In vivo hypotensive activity on the albino’s rat and in vitro antioxidant activities of aqueous extract from Guibourtia tessmannii (Harms) J. Leonard (Cesalpiniaceae) stem barks
March 2023
In Central Africa, stem bark from Guibourtia tessmannii is used in traditional pharmacopeia for the treatment of hypertension. The aim of this study was to scientifically verify the traditional use in the treatment of metabolic pathologies such as arterial hypertension and evaluated its pharmacological potential. Phytochemical tests were evaluated by standard method of laboratory. Antioxidant activities were determined...
Effects of millet on calcium oxalate crystal growth and dissolution
March 2023
The influence of aqueous extract of millet on the crystallization and the dissolution of calcium oxalate (CaOx) crystals were investigated in detail under supersaturated and artificial urinary circumstances in order to understand the effect of the water-soluble components of millet on CaOx kidney stones in humans. To investigate the inhibition effect, different volumes of millet extract were added separately to the...
Traditional knowledge of plants used against upper respiratory tract affections in the Littoral Region of Cameroon
February 2023
Traditional medicine is used by people as an alternative to orthodox drugs to treat respiratory infections. The aim of this research was to document traditional recipes used in the treatment of upper respiratory tract infections such as pharyngitis, cold, and sinusitis in peri-urban and rural areas of the Littoral Region of Cameroon. Ethnobotanical surveys were carried out using semi-structured interview model in French...
Evaluation of antibiotic efficacy of Ocimum gratissimum L. essential oil against Staphylococcus aureus and Pseudomonas aeruginosa
February 2023
Ocimum gratissimum essential oil (EOGT) has been evaluated for its antibacterial efficacy, and its combinational therapy with antibiotics may enhance the therapeutic efficiency against infection-causing bacteria. Herein, we evaluated the chemical composition of EOGT and its antibiotic efficacy against Staphylococcus aureus and Pseudomonas aeruginosa. GC-MS and GC-FID analyzed EOGT. The antibiotic efficacy was determined...
In-vitro assessment of antibacterial effects of combined crude extracts of S. glaucescens and C. swynnertonii with antibiotics
February 2023
Currently, there is an upsurge of bacterial resistance in single-drug treatment regimens. This has stimulated a growing interest in research and development of new antibacterial agents containing several ingredients as one of the means to combat bacterial resistance. Herb-antibiotic combination therapy is one of the reported effective treatment regimens to combat antimicrobial resistance. This study was aimed to assess...
Pachyrhizus toxicity: Genetic variability of mature and immature seeds and its effects on Sclerotium rolfsii and Ralstonia solanacearum
January 2023
Pachyrhizus seeds-induced toxicity is very well-known to have developed in humans, fishes, insects, and some micro-organisms. Yet, there is a paucity of studies addressing it in their germplasm, as well as its effects on some phytopathogens. This work aimed to assess the Pachyrhizus genetic variability on toxicity and to determine Pachyrhizus extract toxicity on Sclerotium rolfsii and Ralstonia solanacearum in vitro. In...
Medicinal plants for the treatment of malaria and typhoid diseases
January 2023
The review concentrated on current literature on medicinal plants for the treatment of malaria and typhoid related diseases, highlighting information about their ethnobotany. The entire plants reviewed showed strong activities, establishing their different traditional applications and capability to control or eliminate malaria and typhoid diseases. Malaria and typhoid diseases are the most problematic public health...
Bioprospecting of the antifungal activity of Patchouli essential oil (Pogostemon cablin Benth) against strains of the genus Candida
January 2023
The incidence of infections caused by Candida has increased worldwide and these strains are becoming resistant to their respective drugs, requiring the search for new drugs with greater efficacy and safety. Natural products are an alternative means of treatment. The essential oil (EO) stands out among these products, due to some biological activities relevant to human health, including antibiotic and antifungal...
Valuation study on the extracts of Ilex guayusa Loes. as an antioxidant and anti-aging raw material
January 2023
Ilex guayusa Loes. is a medicinal plant used by people of the Ecuadorian Amazon for treating various diseases and for its stimulating properties. In recent years, several studies have shown this plant to possess a high concentration of phenolic compounds and a high antioxidant potential, allowing it to be used as an ingredient for cosmetic formulations. This research confirms the presence of phenolic compounds between...
Determination of total phenolic and flavonoid content, antioxidant and cytotoxic activity of the methanol extract of Acacia nilotica pods
December 2022
Acacia nilotica is a medicinal plant used in Niger republic for the treatment of gastrointestinal diseases. The aim of this study was to investigate total phenolic and flavonoid content, antioxidant and cytotoxic activity of the A. nilotica pods collected from Niger republic. The phytochemical contents were examined by colorimetric methods. Antioxidant activity of the methanol extract was screened using DPPH, ABTS and...
Antiedematogenic activity of Petiveria alliacea L. in bothropic poisoning
December 2022
The biodiversity of the Brazilian biomes inspires interest in research about the biological activities of the molecules present in the flora. In this line, Petiveria alliacea a common plant species in the savanna of Tocantins, reported in the treatment for snakebites, was studied to analyze the phytochemical profile and evaluate the activity on the edema caused by Bothrops moojeni snake venom. A qualitative...
Phytochemical study and anti-radical activity of extracts from the oil seeds of Desbordesia glaucescens (Engl.)Tiegh. from Gabon
November 2022
The report focused on the extraction of oilseeds of Desbordesia glaucescens (Engl.) Tiegh. from Gabon as well as on the phytochemical study and evaluation of the anti-free radical activity of the extracts obtained. The extraction was carried out by cold maceration with solvents of increasing polarities: hexane, tricholroethylene, acetone, ethanol and distilled water. The anti-free radical activity was measured by...
Ethnobotanical study, phytochemical composition and in vitro antioxidant activity of the methanol extracts of thirty-two medicinal plants from Southern Nigeria
October 2022
The prevalent disease conditions globally, the detrimental effects, and the resistance of microorganisms to synthetic drugs are really worrisome. Measures to checkmate these situations include researches on the role of medicinal plants in health care delivery. This study is aimed at assessing the antioxidant activities of some medicinal plants normally used for the treatment of various ailments in southern Nigeria and...
Ethnobotanical survey and phytochemical screening of aqueous extracts from Detarium microcarpum Guill. & Perr in Mali
October 2022
Detarium microcarpum Guill. & Perr is a tree which belongs to Caesalpiniacea family and can reach up 10 m of height, with a horizontal root system. It is confined to the arid regions of West and Central Africa, where it mainly occurs in savannah. The aim of this work is to collate information on the use of Detarium microcarpum in folk medicine by traditional health practitioners and herbalists. Moreover, a...
Aqueous extracts of Lentinula edodes, Pleurotus pulmonarius, and Pleurotus sajor-caju: Antifungal activity and inhibition of exoenzyme production by Candida albicans
October 2022
This study was aimed at evaluating the effects of aqueous extracts of Lentinula edodes (SHI), Pleurotus pulmonarius (PUL), and Pleurotus sajor-caju (PSC) on the growth of eight yeast species and the exo-enzyme production by Candida species after exposure to the extracts, which were prepared with the cold extraction methodology and tested against yeasts by the broth microdilution method. Proteinase and phospholipase were...
Ethnopharmacological investigation on Msindzano, a beauty mask used by Comorian women: What plants for what mixtures, for what applications?
September 2022
Although extensively used by Comorian women, limited information exists on Msindzano beauty masks. Thus an ethnopharmacological survey was conducted on two islands of the Comoros archipelago: Ndzuani and Ngazidja. An open-ended, semi-structured questionnaire was employed for data collection on the different plants used for Msindzano preparation, their different mixtures and their different applications. A total of 348...
Piper rivinoides Kunth: A medicinal plant that preserves bioactive chemical substances in its essential oil throughout the seasons
August 2022
The chemical composition and seasonal variation of essential oils (EO) extracted from the aerial parts of the traditional medicinal plant Piper rivinoides were analyzed using gas chromatography (GC) coupled with mass spectrometry (MS) and GC coupled with flame ionization detector (GC-FID) technique, respectively. The wild plants were collected from two different sites in the Atlantic Forest. The analysis allowed us to...
Ethno botanical study of medicinal plants used by Baka people in the treatment of erectile dysfunction
August 2022
Erectile dysfunction is a disease that is increasingly affecting men. The study examined the traditional use of medicinal plants in the treatment of erectile dysfunction among the Baka people in the eastern region of Cameroon. The study took place over interspersed periods from January 2018 to January 2021 in 9 villages. Forty-four people were interviewed via a questionnaire. One hundred and fifty-nine citations and 71...
Medicinal plants and onychomycosis: potential and evidence of antifungal activity - an integrative review of the literature
July 2022
Onychomycosis is a fungal infection of the nails, also known as nail mycosis and Tinea unguium, which affects 6.9 to 23.2% of the general population. It is most commonly found in people aged 60 years and older. Onychomycosis is caused by dermatophyte fungi, non-dermatophyte filamentous fungi and yeast. Treatment includes topical or oral antifungal drugs. The use of other auxiliary, alternative and/or complementary...
Tracking antibacterial components of Pteris multifida Poir and its antibacterial mechanism
June 2022
Pteris multifida is an effective Chinese herb for treating dysentery caused by Escherichia coli. It might be a good veterinary antibiotic alternative. In this study, we optimized the extraction condition based on the antibacterial activity of crude extracts from P. multifida, tracked its antibacterial components, and investigated their antibacterial activity, as well as its antibacterial mechanism. The results revealed...
Phytochemical composition and in vitro antileishmanial activity of Bidens pilosa, Tithonia diversifolia and Sonchus oleraceus extracts
June 2022
Leishmaniasis is the second-largest parasitic killer in the world (after malaria). Currently, there are no effective vaccines or therapeutic interventions thus creating a gap for new alternative remedies in the management of the disease. Medicinal plants offer this attractive option as antileishmanial agents since they are relatively safe, locally available and affordable. The study assessed antileishmanial activity of...
In vivo antimalarial activity, safety and phytochemical screening of Canthium multiflorum (Schumach. &Thonn.) Hiern (Rubiaceae)
June 2022
Canthium multiflorum (Thonn.) Hiern (Rubiaceae) is a popular herb used by traditional healers in western Burkina Faso. C. multiflorum leaves are widely used in decoction to treat malaria. The present study aims to evaluate its in vivo potential against malaria parasites in mice. The antimalarial activity of the organic and aqueous extracts of C. multiflorum leaves was evaluated on Plasmodium berghei Anka in NMRI mice...
Medicinal plants of the African traditional pharmacopoeia in the management of bovine trypanosomosis: A review
June 2022
Traditional medicine has remained the most affordable and readily available source of treatment for primary care in poor African communities. Despite the increasingly common practices of traditional medicine to treat animal diseases, this rich endogenous knowledge is not sufficiently documented. The objective of this review is to synthesize information on ethnoveterinary practices to treat bovine trypanosomiasis in...
Medicinal plants in oral health and the intergenerational transfer of knowledge: Resilience to cocoa culture in southern Bahia
May 2022
Ethnobotanical surveys have proved plant usage in the treatment of oral diseases; however, in areas where cocoa farming influenced socioeconomic reality there is a lack of information about preservation of traditional knowledge related to oral conditions treatment. Family Health Strategy (FHS) users and community experts were interviewed with socioeconomic characteristics and ethnobotanical information being obtained...
Anti-quorum sensing potential of Ageratum conyzoides L. (Asteraceae) extracts from Burkina Faso
May 2022
Pseudomonas aeruginosa causes infections in humans, particularly immune-compromised patients with cystic fibrosis, severe burns, and HIV, resulting in high morbidity and mortality. The pathogenic bacteria, P. aeruginosa, produces virulence factors regulated by the mechanism called quorum sensing system. The aim of this study was to assess the anti-quorum sensing activity of Ageratum conyzoides extracts. Chloroform...
Ethnobotanical and ethno-pharmacological approach to ichthyotoxic plants of Gabon
May 2022
This ethnobotanical and ethno-pharmacological study was conducted to know the plants used in fishing practices and to show their importance in traditional medicine in Gabon. For this study, 100 questionnaires were administered to individuals in the fishing and traditional medical domains. 701 plants belonging to 16 different floristic families, including Fabaceae (41%), Rubiaceae (13%), and Rutaceae (15%) were commonly...
Herbal medicine development and compliance to regulatory guidelines in Imo State Nigeria
April 2022
Herbal medicine is an important age-long resource for healthcare. The aim of this study was to determine the development of herbal medicine in relation to compliance to regulatory guidelines and product development in pursuance of the integration of herbal medicine into the healthcare system in Nigeria. Using Imo State as a case study, a cross-sectional investigation was conducted among the Traditional Medicine...
Antioxidant and antihyperlipidemic activities of unique nicotinyl polysaccharide from the green seaweed Ulva pertusa
April 2022
Nicotinyl derivative of polysaccharide (NU) from the green seaweed Ulva pertusa (Chlorophyta) has unique structure and strong antioxidant activity in vitro. In the present study, in vivo antioxidant and antihyperlipidemic activities were tested in the livers of hyperlipidemic mice. Activity levels of superoxide dismutase, glutathione peroxidase (GSH-PX), catalase, and malondialdehyde were observed. At the 500 mg/kg...
In vitro antiproliferative potential of crude extracts from Carica papaya L. (Caricaceae) black seeds against prostate cancer cell lines'
April 2022
Black seeds from papaya plants are utilized as traditional medicine in African and Asian cultures to improve the functioning of the male reproductive system and management of prostate cancer. This study analyzed the phytochemical composition, antiproliferative activity and cytotoxicity of Carica papaya black seeds against the prostate cancer cells and Vero cells. Phytochemical screening was performed by standard...
Phytochemical analysis and safety evaluation of ethanol roots extract of Erythrina sacleuxii hua in Wistar albino rats
April 2022
Erythrina sacleuxii, one of five Erythrina species found in Kenya, is a stiffly multi-branched deciduous tree reported to have antiplasmodial, antifungal, anti-bacterial and anti-cancer activities. This study aimed at evaluating acute and sub-acute oral toxicity of E. sacleuxii roots ethanolic extract. Phytochemical analysis was conducted on Fourier transform infrared spectroscopy and Gas Chromatography-Mass...
Analgesic, anti-inflammatory and oxytocic activities of Dracaena steudneri Engl. stem bark aqueous extract in Wistar rats
April 2022
Dracaena steudneri Engl. (Dracaenaceae) is a medicinal plant that is used in labour by traditional birth attendants to induce labour, relieve pain and treat various diseases; albeit no documentation. This study determined the analgesic, anti-inflammatory and oxytocic effects of the D. steudneri stem bark aqueous extract. D. steudneri stem bark was collected, authenticated, oven-dried at 45ºC for 48 h, pulverized...
Antibiotic potential of a crude ethanol extract from Asplenium serratum L. fern leaves
March 2022
Asplenium serratum L. (Aspleniaceae) is a terrestrial, epiphytic or humicole fern used as traditional medicine in different countries to treat infection. As such, this study aimed to assess the antibacterial potential of a crude ethanol extract from A. serratum leaves against multidrug-resistant bacteria from a hospital setting. Fern leaves were dried and ground using 96° Gay Lussac ethanol, with the extract...
Acute toxicity, analgesic, and smooth muscle relaxant effects of the aqueous root extract of Asparagus racemosus from Kenya
March 2022
The plant Asparagus racemosus is used traditionally in Kenya for a variety of medicinal purposes including in the management of pain, asthma, and premature labour. However, a dearth of empirical studies means that there is limited information on the acute toxicity and pharmacological effects to support these uses by the local variety of the plant. The aim of this study was, therefore, to evaluate the acute toxicity,...
Brown macroalgae: Promising sources of bioactive products against human herpesviruses
March 2022
Marine brown macroalgae have stood out as important sources of new bioactive products, such as antimicrobial, anticoagulant, anti-inflammatory and antiviral drugs. This study aimed to review the literature on the applications of products derived from brown macroalgae as antiviral agents against human herpesviruses. To date, species of seven distinct orders of brown algae have been studied for this purpose, such as...
Flavonoid content and antioxidant potential of leaf extracts of Passiflora setacea cv BRS Pérola do Cerrado, a new wild passion fruit cultivar
February 2022
Passiflora setacea D.C. is a wild species native to the Brazilian Cerrado, with agronomic and medicinal potentials. The cultivar BRS Pérola do Cerrado is the first registered and protected cultivar of a wild Passiflora and has become an alternative to the passion fruit market due to its desirable characteristics for food, ornamental and pharmaceutic industries. Since plant tissue culture techniques are considered...
Antioxidant and DNA damage protective activities of selected endophytic actinobacteria isolated from Harpagophytum procumbens: A Kalahari desert-adapted plant
February 2022
Given that synthetic antioxidants are currently in use and have been demonstrated to have known negative side effects, it is important to look for natural antioxidant sources. Endophytic actinobacteria, especially those associated with medicinal plants, are one understudied source. The goal of this study was to investigate whether the secondary metabolites of endophytic actinobacteria isolated from Harpagophytum...
Antibacterial, antiquorum sensing, antibiofilm activities and chemical profiling of selected South African medicinal plants against multi-drug resistant bacteria
February 2022
South African indigenous plants have been predominantly studied for their antibacterial abilities, overlooking their antipathogenic and antivirulence (also known as antiquorum sensing) potential. Hence, this study explored the selected medicinal plants as possible agents capable of interfering with bacterial growth, quorum sensing and biofilm formation and identified their respective bioactive compounds. Ten medicinal...
Antiplasmodial activity and phenolic composition of Brazilian Salix humboldtiana Willd. extract and fractions
February 2022
Salix humboldtiana Willd. (Salicaceae) colonizes Brazilian riverine forests and, besides other congeneric species, is traditionally used to treat fever. In folk medicine, it is even used as a Quinine substitute to treat malaria fever. Although its occurrence worldwide was largely reduced between 2000-2015, in Brazil, the case numbers induced by Plasmodium falciparum have increased. Thus, new tools and strategies are...
Evaluation of the anxiolytic effects of acute administration of Passiflora alata extract in wistar rats submitted to swimming
February 2022
Anxiety is present in several psychiatric disorders, and pharmacological treatment has limitations. Therefore, there is a search for new therapeutic approaches. This study aimed to evaluate the anxiolytic effect of acute administration of the dry extract of Passiflora alata (P. alata) leaves in male Wistar rats submitted to swimming. The animals were randomly divided into four groups (n = 8) (G1 to G4). G2 to G4 were...
Ethnobotanical survey of medicinal plants utilized by forest edge communities in southern Sierra Leone
January 2022
A total of 128 medicinal plant species belonging to 71 genera and 46 families were identified and used to treat 42 human ailments. Euphorbiaceae was the leading family with 14 species, followed by Rubiaceae and Leg-Caesalpiniaceae with 12 and 8 species, respectively. Seven species (Coffea stenophylla, Garcinia afzelii, Mitragyna stipulosa, Irvingia gabonensis, Milicia regia, Nauclea diderrichii and Nesogordonia...
Noni essential oil associated with adjuvants in the production of phytoalexins and in the control of soybean anthracnosis
January 2022
Amongst the most important agricultural products in Brazil, the soybean stands out, mainly as an export good. One of the end-of-cycle diseases, Anthracnose, caused by the fungus Colletotrichum truncatum (Schwein.) leads to severe damage to grain quality and yield. The use of natural products as a substitute for conventional pesticides for plant diseases control is an alternative found to reduce food contamination and...
Bioactive small-molecule constituents of Lao plants
December 2021
Laos has a rich plant diversity, and medicinal plants are used extensively in Lao traditional medicine for the treatment of a variety of human diseases. However, only a relatively small number of these plants have been investigated for their major components with potential antitumor, anti-infective, and other types of bioactivities. These species include Asparagus cochinchinensis, Diospyros quaesita, Gongronema...
Optimized flow cytometric protocol and genome size estimation of Sabah snake grass (Clinacanthus nutans)
December 2021
Clinacanthus nutans is an economically important medicinal plant that can be found grown in many countries in the Asian region. Useful medicine properties such as anti-cancer, anti-bacteria, and anti-viral, backed by its high content of phytochemical compounds such vitexin, isovitexin, stigmasterol and lupeol has increased the demand for C. nutans in the market. Extensive work had been carried out on its content and...
Preliminary screening of the antimicrobial activity of nine medicinal plant species from Burkina Faso
November 2021
Infectious diseases, including skin infections, have always been treated by plants and other natural products since ancient times. This study investigated the antimicrobial activity of nine medicinal plant species from Gonsé Forest and Bangreweogo Park, Burkina Faso on seven microbial strains involved in skin infections. Sixty-eight organic and aqueous extracts from leaves, stem and root barks of the nine plants...
Effects of hydromethanol hypocotyls extract of Borassus aethiopum on sperm and gonadal indices of male Wistar rats
November 2021
Infertility resulting from sperm dysfunction is a serious health problem leading to psychological, economic, and medical implications worldwide. Borassus aethiopum is a plant that has been used as an aphrodisiac. This study evaluated the effect of hydromethanol hypocotyls extracts of B. aethiopum on the sperm and gonadal indices of male Wistar rats. The extract was prepared and administered orally at doses of (250, 500...
Ethnobotanical survey on medicinal plants traditionally used for treatment of intestinal parasitosis of animals and humans in Northern Benin
October 2021
Parasitic nematodes of the gastrointestinal (GI) tract remain a major threat to both human beings and livestock. The aim of this study was to document medicinal plants used in the management of intestinal parasitosis in the small ruminants and humans. Information relating to the different plants used in the treatment of human intestinal parasitosis and small ruminants was collected through an ethnobotanical survey...
Phytochemical, elemental and functional group analyses of herbal material and extracts of Cassia sieberiana used in herbal drug formulation
October 2021
Cassia sieberiana is used traditionally for the treatment of several ailments. The lack of knowledge in the levels of essential mineral contents and heavy metal constituents of C. sieberiana normally collected from various sites for preparation of herbal products can pose serious health risks to consumers. The elemental contents (Ca, Mg, K, Na, Cl, Hg, Pb, As, Ni, Cd, Cu, Fe, Mn, Zn, N, S and C) of a mixture of the stem...
Comparing checkerboard, isobologram and CCD methods for drug combination: A case study of ciprofloxacin and plant extracts on Escherichia coli and Shigella
October 2021
To investigate the interactive antimicrobial activity of conventional antibiotics, namely ciprofloxacin and Mangifera indica bark ethanol extract, Psidium guajava leaves essential oil against two Gram-negative bacteria using checkerboard, isobologram, and central composite design (CCD) methods. The checkerboard method was used for the determination of the fractional inhibitory concentration index (FICI) value needed for...
Protective effect of commercial extracts of oregano (Lippia graveolens) against cardiac ischemia-reperfusion damage
October 2021
Cardiac ischemia includes severe damage to heart muscle tissue due to decreased or cessation of blood flow, which involves failure to supply nutrients and oxygenation to heart cells. Causes can include blockages due to fat and cholesterol deposits. These damages include cell apoptosis, calcium and sodium concentration imbalance, loss of contraction force, and formation of reactive oxygen species. In the present work,...
SARS Cov-2 Structure, biology, immunology and clinical course: Exploring the value of traditional medicine in limiting COVID-19 individual risk and disease outcomes
October 2021
Since the onset of COVID-19 in early 2020, various approaches have been adopted worldwide by various state health authorities containing the ravaging pandemic. Tanzania adopted additional approach based on Tanzanian Traditional Medicines. This review aimed to explore the suitability of this local approach based on evaluation of the virus biology, pathogenesis and immunology in relation to the traditional medicines,...
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