Journal of
Pharmacognosy and Phytotherapy

  • Abbreviation: J. Pharmacognosy Phytother.
  • Language: English
  • ISSN: 2141-2502
  • DOI: 10.5897/JPP
  • Start Year: 2009
  • Published Articles: 226

JPP Articles

Analysis of bioactive chemical compounds of Aspergillus niger by using gas chromatography-mass spectrometry and fourier-transform infrared spectroscopy

August 2015

Bioactives are chemical compounds often referred to as secondary metabolites. Thirty five bioactive compounds were identified in the methanolic extract of Aspergillus niger. The identification of bioactive chemical compounds is based on the peak area, retention time molecular weight and molecular formula. Gas chromatography-mass spectrometry (GC-MS) analysis of Aspergillus niger revealed the existence of the...

Author(s): Imad Hadi Hameed, Lena Fadhil Hamza and Sabreen A. Kamal

Ethnobotanical survey of healing medicinal plants traditionally used in the main Moroccan cities

August 2015

The present study is a survey conducted to indicate the healing medicinal plants, traditionally used by the Moroccan population, and especially to select the healing plants mainly used in the form of essential oils. This survey allowed an inventory of 59 species of healing plants belonging to 37 families. The results showed that the whole plant is the most commonly used part (31%), followed by the leaves (29%). Most...

Author(s): Messaoudi Moussi I., Filali, H., Tazi, A. and Hakkou, F.  

Preliminary screening of anti-inflammatory effect of phytochemicals on chemotaxis of human neutrophils

August 2015

Neutrophils are leukocytes that are actively recruited to sites of tissue infection and/or injury by directed movement (chemotaxis). In vitro assessment of inhibition of neutrophil chemotaxis is a physiologic indicator of anti-inflammatory potential. To identify nontoxic, anti-inflammatory agents, plant-derived compounds (curcumin, resveratrol, rosmarinic acid and piperine) were assessed for effects on in vitro...

Author(s): Uthayashanker R. Ezekiel and Rita M. Heuertz

Identification of five newly described bioactive chemical compounds in methanolic extract of Mentha viridis by using gas chromatography - mass spectrometry (GC-MS)

July 2015

The bioactive compounds were screened by gas chromatography-mass spectrometry (GC-MS) method. Twenty one bioactive phytochemical compounds were identified in the methanolic extract of Mentha viridis using GC-MS method. The identification of phytochemical compounds is based on the peak area, retention time, molecular weight and molecular formula. GC-MS analysis of M. viridis revealed the existence of the...

Author(s): Imad Hadi Hameed, Hussein J. Hussein, Muhanned Abdulhasan Kareem, and Nidaa Shihab Hamad

Analgesic and anti-inflammatory effects of the ethanol extract of Elytraria marginata Vahl (whole plant) in Wistar rats

July 2015

The analgesic and anti-inflammatory effects of the ethanol extract of Elytraria marginata were studied using hot plate, thermal-induced pain and carrageenan-induced acute inflammation models in adult Wister rats. The preliminary phytochemical constituents of the extract were also ascertained. Inflammation was induced by injecting 0.1 ml of 1% carrageenan into the sub-planter surface of the right hind paw of the rats....

Author(s): J.S. Ashidi, O.J. Ojetola, P.I. Aziba and E.O. Ajaiyeoba

Antinociceptive and anti-inflammatory properties of Vernonia pauciflora Willd. (Asteraceae) Ethanol Extracts

June 2015

Analgesic and anti-inflammatory properties of Vernonia pauciflora crude ethanol extract were studied in order to verify the antinociceptive and anti-inflammatory effect. The preliminary phytochemical screening of the leaf extract revealed that it contained cyanogenetic glycosides, flavonoids, terpenes with no trace of alkaloids. The analgesic screening of the extract against acetic acid-induced writhing in mice showed...

Author(s): Ukwubile Cletus Anes

Gas chromatography mass spectrum and fourier-transform infrared spectroscopy analysis of methanolic extract of Rosmarinus oficinalis leaves

June 2015

The aims of the study were to investigate the presence of phytochemical compounds from the leaves of Rosmarinus oficinalis, using methanolic extraction and report the main functional components by using FT-IR. The phytochemical compound screened by GC-MS method. Seventeen bioactive phytochemical compounds were identified in the methanolic extract of R. oficinalis. The identification of phytochemical compounds is based...

Author(s): Imad Hadi Hameed, Israa Adnan Ibraheam and Hawraa Jawad Kadhim  

Palliative treatment of cancer in resource poor settings: Traditional medicine perspective

May 2015

This study aimed to determine the suitability of ethnomedicinal plants as a suitable option for palliative care of cancer in Namibia. To achieve this, key informant interviews were conducted in central and northern parts of Namibia on the use of ethnomedicinal plant products for palliation of cancer. Information from surveys on the medicinal use of plants in Oshikoto and Zambezi regions of Namibia for ailments such as...

Author(s): Florence Dushimemaria and Davis R. Mumbengegwi  

Antibacterial attributes of extracts of Phyllantus amarus and Phyllantus niruri on Escherichia coli the causal organism of urinary tract infection

May 2015

In view of the prevalence of urinary tract infection (UTI) worldwide, the increasing resistance of pathogenic bacteria to conventional antibiotics and their side effects, the aerial part and root of Phyllanthus amarus (Schum. and Thonn.) and Phyllanthus niruri (L.) were analysed for mineral and phytochemical constituents, and their ethanol extracts screened against five clinical isolates of Escherichia coli associated...

Author(s): Idayat Titilayo Gbadamosi

Antiprotozoal and cytotoxic activities, and the acute toxicity of extracts from of Brucea sumatrana Roxb. (Simaroubaceae) leaves collected in Mai-Ndombe, Democratic Republic of Congo

April 2015

Results from the in vitro evaluation of the antiprotozoal activity of the aqueous extract, the 80% methanol extract and its fractions from the leaves of Brucea sumatrana against Trypanosoma brucei brucei, Trypanosoma cruzi, Lesihmania infantum, the multidrug-resistant K1 and chloroquine-sensitive NF54 strains of Plasmodium falciparum indicated that all samples from the leaves extract presented interesting antiprotozoal...

Author(s): Cimanga R. Kanyanga, Tshodi M. Ehata, Nsaka S. Lumpu, Kikweta C. Munduku, Mbenza A. Phuati, Kambu O. Kabangu, Cos, P., Maes, L., Apers, S., Vlietinck, A. J. and Pieters, L.

New pentacyclic triterpene ester and flavone glycoside from the biologically active extract of Carduus pycnocephalus L.

April 2015

Bioassay guided phytochemical investigation of petroleum ether, chloroform and butanol  fractions obtained from biologically active total alcoholic extract of Carduus pycnocephalus led to isolation of  two new compounds, 3-O-acetyl-ursolic acid-28-ethyl ester (compound 1) and diosmetin-7-O-α-L-arabinopyransyl (1```→4``)-β-D- glucopyranoside (compound 5) along with  three  known...

Author(s): Wafaa H. B. Hassan, Hanan M. Al-Youssef, Latifa AL-Shammari and Rehab H. Abdallah

Characterization of alkaloid constitution and evaluation of antimicrobial activity of Solanum nigrum using gas chromatography mass spectrometry (GC-MS)

April 2015

In this study, the alkaloid compounds of Solanum nigrum have been evaluated. The chemical compositions of the leaf methanol extract of S. nigrum were investigated using gas chromatography-mass specroscopy (GC-MS). GC-MS analysis of S. nigrum alkaloid leaf methanol extract revealed the existence of the cyclopentasiloxane-decamethyl, L-proline, ethylester, 2-ethyl-1-butanol, methyl ether, cyclopentasiloxane-ocamethyl,...

Author(s): Huda Jasim, Ameera Omran Hussein, Imad Hadi Hameed and Muhanned Abdulhasan Kareem

Phytochemical studies and thin layer chromatography of leaves and flower extracts of Senna siamea lam for possible biomedical applications

March 2015

Senna siamea is a medium-size, evergreen plant which has been utilized as a source of food, medicine and other agricultural purposes in different communities. However, there is dearth of information in regard to its possible biomedicinal uses, especially in Nigeria. Thus the preliminary phytochemical analysis and thin layer chromatography (TLC) separation was done using methanol, n-hexane and ethyl acetate (1:3:1)...

Author(s): Ismail Adamu Hassan, Idris Abdullahi Nasiru, Amina Muhammed Malut, Ibrahim Abdulkadir S. and Audu Sani Ali

Separate and co-administration of Amaranthus spinosus and vitamin C modulates cardiovascular disease risk in high fat diet-fed experimental rats

March 2015

Report indicates that global death from cardiovascular diseases is more than any other diseases hence research is being intensified to provide scientific data in support of the use of traditional plants for its management. In this study, the efficacy of Amaranthus spinosus on lipid disorder occasioned by dietary regimen supplemented with lard and its role in oxidative stress was compared with vitamin C. Forty adult male...

Author(s): Abayomi S. Faponle, Adeleke Atunnise, Bukunola O. Adegbesan, Olugbenga O. Ogunlabi, Kuburat T. Odufuwa and Emmanuel O. Ajani

Herbal medicines use among diabetic patients in Oriental Morocco

February 2015

The aim of this study was to determine the prevalence of herbal medicines (HM) use among diabetic patients in Oriental Morocco, in order to establish an updated inventory of HM consumption and determine the predictive factors of their use in our patients. We conducted a cross-sectional study during three months from March, 2013 to May, 2013 including all diabetic patients consulting at the Department of Endocrinology...

Author(s): Zayneb Alami, Hayat Aynaou, Bouchra Alami, Youssef Hdidou and Hanane Latrech  

Pharmacological properties of Pomaria sandersonii, Pentanisia prunelloides and Alepidea amatymbica extracts using in vitro assays

January 2015

The antimicrobial, anti-inflammatory and free radical scavenging activities of root crude acetone extracts and fractions of different polarities from Pomaria sandersonii (Fabaceae), Pentanisia prunelloides (Rubiaceae) and Alepidea amatymbica (Apiaceae) were determined using in vitro assays. The antioxidant properties of extracts and fractions were assessed by reduction of 2, 2´-azinobis...

Author(s): Muleya, E., , Ahmed, A. S., Sipamla, A. M., Mtunzi, F. M. and Mutatu, W.  

Effect of geographical location and antibacterial activities of essential oils from Ivoirian Chromolaena odorata (L) R. M. King & Robinson (Asteraceae)

September 2014

Essential oil yield and chemical composition of fresh leaves of Chromolaena odorata obtained by hydro-distillation collected from five different sites in Abidjan were investigated. The chemical composition of the essential oil was analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). From each locality, leaves were collected during sunny period to look for some correlation between...

Author(s): Daouda Touré,, Bi Koffi F. P Kouamé, Gustave Bedi, Allico Joseph, Nathalie Guessennd, Raphael Oussou, Jean Claude Chalchat, Mireille Dosso and Felix Tonzibo

Risk of liver damage, reduced serum T3 and TSH, reduced placental and litter birth weights are some of the outcomes of Hybanthus enneaspermus infusion to pregnant rats

June 2014

Hybanthus enneaspermus is used by traditional birth attendants (TBAs) in southwest Nigeria in antenatal care. We examined the effects of oral administration of aqueous leaf extract of H. enneaspermus (HEaq) on liver weight and assay, maternal-thyroid hormones, foetal growth and litters birth weights in Sprague-Dawley (SD) rats. Twelve pregnant SD rats were used for this study. Control group received distilled water...

Author(s): Awobajo F. O., Iranloye B. O., Olatunji-Bello I. I. and Adegoke O. A.

African medicinal plant derived products as therapeutic arsenals against multidrug resistant microorganisms

June 2014

Infectious diseases due to resistant pathogenic strains are rampant and the burden is worsened by the emergence and spread of microorganisms resistant to cheap and effective first-choice drugs. Medicinal plants could be an alternative solution to this and the aim of the present review is to summarize available evidence and knowledge concerning African medicinal plants used to treat multidrug resistant (MDR) bacteria,...

Author(s): Assob Jules Clement Nguedia and Nsagha Dickson Shey

Immunomodulatory activities of methanol extract of the whole aerial part of Phyllantus niruri L.

May 2014

In this study, the effect of methanol extract of whole aerial parts of Phyllantus niruri on some specific and non-specific immune response was investigated. The effects of P. niruri on in vivo leucocyte mobilization, delayed type hypersensitivity (DTHR) response, and humoral antibody (HA) response were determined in rats. Acute toxicity profile of P. niruri was evaluated in mice....

Author(s): C. O. Eze, C. S. Nworu, C. O. Esimone and V. C. Okore

Acute toxicity studies, antioxidant and in vitro antibacterial activities of extract from the barks of Ricinodendron heudoletti (Euphorbiaceae)

May 2014

Many bacteria are involved in infectious diseases. Most of these bacteria become resistant to the most commonly used synthetic drugs. In Cameroon, natural substance seem to be an alternative to this problem. Thus the aim of this research was to investigate the acute toxicity, antioxidant activities and the in vitro antibacterial of the methanol extract of Ricinodendron heudelotii (Euphorbiaceae) against twelve...

Author(s): Victor Alain Oyono, Charles Fokunang, Jean Paul Assam Assam, Steve Voundi, Peguy Tsafack, Emmanuel Tekwu Mouafo, Bonaventure Tchaleu Ngandjui and Véronique Penlap Beng

Antibacterial and antifungal screening of extracts from six medicinal plants collected in Kinshasa-Democratic Republic of Congo against clinical isolate pathogens

April 2014

Results from the in vitro evaluation of the antibacterial and antifungal activities of six plant extracts indicated that the aqueous and the methanol extracts of Acalypha wilkesiana leaves and Ageratum conyzoides leaves exhibited good and efficient antifungal activity against Candida albicans with minimum inhibitory concentration (MIC) of 31.25 µg/ml and minimum fungicidal concentration (MFC) of 62.5 µg/ml)...

Author(s): Cimanga Kanyanga R, Kikweta Munduku C, Tshodi Ehata M, Nsaka Lumpu S, Mbamu Maya B., Manienga, K, Bumoyi, M and Kambu Kabangu O.

Antioxidant effects of curcumin against cadmium chloride-induced oxidative stress in the blood of rats

April 2014

Humans are exposed to a number of toxic elements in the environment. Cadmium, widely used in industry, is a great environmental health problem of both humans and animals. Effects of reactive oxygen species (ROS) generation have been postulated to be major contributors to cadmium-exposure related disease. The aim of this study was to investigate the effect of curcumin on oxidative stress in rats exposed to cadmium....

Author(s): Atef M. M. Attia, Fatma A. A. Ibrahim, Noha A. Abd EL-Latif and Samir W. Aziz

Phytochemical analysis of the methanol leaves extract of Paullinia pinnata linn

February 2014

The aim of this study seeks to investigate the presence of steroids, triterpenes, alkaloids, saponins, tannins, anthraquinones and flavonoids compounds as the possible agent responsible for the medicinal activities of the leaf of the plant Paullinia pinnata and also to carry out phytochemical screening of the dried leaf of the plant, to extract and fractionate the leaf and finally to carry out thin layer chromatography...

Author(s): Yusuf, A. Z., Zakir, A., Shemau, Z., Abdullahi, M. and Halima, S. A.

Phytochemical profiling of phytoconstituents of grape, Jatropha curcas and Neem (Azadirachta indica) extracts

February 2014

This study investigated the phytoconstituents in Neem (seed and flower), Jatropha curcas (stem and root bark) and grape (stem bark and leaves) in some selected solvents. Phytochemical screening revealed the presence of bioactive compound saponin in all the parts of the three plants in water extract only. Saponin was absent in other solvents used (ethanol, ethyl acetate, propan-2-ol, methanol, n-butanol and acetone)....

Author(s): Olabinri B. M., Adepoju E. A., Zainab A. A. and Ahmed A. A.

Antitrypanosomal activity of Aristolochia ringens against Trypanosoma congolense infection in mice

January 2014

The methanolic extract of Aristolochia ringens whole plant, commonly used in the traditional treatment of various diseases in humans and animal by some phytotherapist in Nigeria, was evaluated for anti-trypanosomal efficacy in mice infected with Trypanosoma congolense. Following three days dose intra-peritoneal administration, the extract produced anti-trypanosomal effect at the three dosage levels of the four tested...

Author(s): Osho, I. B. and Lajide L.

Antidiabetic potential of liquid-liquid partition fractions of ethanolic seed extract of Corchorus olitorious

January 2014

The Corchorus olitorius seeds were pulverized (grounded) to powder. The powdered seed (200 g) was extracted with 500 ml of ethanol (99.9%) within a period of 24 h and the procedure repeated 3 times using the same powdered extract. Extraction and fractionation were carried out with some modification in the choice of primary solvent (water) and partitioning (separating) solvents (hexane, chloroform, ethyl acetate and...

Author(s): Maxwell Osaronowen Egua, Emmanuel Udo Etuk, Shaibu Oricha Bello and Sanusi Wara Hassan

In vitro potential anthelmintic activity of bulbils of Dioscorea bulbifera L. on earthworms and liverflukes

December 2013

Ethnobotanical information from Nigeria specifies the usage of Dioscorea bulbifera L. (Dioscoreaceae) in treatment of parasitic diseases in human and thus, could be of value in preventing the development of resistance to common synthetic anthelmintics. The present study was designed to evaluate the in vitro anthelmintic activity of methanolic extracts of the flesh and peel of the bulbils of D. bulbifera, on Fasciola...

Author(s): Adedapo Adedayo Adeniran and Mubo Adeola Sonibare

Quantitative phytochemical and elemental analysis of Guiera senegalensis leaf extract

December 2013

Guiera senegalensis is a shrub found in the savannah region of west and central Africa that is widely used in traditional medicine for the remedy of many ailments/diseases. In this study, some of the phytochemicals and elements present in its leaves were quantified. Alkaloids content was found to be 21.98 g/100 g, saponins 0.28 g/100 g and tannins 0.40 g/100 g. The results showed that alkaloids content is high while...

Author(s): Mohammed, S. Y.

In vivo and in vitro antibacterial activities of Momordica charantia on Salmonella typhi and its effect on liver function in typhoid-infected rats

November 2013

Typhoid fever is a disease prevalent in the tropics. In spite of the availability of various therapies, treatment of patients with the disease has been quite challenging in the face of resistance to drugs used. Momordica charantia has been used locally to treat typhoid. This study investigated the antimicrobial potency of methanolic extract of M. charantia leaves on Salmonella typhi in male albino rats (Sprague dawley)...

Author(s): Adeyi, A. O., Jinadu, A. M., Arojojoye, O. A., Alao, O. O., Ighodaro, O. M. and Adeyi, O. E.

Hepatoprotective effects of natural Calculus Bovis against diethylnitrosamine induced hepatic injury in rats

November 2013

Natural Calculus Bovis (NCB) is an important Chinese medical material commonly referred to as pigment gallstones of cows, which has been applied in many effective traditionally preparations of Chinese medicine for many years. The purpose of the study was to investigate effects of NCB on diethylnitrosamine induced hepatic injury in rats. Hepatoprotective and antioxidant effect of NCB on liver injury were also analyzed....

Author(s): Tien-Chun Wan, Chih-Ming Chen and Liang-Chuan Lin

Medicinal importance of genus Origanum: A review

October 2013

Genus Origanum is important medicinally as it has antimicrobial, antifungal, antioxidant, antibacterial, antithrombin, antimutagenic, angiogenic, antiparasetic and antihyperglycaemic activities. Phytochemical investigations of the species of this genus have resulted in the extraction of a number of important bioactive compounds. This emphasizes on the need of extensive study for reporting the additional...

Author(s): Shayista Chishti, Zahoor A. Kaloo and Phalestine Sultan

Antimicrobial effect of Microdacyn 60, OxOral, and sodium hypochlorite 5.25% in anaerobic bacteria

October 2013

Irrigants have traditionally been used in the root canal. Sodium hypochlorite (NaOCl) is the most commonly used solution, because of its advantages; however, it is known to be toxic to periradicular tissues and can cause necrosis of support tissues and edema. The objective of this study is to compare the antimicrobial effect of Microdacyn 60®, OxOral®, and NaOCl 5.25% against Streptococcus sobrinus,...

Author(s): Elvia Denisse Mena-Mendivil, Jorge Jaime Flores-Treviño, Idalia Rodríguez-Delgado, Myriam A. de la Garza-Ramos, Hilda H. Torre-Martínez and Gustavo Israel Martínez- González

Evaluation of anti-acne activity of hydroalcoholic extract of Punica granatum Linn.

September 2013

Nature always stands as a golden mark to exemplify the outstanding phenomena of symbiosis. Acne vulgaris is an extremely common disorder affecting many adolescents and adults throughout their lifetimes. The pathogenesis of acne is multifactorial and is thought to involve excess sebum, follicular hyperkeratinization, bacterial colonization, and inflammation. Pomegranate, Punica granatum Linn....

Author(s): Revan S. Karodi, Mahendrakumar C. B.  and Kiran Bhise

Ethnobotanical survey of plants used in the management of fertility and preliminary phytochemical evaluation of Abelmoschus esculentus (L.) Moench

September 2013

The rise and fall in fertility level remain a serious concern in economic planning nations. In spite of concerted efforts of governmental and non-governmental organization to control birth through campaign and provision of safe sex devices, yet not much success has been recorded. There is dearth of information on plants traditionally used for fertility regulation in literature. In this study an ethnobotanical survey of...

Author(s): J. S. Ashidi, E. A. Olaosho and A. E. Ayodele

Evaluation of phytochemical and pharmacological properties of Mikania cordata (Asteraceae) leaves

September 2013

The ethanol extract of the dried leaves of Mikania cordata (Family-Asteraceae) was investigated for its possible bioactive chemical groups and antinociceptive, cytotoxic and antibacterial activities in animal models. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 125 and 250 mg/kg body weight (p<0.001) comparable to the standard drug...

Author(s): Abdullah Al Nayeem, Amina Khatun, Md. Shafiur Rahman and Mahmudur Rahman

Drying characteristics of Safed Musli (Chlorophytum borivilianum) and its effect on colour and saponin content

August 2013

An experiment was carried out to adjudge the effect of different drying techniques of post harvest on colour and saponin content of Safed Musli (Chlorophytum borivilianum), a medicinal plant belonging to the family Liliaceae, has been traditionally used as adaptogenic drug. The present study was done on drying of fresh Safed Musli root in different condition like: shade, sun, solar and cabinet dryer. The moisture...

Author(s): Ravi Agrawal, A. Upadhyay and Preeti Sagar Nayak

Phytochemical properties and effect of aqueous extract of Jatropha caucus root bark on some bacterial isolates

August 2013

Phytochemical properties and effect of aqueous extract of Jatropha caucus root bark on some bacteria isolates was investigated. The root bark extract revealed the presence of carbohydrates, alkaloids, flavonoids, saponins, cardiac glycosides and terpenes/steroids. The extract applied in graded concentrations of 200, 400 and 600 mg/ml inhibited the multiplication of Staphylococcus...

Author(s): M. S. Auwal, A. L. Fatima, A. Shuaibu, A. M. Ismaila, A. S. Kyari, A. B. Thaluvwa and A. B. Njobdi

Microscopical and physicochemical studies of Indigofera barberi (Fabaceae) stem

August 2013

The present study mainly focuses on the establishment of pharmacognostical standards ofIndigofera barberi stem. I. barberi is a small diaceous shrub which belongs to the family Fabaceae and is distributed in India. The whole plant is medicinally reported or claimed to cure several diseases in traditional system of medicine folklore in particularl. This study aimed for the pharmacognostic study of the stem has...

Author(s): T. Rajeshwar, T. Yadagiri Rao, K. N. V. Rao and S. Sandhya

Evaluation of retinoblastoma (Rb) and protein-53 (p53) gene expression levels in breast cancer cell lines (MCF-7) induced with some selected cytotoxic plants

July 2013

Many Nigerian plants have been hypothesized to have anticancer potentials. However, not many of them have been subjected to acceptable scientific evaluation for their potential anticancer effects. In this study, six of such plants were selected to evaluate the effects of their crude, hexane, chloroform, ethylacetate, detanninfied and tannin fractions for brine shrimp lethality assay and the most cytotoxic fractions of...

Author(s): Samuel Titilola Aderonke, James Ayorinde Babatunde, Oshodi Temitope Adesola, Odii Uchennaya Okereke, Chidume Innocent, Makinde Oluwaseun Elisha, Oguntoye Lanre Abolaji and Magbagbeola Olubunmi Abiola

Pharmacognostic and hypoglycemic studies of Achyranthus aspera L.

July 2013

In the present study, the ethanolic extract of Achyranthus aspera L. Leaves (EEA) were investigated for their pharmacognostic characteristics and hypoglycemic effects. The pharmacognosy of the plant was carried out using microscopic and macroscopic tools. Macroscopic studies revealed that the leaves were cauline, ramel, opposite, exstipulate, simple, sub-sessile, ovate, entire, acute, unicostate, reticulate,...

Author(s): Ishtiaq Ahmad, Muhammad Ibrar, Barkatullah, Naveed Muhammad, Zahir Muhammad and Niaz Ali

Nitric oxide-dependent vasodilation and intracellular Ca2+ concentration increase induced by 6,8-dihydroxy-4’-methoxyflavone in rat aorta

July 2013

In this study, we attempted to evaluate the role of endothelium-derived hyperpolarizing factor (EDHF) in the vasorelaxant response induced by 6,8-Dihydroxy-4’-methoxyflavone (DMF) in isolated rat aorta rings by using functional and biochemical approaches. Thoracic aortic rings were isolated and suspended in organ baths, and the effects of DMF were studied by means of isometric tension recording...

Author(s): Fidèle Ntchapda, Emmanuel Talla, Bonaventure Christian Obono, Bernard Dabolé, Daniele Guido, Francesco Moccia, Franco Tanzi, Joseph Mbafor Tanyiand Théophile Dimo

In silico docking analysis of constituents of Zingiber officinale as antidepressant

June 2013

Depression is among the leading causes of disability worldwide and its global burden seems to further increase in the future. In the present study, in silico approach was used to assess the use of constituents of Zingiber officinale as potential agents that could act as antidepressant agents. Docking studies of Gingerol and Shogoal were carried out using Argus lab 4.0.1. Analysis of the results of...

Author(s): Sibi P. Ittiyavirah and Meera Paul

Evaluation of analgesic, antipyretic and anti-inflammatory effects of methanol extract of traditional herbal medicine using rodents

June 2013

The analgesic, antipyretic and anti-inflammatory effects of methanol extract of botanical medicine prepared by taking equal amounts of dried stems of Tinospora cordifolia Willd, fruits of Emblica officinalis Gaertn and rhizomes of Cyperus rotundus Linn were evaluated using standard methods. These botanicals have been traditionally used in Indian system of medicine for treatment of fever,...

Author(s): Mradu Gupta, Dalia Banerjee and Arup Mukherjee

Endocrinological and metabolic effects of a polyherbal decoction of five Nigerian folkloric herbs on haloperidol induced hyperprolactinemia

June 2013

Hyperprolactinemia is a major cause of infertility, and herbal remedies have been employed locally for treatment. This study was therefore designed to investigate the effects of a poly herbal mixture consisting of Bambusa vulgaris, Momordica charantia, Rauwolfia vomitoria, Ficus sur, and Clerodendrum capitatum on the reproductive hormones and metabolic parameters of haloperidol-induced...

Author(s): Samuel, T. A., Okonkwo, C. L., Ezeazuka, S. K. and Ekpoiba, A. J.

Acetyl and buteryl cholinesterase inhibitory effect of Peltophorum pterocarpum (DC) Backer ex K. Heyne (family Leguminosae)

May 2013

Peltophorum pterocarpum, family Leguminosae is a tree natural to tropical South-Eastern Asia and was brought to Nigeria by immigrants. It has been used traditionally by the South Western people of the country as memory enhancer and anti-ageing. The present study was done to assess the cholinesterase inhibitory activity of the extracts and fractions of P. pterocarpum using spectrophotometric and thin layer...

Author(s): O. Elufioye Taiwo, M. Obuotor Efere, M. Agbedahunsi Joseph and A. Adesanya Saburi

Chemical composition and biological activity of essential oils of Cleopatra mandarin (Citrus reshni) cultivated in Egypt

May 2013

A comparative study of the essential oils isolated from the leaf and fruit peel of Cleopatra mandarin (Citrus reshni) was carried out using gas liquid chromatography (GLC) and GLC/mass analysis (MS). Over 140 components were observed in GLC/MS, of which 123 could be identified. 112 compounds were quantitatively analyzed in the leaf oil with linalool as a major component. The total identified components in the fruit peel...

Author(s): Dalia I. Hamdan, Rehab H. Abdulla, Maged E. Mohamed and Assem M. El-Shazly

Biochemical effects of leaf extracts of Gongronema latifolium and selenium supplementation in alloxan induced diabetic rats

May 2013

This study evaluated the effect of selenium and extracts of Gongronema latifolium on some biochemical parameters in alloxan-induced diabetic rats. Forty male albino rats equally divided into eight experimental groups were used. Two groups served as normal and diabetic control and received placebo treatment. Four diabetic test groups were treated with G. latifolium extract, glibenclamide, combination...

Author(s): E. E. J. Iweala, F. O Uhegbu and O. A. Adesanoye

Systematic pharmacognostical, phytochemical and pharmacological review on an ethno medicinal plant, Basella alba L.

April 2013

The ethno medicinal plant Basella alba belongs to the family Basellaceae, and commonly known as malabar spinach, indian spinach, ceylon spinach and vine spinach. Although it has been reported in ancient systems of medicine, it did not gain much importance and has always remained controversial. It has been found to be a good source of calcium, iron, vitamin A and vitamin C. In the Indian system of medicine, the...

Author(s): Shankul Kumar, A. K. Prasad, S. V. Iyer and S. K. Vaidya

Pharmacognostic, larvicidal and phytotoxic profile of Coleus forskohlii and Rosmarinus officinalis

April 2013

This study was performed to conduct the pharmacognostic study of Coleus forskohlii Linn. and Rosmarinus officinalis and find larvicidal and phytotoxic effects of these plants. The pharmacognostic parameters for both plants were set out using macroscopic and microscopic methods and the larvicidal and phytotoxic potential was determined using recommended methods. Various pharmacognostic parameters such...

Author(s): Saeed Ullah, Muhammad Ibrar, Barkatullah, Naveed Muhammad and Roohullah

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