Tracking antibacterial components of Pteris multifida Poir and its antibacterial mechanism
June 2022
Pteris multifida is an effective Chinese herb for treating dysentery caused by Escherichia coli. It might be a good veterinary antibiotic alternative. In this study, we optimized the extraction condition based on the antibacterial activity of crude extracts from P. multifida, tracked its antibacterial components, and investigated their antibacterial activity, as well as its antibacterial mechanism. The results revealed...
Medicinal plants of the African traditional pharmacopoeia in the management of bovine trypanosomosis: A review
June 2022
Traditional medicine has remained the most affordable and readily available source of treatment for primary care in poor African communities. Despite the increasingly common practices of traditional medicine to treat animal diseases, this rich endogenous knowledge is not sufficiently documented. The objective of this review is to synthesize information on ethnoveterinary practices to treat bovine trypanosomiasis in...
In vivo antimalarial activity, safety and phytochemical screening of Canthium multiflorum (Schumach. &Thonn.) Hiern (Rubiaceae)
June 2022
Canthium multiflorum (Thonn.) Hiern (Rubiaceae) is a popular herb used by traditional healers in western Burkina Faso. C. multiflorum leaves are widely used in decoction to treat malaria. The present study aims to evaluate its in vivo potential against malaria parasites in mice. The antimalarial activity of the organic and aqueous extracts of C. multiflorum leaves was evaluated on Plasmodium berghei Anka in NMRI mice...
Phytochemical composition and in vitro antileishmanial activity of Bidens pilosa, Tithonia diversifolia and Sonchus oleraceus extracts
June 2022
Leishmaniasis is the second-largest parasitic killer in the world (after malaria). Currently, there are no effective vaccines or therapeutic interventions thus creating a gap for new alternative remedies in the management of the disease. Medicinal plants offer this attractive option as antileishmanial agents since they are relatively safe, locally available and affordable. The study assessed antileishmanial activity of...
Anti-quorum sensing potential of Ageratum conyzoides L. (Asteraceae) extracts from Burkina Faso
May 2022
Pseudomonas aeruginosa causes infections in humans, particularly immune-compromised patients with cystic fibrosis, severe burns, and HIV, resulting in high morbidity and mortality. The pathogenic bacteria, P. aeruginosa, produces virulence factors regulated by the mechanism called quorum sensing system. The aim of this study was to assess the anti-quorum sensing activity of Ageratum conyzoides extracts. Chloroform...
Ethnobotanical and ethno-pharmacological approach to ichthyotoxic plants of Gabon
May 2022
This ethnobotanical and ethno-pharmacological study was conducted to know the plants used in fishing practices and to show their importance in traditional medicine in Gabon. For this study, 100 questionnaires were administered to individuals in the fishing and traditional medical domains. 701 plants belonging to 16 different floristic families, including Fabaceae (41%), Rubiaceae (13%), and Rutaceae (15%) were commonly...
Medicinal plants in oral health and the intergenerational transfer of knowledge: Resilience to cocoa culture in southern Bahia
May 2022
Ethnobotanical surveys have proved plant usage in the treatment of oral diseases; however, in areas where cocoa farming influenced socioeconomic reality there is a lack of information about preservation of traditional knowledge related to oral conditions treatment. Family Health Strategy (FHS) users and community experts were interviewed with socioeconomic characteristics and ethnobotanical information being obtained...
Phytochemical analysis and safety evaluation of ethanol roots extract of Erythrina sacleuxii hua in Wistar albino rats
April 2022
Erythrina sacleuxii, one of five Erythrina species found in Kenya, is a stiffly multi-branched deciduous tree reported to have antiplasmodial, antifungal, anti-bacterial and anti-cancer activities. This study aimed at evaluating acute and sub-acute oral toxicity of E. sacleuxii roots ethanolic extract. Phytochemical analysis was conducted on Fourier transform infrared spectroscopy and Gas Chromatography-Mass...
In vitro antiproliferative potential of crude extracts from Carica papaya L. (Caricaceae) black seeds against prostate cancer cell lines'
April 2022
Black seeds from papaya plants are utilized as traditional medicine in African and Asian cultures to improve the functioning of the male reproductive system and management of prostate cancer. This study analyzed the phytochemical composition, antiproliferative activity and cytotoxicity of Carica papaya black seeds against the prostate cancer cells and Vero cells. Phytochemical screening was performed by standard...
Herbal medicine development and compliance to regulatory guidelines in Imo State Nigeria
April 2022
Herbal medicine is an important age-long resource for healthcare. The aim of this study was to determine the development of herbal medicine in relation to compliance to regulatory guidelines and product development in pursuance of the integration of herbal medicine into the healthcare system in Nigeria. Using Imo State as a case study, a cross-sectional investigation was conducted among the Traditional Medicine...
Analgesic, anti-inflammatory and oxytocic activities of Dracaena steudneri Engl. stem bark aqueous extract in Wistar rats
April 2022
Dracaena steudneri Engl. (Dracaenaceae) is a medicinal plant that is used in labour by traditional birth attendants to induce labour, relieve pain and treat various diseases; albeit no documentation. This study determined the analgesic, anti-inflammatory and oxytocic effects of the D. steudneri stem bark aqueous extract. D. steudneri stem bark was collected, authenticated, oven-dried at 45ºC for 48 h, pulverized...
Antioxidant and antihyperlipidemic activities of unique nicotinyl polysaccharide from the green seaweed Ulva pertusa
April 2022
Nicotinyl derivative of polysaccharide (NU) from the green seaweed Ulva pertusa (Chlorophyta) has unique structure and strong antioxidant activity in vitro. In the present study, in vivo antioxidant and antihyperlipidemic activities were tested in the livers of hyperlipidemic mice. Activity levels of superoxide dismutase, glutathione peroxidase (GSH-PX), catalase, and malondialdehyde were observed. At the 500 mg/kg...
Brown macroalgae: Promising sources of bioactive products against human herpesviruses
March 2022
Marine brown macroalgae have stood out as important sources of new bioactive products, such as antimicrobial, anticoagulant, anti-inflammatory and antiviral drugs. This study aimed to review the literature on the applications of products derived from brown macroalgae as antiviral agents against human herpesviruses. To date, species of seven distinct orders of brown algae have been studied for this purpose, such as...
Acute toxicity, analgesic, and smooth muscle relaxant effects of the aqueous root extract of Asparagus racemosus from Kenya
March 2022
The plant Asparagus racemosus is used traditionally in Kenya for a variety of medicinal purposes including in the management of pain, asthma, and premature labour. However, a dearth of empirical studies means that there is limited information on the acute toxicity and pharmacological effects to support these uses by the local variety of the plant. The aim of this study was, therefore, to evaluate the acute toxicity,...
Antibiotic potential of a crude ethanol extract from Asplenium serratum L. fern leaves
March 2022
Asplenium serratum L. (Aspleniaceae) is a terrestrial, epiphytic or humicole fern used as traditional medicine in different countries to treat infection. As such, this study aimed to assess the antibacterial potential of a crude ethanol extract from A. serratum leaves against multidrug-resistant bacteria from a hospital setting. Fern leaves were dried and ground using 96° Gay Lussac ethanol, with the extract...
Evaluation of the anxiolytic effects of acute administration of Passiflora alata extract in wistar rats submitted to swimming
February 2022
Anxiety is present in several psychiatric disorders, and pharmacological treatment has limitations. Therefore, there is a search for new therapeutic approaches. This study aimed to evaluate the anxiolytic effect of acute administration of the dry extract of Passiflora alata (P. alata) leaves in male Wistar rats submitted to swimming. The animals were randomly divided into four groups (n = 8) (G1 to G4). G2 to G4 were...
Flavonoid content and antioxidant potential of leaf extracts of Passiflora setacea cv BRS Pérola do Cerrado, a new wild passion fruit cultivar
February 2022
Passiflora setacea D.C. is a wild species native to the Brazilian Cerrado, with agronomic and medicinal potentials. The cultivar BRS Pérola do Cerrado is the first registered and protected cultivar of a wild Passiflora and has become an alternative to the passion fruit market due to its desirable characteristics for food, ornamental and pharmaceutic industries. Since plant tissue culture techniques are considered...
Antiplasmodial activity and phenolic composition of Brazilian Salix humboldtiana Willd. extract and fractions
February 2022
Salix humboldtiana Willd. (Salicaceae) colonizes Brazilian riverine forests and, besides other congeneric species, is traditionally used to treat fever. In folk medicine, it is even used as a Quinine substitute to treat malaria fever. Although its occurrence worldwide was largely reduced between 2000-2015, in Brazil, the case numbers induced by Plasmodium falciparum have increased. Thus, new tools and strategies are...
Antioxidant and DNA damage protective activities of selected endophytic actinobacteria isolated from Harpagophytum procumbens: A Kalahari desert-adapted plant
February 2022
Given that synthetic antioxidants are currently in use and have been demonstrated to have known negative side effects, it is important to look for natural antioxidant sources. Endophytic actinobacteria, especially those associated with medicinal plants, are one understudied source. The goal of this study was to investigate whether the secondary metabolites of endophytic actinobacteria isolated from Harpagophytum...
Antibacterial, antiquorum sensing, antibiofilm activities and chemical profiling of selected South African medicinal plants against multi-drug resistant bacteria
February 2022
South African indigenous plants have been predominantly studied for their antibacterial abilities, overlooking their antipathogenic and antivirulence (also known as antiquorum sensing) potential. Hence, this study explored the selected medicinal plants as possible agents capable of interfering with bacterial growth, quorum sensing and biofilm formation and identified their respective bioactive compounds. Ten medicinal...
Ethnobotanical survey of medicinal plants utilized by forest edge communities in southern Sierra Leone
January 2022
A total of 128 medicinal plant species belonging to 71 genera and 46 families were identified and used to treat 42 human ailments. Euphorbiaceae was the leading family with 14 species, followed by Rubiaceae and Leg-Caesalpiniaceae with 12 and 8 species, respectively. Seven species (Coffea stenophylla, Garcinia afzelii, Mitragyna stipulosa, Irvingia gabonensis, Milicia regia, Nauclea diderrichii and Nesogordonia...
Noni essential oil associated with adjuvants in the production of phytoalexins and in the control of soybean anthracnosis
January 2022
Amongst the most important agricultural products in Brazil, the soybean stands out, mainly as an export good. One of the end-of-cycle diseases, Anthracnose, caused by the fungus Colletotrichum truncatum (Schwein.) leads to severe damage to grain quality and yield. The use of natural products as a substitute for conventional pesticides for plant diseases control is an alternative found to reduce food contamination and...
Bioactive small-molecule constituents of Lao plants
December 2021
Laos has a rich plant diversity, and medicinal plants are used extensively in Lao traditional medicine for the treatment of a variety of human diseases. However, only a relatively small number of these plants have been investigated for their major components with potential antitumor, anti-infective, and other types of bioactivities. These species include Asparagus cochinchinensis, Diospyros quaesita, Gongronema...
Optimized flow cytometric protocol and genome size estimation of Sabah snake grass (Clinacanthus nutans)
December 2021
Clinacanthus nutans is an economically important medicinal plant that can be found grown in many countries in the Asian region. Useful medicine properties such as anti-cancer, anti-bacteria, and anti-viral, backed by its high content of phytochemical compounds such vitexin, isovitexin, stigmasterol and lupeol has increased the demand for C. nutans in the market. Extensive work had been carried out on its content and...
Preliminary screening of the antimicrobial activity of nine medicinal plant species from Burkina Faso
November 2021
Infectious diseases, including skin infections, have always been treated by plants and other natural products since ancient times. This study investigated the antimicrobial activity of nine medicinal plant species from Gonsé Forest and Bangreweogo Park, Burkina Faso on seven microbial strains involved in skin infections. Sixty-eight organic and aqueous extracts from leaves, stem and root barks of the nine plants...
Effects of hydromethanol hypocotyls extract of Borassus aethiopum on sperm and gonadal indices of male Wistar rats
November 2021
Infertility resulting from sperm dysfunction is a serious health problem leading to psychological, economic, and medical implications worldwide. Borassus aethiopum is a plant that has been used as an aphrodisiac. This study evaluated the effect of hydromethanol hypocotyls extracts of B. aethiopum on the sperm and gonadal indices of male Wistar rats. The extract was prepared and administered orally at doses of (250, 500...
Phytochemical, elemental and functional group analyses of herbal material and extracts of Cassia sieberiana used in herbal drug formulation
October 2021
Cassia sieberiana is used traditionally for the treatment of several ailments. The lack of knowledge in the levels of essential mineral contents and heavy metal constituents of C. sieberiana normally collected from various sites for preparation of herbal products can pose serious health risks to consumers. The elemental contents (Ca, Mg, K, Na, Cl, Hg, Pb, As, Ni, Cd, Cu, Fe, Mn, Zn, N, S and C) of a mixture of the stem...
Ethnobotanical survey on medicinal plants traditionally used for treatment of intestinal parasitosis of animals and humans in Northern Benin
October 2021
Parasitic nematodes of the gastrointestinal (GI) tract remain a major threat to both human beings and livestock. The aim of this study was to document medicinal plants used in the management of intestinal parasitosis in the small ruminants and humans. Information relating to the different plants used in the treatment of human intestinal parasitosis and small ruminants was collected through an ethnobotanical survey...
Protective effect of commercial extracts of oregano (Lippia graveolens) against cardiac ischemia-reperfusion damage
October 2021
Cardiac ischemia includes severe damage to heart muscle tissue due to decreased or cessation of blood flow, which involves failure to supply nutrients and oxygenation to heart cells. Causes can include blockages due to fat and cholesterol deposits. These damages include cell apoptosis, calcium and sodium concentration imbalance, loss of contraction force, and formation of reactive oxygen species. In the present work,...
Studies of the anti-hyperglycemic and antioxidant activities of the extract of aerial yam (Dioscorea bulbifera)
October 2021
This study investigated the anti-hyperglycemic and antioxidant activities of methanol extract of Dioscorea bulbifera with a view to studying the possibility of utilizing the yam in the management of hyperglycemia. Methanol extracts of the peels (MEPL), fresh (MEFL), and the whole tuber (MEWT) were prepared, phytochemically screened and assayed for α-amylase. Hyperglycemia was induced in rats using intraperitoneal...
Comparing checkerboard, isobologram and CCD methods for drug combination: A case study of ciprofloxacin and plant extracts on Escherichia coli and Shigella
October 2021
To investigate the interactive antimicrobial activity of conventional antibiotics, namely ciprofloxacin and Mangifera indica bark ethanol extract, Psidium guajava leaves essential oil against two Gram-negative bacteria using checkerboard, isobologram, and central composite design (CCD) methods. The checkerboard method was used for the determination of the fractional inhibitory concentration index (FICI) value needed for...
Comparative study of wild chamomile plants from the north-west of Morocco: Bioactive components and total antioxidant activity
October 2021
Morocco presents numerous plants due its localization between the Mediterranean Sea and Atlantic Ocean and the variability of its mountainous terrain, with a rich range of medicinal plants. Cladanthus mixtus (L.) Oberpr. & Vogt and Matricaria chamomilla L., two Asteraceae (Compositae) from Beni Hassane region in north-western Morocco are both used in traditional medicine for the treatment of different ailments. The...
SARS Cov-2 Structure, biology, immunology and clinical course: Exploring the value of traditional medicine in limiting COVID-19 individual risk and disease outcomes
October 2021
Since the onset of COVID-19 in early 2020, various approaches have been adopted worldwide by various state health authorities containing the ravaging pandemic. Tanzania adopted additional approach based on Tanzanian Traditional Medicines. This review aimed to explore the suitability of this local approach based on evaluation of the virus biology, pathogenesis and immunology in relation to the traditional medicines,...
Composition and antioxidant potential of leaf and stem essential oils from Nigerian Indigofera spicata Forssk
September 2021
The chemical compositions and antioxidant evaluation of the essential oils (EOs) obtained by hydrodistillation from the leaf and stem of Indigofera spicata Forssk (Fabaceae) grown in Nigeria have been studied. The EOs were analyzed using gas chromatography coupled with mass spectrometry (GC-MS) and the antioxidant potential was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging ability method....
Chemical investigation, toxic potential and acetylcholinesterase inhibitory effect of Parkia platycephala leaf and seed extracts
September 2021
The present work evaluated the inhibitor potential of acetylcholinesterase, the preliminary toxicity and determination of active components of different leaf and seed extracts of Parkia platycephala. All extracts were obtained through hot extraction in a closed system (Soxhlet). To obtain the leaf and seed hexanic, methanolic, and ethanolic extracts (LHE, LME, LEE, and SHE, SME, and SEE), sequential extraction was...
Piper multinodum C.DC. (Piperaceae) essential oils chemical variation and biological activity against Mycobacterium tuberculosis
September 2021
Piper multinodum C.DC. belongs to the Piperaceae family, and is known as “Jaborandi-manso”. This species has no reported botanical, chemical, pharmacological and/or toxicological scientific studies, and has restricted occurrence in degraded Brazilian biomes. The Piper genus is known to be aromatic, the essential oils (EO) obtained from different organs have demonstrated significant biological activities, and...
Effect of n-hexane extract of baobab (Adansonia digitata) fruit on biochemical parameters of l-ng-nitro arginine methyl ester induced hypertension in rats
September 2021
L-NG-Nitro arginine methyl ester (L-NAME) was used to induce hypertension in this experiment and the intervention plant extract was Adansonia digitata fruit. A total of 30 rats were used for this research and divided into 6 groups of 5 animals each. Group 1 was control (water and feed ad libidum), group 2 (L-NAME), group 3 (ramipril 10 mg/kg), group 4 (A. digitata 200 mg/kg), group 5 (A. digitata 400 mg/kg) and group 6...
Therapeutic applications of Caryocar brasiliense: Systematic review
September 2021
The interest and search for natural active principles with therapeutic properties from plants are growing, given their potential for use by the cosmetic and pharmaceutical industries. Thus, the objective of this review was to carry out a systematic analysis of scientific productions that have explored some therapeutic potential of Caryocar brasiliense. The methodology of the preferred reporting items was adopted for...
Comparative studies of antioxidant and anti-inflammatory potentials of ethanolic leaf extract of Sorghum bicolor and Zea mays
August 2021
This study was designed to investigate the anti-inflammatory and anti-oxidant potentials of leaf extracts of Zea mays (maize) and Sorghum bicolor (sorghum) with a view of utilizing them as herbal tea on the management and treatment of oxidant and inflammatory disorders. The powdered plant materials: (Z. mays, (30 g), S. bicolor (30 g), mixture (15 g of Z. mays + 15 g of S. bicolor) were soaked separately in 80% (v/v)...
Chemical characterization and toxicological analyses of hydroalcoholic extracts from the stem and leaves of mangabeira (Hancornia speciosa Gomes) as a guide for the development of green cosmetics
August 2021
The increasing interest in green cosmetics has a major influence on the cosmetics market, whether due to the incorporation of the functionalities of the extracts, or the substitution of synthetic ingredients with natural ones. Yet, the natural substances found in those products must be evaluated for their chemical characterization and toxicity. This study determined the chemical profile and assessed the toxicity of stem...
Assessment of minimum growth conditions for in vitro conservation of Passiflora edulis Sims
August 2021
Passiflora edulis Sims, besides having economic and social importance, is included in the medicinal plant list that is considered of interest by the Unified Health System (Sistema Único de Saúde – SUS). Due to its high nutritional value, this species is widely used in food, cosmetics and pharmaceutical industries. It also contains carotenoids, as well as passiflorine and maracugine, which have...
Traditional Chinese medicine Zizhu ointment alleviates inflammatory activity during wound healing in diabetic rats
August 2021
Diabetic ulcers are a severe complication in patients with diabetes that often lead to amputation. The etiology of diabetes-induced wound healing impairment is multi-faceted. Persistent inflammation and deficient tissue regeneration have been suggested to impair wound healing in diabetes patients. Although new therapeutic approaches have been developed, many chronic wound treatments remain unsatisfactory, and more...
Effects of Boswellia serrata, Zingiber officinale and Ginkgo biloba extracts in combination on memory impairment in mice
July 2021
Cognitive decline induced by oxidative brain damage is the critical pathological hallmark of Alzheimer’s disease. Studies have shown that individual administration of Boswellia serrata Roxb (BS), Zingiber officinale Roscoe (ZO) and Ginkgo biloba L. (GB) extracts improved memory and learning through a different mechanism of actions. This study aims to compare the individual effects of each extract with their...
Study of seasonality and location effects on the chemical composition of essential oils from Eugenia uniflora leaves
July 2021
The essential oils of Eugenia uniflora leave possess several biological activities but a great variability in their chemical composition is observed. In the present study, gas chromatography and mass spectrometry were applied to examine the essential oil from leaves of four different specimens over the seasons of the year, two of which are located in a habitat of a Brazilian metropolis, and the other two in a natural...
Pachyrhizus spp. seed extracts control the Sclerotium rolfsii Sacc. mycelial growth
July 2021
The present paper aimed to characterize the bioactivity being exerted on Sclerotium rolfsii Sacc. in vitro by seed aqueous extracts from 64 yam bean (Pachyrhizus spp.) genotypes as well as their maceration times (0, 48 and 72 h). Three experiments were carried out following a completely randomized design with 64 treatments (potato-dextrose-agar PDA+extracts) with two controls (PDA with no extract and PDA+Cabrio® Top...
Metabolic profile of wistar rats after consumption of flour prepared with grains and fruits
July 2021
The occurrence of chronic and degenerative diseases, such as obesity, diabetes, cardiovascular disease (CVD), and cancer is increasing sharply. In the last years, there has been an increase in interest in the consumption of foods with functional properties that are related to weight loss and disease prevention. For these reasons, this study aimed to evaluate the effects of flour prepared with grains and fruits on the...
Analysis by GC (Ir), GC/MS and mosquito repellent effect of essential oils against Anopheles gambiae: Case of stem bark of Sterculia tragacantha Lindl (Sterculiaceae) from Côte d'Ivoire
July 2021
The objectives of this study were to determine the chemical composition and to evaluate the mosquito repellent property of essential oils extracted from the bark of the stem of Sterculia tragacantha Lindl on Anopheles gambiae, vector of malaria. The essential oil of the stem bark of S. tragacantha Lindl is extracted by hydrodistillation and their chemical compositions were identified by GC (Ir) and GC-MS. This oil has...
Anti-bacterial activity of secondary metabolites from Chrysanthemum cinerariaefolium
June 2021
This study evaluated antibacterial activity of Chrysanthemum cinerariaefolium (pyrethrum) flower dichloromethane crude extract, fractions and isolated compounds; pyrethrin II, jasmolin I and cinerolone against methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Staphylococcus aureus and Shigella sonnei. The isolated compounds were obtained by carrying out column chromatography on dichloromethane...
Phytochemical properties and antimicrobial activity of Buchholzia coriacea and Psychotria microphylla leaf extracts on bacterial pathogens isolated from aquatic environments in Nigeria
June 2021
The use of medicinal plants as alternative therapy for the treatment of microbial infections is significant in the maintenance of good health, especially in developing countries. The aim of this study was to determine the phytochemical composition and antimicrobial activity of Buchholzia coriacea and Psychotria microphylla leaf extracts on bacteria isolated from aquatic environments in Nigeria. Exactly 736 water samples...
Indigenous knowledge of plant uses by the community of Batiaghata, Khulna, Bangladesh
June 2021
Southwestern region of Bangladesh is very rich in floral diversity, and their diversified uses. An extensive survey was conducted to investigate ethnobotanical applications of botanical species by the community of Khulna, Bangladesh. We focused on plants and community relationships, identify the most important species used, determine the relative importance of the species surveyed and calculated the Fidelity level (FI)...
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