Comprehensive liquid chromatography-mass spectrometry-based metabolomic analysis of Moringa oleifera seeds
September 2023
Moringa oleifera seeds which are less explored and nutriment-rich have attracted scientific interest as the seed kernels contain numerous bioactive components with a variety of traditional uses. Besides its medicinal uses, Moringa oleifera biodiesel has shown remarkable potentiality in conducing to the decrease of greenhouse gases and guaranteeing sustainable supply of energy. In this study, the comprehensive analysis...
Effect of Canarium schweinfurthii leaf and pulp extracts on blood glucose levels in oral glucose load - induced hyperglycemia in Wistar albino rats
September 2023
Canarium schweinfurthii is a common medicinal plant used as food and medicine in communities of central Uganda. Local communities and herbalists commonly used it in the management of diabetes mellitus type 2 with limited information on its effectiveness. Study assessed the hypoglycemic effect of C. schweinfurthii aqueous and total crude leaf and pulp extracts on blood glucose levels in Wistar albino rats. An...
Chemical characterization of bottlebrush leaves found in NISLT premises, Samonda, Ibadan, Nigeria.
August 2023
This study investigated the chemical composition of Bottlebrush leaves for its ascribed mythical medicinal uses. Bottlebrush leaves were collected from the Nigerian institute of science laboratory technology premises in Ibadan, Nigeria. Proximate analyses, phytochemical screening, elemental analysis and antioxidant analysis were carried out on the leaves extract. This study has provided a scientific justification that...
Pre-sowing treatments to improve seed germination and seedling growth of Commiphora swynnertonii (Burrt.) and Synadenium glaucescens (Pax.)
July 2023
Medicinal and pesticidal plant propagation is hampered by poor seed germination due to seed dormancy. This study aimed to enhance seed germination and seedling growth using various pre-sowing treatments. A triplicated two-factor experiment in a Randomized Complete Block design was used. Soaking in water at 25°C for 24 h (T1), soaking in 60°C hot water for 10 min (T2), 10 ppm Potassium nitrate (KNO3) treatment...
Inhibition and dissolution of calcium oxalate crystals and kidney stones by the extract of Kalanchoe pinnata
June 2023
Kalanchoe pinnata leaves are used in South Asia as a natural kidney stone treatment. In vitro studies were conducted in supersaturated and artificial urine solutions to evaluate the antiurolithic properties of K. pinnata leaf extract on calcium oxalate monohydrate (COM) and surgically extracted kidney stones. Key organic acids present in the plant extract were also examined in artificial urine to investigate inhibition...
Anti-inflammatory effect of chaya extracts fractions
June 2023
Patients with Type 2 diabetes often experience chronic inflammation due to the overexpression of NF-kB-regulated pro-inflammatory proteins, such as TNF-alpha, IL-6 and IL-1. Chaya (Cnidoscolus aconitifolius) extracts have been reported to decrease this expression, but fractions of these extracts have not been studied. The present work focused on determining the anti-inflammatory effect of fractions of aqueous extracts...
Palyno-morphological assessment of Asteraceae taxa grown in Qarshi Botanical garden at Qarshi Industries (Pvt.) Ltd by using LM and SEM, Pakistan
May 2023
The present study covers the micro-morphological characteristics of 32 taxa of Asteraceae family from Qarshi Botanical Garden at Qarshi Industries (Pvt.) Ltd., Hattar Haripur, Pakistan. The morpho-palynological characters studied were size, shape, polar and equatorial diameter and their exine ornamentation using light microscopy (LM) and scanning electron microscopy (SEM) for its taxonomic significance. In the present...
Sedative and hypnotic effects of the compatibility of Schisandra chinensis and Polygala tenuifolia on insomnia mice
May 2023
The objective of this study is to study the sedative and hypnotic effects of the compatibility of Schisandra chinensis (SC) and Polygala tenuifolia (PT) on insomnia mice and its mechanisms. The 160 SPF KM mice were divided into 8 groups with 20 each group (10 female and 10 male mice), including control, model, estazolam, SC, PT, SC-PT 1:1, SC-PT 1:2, and SC-PT 2:1 group. Insomnia mice model was established with...
Citrullus lanatus plant response to irrigation water magnetized in sandy soil
May 2023
In this study, the productivity of the red watermelon (Citrullus lanatus) crop in arid regions with saline water is examined in relation to the effects of magnetic treatment of irrigation water. The greenhouse experiments compared two treatments (magnetic treatment of irrigation water) and (no magnetic treatment of irrigation water). Magnetic treatment device delta water with a power of 14500 gausses (1.45 T) that was...
Evaluation of catechin, lupeol, and betulinic acid as markers for the chromatographic quality Control of Albizia coriaria raw materials; an experimental study
May 2023
Albizia coriaria stembark is among the most common raw materials used to manufacture herbal products in Uganda. While the plant material is sourced from the wild, there are neither monographs nor chemical analytical methods for its standardisation. In addition, good cultivation, harvesting, and manufacturing practices are not mandatory. This leads to inconsistent quality of raw materials and products. This work...
HPLC determination of polyphenols of the flowers of Digitalis lamarckii, Xeranthemum annuum, Epilobium hirsutum and Silene compacta from Bolu (Turkey)
May 2023
There have been a growing interest since decades in the medicinal plants in terms of preventive health care and treatment of various diseases. On the other hand, polyphenolic compounds present in medicinal plants are known to have antioxidant potency. In the current work, the quantitative HPLC analysis of the flowers of four plants grown in Bolu-Turkey, Silene compacta, Digitalis lamarckii, Xeranthemum annuum L., and...
Phytochemical screening, anti-inflammatory and immunomodulatory activities of Acanthospermum hispidum and Croton zambesicus collected in the Republic of Benin
April 2023
This study aims to characterize chemical groups of metabolites in extracts of Acanthospermum hispidum and Croton zambesicus, and to evaluate their anti-inflammatory activities and their immunomodulatory effect on two pro-inflammatory cytokines (TNFα and IL6). The phytochemical screening was done on the powders of both plants by staining and precipitation reactions. Anti-inflammatory activity was performed in vivo...
Amazonian andiroba oil (Carapa guianensis Aubl.) minimizes the formation of postoperative adhesions in the uterus and ovaries of sheep
March 2023
Postoperative adhesions (POA) are postsurgical fibrinolytic connections that can cause complications, and alternative materials have drawn attention to their prevention. The aim of this study is to evaluate the effect of andiroba oil in preventing POA in the uterus and ovaries of sheep. Sixteen female Santa Inês adult sheep were randomly divided into two groups, a control group (CCG) with eight of them submitted...
Phytochemical screening and gas chromatography-mass spectrometry analysis of Euphorbia ingens organic root extract
March 2023
Euphorbia ingens is a woody, succulent tree with ethnomedicinal applications; however, its chemical constituents are not well documented. This study determined the phytochemical profile of Euphorbia ingens dichloromethane-methanol root bark extract. Following sample collection and preparation, extraction was done using the cold percolation technique. This was followed by qualitative phytochemical screening and gas...
Effects of millet on calcium oxalate crystal growth and dissolution
March 2023
The influence of aqueous extract of millet on the crystallization and the dissolution of calcium oxalate (CaOx) crystals were investigated in detail under supersaturated and artificial urinary circumstances in order to understand the effect of the water-soluble components of millet on CaOx kidney stones in humans. To investigate the inhibition effect, different volumes of millet extract were added separately to the...
In vivo hypotensive activity on the albino’s rat and in vitro antioxidant activities of aqueous extract from Guibourtia tessmannii (Harms) J. Leonard (Cesalpiniaceae) stem barks
March 2023
In Central Africa, stem bark from Guibourtia tessmannii is used in traditional pharmacopeia for the treatment of hypertension. The aim of this study was to scientifically verify the traditional use in the treatment of metabolic pathologies such as arterial hypertension and evaluated its pharmacological potential. Phytochemical tests were evaluated by standard method of laboratory. Antioxidant activities were determined...
Evaluation of antibiotic efficacy of Ocimum gratissimum L. essential oil against Staphylococcus aureus and Pseudomonas aeruginosa
February 2023
Ocimum gratissimum essential oil (EOGT) has been evaluated for its antibacterial efficacy, and its combinational therapy with antibiotics may enhance the therapeutic efficiency against infection-causing bacteria. Herein, we evaluated the chemical composition of EOGT and its antibiotic efficacy against Staphylococcus aureus and Pseudomonas aeruginosa. GC-MS and GC-FID analyzed EOGT. The antibiotic efficacy was determined...
Traditional knowledge of plants used against upper respiratory tract affections in the Littoral Region of Cameroon
February 2023
Traditional medicine is used by people as an alternative to orthodox drugs to treat respiratory infections. The aim of this research was to document traditional recipes used in the treatment of upper respiratory tract infections such as pharyngitis, cold, and sinusitis in peri-urban and rural areas of the Littoral Region of Cameroon. Ethnobotanical surveys were carried out using semi-structured interview model in French...
In-vitro assessment of antibacterial effects of combined crude extracts of S. glaucescens and C. swynnertonii with antibiotics
February 2023
Currently, there is an upsurge of bacterial resistance in single-drug treatment regimens. This has stimulated a growing interest in research and development of new antibacterial agents containing several ingredients as one of the means to combat bacterial resistance. Herb-antibiotic combination therapy is one of the reported effective treatment regimens to combat antimicrobial resistance. This study was aimed to assess...
Medicinal plants for the treatment of malaria and typhoid diseases
January 2023
The review concentrated on current literature on medicinal plants for the treatment of malaria and typhoid related diseases, highlighting information about their ethnobotany. The entire plants reviewed showed strong activities, establishing their different traditional applications and capability to control or eliminate malaria and typhoid diseases. Malaria and typhoid diseases are the most problematic public health...
Bioprospecting of the antifungal activity of Patchouli essential oil (Pogostemon cablin Benth) against strains of the genus Candida
January 2023
The incidence of infections caused by Candida has increased worldwide and these strains are becoming resistant to their respective drugs, requiring the search for new drugs with greater efficacy and safety. Natural products are an alternative means of treatment. The essential oil (EO) stands out among these products, due to some biological activities relevant to human health, including antibiotic and antifungal...
Pachyrhizus toxicity: Genetic variability of mature and immature seeds and its effects on Sclerotium rolfsii and Ralstonia solanacearum
January 2023
Pachyrhizus seeds-induced toxicity is very well-known to have developed in humans, fishes, insects, and some micro-organisms. Yet, there is a paucity of studies addressing it in their germplasm, as well as its effects on some phytopathogens. This work aimed to assess the Pachyrhizus genetic variability on toxicity and to determine Pachyrhizus extract toxicity on Sclerotium rolfsii and Ralstonia solanacearum in vitro. In...
Valuation study on the extracts of Ilex guayusa Loes. as an antioxidant and anti-aging raw material
January 2023
Ilex guayusa Loes. is a medicinal plant used by people of the Ecuadorian Amazon for treating various diseases and for its stimulating properties. In recent years, several studies have shown this plant to possess a high concentration of phenolic compounds and a high antioxidant potential, allowing it to be used as an ingredient for cosmetic formulations. This research confirms the presence of phenolic compounds between...
Determination of total phenolic and flavonoid content, antioxidant and cytotoxic activity of the methanol extract of Acacia nilotica pods
December 2022
Acacia nilotica is a medicinal plant used in Niger republic for the treatment of gastrointestinal diseases. The aim of this study was to investigate total phenolic and flavonoid content, antioxidant and cytotoxic activity of the A. nilotica pods collected from Niger republic. The phytochemical contents were examined by colorimetric methods. Antioxidant activity of the methanol extract was screened using DPPH, ABTS and...
Antiedematogenic activity of Petiveria alliacea L. in bothropic poisoning
December 2022
The biodiversity of the Brazilian biomes inspires interest in research about the biological activities of the molecules present in the flora. In this line, Petiveria alliacea a common plant species in the savanna of Tocantins, reported in the treatment for snakebites, was studied to analyze the phytochemical profile and evaluate the activity on the edema caused by Bothrops moojeni snake venom. A qualitative...
Phytochemical study and anti-radical activity of extracts from the oil seeds of Desbordesia glaucescens (Engl.)Tiegh. from Gabon
November 2022
The report focused on the extraction of oilseeds of Desbordesia glaucescens (Engl.) Tiegh. from Gabon as well as on the phytochemical study and evaluation of the anti-free radical activity of the extracts obtained. The extraction was carried out by cold maceration with solvents of increasing polarities: hexane, tricholroethylene, acetone, ethanol and distilled water. The anti-free radical activity was measured by...
Ethnobotanical survey and phytochemical screening of aqueous extracts from Detarium microcarpum Guill. & Perr in Mali
October 2022
Detarium microcarpum Guill. & Perr is a tree which belongs to Caesalpiniacea family and can reach up 10 m of height, with a horizontal root system. It is confined to the arid regions of West and Central Africa, where it mainly occurs in savannah. The aim of this work is to collate information on the use of Detarium microcarpum in folk medicine by traditional health practitioners and herbalists. Moreover, a...
Ethnobotanical study, phytochemical composition and in vitro antioxidant activity of the methanol extracts of thirty-two medicinal plants from Southern Nigeria
October 2022
The prevalent disease conditions globally, the detrimental effects, and the resistance of microorganisms to synthetic drugs are really worrisome. Measures to checkmate these situations include researches on the role of medicinal plants in health care delivery. This study is aimed at assessing the antioxidant activities of some medicinal plants normally used for the treatment of various ailments in southern Nigeria and...
Aqueous extracts of Lentinula edodes, Pleurotus pulmonarius, and Pleurotus sajor-caju: Antifungal activity and inhibition of exoenzyme production by Candida albicans
October 2022
This study was aimed at evaluating the effects of aqueous extracts of Lentinula edodes (SHI), Pleurotus pulmonarius (PUL), and Pleurotus sajor-caju (PSC) on the growth of eight yeast species and the exo-enzyme production by Candida species after exposure to the extracts, which were prepared with the cold extraction methodology and tested against yeasts by the broth microdilution method. Proteinase and phospholipase were...
Ethnopharmacological investigation on Msindzano, a beauty mask used by Comorian women: What plants for what mixtures, for what applications?
September 2022
Although extensively used by Comorian women, limited information exists on Msindzano beauty masks. Thus an ethnopharmacological survey was conducted on two islands of the Comoros archipelago: Ndzuani and Ngazidja. An open-ended, semi-structured questionnaire was employed for data collection on the different plants used for Msindzano preparation, their different mixtures and their different applications. A total of 348...
Ethno botanical study of medicinal plants used by Baka people in the treatment of erectile dysfunction
August 2022
Erectile dysfunction is a disease that is increasingly affecting men. The study examined the traditional use of medicinal plants in the treatment of erectile dysfunction among the Baka people in the eastern region of Cameroon. The study took place over interspersed periods from January 2018 to January 2021 in 9 villages. Forty-four people were interviewed via a questionnaire. One hundred and fifty-nine citations and 71...
Piper rivinoides Kunth: A medicinal plant that preserves bioactive chemical substances in its essential oil throughout the seasons
August 2022
The chemical composition and seasonal variation of essential oils (EO) extracted from the aerial parts of the traditional medicinal plant Piper rivinoides were analyzed using gas chromatography (GC) coupled with mass spectrometry (MS) and GC coupled with flame ionization detector (GC-FID) technique, respectively. The wild plants were collected from two different sites in the Atlantic Forest. The analysis allowed us to...
Medicinal plants and onychomycosis: potential and evidence of antifungal activity - an integrative review of the literature
July 2022
Onychomycosis is a fungal infection of the nails, also known as nail mycosis and Tinea unguium, which affects 6.9 to 23.2% of the general population. It is most commonly found in people aged 60 years and older. Onychomycosis is caused by dermatophyte fungi, non-dermatophyte filamentous fungi and yeast. Treatment includes topical or oral antifungal drugs. The use of other auxiliary, alternative and/or complementary...
Medicinal plants of the African traditional pharmacopoeia in the management of bovine trypanosomosis: A review
June 2022
Traditional medicine has remained the most affordable and readily available source of treatment for primary care in poor African communities. Despite the increasingly common practices of traditional medicine to treat animal diseases, this rich endogenous knowledge is not sufficiently documented. The objective of this review is to synthesize information on ethnoveterinary practices to treat bovine trypanosomiasis in...
Tracking antibacterial components of Pteris multifida Poir and its antibacterial mechanism
June 2022
Pteris multifida is an effective Chinese herb for treating dysentery caused by Escherichia coli. It might be a good veterinary antibiotic alternative. In this study, we optimized the extraction condition based on the antibacterial activity of crude extracts from P. multifida, tracked its antibacterial components, and investigated their antibacterial activity, as well as its antibacterial mechanism. The results revealed...
In vivo antimalarial activity, safety and phytochemical screening of Canthium multiflorum (Schumach. &Thonn.) Hiern (Rubiaceae)
June 2022
Canthium multiflorum (Thonn.) Hiern (Rubiaceae) is a popular herb used by traditional healers in western Burkina Faso. C. multiflorum leaves are widely used in decoction to treat malaria. The present study aims to evaluate its in vivo potential against malaria parasites in mice. The antimalarial activity of the organic and aqueous extracts of C. multiflorum leaves was evaluated on Plasmodium berghei Anka in NMRI mice...
Phytochemical composition and in vitro antileishmanial activity of Bidens pilosa, Tithonia diversifolia and Sonchus oleraceus extracts
June 2022
Leishmaniasis is the second-largest parasitic killer in the world (after malaria). Currently, there are no effective vaccines or therapeutic interventions thus creating a gap for new alternative remedies in the management of the disease. Medicinal plants offer this attractive option as antileishmanial agents since they are relatively safe, locally available and affordable. The study assessed antileishmanial activity of...
Anti-quorum sensing potential of Ageratum conyzoides L. (Asteraceae) extracts from Burkina Faso
May 2022
Pseudomonas aeruginosa causes infections in humans, particularly immune-compromised patients with cystic fibrosis, severe burns, and HIV, resulting in high morbidity and mortality. The pathogenic bacteria, P. aeruginosa, produces virulence factors regulated by the mechanism called quorum sensing system. The aim of this study was to assess the anti-quorum sensing activity of Ageratum conyzoides extracts. Chloroform...
Ethnobotanical and ethno-pharmacological approach to ichthyotoxic plants of Gabon
May 2022
This ethnobotanical and ethno-pharmacological study was conducted to know the plants used in fishing practices and to show their importance in traditional medicine in Gabon. For this study, 100 questionnaires were administered to individuals in the fishing and traditional medical domains. 701 plants belonging to 16 different floristic families, including Fabaceae (41%), Rubiaceae (13%), and Rutaceae (15%) were commonly...
Medicinal plants in oral health and the intergenerational transfer of knowledge: Resilience to cocoa culture in southern Bahia
May 2022
Ethnobotanical surveys have proved plant usage in the treatment of oral diseases; however, in areas where cocoa farming influenced socioeconomic reality there is a lack of information about preservation of traditional knowledge related to oral conditions treatment. Family Health Strategy (FHS) users and community experts were interviewed with socioeconomic characteristics and ethnobotanical information being obtained...
Phytochemical analysis and safety evaluation of ethanol roots extract of Erythrina sacleuxii hua in Wistar albino rats
April 2022
Erythrina sacleuxii, one of five Erythrina species found in Kenya, is a stiffly multi-branched deciduous tree reported to have antiplasmodial, antifungal, anti-bacterial and anti-cancer activities. This study aimed at evaluating acute and sub-acute oral toxicity of E. sacleuxii roots ethanolic extract. Phytochemical analysis was conducted on Fourier transform infrared spectroscopy and Gas Chromatography-Mass...
Analgesic, anti-inflammatory and oxytocic activities of Dracaena steudneri Engl. stem bark aqueous extract in Wistar rats
April 2022
Dracaena steudneri Engl. (Dracaenaceae) is a medicinal plant that is used in labour by traditional birth attendants to induce labour, relieve pain and treat various diseases; albeit no documentation. This study determined the analgesic, anti-inflammatory and oxytocic effects of the D. steudneri stem bark aqueous extract. D. steudneri stem bark was collected, authenticated, oven-dried at 45ºC for 48 h, pulverized...
Antioxidant and antihyperlipidemic activities of unique nicotinyl polysaccharide from the green seaweed Ulva pertusa
April 2022
Nicotinyl derivative of polysaccharide (NU) from the green seaweed Ulva pertusa (Chlorophyta) has unique structure and strong antioxidant activity in vitro. In the present study, in vivo antioxidant and antihyperlipidemic activities were tested in the livers of hyperlipidemic mice. Activity levels of superoxide dismutase, glutathione peroxidase (GSH-PX), catalase, and malondialdehyde were observed. At the 500 mg/kg...
In vitro antiproliferative potential of crude extracts from Carica papaya L. (Caricaceae) black seeds against prostate cancer cell lines'
April 2022
Black seeds from papaya plants are utilized as traditional medicine in African and Asian cultures to improve the functioning of the male reproductive system and management of prostate cancer. This study analyzed the phytochemical composition, antiproliferative activity and cytotoxicity of Carica papaya black seeds against the prostate cancer cells and Vero cells. Phytochemical screening was performed by standard...
Herbal medicine development and compliance to regulatory guidelines in Imo State Nigeria
April 2022
Herbal medicine is an important age-long resource for healthcare. The aim of this study was to determine the development of herbal medicine in relation to compliance to regulatory guidelines and product development in pursuance of the integration of herbal medicine into the healthcare system in Nigeria. Using Imo State as a case study, a cross-sectional investigation was conducted among the Traditional Medicine...
Acute toxicity, analgesic, and smooth muscle relaxant effects of the aqueous root extract of Asparagus racemosus from Kenya
March 2022
The plant Asparagus racemosus is used traditionally in Kenya for a variety of medicinal purposes including in the management of pain, asthma, and premature labour. However, a dearth of empirical studies means that there is limited information on the acute toxicity and pharmacological effects to support these uses by the local variety of the plant. The aim of this study was, therefore, to evaluate the acute toxicity,...
Antibiotic potential of a crude ethanol extract from Asplenium serratum L. fern leaves
March 2022
Asplenium serratum L. (Aspleniaceae) is a terrestrial, epiphytic or humicole fern used as traditional medicine in different countries to treat infection. As such, this study aimed to assess the antibacterial potential of a crude ethanol extract from A. serratum leaves against multidrug-resistant bacteria from a hospital setting. Fern leaves were dried and ground using 96° Gay Lussac ethanol, with the extract...
Brown macroalgae: Promising sources of bioactive products against human herpesviruses
March 2022
Marine brown macroalgae have stood out as important sources of new bioactive products, such as antimicrobial, anticoagulant, anti-inflammatory and antiviral drugs. This study aimed to review the literature on the applications of products derived from brown macroalgae as antiviral agents against human herpesviruses. To date, species of seven distinct orders of brown algae have been studied for this purpose, such as...
Evaluation of the anxiolytic effects of acute administration of Passiflora alata extract in wistar rats submitted to swimming
February 2022
Anxiety is present in several psychiatric disorders, and pharmacological treatment has limitations. Therefore, there is a search for new therapeutic approaches. This study aimed to evaluate the anxiolytic effect of acute administration of the dry extract of Passiflora alata (P. alata) leaves in male Wistar rats submitted to swimming. The animals were randomly divided into four groups (n = 8) (G1 to G4). G2 to G4 were...
Flavonoid content and antioxidant potential of leaf extracts of Passiflora setacea cv BRS Pérola do Cerrado, a new wild passion fruit cultivar
February 2022
Passiflora setacea D.C. is a wild species native to the Brazilian Cerrado, with agronomic and medicinal potentials. The cultivar BRS Pérola do Cerrado is the first registered and protected cultivar of a wild Passiflora and has become an alternative to the passion fruit market due to its desirable characteristics for food, ornamental and pharmaceutic industries. Since plant tissue culture techniques are considered...
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