts of Picralima nitida on α-amylase and α-glucosidase enzymes. The methanolic, aqueous and coconut water extracts were obtained using 70% methanol, distilled water and coconut water, respectively. Antioxidant properties were studied in vitro using DPPH (1, 1-diphenyl-2-pricrylhydrazyl) radical scavenging,...

Author(s): Akinwunmi Kemi Feyisayo and Amadi Chizi Victor  

January 2019

Utilization, cultivation practice and economic role of medicinal plants in Debre Markos Town, East Gojjam Zone, Amhara Region, Ethiopia

Medicinal plants are useful for primary healthcare as a remedy for diseases and injury, while they are also used traditionally as food and beverages. Despite the wide role of medicinal plant, traditional utilization and management practices are not well documented in Debre Markos Town. Thus, this study was conducted to assess utilization and cultivation practice of the medicinal plants and to identify commonly used...

Author(s): Yebirzaf Yeshiwas, Esubalew Tadele and Mahlet Workie  

December 2018

Medicinal plant use and conservation practices by communities in the Togo Plateau Forest Reserve, Ghana

The use of plants for medicine has constituted an important aspect of primary healthcare delivery system of people throughout the world for many centuries. Nonetheless, information on medicinal plants and their conservation are still lacking in some areas, including the Togo Plateau Forest Reserve in Ghana. This paper investigates the ethnobotany of the Togo Plateau Forest Reserve, Ghana, to document the traditional...

Author(s): Gilchrist K. Faith Dogor, Ruby A. Nyarko, Alexander K. Anning and Alfred  Oteng-Yeboah

December 2018

Evaluation of cytotoxic and antitumor activity of perillaldehyde 1,2-epoxide

The study aimed to evaluate cytotoxicity and antitumor activity of perillaldehyde 1,2-epoxide (PE), a p-menthane monoterpene derivative against four human tumor cell lines ovarian cancer (OVCAR-8), colon carcinoma (HCT-116), glioblastoma (SF-295) and leukemia (HL-60) using the colorimetric MTT assay. PE showed a high degree of inhibition of cell proliferation (GI = 95.66 to 99.71%) and IC50 16.14 μM (± 1.86),...

Author(s): Luciana Nalone Andrade, Patrícia Severino, Ricardo Guimarães Amaral, Grace Anne Azevedo Dória, Andressa da Silva, Melina Alves, Ricardo Luiz Cavalcante Albuquerque Júnior, Maria Claudia Santos Luciano, Cláudia Ó Pessoa, Adriana Andrade Carvalho and  Damião Pergentino de Sousa  

December 2018

Diversity and use of wild edible plants by migratory shepherds in the Himachal Pradesh of the Western Himalayas, India

The present study was carried out in Himachal Pradesh of the Western Himalayas, India to obtain information on the wild edible plants used by the migratory shepherds. The shepherds started their migration in July from Chitkul, Rakchham, Batseri, Sangla and Kamru of district Kinnaur (Himachal Pradesh). Questionnaire for the survey, personal field visits and participatory observations were used to collect information...

Author(s): Radha, Sunil Puri and Sanjeev Kumar  

December 2018

Ethnobotanical study of indigenous knowledge on medicinal plants used to treat diseases in selected districts of Amhara Regional State, Ethiopia

This study was conducted in four districts of Amhara Region, Ethiopia. The aim of the study was to assess medicinal plants found in Menz gera, Siyadebirna Wayu, Antsokiya gemza and Bugna districts, Amhara region, Ethiopia. The ethnobotanical surveys were carried out from September 2017 to June 2018 using a semi-structured checklist consisting of questions or issues prepared in advance. Two separate questionnaires were...

Author(s): Tewodros Kelemu and Worku Wolde  

December 2018

Selenium-enriched polysaccharides from pyracantha fortuneana (Se-PFPs) augment docetaxel-induced tumor suppression in human ovarian cancer

Pyracantha fortuneana (Maxim.) contains many healthy ingredients, including selenium-enriched polysaccharides. Selenium-enriched polysaccharides from P. fortuneana (Se-PFPs) have anti-mutation and anti-oxidation activities, along with anti-tumor activity in ovarian cancer and breast cancer cells. Docetaxel (DTX) is widely applied in therapeutic treatment for ovarian cancer. However, its use in clinics is restricted due...

Author(s): Zhengtai Liu, Liyue Gai, Jiayuan Qu, Chong Guo, Yuwen Zhao, Yu Yang, Xiaoyue Wen and Chengfu Yuan

December 2018

Comparative analysis of capsaicin in twenty nine varieties of unexplored Capsicum and its antimicrobial activity against bacterial and fungal pathogens

In this study, the capsaicin content of chile pepper extracts from 29 unexplored varieties of Capsicum (twenty five varieties of Capsicum chinense and five of Capsicum annuum) was quantified and correlated with the antimicrobial potential against bacterial and fungal pathogens. The capsaicin content and bactericidal activity against numerous human pathogens (Salmonella, Escherichia coli O157:H7, Listeria monocytogenes,...

Author(s): Morrine A. Omolo, Zen-Zi Wong, Weih G. Borh, Grant A. Hedblom, Kamal Dev, and David J. Baumler,  

December 2018

Hepato-protective potentials of Sterculia setigera stem-bark extract on acetominophen induced hepato toxicity in Wistar albino rats

The study was set to investigate the potency of stem bark extract of Sterculia setigera as a hepato-protective agent against acute administration (overdose) of acetaminophen in experimental animals. Experimental animals were grouped into six treatments with each group containing five rats. Group 1 was the placebo, Group II was the standard treatment orally administered acetaminophen at a dosage of 250 mg/kgbw and...

Author(s): Garba M. H., Sherifat M. L., Abdul-Majeed A. O., Hafsa L. M., Awal A.B., Sa’adu A. A. and Lekene B. J.  

December 2018

Phytochemical analysis, antioxidant, antibacterial and combinational effects of medicinal plants used by Bapedi traditional healers to prepare herbal mixtures

The aim of this study is to evaluate the biological activities of some plant species used in the preparation of herbal mixtures and determine the combinational effects. The plant materials were collected from traders who use them to prepare herbal mixtures claimed to be blood purifiers, pain-relievers, anti-diarrheal and aphrodisiac medicines. An aqueous decoction of each plant species was prepared. Thin layer...

Author(s): Mashilo Mash Matotoka and Peter Masoko  

November 2018

In vivo efficacy of Dialium guineense fruit pulp on hemeoxygenase-1 and angiotensin converting enzyme in experimental diabetes

The study aims to investigate the effect of aqueous fruit pulp of Dialium guineense on hemeoxygenase, and insulin release, inhibition of angiotensin converting enzyme (ACE) and possible hypoglycemia in streptozotocin-induced diabetic rats. Twenty four male Wistar rats were grouped into control, diabetic (Dm), diabetic + 300 mg/kg body weight Dialium guineese (Dm+ DG) and diabetic + 100 mg/kg metformin (Dm +MET). Apart...

Author(s): Etah E. Nkanu, Gabriel Ujong, Victoria Okon and Iya Eze Bassey  

November 2018

Evaluation of the phytochemical composition, antimicrobial and anti-radical activities of Mitracarpus scaber (Rubiaceae)

Mitracarpus scaber is a medicinal plant used in traditional practices for the treatment of dermatoses and liver diseases. The objective of this study was to quantify the content of phenolic compounds and to evaluate the anti-radical and antimicrobial activities of four types of its total extracts on ten microbial strains. The Folin-Ciocalteu method was used to determine total phenol content, condensed tannin content by...

Author(s): Ouadja B., Anani K., Djeri B., Ameyapoh Y.O. and Karou D. S.  

November 2018

Bio-guided anti-cariogenic and phytochemical valorization of Guiera senegalensis and Pseudocedrela kotschyi stem extracts

The objective of the present study is to carry out bio-guided phytochemical investigation of Guiera senegalensis and Pseudocedrela kotschyi stem extracts. The two plants are used as toothpicks for oral hygiene. The inhibition test revealed a bacteriostatic effect of hexane extract PK1 of P. kotschyi against Streptococcus mutans ATCC 25175 and Streptococcus salivarius ATCC 20560, two bacterial cariogenic strains, with a...

Author(s): Guessan Bi Goblé Landry, , Kadja Amani Brice, Cottet Kevin, Lecouvey Marc, Mamyrbékova-Békro Janat Akhanovna and Békro Yves-Alain  

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